Published in Birth Defects Res A Clin Mol Teratol on April 01, 2010
Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreERT2; Ihhfl/fl mice. Arthritis Res Ther (2014) 1.01
Disrupting hedgehog and WNT signaling interactions promotes cleft lip pathogenesis. J Clin Invest (2014) 0.99
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Definition of critical periods for Hedgehog pathway antagonist-induced holoprosencephaly, cleft lip, and cleft palate. PLoS One (2015) 0.87
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Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. PLoS One (2014) 0.84
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Pai syndrome: median cleft lip, corpus callosum lipoma, and fibroepithelial skin tag. Eplasty (2014) 0.79
Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling. Mol Endocrinol (2014) 0.76
Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate. Pediatr Res (2012) 0.76
Additional Risk Minimisation Measures for Medicinal Products in the European Union: A Review of the Implementation and Effectiveness of Measures in the United Kingdom by One Marketing Authorisation Holder. Pharmaceut Med (2017) 0.75
Identification and Validation of Novel Hedgehog-Responsive Enhancers Predicted by Computational Analysis of Ci/Gli Binding Site Density. PLoS One (2015) 0.75
The association study of nonsyndromic cleft lip with or without cleft palate identified risk variants of the GLI3 gene in a Chinese population. J Genet (2017) 0.75
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Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev (2002) 8.56
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Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci U S A (2003) 2.25
Molecular interactions coordinating the development of the forebrain and face. Dev Biol (2005) 2.12
Holoprosencephaly: clinical, anatomic, and molecular dimensions. Birth Defects Res A Clin Mol Teratol (2006) 2.11
Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol (2004) 2.01
The mutational spectrum of the sonic hedgehog gene in holoprosencephaly: SHH mutations cause a significant proportion of autosomal dominant holoprosencephaly. Hum Mol Genet (1999) 2.00
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Unraveling human cleft lip and palate research. J Dent Res (2008) 1.44
Mouse genetic models of cleft lip with or without cleft palate. Birth Defects Res A Clin Mol Teratol (2008) 1.41
Sequence of developmental alterations following acute ethanol exposure in mice: craniofacial features of the fetal alcohol syndrome. Am J Anat (1983) 1.40
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A (2005) 1.40
Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc Natl Acad Sci U S A (2002) 1.37
Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8. Alcohol Clin Exp Res (2009) 1.35
Fetal alcohol exposure impairs Hedgehog cholesterol modification and signaling. Lab Invest (2007) 1.32
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The etiopathogenesis of cleft lip and cleft palate: usefulness and caveats of mouse models. Curr Top Dev Biol (2008) 1.27
Frequency of holoprosencephaly in the International Clearinghouse Birth Defects Surveillance Systems: searching for population variations. Birth Defects Res A Clin Mol Teratol (2008) 1.18
Expression patterns of Hedgehog signalling pathway members during mouse palate development. Gene Expr Patterns (2005) 1.14
Murine models of holoprosencephaly. Curr Top Dev Biol (2008) 1.10
Cognitive dysfunction in adult males with non-syndromic clefts of the lip and/or palate. Neuropsychologia (2002) 1.10
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Mouse Shh is required for prechordal plate maintenance during brain and craniofacial morphogenesis. Dev Biol (2008) 1.04
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Hindbrain and cranial nerve dysmorphogenesis result from acute maternal ethanol administration. Dev Neurosci (2002) 0.99
The multidisciplinary evaluation and management of cleft lip and palate. South Med J (2006) 0.98
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Phorbol esters inhibit the Hedgehog signalling pathway downstream of Suppressor of Fused, but upstream of Gli. Oncogene (2007) 0.94
Cleft lip and palate: association with other congenital malformations. J Clin Pediatr Dent (2009) 0.93
The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly. Cell Mol Life Sci (2000) 0.92
Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling. Toxicol Sci (2007) 0.87
An investigation of the relationship between associated congenital malformations and the mental and psychomotor development of children with clefts. Cleft Palate Craniofac J (2003) 0.87
Cyclopamine-induced holoprosencephaly and associated craniofacial malformations in the golden hamster: anatomic and molecular events. Pediatr Dev Pathol (1999) 0.87
Olfactory deficits in boys with cleft palate. Pediatrics (1988) 0.83
Gene-environment interactions in rare diseases that include common birth defects. Birth Defects Res A Clin Mol Teratol (2005) 0.82
Incidence of neurological soft signs in children with isolated cleft of the lip or palate. Percept Mot Skills (2008) 0.79
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A comparative study of craniofacial growth during secondary palate development in four strains of mice. J Craniofac Genet Dev Biol (1982) 0.77
Metopic suture in fetuses with holoprosencephaly at 11 + 0 to 13 + 6 weeks of gestation. Ultrasound Obstet Gynecol (2006) 0.76
Width of the craniofacial complex during formation of the secondary palate. Cleft Palate J (1971) 0.76
Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell (2005) 3.43
The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell (2007) 3.00
Hedgehog signaling promotes prostate xenograft tumor growth. Endocrinology (2004) 2.47
Drosophila Dpp morphogen movement is independent of dynamin-mediated endocytosis but regulated by the glypican members of heparan sulfate proteoglycans. Cell (2004) 2.28
Axon regeneration pathways identified by systematic genetic screening in C. elegans. Neuron (2011) 1.78
Novel role for the orphan nuclear receptor Dax1 in embryogenesis, different from steroidogenesis. Mol Genet Metab (2006) 1.77
Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc. Development (2005) 1.70
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling. Exp Cell Res (2006) 1.59
cRGD-functionalized, DOX-conjugated, and ⁶⁴Cu-labeled superparamagnetic iron oxide nanoparticles for targeted anticancer drug delivery and PET/MR imaging. Biomaterials (2011) 1.56
Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation. Dev Biol (2002) 1.54
Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. Development (2002) 1.49
Concern Concomitant targeting of multiple key transcription factors effectively disrupts cancer stem cells enriched in side population of human pancreatic cancer cells. PLoS One (2013) 1.49
Protective role of supplement with foreign Bifidobacterium and Lactobacillus in experimental hepatic ischemia-reperfusion injury. J Gastroenterol Hepatol (2006) 1.48
Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse. Toxicol Sci (2008) 1.46
Differential stage-dependent regulation of prostatic epithelial morphogenesis by Hedgehog signaling. Dev Biol (2013) 1.45
Nrf2-mediated transcriptional induction of antioxidant response in mouse embryos exposed to ethanol in vivo: implications for the prevention of fetal alcohol spectrum disorders. Antioxid Redox Signal (2008) 1.38
Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 8. Alcohol Clin Exp Res (2009) 1.35
Reprogramming of genetic networks during initiation of the Fetal Alcohol Syndrome. Dev Dyn (2007) 1.34
Inactivation of Apc in the mouse prostate causes prostate carcinoma. Cancer Res (2007) 1.33
Magnetic resonance microscopy defines ethanol-induced brain abnormalities in prenatal mice: effects of acute insult on gestational day 7. Alcohol Clin Exp Res (2009) 1.32
Functional compensation in Hedgehog signaling during mouse prostate development. Dev Biol (2006) 1.29
Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence. J Biol Chem (2002) 1.29
Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol (2007) 1.26
Models of inflammation of the lower urinary tract. Neurourol Urodyn (2011) 1.25
Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity. Proc Natl Acad Sci U S A (2003) 1.23
Blockade of NGF and trk receptors inhibits increased peripheral mechanical sensitivity accompanying cystitis in rats. Am J Physiol Regul Integr Comp Physiol (2008) 1.21
Lack of demonstrable autocrine hedgehog signaling in human prostate cancer cell lines. J Urol (2007) 1.20
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal (2011) 1.20
Polypropylene mesh tape for stress urinary incontinence: complications of urethral erosion and outlet obstruction. J Urol (2002) 1.18
Maternal oral intake mouse model for fetal alcohol spectrum disorders: ocular defects as a measure of effect. Alcohol Clin Exp Res (2006) 1.18
Impact of bacteremia on the pathogenesis of experimental pneumococcal meningitis. J Infect Dis (2008) 1.18
Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent. PLoS One (2012) 1.17
Chronic bacterial infection and inflammation incite reactive hyperplasia in a mouse model of chronic prostatitis. Prostate (2007) 1.17
Acute bacterial inflammation of the mouse prostate. Prostate (2011) 1.16
Abnormal cortical thickness alterations in fetal alcohol spectrum disorders and their relationships with facial dysmorphology. Cereb Cortex (2011) 1.15
Anchorage-independent culture maintains prostate stem cells. Dev Biol (2007) 1.15
Isolation and characterization of an immortalized mouse urogenital sinus mesenchyme cell line. Prostate (2006) 1.14
Sonic hedgehog-responsive genes in the fetal prostate. J Biol Chem (2008) 1.11
Depleting gene activities in early Drosophila embryos with the "maternal-Gal4-shRNA" system. Genetics (2012) 1.10
Retinoic acid induces prostatic bud formation. Dev Dyn (2008) 1.09
H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1. J Biol Chem (2003) 1.09
IL-1 induces IGF-dependent epithelial proliferation in prostate development and reactive hyperplasia. Sci Signal (2009) 1.09
Double CO(2) fixation in photosynthesis-fermentation model enhances algal lipid synthesis for biodiesel production. Bioresour Technol (2009) 1.08
Multifunctional SPIO/DOX-loaded wormlike polymer vesicles for cancer therapy and MR imaging. Biomaterials (2010) 1.07
Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development. Dev Dyn (2005) 1.07
Peptide-mediated protection from ethanol-induced neural tube defects. Dev Neurosci (2005) 1.07
Historical records of airborne polycyclic aromatic hydrocarbons by analyzing dated corks of the bark pocket in a Longpetiole Beech tree. Environ Sci Technol (2004) 1.07
Magnetic resonance microscopy-based analyses of the brains of normal and ethanol-exposed fetal mice. Birth Defects Res A Clin Mol Teratol (2010) 1.06
Regional brain volume reductions relate to facial dysmorphology and neurocognitive function in fetal alcohol spectrum disorders. Hum Brain Mapp (2011) 1.05
Hedgehog signaling in the prostate. J Urol (2007) 1.04
Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines. BMC Cell Biol (2008) 1.04
Multifunctional stable and pH-responsive polymer vesicles formed by heterofunctional triblock copolymer for targeted anticancer drug delivery and ultrasensitive MR imaging. ACS Nano (2010) 1.02
A selective cysteinyl leukotriene receptor 2 antagonist blocks myocardial ischemia/reperfusion injury and vascular permeability in mice. J Pharmacol Exp Ther (2011) 1.02
The expression of microRNA-375 in plasma and tissue is matched in human colorectal cancer. BMC Cancer (2014) 1.02
Protection from ethanol-induced limb malformations by the superoxide dismutase/catalase mimetic, EUK-134. FASEB J (2004) 1.02
Callosal thickness reductions relate to facial dysmorphology in fetal alcohol spectrum disorders. Alcohol Clin Exp Res (2011) 1.00
Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder. Neuropsychol Rev (2011) 0.99
Hedgehog pathway activity in the LADY prostate tumor model. Mol Cancer (2007) 0.99
Hindbrain and cranial nerve dysmorphogenesis result from acute maternal ethanol administration. Dev Neurosci (2002) 0.99
The role of NOX enzymes in ethanol-induced oxidative stress and apoptosis in mouse embryos. Toxicol Lett (2009) 0.98
Induction of the Nrf2-driven antioxidant response by tert-butylhydroquinone prevents ethanol-induced apoptosis in cranial neural crest cells. Biochem Pharmacol (2010) 0.98
Role of interleukins, IGF and stem cells in BPH. Differentiation (2011) 0.97
Genesis of teratogen-induced holoprosencephaly in mice. Am J Med Genet C Semin Med Genet (2010) 0.97
Intertwined nanocarbon and manganese oxide hybrid foam for high-energy supercapacitors. Small (2013) 0.97
Acute acrolein-induced cystitis in mice. BJU Int (2007) 0.97
Hedgehog signaling in myofibroblasts directly promotes prostate tumor cell growth. Integr Biol (Camb) (2012) 0.97
Oil accumulation mechanisms of the oleaginous microalga Chlorella protothecoides revealed through its genome, transcriptomes, and proteomes. BMC Genomics (2014) 0.97
Paracrine sonic hedgehog signalling by prostate cancer cells induces osteoblast differentiation. Mol Cancer (2009) 0.95
Detection of dental fluorosis-associated quantitative trait Loci on mouse chromosomes 2 and 11. Cells Tissues Organs (2008) 0.94
Hydrocephalus induces dynamic spatiotemporal regulation of aquaporin-4 expression in the rat brain. Cerebrospinal Fluid Res (2010) 0.94
Effect of lanthanide ions on dynamic nuclear polarization enhancement and liquid-state T1 relaxation. Magn Reson Med (2012) 0.93
Agrin function associated with ocular development is a target of ethanol exposure in embryonic zebrafish. Birth Defects Res A Clin Mol Teratol (2011) 0.93
Ventromedian forebrain dysgenesis follows early prenatal ethanol exposure in mice. Neurotoxicol Teratol (2010) 0.93
Chronic neurological deficits in mice after perinatal hypoxia and ischemia correlate with hemispheric tissue loss and white matter injury detected by MRI. Dev Neurosci (2011) 0.92
Perturbation of retinoic acid (RA)-mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanol. Birth Defects Res A Clin Mol Teratol (2007) 0.92
Stabilization of Nrf2 protein by D3T provides protection against ethanol-induced apoptosis in PC12 cells. PLoS One (2011) 0.92
TrkB receptor agonist 7, 8 dihydroxyflavone triggers profound gender- dependent neuroprotection in mice after perinatal hypoxia and ischemia. CNS Neurol Disord Drug Targets (2013) 0.91
Concurrent dietary administration of D-SAL and ethanol diminishes ethanol's teratogenesis. Alcohol Clin Exp Res (2007) 0.91
Do pad tests and voiding diaries affect patient willingness to participate in studies of incontinence treatment outcomes? J Urol (2004) 0.91
Study on intestinal absorption and pharmacokinetic characterization of diester diterpenoid alkaloids in precipitation derived from fuzi-gancao herb-pair decoction for its potential interaction mechanism investigation. J Ethnopharmacol (2013) 0.90
Ethanol antagonist peptides: structural specificity without stereospecificity. J Pharmacol Exp Ther (2004) 0.89
In vivo study of experimental pneumococcal meningitis using magnetic resonance imaging. BMC Med Imaging (2008) 0.89
A population of progenitor cells in the basal and intermediate layers of the murine bladder urothelium contributes to urothelial development and regeneration. Dev Dyn (2014) 0.88
Mitogen-activated protein kinase modulates ethanol inhibition of cell adhesion mediated by the L1 neural cell adhesion molecule. Proc Natl Acad Sci U S A (2013) 0.87
Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling. Toxicol Sci (2007) 0.87
The human prostate expresses sonic hedgehog during fetal development. J Urol (2002) 0.87
The Kv2.1 channels mediate neuronal apoptosis induced by excitotoxicity. J Neurochem (2008) 0.87
A ubiquitin E2 variant protein acts in axon termination and synaptogenesis in Caenorhabditis elegans. Genetics (2010) 0.86
Suspended microfluidics. Proc Natl Acad Sci U S A (2013) 0.86
Urologic and plastic surgical collaboration for continent diversion when urine leakage is complicated by pressure ulcers or obesity. J Spinal Cord Med (2003) 0.85
The role of loop F residues in determining differential d-tubocurarine potencies in mouse and human 5-hydroxytryptamine 3A receptors. Biochemistry (2007) 0.85
An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice. Am J Physiol Lung Cell Mol Physiol (2003) 0.84
Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells. BMC Dev Biol (2009) 0.83
Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice. Neurotoxicol Teratol (2013) 0.83