Published in Exp Cell Res on December 14, 2006
G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem (2008) 1.08
Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells. Oncotarget (2015) 0.84
G2E3 attenuating replicative stress. Aging (Albany NY) (2015) 0.75
CRM1 is an export receptor for leucine-rich nuclear export signals. Cell (1997) 18.60
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53. FEBS Lett (1997) 11.19
CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature (1997) 10.49
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (1995) 10.18
SCF and Cullin/Ring H2-based ubiquitin ligases. Annu Rev Cell Dev Biol (1999) 9.54
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (1995) 8.68
Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216. Science (1997) 8.43
Isolation of a human cyclin cDNA: evidence for cyclin mRNA and protein regulation in the cell cycle and for interaction with p34cdc2. Cell (1989) 8.19
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature (1997) 8.04
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein. EMBO J (1998) 4.98
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet (2001) 4.23
Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Genes Dev (1997) 3.83
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem (2003) 3.68
Chfr defines a mitotic stress checkpoint that delays entry into metaphase. Nature (2000) 3.34
A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals. Exp Cell Res (2000) 3.30
The MDM2 RING-finger domain is required to promote p53 nuclear export. Nat Cell Biol (2000) 3.25
Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. J Cell Sci (1994) 3.00
Aurora kinases link chromosome segregation and cell division to cancer susceptibility. Curr Opin Genet Dev (2004) 2.96
Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins. J Cell Biol (2002) 2.51
The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis. EMBO J (2000) 2.50
Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol Cell Biol (2000) 2.34
The differential localization of human cyclins A and B is due to a cytoplasmic retention signal in cyclin B. EMBO J (1994) 2.32
Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes Dev (1996) 2.32
Brca2 is required for embryonic cellular proliferation in the mouse. Genes Dev (1997) 2.20
APC/C and SCF: controlling each other and the cell cycle. Curr Biol (2004) 2.14
Localization of human Cdc25C is regulated both by nuclear export and 14-3-3 protein binding. Oncogene (2001) 1.83
Calreticulin Is a receptor for nuclear export. J Cell Biol (2001) 1.79
Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm. Proc Natl Acad Sci U S A (2000) 1.67
The importance of p53 location: nuclear or cytoplasmic zip code? Drug Resist Updat (2003) 1.61
Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation. Mol Cell Biol (2002) 1.57
A novel transferable nuclear export signal mediates CRM1-independent nucleocytoplasmic shuttling of the human cytomegalovirus transactivator protein pUL69. EMBO J (2001) 1.55
SUMO: of branched proteins and nuclear bodies. Oncogene (2001) 1.52
Structure and function of the nucleolus in the spotlight. Curr Opin Cell Biol (2006) 1.51
A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. J Biol Chem (1999) 1.48
Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells. J Cell Biol (2004) 1.41
DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF. Cancer Res (2005) 1.40
Combinatorial control of cyclin B1 nuclear trafficking through phosphorylation at multiple sites. J Biol Chem (2000) 1.27
DNA damage-induced translocation of the Werner helicase is regulated by acetylation. J Biol Chem (2002) 1.19
The spliceosome: a novel multi-faceted target for therapy. Trends Biochem Sci (2005) 1.18
Requirement of Cks2 for the first metaphase/anaphase transition of mammalian meiosis. Science (2003) 1.18
Nucleolar delocalization of human topoisomerase I in response to topotecan correlates with sumoylation of the protein. J Biol Chem (2001) 1.18
Exportin 7 defines a novel general nuclear export pathway. EMBO J (2004) 1.17
Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells. Oncogene (2005) 1.15
The G(2) DNA damage checkpoint delays expression of genes encoding mitotic regulators. J Biol Chem (2001) 1.13
The promyelocytic leukemia nuclear body: sites of activity? Biochem Cell Biol (2002) 1.07
Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: an overview. Mol Cell Endocrinol (2006) 0.98
A novel nuclear export signal in Smad1 is essential for its signaling activity. J Biol Chem (2003) 0.95
Morbillivirus nucleoprotein possesses a novel nuclear localization signal and a CRM1-independent nuclear export signal. Virology (2006) 0.93
The Wilms' tumour suppressor protein, WT1, undergoes CRM1-independent nucleocytoplasmic shuttling. FEBS Lett (2003) 0.92
Roles of DNA topoisomerases in chromosome segregation and mitosis. Mutat Res (2003) 0.89
NYD-SP6, a novel gene potentially involved in regulating testicular development/spermatogenesis. Biochem Biophys Res Commun (2002) 0.84
Mapping a nucleolar targeting sequence of an RNA binding nucleolar protein, Nop25. Exp Cell Res (2006) 0.82
HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol (2010) 1.75
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
Participation of miR-200 in pulmonary fibrosis. Am J Pathol (2011) 1.43
miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2012) 1.29
miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J (2013) 1.15
G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem (2008) 1.08
Participation of the receptor for advanced glycation end products in efferocytosis. J Immunol (2011) 1.03
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02
Participation of mitochondrial respiratory complex III in neutrophil activation and lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.01
Retracted miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. FASEB J (2012) 0.99
The human long noncoding RNA lnc-IL7R regulates the inflammatory response. Eur J Immunol (2014) 0.97
Extracellular histones inhibit efferocytosis. Mol Med (2012) 0.92
Urokinase-type plasminogen activator inhibits efferocytosis of neutrophils. Am J Respir Crit Care Med (2010) 0.88
Differential activation of RAGE by HMGB1 modulates neutrophil-associated NADPH oxidase activity and bacterial killing. Am J Physiol Cell Physiol (2011) 0.87
Poly(ADP-ribosyl)ation of high mobility group box 1 (HMGB1) protein enhances inhibition of efferocytosis. Mol Med (2012) 0.86
Identification of TLT2 as an engulfment receptor for apoptotic cells. J Immunol (2012) 0.80
Experimental cerebral malaria develops independently of endothelial expression of intercellular adhesion molecule-1 (icam-1). J Biol Chem (2013) 0.79
The receptor for urokinase regulates TLR2 mediated inflammatory responses in neutrophils. PLoS One (2011) 0.77
Metabolic characterization and RNA profiling reveal glycolytic dependence of pro-fibrotic phenotype of alveolar macrophages in lung fibrosis. Am J Physiol Lung Cell Mol Physiol (2017) 0.75
Adult T-cell leukemia/lymphoma in an adolescent presenting with skin lesions. Pediatr Dermatol (2008) 0.75