Published in Am J Physiol Lung Cell Mol Physiol on January 23, 2009
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
Role of dendritic cells and alveolar macrophages in regulating early host defense against pulmonary infection with Cryptococcus neoformans. Infect Immun (2009) 1.26
HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6. PLoS Pathog (2011) 1.26
HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol (2013) 1.17
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death. Cell Death Differ (2012) 1.01
GSK3β-dependent inhibition of AMPK potentiates activation of neutrophils and macrophages and enhances severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2014) 0.91
Classical ROS-dependent and early/rapid ROS-independent release of Neutrophil Extracellular Traps triggered by Leishmania parasites. Sci Rep (2015) 0.90
Energy crisis: the role of oxidative phosphorylation in acute inflammation and sepsis. Biochim Biophys Acta (2014) 0.89
Human resistin promotes neutrophil proinflammatory activation and neutrophil extracellular trap formation and increases severity of acute lung injury. J Immunol (2014) 0.89
Modulation of SCF beta-TrCP-dependent I kappaB alpha ubiquitination by hydrogen peroxide. J Biol Chem (2009) 0.88
Inhibition of neutrophil apoptosis by PAI-1. Am J Physiol Lung Cell Mol Physiol (2011) 0.87
Mitochondrial-derived reactive oxygen species play a vital role in the salicylic acid signaling pathway in Arabidopsis thaliana. PLoS One (2015) 0.86
Reactive oxygen species in unstimulated hemocytes of the pacific oyster Crassostrea gigas: a mitochondrial involvement. PLoS One (2012) 0.85
A Metabolic Shift toward Pentose Phosphate Pathway Is Necessary for Amyloid Fibril- and Phorbol 12-Myristate 13-Acetate-induced Neutrophil Extracellular Trap (NET) Formation. J Biol Chem (2015) 0.79
Prognostic significance of ubiquinol-cytochrome c reductase hinge protein expression in patients with clear cell renal cell carcinoma. Am J Cancer Res (2016) 0.78
Myeloid nuclear differentiation antigen, neutrophil apoptosis and sepsis. Front Immunol (2012) 0.77
Mitochondrial Dysfunction and Immune Cell Metabolism in Sepsis. Infect Chemother (2017) 0.75
Mitochondria and apoptosis. Science (1998) 23.41
Missing pieces in the NF-kappaB puzzle. Cell (2002) 17.83
Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol (2005) 8.06
Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc (2007) 6.57
Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem (2003) 5.04
Neutrophils and acute lung injury. Crit Care Med (2003) 4.56
Neutrophils in development of multiple organ failure in sepsis. Lancet (2006) 3.64
Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radic Biol Med (2007) 3.56
Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species. J Biol Chem (2004) 3.00
Assaying mitochondrial respiratory complex activity in mitochondria isolated from human cells and tissues. Methods Cell Biol (2001) 3.00
Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol (2000) 2.58
Dynamic redox control of NF-kappaB through glutaredoxin-regulated S-glutathionylation of inhibitory kappaB kinase beta. Proc Natl Acad Sci U S A (2006) 2.51
Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I). J Biol Chem (2004) 2.42
Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am J Physiol Heart Circ Physiol (2007) 2.24
The cytochrome bc1 complex: function in the context of structure. Annu Rev Physiol (2004) 2.22
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15
Role of oxidants in NF-kappa B activation and TNF-alpha gene transcription induced by hypoxia and endotoxin. J Immunol (2000) 2.14
Methodology for the measurement of mucociliary function in the mouse by scintigraphy. J Appl Physiol (1985) (2001) 2.10
Superoxide dismutase and catalase conjugated to polyethylene glycol increases endothelial enzyme activity and oxidant resistance. J Biol Chem (1988) 1.98
The kinetic properties of citrate synthase from rat liver mitochondria. Biochem J (1969) 1.86
Activation of NF kappa B by the respiratory burst of macrophages. Free Radic Biol Med (1996) 1.79
Mitochondrial function in sepsis: acute phase versus multiple organ failure. Crit Care Med (2007) 1.68
Redox-sensitive kinases of the nuclear factor-kappaB signaling pathway. Antioxid Redox Signal (2006) 1.67
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61
Glutathione, stress responses, and redox signaling in lung inflammation. Antioxid Redox Signal (2005) 1.59
Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury. J Immunol (2001) 1.58
Oxidized LDL induces mitochondrially associated reactive oxygen/nitrogen species formation in endothelial cells. Am J Physiol Heart Circ Physiol (2005) 1.34
Activation of mitogen-activated protein kinases by lysophosphatidylcholine-induced mitochondrial reactive oxygen species generation in endothelial cells. Am J Pathol (2006) 1.33
Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta (1995) 1.33
The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J Immunol (2003) 1.32
Reactive oxygen species production by the mitochondrial respiratory chain in isolated rat hepatocytes and liver mitochondria: studies using myxothiazol. Arch Biochem Biophys (2002) 1.27
Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med (2003) 1.27
Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol (2007) 1.26
Myxothiazol induces H(2)O(2) production from mitochondrial respiratory chain. Biochem Biophys Res Commun (2001) 1.24
Myxothiazol, a new inhibitor of the cytochrome b-c1 segment of th respiratory chain. Biochim Biophys Acta (1981) 1.21
Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem (2004) 1.19
Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol (2008) 1.18
Modulation of reactive oxygen species in pancreatic cancer. Clin Cancer Res (2007) 1.18
Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Am J Physiol Cell Physiol (2007) 1.14
Reactivity of 2',7'-dichlorodihydrofluorescein and dihydrorhodamine 123 and their oxidized forms toward carbonate, nitrogen dioxide, and hydroxyl radicals. Free Radic Biol Med (2005) 1.14
Participation of superoxide in neutrophil activation and cytokine production. Biochim Biophys Acta (2006) 1.12
Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis. Shock (2007) 1.12
Hydrogen peroxide has opposing effects on IKK activity and IkappaBalpha breakdown in airway epithelial cells. Am J Respir Cell Mol Biol (2001) 1.12
Metformin prevents endotoxin-induced liver injury after partial hepatectomy. J Pharmacol Exp Ther (2005) 1.12
An inhibitor of mitochondrial respiration which binds to cytochrome b and displaces quinone from the iron-sulfur protein of the cytochrome bc1 complex. J Biol Chem (1984) 1.08
Oxidation of Ikappa Balpha at methionine 45 is one cause of taurine chloramine-induced inhibition of NF-kappa B activation. J Biol Chem (2002) 1.07
Myxothiazol, an antibiotic from Myxococcus fulvus (myxobacterales). I. Cultivation, isolation, physico-chemical and biological properties. J Antibiot (Tokyo) (1980) 1.06
Mitochondrial Complex I: structural and functional aspects. Biochim Biophys Acta (2006) 0.98
The ubiquinol/bc1 redox couple regulates mitochondrial oxygen radical formation. Arch Biochem Biophys (2001) 0.97
Modulation of bone marrow-derived neutrophil signaling by H2O2: disparate effects on kinases, NF-kappaB, and cytokine expression. Am J Physiol Cell Physiol (2003) 0.96
Hemorrhage activates NF-kappa B in murine lung mononuclear cells in vivo. Am J Physiol (1996) 0.95
Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury. J Immunol (2006) 0.92
Potent inhibitors of the Qi site of the mitochondrial respiration complex III. J Med Chem (2006) 0.81
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med (2003) 28.68
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Intensive Care Med (2003) 10.39
Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem (2003) 8.34
The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. Crit Care Med (2004) 5.23
High mobility group box 1 protein interacts with multiple Toll-like receptors. Am J Physiol Cell Physiol (2005) 5.04
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
Transfusion-related acute lung injury: definition and review. Crit Care Med (2005) 3.98
Urine IL-18 is an early diagnostic marker for acute kidney injury and predicts mortality in the intensive care unit. J Am Soc Nephrol (2005) 3.38
Involvement of reactive oxygen species in Toll-like receptor 4-dependent activation of NF-kappa B. J Immunol (2004) 2.89
HMGB1 develops enhanced proinflammatory activity by binding to cytokines. J Immunol (2008) 2.80
miR-147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc Natl Acad Sci U S A (2009) 2.74
Activation of gene expression in human neutrophils by high mobility group box 1 protein. Am J Physiol Cell Physiol (2003) 2.50
IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A (2005) 2.46
The passive leg-raising maneuver cannot accurately predict fluid responsiveness in patients with intra-abdominal hypertension. Crit Care Med (2010) 2.26
HMGB1 contributes to the development of acute lung injury after hemorrhage. Am J Physiol Lung Cell Mol Physiol (2005) 2.21
Diagnostic and prognostic implications of endotoxemia in critical illness: results of the MEDIC study. J Infect Dis (2004) 2.17
Activation of AMPK attenuates neutrophil proinflammatory activity and decreases the severity of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 2.15
Improvement of left ventricular relaxation as assessed by tissue Doppler imaging in fluid-responsive critically ill septic patients. Intensive Care Med (2012) 2.11
Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis. Am J Respir Crit Care Med (2006) 2.05
Recombinant human activated protein C reduces human endotoxin-induced pulmonary inflammation via inhibition of neutrophil chemotaxis. Blood (2004) 1.95
Sepsis. Am J Med (2007) 1.93
Severe sepsis and septic shock: review of the literature and emergency department management guidelines. Ann Emerg Med (2006) 1.82
Recombinant human platelet-activating factor acetylhydrolase for treatment of severe sepsis: results of a phase III, multicenter, randomized, double-blind, placebo-controlled, clinical trial. Crit Care Med (2004) 1.80
Effectiveness of medical resident education in mechanical ventilation. Am J Respir Crit Care Med (2002) 1.79
Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77
Antiinflammatory effects of hydrogen peroxide in neutrophil activation and acute lung injury. Am J Respir Crit Care Med (2009) 1.77
LY315920NA/S-5920, a selective inhibitor of group IIA secretory phospholipase A2, fails to improve clinical outcome for patients with severe sepsis. Crit Care Med (2005) 1.77
HMGB1 inhibits macrophage activity in efferocytosis through binding to the alphavbeta3-integrin. Am J Physiol Cell Physiol (2010) 1.75
Extracellular superoxide dismutase haplotypes are associated with acute lung injury and mortality. Am J Respir Crit Care Med (2008) 1.73
Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol (2011) 1.70
HMGB1 is markedly elevated within 6 hours of mechanical trauma in humans. Shock (2009) 1.64
Postoperative ketamine administration decreases morphine consumption in major abdominal surgery: a prospective, randomized, double-blind, controlled study. Anesth Analg (2008) 1.64
Beta-adrenergic agonist therapy as a potential treatment for acute lung injury. Am J Respir Crit Care Med (2006) 1.63
Post-transcriptional regulation of urokinase-type plasminogen activator receptor expression in lipopolysaccharide-induced acute lung injury. Am J Respir Crit Care Med (2008) 1.62
Participation of the urokinase receptor in neutrophil efferocytosis. Blood (2009) 1.62
Potential role of high-mobility group box 1 in cystic fibrosis airway disease. Am J Respir Crit Care Med (2008) 1.62
Mitochondrial respiratory complex I regulates neutrophil activation and severity of lung injury. Am J Respir Crit Care Med (2008) 1.61
A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. Chest (2005) 1.57
Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. Crit Care Med (2003) 1.53
Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem (2010) 1.52
Reducing mortality in sepsis: new directions. Crit Care (2002) 1.52
The decline and fate of an iron-induced subarctic phytoplankton bloom. Nature (2004) 1.50
Genetic polymorphisms and sepsis. Shock (2005) 1.50
The role of leptin in the development of pulmonary neutrophilia in infection and acute lung injury. Crit Care Med (2014) 1.49
MicroRNAs in immune response and macrophage polarization. Arterioscler Thromb Vasc Biol (2013) 1.48
Hemorrhage-induced acute lung injury is TLR-4 dependent. Am J Physiol Regul Integr Comp Physiol (2004) 1.48
ADDRESS (ADministration of DRotrecogin alfa [activated] in Early stage Severe Sepsis) long-term follow-up: one-year safety and efficacy evaluation. Crit Care Med (2007) 1.46
High mobility group protein-1 inhibits phagocytosis of apoptotic neutrophils through binding to phosphatidylserine. J Immunol (2008) 1.45
Participation of miR-200 in pulmonary fibrosis. Am J Pathol (2011) 1.43
Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury. Am J Respir Crit Care Med (2006) 1.42
Diagnosis of central hypovolemia by using passive leg raising. Intensive Care Med (2007) 1.39
Interleukin-1 receptor-associated kinase (IRAK) -1-mediated NF-kappaB activation requires cytosolic and nuclear activity. FASEB J (2008) 1.39
Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med (2005) 1.33
Anti-high-mobility group box chromosomal protein 1 antibodies improve survival of rats with sepsis. World J Surg (2006) 1.30
miR-21 regulates chronic hypoxia-induced pulmonary vascular remodeling. Am J Physiol Lung Cell Mol Physiol (2012) 1.29
The last 100 years of sepsis. Am J Respir Crit Care Med (2005) 1.27
PAI-1 inhibits neutrophil efferocytosis. Proc Natl Acad Sci U S A (2008) 1.27
Early alterations in neutrophil activation are associated with outcome in acute lung injury. Am J Respir Crit Care Med (2003) 1.27
p53 Attenuates lipopolysaccharide-induced NF-kappaB activation and acute lung injury. J Immunol (2009) 1.27
Involvement of vitronectin in lipopolysaccaride-induced acute lung injury. J Immunol (2007) 1.26
MicroRNA let-7c regulates macrophage polarization. J Immunol (2013) 1.23
Intensive insulin therapy in critical illness. Am J Respir Crit Care Med (2005) 1.23
Phosphoinositide 3-kinase and Akt occupy central roles in inflammatory responses of Toll-like receptor 2-stimulated neutrophils. J Immunol (2004) 1.21
Role of extracellular superoxide in neutrophil activation: interactions between xanthine oxidase and TLR4 induce proinflammatory cytokine production. Am J Physiol Cell Physiol (2008) 1.18
AMP-activated protein kinase enhances the phagocytic ability of macrophages and neutrophils. FASEB J (2011) 1.17
HMGB1 promotes neutrophil extracellular trap formation through interactions with Toll-like receptor 4. Am J Physiol Lung Cell Mol Physiol (2013) 1.17
Participation of mammalian target of rapamycin complex 1 in Toll-like receptor 2- and 4-induced neutrophil activation and acute lung injury. Am J Respir Cell Mol Biol (2009) 1.16
miR-145 regulates myofibroblast differentiation and lung fibrosis. FASEB J (2013) 1.15
Exposure to hydrogen peroxide diminishes NF-kappaB activation, IkappaB-alpha degradation, and proteasome activity in neutrophils. Am J Physiol Cell Physiol (2007) 1.14
Enterococci increase the morbidity and mortality associated with severe intra-abdominal infections in elderly patients hospitalized in the intensive care unit. J Antimicrob Chemother (2011) 1.13
Participation of superoxide in neutrophil activation and cytokine production. Biochim Biophys Acta (2006) 1.12
Pharmacokinetics of intravenous and oral levofloxacin in critically ill adults in a medical intensive care unit. Pharmacotherapy (2002) 1.11
Functional and genomic changes induced by alveolar transmigration in human neutrophils. Am J Physiol Lung Cell Mol Physiol (2006) 1.09
Bone transport in the management of posttraumatic bone defects in the lower extremity. J Trauma (2004) 1.09
G2E3 is a dual function ubiquitin ligase required for early embryonic development. J Biol Chem (2008) 1.08
Pharmacokinetics and pharmacodynamics of imipenem during continuous renal replacement therapy in critically ill patients. Antimicrob Agents Chemother (2005) 1.07
Toll-like receptors 2 and 4: initiators of non-septic inflammation in critical care medicine? Intensive Care Med (2010) 1.07
Evidence for extracellular superoxide dismutase as a mediator of hemorrhage-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2003) 1.07
IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res (2002) 1.05
Involvement of PKCalpha/beta in TLR4 and TLR2 dependent activation of NF-kappaB. Cell Signal (2005) 1.05
HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury. Intensive Care Med (2007) 1.04
Participation of the receptor for advanced glycation end products in efferocytosis. J Immunol (2011) 1.03
S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem (2009) 1.02
miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem (2013) 1.02
Toll-like receptor 4 engagement inhibits adenosine 5'-monophosphate-activated protein kinase activation through a high mobility group box 1 protein-dependent mechanism. Mol Med (2012) 1.01
Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase. J Biol Chem (2009) 0.99
Involvement of SHIP in TLR2-induced neutrophil activation and acute lung injury. J Immunol (2005) 0.99
Retracted miR-31 is a negative regulator of fibrogenesis and pulmonary fibrosis. FASEB J (2012) 0.99