Published in J Mol Biol on December 19, 2006
Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J (2011) 1.30
Structure of the yeast SR protein Npl3 and Interaction with mRNA 3'-end processing signals. J Mol Biol (2007) 0.93
ICP27 phosphorylation site mutants are defective in herpes simplex virus 1 replication and gene expression. J Virol (2009) 0.92
ICP27 phosphorylation site mutants display altered functional interactions with cellular export factors Aly/REF and TAP/NXF1 but are able to bind herpes simplex virus 1 RNA. J Virol (2009) 0.90
Identification of the RGG box motif in Shadoo: RNA-binding and signaling roles? Bioinform Biol Insights (2008) 0.81
Specific sequences within arginine-glycine-rich domains affect mRNA-binding protein function. Nucleic Acids Res (2009) 0.79
Interactions affected by arginine methylation in the yeast protein-protein interaction network. Mol Cell Proteomics (2013) 0.79
Peptides modeled on the RGG domain of AUF1/hnRNP-D regulate 3' UTR-dependent gene expression. Int Immunopharmacol (2013) 0.78
SRPK1 and Akt Protein Kinases Phosphorylate the RS Domain of Lamin B Receptor with Distinct Specificity: A Combined Biochemical and In Silico Approach. PLoS One (2016) 0.77
In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1. FEBS Open Bio (2013) 0.75
Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell (2004) 6.92
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J (2004) 3.32
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell (2005) 2.11
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci (2004) 1.89
The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell (2012) 1.83
NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J (2008) 1.81
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Mol Cell (2012) 1.68
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev (2009) 1.65
Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol (2006) 1.59
Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A (2009) 1.56
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proc Natl Acad Sci U S A (2003) 1.55
Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol (2002) 1.53
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem (2005) 1.43
Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell (2005) 1.42
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell (2005) 1.42
Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A (2011) 1.42
Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A (2009) 1.39
The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J Biol Chem (2002) 1.37
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (2009) 1.36
Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol (2008) 1.35
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem (2003) 1.35
Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. J Cell Biol (2011) 1.32
Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J (2011) 1.30
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
The 20S proteasome processes NF-kappaB1 p105 into p50 in a translation-independent manner. EMBO J (2006) 1.27
The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes. Mol Cell (2009) 1.26
The role of the putative catalytic base in the phosphoryl transfer reaction in a protein kinase: first-principles calculations. J Am Chem Soc (2003) 1.26
Ligand-induced global transitions in the catalytic domain of protein kinase A. Proc Natl Acad Sci U S A (2009) 1.25
Enhanced intracellular mobility and nuclear accumulation of DNA plasmids associated with a karyophilic protein. Hum Gene Ther (2005) 1.22
Stabilization of RelB requires multidomain interactions with p100/p52. J Biol Chem (2008) 1.21
The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site. J Biol Chem (2002) 1.20
Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol (2007) 1.19
The specificity of innate immune responses is enforced by repression of interferon response elements by NF-κB p50. Sci Signal (2011) 1.18
Coupled motions in the SH2 and kinase domains of Csk control Src phosphorylation. J Mol Biol (2005) 1.18
PRMT5 dimethylates R30 of the p65 subunit to activate NF-κB. Proc Natl Acad Sci U S A (2013) 1.17
Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2008) 1.17
The IkappaBalpha/NF-kappaB complex has two hot spots, one at either end of the interface. Protein Sci (2008) 1.15
Structural basis for the regulation of protein kinase A by activation loop phosphorylation. J Biol Chem (2012) 1.14
Transcriptional outcome of Wnt-Frizzled signal transduction in inflammation: evolving concepts. J Immunol (2008) 1.13
NF-kappaB p52:RelB heterodimer recognizes two classes of kappaB sites with two distinct modes. EMBO Rep (2008) 1.12
Analysis of the RelA:CBP/p300 interaction reveals its involvement in NF-κB-driven transcription. PLoS Biol (2013) 1.08
Structural basis for peptide binding in protein kinase A. Role of glutamic acid 203 and tyrosine 204 in the peptide-positioning loop. J Biol Chem (2002) 1.08
Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol (2013) 1.08
Coupling phosphoryl transfer and substrate interactions in protein kinases. Biochim Biophys Acta (2005) 1.06
Solvent exposed non-contacting amino acids play a critical role in NF-kappaB/IkappaBalpha complex formation. J Mol Biol (2002) 1.05
Crystal structure of a free kappaB DNA: insights into DNA recognition by transcription factor NF-kappaB. J Mol Biol (2004) 1.04
A novel disulfide bond in the SH2 Domain of the C-terminal Src kinase controls catalytic activity. J Mol Biol (2006) 1.03
Dynamic coupling between the SH2 domain and active site of the COOH terminal Src kinase, Csk. J Mol Biol (2004) 1.02
Proteins at work: a combined small angle X-RAY scattering and theoretical determination of the multiple structures involved on the protein kinase functional landscape. J Biol Chem (2010) 1.02
A structural basis for IκB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol (2013) 1.01
X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites. J Mol Biol (2007) 1.01
A structural guide to proteins of the NF-kappaB signaling module. Cold Spring Harb Perspect Biol (2009) 0.99
The transcriptional specificity of NF-κB dimers is coded within the κB DNA response elements. Cell Rep (2012) 0.99
Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2009) 0.99
Communication pathways between the nucleotide pocket and distal regulatory sites in protein kinases. Acc Chem Res (2004) 0.98
Flexible regions within I{kappa}B{alpha} create the ubiquitin-independent degradation signal. J Biol Chem (2010) 0.97
NF-kappaB RelB forms an intertwined homodimer. Structure (2005) 0.97
Phosphoryl transfer step in the C-terminal Src kinase controls Src recognition. J Biol Chem (2004) 0.96
Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Mol Cell Biol (2004) 0.96
Nucleotide-induced conformational changes in the Saccharomyces cerevisiae SR protein kinase, Sky1p, revealed by X-ray crystallography. Biochemistry (2003) 0.95
Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry (2007) 0.95
Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol (2010) 0.94
p105.Ikappa Bgamma and prototypical Ikappa Bs use a similar mechanism to bind but a different mechanism to regulate the subcellular localization of NF-kappa B. J Biol Chem (2002) 0.93
Role of lysine methylation of NF-κB in differential gene regulation. Proc Natl Acad Sci U S A (2013) 0.92
KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and regulates cytoplasmic retention of IkappaBbeta x NF-kappaB complexes. J Biol Chem (2003) 0.91
Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry (2011) 0.91
SR protein kinase 1 is resilient to inactivation. Structure (2007) 0.90
Deletion of the N-terminus of SF2/ASF permits RS-domain-independent pre-mRNA splicing. PLoS One (2007) 0.90
Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry (2009) 0.90
C6 pyridinium ceramide influences alternative pre-mRNA splicing by inhibiting protein phosphatase-1. Nucleic Acids Res (2011) 0.88
Mechanistic insights into Sky1p, a yeast homologue of the mammalian SR protein kinases. Biochemistry (2002) 0.87
Nucleotide release sequences in the protein kinase SRPK1 accelerate substrate phosphorylation. Biochemistry (2012) 0.87
SRC tail phosphorylation is limited by structural changes in the regulatory tyrosine kinase Csk. J Biol Chem (2006) 0.86
Identifying critical non-catalytic residues that modulate protein kinase A activity. PLoS One (2009) 0.86
Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation reactions. J Biol Chem (2007) 0.86
Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol (2011) 0.85
Identification of functionally distinct regions that mediate biological activity of the protein kinase a homolog Tpk2. J Biol Chem (2007) 0.85
Chemical clamping allows for efficient phosphorylation of the RNA carrier protein Npl3. J Biol Chem (2004) 0.85
Distal loop flexibility of a regulatory domain modulates dynamics and activity of C-terminal SRC kinase (csk). PLoS Comput Biol (2013) 0.84
Probing the nucleotide binding domain of the osmoregulator EnvZ using fluorescent nucleotide derivatives. Biochemistry (2002) 0.84
Novel destabilization of nucleotide binding by the gamma phosphate of ATP in the yeast SR protein kinase Sky1p. Biochemistry (2003) 0.83