Published in J Mol Biol on July 26, 2008
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev (2009) 1.65
Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma (2013) 1.53
Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J (2011) 1.30
Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J (2010) 1.23
Partitioning RS domain phosphorylation in an SR protein through the CLK and SRPK protein kinases. J Mol Biol (2013) 1.08
Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J Mol Biol (2009) 0.99
Mechanism of dephosphorylation of the SR protein ASF/SF2 by protein phosphatase 1. J Mol Biol (2010) 0.94
Applying the brakes to multisite SR protein phosphorylation: substrate-induced effects on the splicing kinase SRPK1. Biochemistry (2011) 0.91
Predicting sequence and structural specificities of RNA binding regions recognized by splicing factor SRSF1. BMC Genomics (2011) 0.90
Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry (2009) 0.90
N-terminus of the protein kinase CLK1 induces SR protein hyperphosphorylation. Biochem J (2014) 0.86
Conserved proline-directed phosphorylation regulates SR protein conformation and splicing function. Biochem J (2015) 0.85
Regulating SR protein phosphorylation through regions outside the kinase domain of SRPK1. J Mol Biol (2011) 0.85
Posttranscriptional Regulation of Splicing Factor SRSF1 and Its Role in Cancer Cell Biology. Biomed Res Int (2015) 0.82
Splicing kinase SRPK1 conforms to the landscape of its SR protein substrate. Biochemistry (2013) 0.79
Recruiting a silent partner for activation of the protein kinase SRPK1. Biochemistry (2014) 0.77
Intra-domain Cross-talk Regulates Serine-arginine Protein Kinase 1-dependent Phosphorylation and Splicing Function of Transformer 2β1. J Biol Chem (2015) 0.76
Important miRs of pathways in different tumor types. PLoS Comput Biol (2013) 0.76
Structural basis for regulation of RNA-binding proteins by phosphorylation. ACS Chem Biol (2015) 0.76
Directional Phosphorylation and Nuclear Transport of the Splicing Factor SRSF1 Is Regulated by an RNA Recognition Motif. J Mol Biol (2016) 0.75
In vitro characterization of the RS motif in N-terminal head domain of goldfish germinal vesicle lamin B3 necessary for phosphorylation of the p34cdc2 target serine by SRPK1. FEBS Open Bio (2013) 0.75
Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem Sci (2000) 10.77
Sorting out the complexity of SR protein functions. RNA (2000) 9.25
Pre-mRNA splicing and human disease. Genes Dev (2003) 9.13
Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell (1993) 8.07
Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature (1994) 6.97
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for pre-mRNA splicing in vitro. Cell (1985) 6.85
The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nat Struct Mol Biol (2007) 6.16
The essential pre-mRNA splicing factor SF2 influences 5' splice site selection by activating proximal sites. Cell (1990) 5.67
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev (1994) 4.50
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell (2001) 4.01
Crystal structure of glycogen synthase kinase 3 beta: structural basis for phosphate-primed substrate specificity and autoinhibition. Cell (2001) 3.93
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell (1996) 3.54
Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins. Mol Cell (2001) 3.34
Unbalanced alternative splicing and its significance in cancer. Bioessays (2006) 3.17
A novel role for shuttling SR proteins in mRNA translation. Genes Dev (2004) 3.02
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. J Cell Biol (1998) 2.69
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci (1994) 2.62
A molecular link between SR protein dephosphorylation and mRNA export. Proc Natl Acad Sci U S A (2004) 2.49
Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors. Mol Cell Biol (1999) 2.36
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell (2005) 2.11
The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol Cell Biol (1999) 2.09
Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors. J Cell Biol (1999) 2.00
Conserved SR protein kinase functions in nuclear import and its action is counteracted by arginine methylation in Saccharomyces cerevisiae. J Cell Biol (2000) 1.96
The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem (1999) 1.90
Ordered multisite protein phosphorylation. Analysis of glycogen synthase kinase 3 action using model peptide substrates. J Biol Chem (1990) 1.88
Transportin-SR2 mediates nuclear import of phosphorylated SR proteins. Proc Natl Acad Sci U S A (2001) 1.80
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Exp Cell Res (1998) 1.63
Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins. J Biol Chem (2004) 1.53
Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem (2005) 1.43
Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell (2005) 1.42
Alternative splicing: a new drug target of the post-genome era. Biochim Biophys Acta (2005) 1.30
Ordered multi-site phosphorylation of the splicing factor ASF/SF2 by SRPK1. J Mol Biol (2007) 1.19
Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model. Proc Natl Acad Sci U S A (2008) 11.86
Regulation of protein kinases; controlling activity through activation segment conformation. Mol Cell (2004) 6.92
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling. Cell (2012) 6.80
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells. Nat Struct Mol Biol (2009) 6.37
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response. Nature (2011) 6.25
Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature (2011) 6.10
Nuclear receptor-induced chromosomal proximity and DNA breaks underlie specific translocations in cancer. Cell (2009) 5.74
Tumor imaging by means of proteolytic activation of cell-penetrating peptides. Proc Natl Acad Sci U S A (2004) 4.95
Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping. Mol Cell (2009) 4.71
Concern Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules. Proc Natl Acad Sci U S A (2008) 4.31
A versatile assay for high-throughput gene expression profiling on universal array matrices. Genome Res (2004) 4.19
Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature (2007) 4.12
ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell (2005) 3.96
Profiling alternative splicing on fiber-optic arrays. Nat Biotechnol (2002) 3.94
The splicing factor SC35 has an active role in transcriptional elongation. Nat Struct Mol Biol (2008) 3.86
Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases. Proc Natl Acad Sci U S A (2007) 3.44
A fourth IkappaB protein within the NF-kappaB signaling module. Cell (2007) 3.34
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers. EMBO J (2004) 3.32
Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. Proc Natl Acad Sci U S A (2013) 2.95
SR proteins in vertical integration of gene expression from transcription to RNA processing to translation. Mol Cell (2009) 2.73
ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS. Proc Natl Acad Sci U S A (2010) 2.65
Timing of plant immune responses by a central circadian regulator. Nature (2011) 2.60
Pre-mRNA splicing: where and when in the nucleus. Trends Cell Biol (2011) 2.54
Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell (2013) 2.43
Functional integration of transcriptional and RNA processing machineries. Curr Opin Cell Biol (2008) 2.38
A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol Cell (2008) 2.29
A dynamic mechanism for AKAP binding to RII isoforms of cAMP-dependent protein kinase. Mol Cell (2006) 2.27
MitoNEET is a uniquely folded 2Fe 2S outer mitochondrial membrane protein stabilized by pioglitazone. Proc Natl Acad Sci U S A (2007) 2.19
Sensitive ChIP-DSL technology reveals an extensive estrogen receptor alpha-binding program on human gene promoters. Proc Natl Acad Sci U S A (2007) 2.17
SR proteins and related factors in alternative splicing. Adv Exp Med Biol (2007) 2.12
Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Res (2006) 2.11
Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol Cell (2005) 2.11
Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis. Mol Cell Biol (2007) 2.04
SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymerase. Cell (2013) 1.97
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci (2004) 1.89
Dilated cardiomyopathy caused by tissue-specific ablation of SC35 in the heart. EMBO J (2004) 1.88
The Akt-SRPK-SR axis constitutes a major pathway in transducing EGF signaling to regulate alternative splicing in the nucleus. Mol Cell (2012) 1.83
NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J (2008) 1.81
Bioinformatic design of A-kinase anchoring protein-in silico: a potent and selective peptide antagonist of type II protein kinase A anchoring. Proc Natl Acad Sci U S A (2003) 1.80
Topological frustration and the folding of interleukin-1 beta. J Mol Biol (2005) 1.77
Processive phosphorylation of alternative splicing factor/splicing factor 2. Proc Natl Acad Sci U S A (2003) 1.75
The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S cluster. J Biol Chem (2007) 1.72
NEMO ensures signaling specificity of the pleiotropic IKKβ by directing its kinase activity toward IκBα. Mol Cell (2012) 1.68
Regulation of SR protein phosphorylation and alternative splicing by modulating kinetic interactions of SRPK1 with molecular chaperones. Genes Dev (2009) 1.65
Control of protein functional dynamics by peptide linkers. Biopolymers (2005) 1.61
Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J Mol Biol (2006) 1.59
Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein. Nat Biotechnol (2009) 1.59
Kinetic control of negative feedback regulators of NF-kappaB/RelA determines their pathogen- and cytokine-receptor signaling specificity. Proc Natl Acad Sci U S A (2009) 1.56
Genome-wide analysis reveals SR protein cooperation and competition in regulated splicing. Mol Cell (2013) 1.56
Phosphorylation reaction in cAPK protein kinase-free energy quantum mechanical/molecular mechanics simulations. J Phys Chem B (2007) 1.55
Crystal structure of NF-kappaB (p50)2 complexed to a high-affinity RNA aptamer. Proc Natl Acad Sci U S A (2003) 1.55
Phosphorylation driven motions in the COOH-terminal Src kinase, CSK, revealed through enhanced hydrogen-deuterium exchange and mass spectrometry (DXMS). J Mol Biol (2002) 1.53
Regulation of splicing by SR proteins and SR protein-specific kinases. Chromosoma (2013) 1.53
Systems-based design of bi-ligand inhibitors of oxidoreductases: filling the chemical proteomic toolbox. Chem Biol (2004) 1.52
SON controls cell-cycle progression by coordinated regulation of RNA splicing. Mol Cell (2011) 1.52
Dephosphorylation-dependent sorting of SR splicing factors during mRNP maturation. Mol Cell (2005) 1.51
Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell (2013) 1.47
A proteome-wide analysis of kinase-substrate network in the DNA damage response. J Biol Chem (2010) 1.46
A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Genes Dev (2005) 1.45
Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J Biol Chem (2005) 1.43
Regulated cellular partitioning of SR protein-specific kinases in mammalian cells. Mol Biol Cell (2005) 1.42
PKR and eIF2alpha: integration of kinase dimerization, activation, and substrate docking. Cell (2005) 1.42
Interaction between the RNA binding domains of Ser-Arg splicing factor 1 and U1-70K snRNP protein determines early spliceosome assembly. Proc Natl Acad Sci U S A (2011) 1.42
Crystal structure of Miner1: The redox-active 2Fe-2S protein causative in Wolfram Syndrome 2. J Mol Biol (2009) 1.41
An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth. J Cell Biol (2006) 1.40
Dynamic changes in protein-protein interaction and protein phosphorylation probed with amine-reactive isotope tag. Mol Cell Proteomics (2005) 1.39
Kinetic enhancement of NF-kappaBxDNA dissociation by IkappaBalpha. Proc Natl Acad Sci U S A (2009) 1.39
Profiling alternatively spliced mRNA isoforms for prostate cancer classification. BMC Bioinformatics (2006) 1.39
Treatment of terminal peritoneal carcinomatosis by a transducible p53-activating peptide. PLoS Biol (2004) 1.38
Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet (2012) 1.37
The kappa B DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J Biol Chem (2002) 1.37
A multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation. Genomics (2011) 1.37
Kinase domain insertions define distinct roles of CLK kinases in SR protein phosphorylation. Structure (2009) 1.36
Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J Mol Biol (2008) 1.35
X-ray crystal structure of an IkappaBbeta x NF-kappaB p65 homodimer complex. J Biol Chem (2003) 1.35
Extracting function from a beta-trefoil folding motif. Proc Natl Acad Sci U S A (2008) 1.34
Attenuation of yeast UPR is essential for survival and is mediated by IRE1 kinase. J Cell Biol (2011) 1.32
Distinct interaction modes of an AKAP bound to two regulatory subunit isoforms of protein kinase A revealed by amide hydrogen/deuterium exchange. Protein Sci (2005) 1.32
Facile transfer of [2Fe-2S] clusters from the diabetes drug target mitoNEET to an apo-acceptor protein. Proc Natl Acad Sci U S A (2011) 1.31
Phosphorylation mechanism and structure of serine-arginine protein kinases. FEBS J (2011) 1.30
Contribution of non-catalytic core residues to activity and regulation in protein kinase A. J Biol Chem (2009) 1.29
Characteristics and regulatory elements defining constitutive splicing and different modes of alternative splicing in human and mouse. RNA (2005) 1.28
Retracted Nuclear receptor-enhanced transcription requires motor- and LSD1-dependent gene networking in interchromatin granules. Cell (2008) 1.27