Published in J Biol Chem on June 25, 1979
N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol (2007) 4.63
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc Natl Acad Sci U S A (1999) 2.76
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A (1997) 2.12
Role of astrocytes in cerebrovascular regulation. J Appl Physiol (1985) (2006) 1.82
Mechanisms, diagnosis and management of hepatic encephalopathy. Nat Rev Gastroenterol Hepatol (2010) 1.58
Decreased astrocytic thrombospondin-1 secretion after chronic ammonia treatment reduces the level of synaptic proteins: in vitro and in vivo studies. J Neurochem (2014) 1.45
Encephalopathy in acute liver failure resulting from acetaminophen intoxication: new observations with potential therapy. Crit Care Med (2011) 1.43
The blood-brain barrier and glutamate. Am J Clin Nutr (2009) 1.41
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate-glutamine neurotransmitter cycle and functional neuroenergetics. Philos Trans R Soc Lond B Biol Sci (1999) 1.32
The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. Annu Rev Nutr (2007) 1.28
Astrocyte glutamine synthetase: importance in hyperammonemic syndromes and potential target for therapy. Neurotherapeutics (2010) 1.19
Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia. Theor Biol Med Model (2007) 1.05
Fueling and imaging brain activation. ASN Neuro (2012) 1.04
Effect of glutamine synthetase inhibition on astrocyte swelling and altered astroglial protein expression during hyperammonemia in rats. Neuroscience (2005) 0.97
A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells. Biochem J (1993) 0.95
Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes? Neurochem Res (2012) 0.92
The role of glutamine synthetase and glutamate dehydrogenase in cerebral ammonia homeostasis. Neurochem Res (2012) 0.91
15N n.m.r. measurement of the in vivo rate of glutamine synthesis and utilization at steady state in the brain of the hyperammonaemic rat. Biochem J (1993) 0.91
Utilization of [15N]glutamate by cultured astrocytes. Biochem J (1986) 0.89
Glutamate metabolism in the brain focusing on astrocytes. Adv Neurobiol (2014) 0.88
13N as a tracer for studying glutamate metabolism. Neurochem Int (2010) 0.87
Modeling the glutamate-glutamine neurotransmitter cycle. Front Neuroenergetics (2013) 0.86
Central Role of Glutamate Metabolism in the Maintenance of Nitrogen Homeostasis in Normal and Hyperammonemic Brain. Biomolecules (2016) 0.86
In vivo activity of glutaminase in the brain of hyperammonaemic rats measured by 15N nuclear magnetic resonance. Biochem J (1995) 0.86
Dependence of in vivo glutamine synthetase activity on ammonia concentration in rat brain studied by 1H - 15N heteronuclear multiple-quantum coherence-transfer NMR. Biochem J (1995) 0.84
Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized (1)H and (15)N NMR spectroscopy. J Cereb Blood Flow Metab (2011) 0.82
Quantitative in silico Analysis of Neurotransmitter Pathways Under Steady State Conditions. Front Endocrinol (Lausanne) (2013) 0.82
Human (13)N-ammonia PET studies: the importance of measuring (13)N-ammonia metabolites in blood. Metab Brain Dis (2010) 0.82
Blood-brain barrier permeability for ammonia in patients with different grades of liver fibrosis is not different from healthy controls. J Cereb Blood Flow Metab (2010) 0.82
Brain alanine formation as an ammonia-scavenging pathway during hyperammonemia: effects of glutamine synthetase inhibition in rats and astrocyte-neuron co-cultures. J Cereb Blood Flow Metab (2013) 0.81
Piscine insights into comparisons of anoxia tolerance, ammonia toxicity, stroke and hepatic encephalopathy. Comp Biochem Physiol A Mol Integr Physiol (2006) 0.80
13N isotope studies of glutamine assimilation pathways in Neurospora crassa. J Bacteriol (1989) 0.80
Quantitative analysis of neurotransmitter pathways under steady state conditions - a perspective. Front Endocrinol (Lausanne) (2013) 0.80
Possible treatment of end-stage hyperammonemic encephalopathy by inhibition of glutamine synthetase. Metab Brain Dis (2012) 0.80
Interactions in the Metabolism of Glutamate and the Branched-Chain Amino Acids and Ketoacids in the CNS. Neurochem Res (2016) 0.79
Effect of glutamine synthetase inhibition on brain and interorgan ammonia metabolism in bile duct ligated rats. J Cereb Blood Flow Metab (2013) 0.78
How Glutamate Is Managed by the Blood-Brain Barrier. Biology (Basel) (2016) 0.76
Glutamine-Glutamate Cycle Flux Is Similar in Cultured Astrocytes and Brain and Both Glutamate Production and Oxidation Are Mainly Catalyzed by Aspartate Aminotransferase. Biology (Basel) (2017) 0.75
Minireview on Glutamine Synthetase Deficiency, an Ultra-Rare Inborn Error of Amino Acid Biosynthesis. Biology (Basel) (2016) 0.75
Imine reductases: a comparison of glutamate dehydrogenase to ketimine reductases in the brain. Neurochem Res (2013) 0.75
Organ Distribution of (13)N Following Intravenous Injection of [(13)N]Ammonia into Portacaval-Shunted Rats. Neurochem Res (2016) 0.75
In vivo N-15 MRS study of glutamate metabolism in the rat brain. Anal Biochem (2016) 0.75
The Glutamate Dehydrogenase Pathway and Its Roles in Cell and Tissue Biology in Health and Disease. Biology (Basel) (2017) 0.75
[15N]alanine and [15N]ammonia metabolism in vivo. Biochem J (1991) 0.75
Role of Bioflavonoid Quercetin on Expression of Urea Cycle Enzymes, Astrocytic and Inflammatory Markers in Hyperammonemic Rats. Indian J Clin Biochem (2016) 0.75
Effects of acute exposure to exogenous ammonia on cerebral monoaminergic neurotransmitters in juvenile Solea senegalensis. Ecotoxicology (2011) 0.75
Carrier rates in the midwestern United States for GJB2 mutations causing inherited deafness. JAMA (1999) 2.56
Disorders of sexual potency in the male: a clinical and statistical study of some factors related to short-term prognosis. Br J Psychiatry (1969) 2.36
Biochemistry and physiology of brain ammonia. Physiol Rev (1987) 2.30
Sister Mary Joseph's nodule: a clinical and histologic study. J Am Acad Dermatol (1984) 2.28
Biochemistry of sulfur-containing amino acids. Annu Rev Biochem (1983) 2.14
A laboratory medicine residency training program that includes clinical consultation and research. Arch Pathol Lab Med (1990) 2.07
Exfoliated cells and in vitro growth in colorectal cancer. Br J Surg (1987) 1.99
Blood Lead Determinations as a Health Department Laboratory Service. Am J Public Health Nations Health (1942) 1.91
Master's performance in the New York City Marathon 1983-1999. Br J Sports Med (2004) 1.85
Preliminary characterization of calcium binding in islet-cell plasma membranes. Diabetologia (1980) 1.75
Stable and specific association between the yeast recombination and DNA repair proteins RAD1 and RAD10 in vitro. Mol Cell Biol (1992) 1.71
A new route for synthesis of dimethylsulphoniopropionate in marine algae. Nature (1997) 1.69
The syndrome of painful legs and moving toes. Mov Disord (1994) 1.59
Differential effect of shear stress on extracellular signal-regulated kinase and N-terminal Jun kinase in endothelial cells. Gi2- and Gbeta/gamma-dependent signaling pathways. J Biol Chem (1997) 1.57
Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann Neurol (1982) 1.48
Intravesical pH: a potentially important variable affecting efficacy and the further development of anthracycline chemotherapy for superficial bladder cancer. BJU Int (2002) 1.44
Effects of short-chain fatty acids on primary urothelial cells in culture: implications for intravesical use in enterocystoplasties. J Lab Clin Med (1998) 1.42
A high affinity calcium-stimulated magnesium-dependent adenosine triphosphatase in rat adipocyte plasma membranes. J Biol Chem (1980) 1.40
Intravesical chemotherapy with gamma linolenic acid becomes a realistic prospect in serum-free applications: in vitro cytotoxicity and systemic absorption studies. J Urol (1998) 1.40
A sensitive and precise isotopic assay of ATPase activity. Anal Biochem (1978) 1.33
Functional differences of the PDS gene product are associated with phenotypic variation in patients with Pendred syndrome and non-syndromic hearing loss (DFNB4). Hum Mol Genet (2000) 1.30
Androgen function in "psychogenic" and "constitutional" types of impotence. Br Med J (1970) 1.29
A factual study of male potency disorders. Br J Psychiatry (1968) 1.28
Diagnosis and management of "endocrine impotence". Br Med J (1972) 1.27
Cerebral carbohydrate metabolism during acute hypoxia and recovery. J Neurochem (1972) 1.26
Isolation and properties of a new glutamine transaminase from rat kidney. J Biol Chem (1974) 1.24
The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia. J Clin Invest (1979) 1.24
Asparagine transaminase from rat liver. J Biol Chem (1977) 1.24
Nitrogen-13 as a biochemical tracer. Adv Enzymol Relat Areas Mol Biol (1985) 1.23
Glutathione is present in high concentrations in cultured astrocytes but not in cultured neurons. Brain Res (1989) 1.21
Cerebral oxidative metabolism and blood flow during acute hypoglycemia and recovery in unanesthetized rats. J Neurochem (1982) 1.18
Neurological complications associated with parenteral treatment: central pontine myelinolysis and Wernicke's encephalopathy. Br Med J (Clin Res Ed) (1986) 1.18
Monoclonal antibody to calmodulin: development, characterization, and comparison with polyclonal anti-calmodulin antibodies. Anal Biochem (1991) 1.17
Carbohydrate and energy metabolism in perinatal rat brain: relation to survival in anoxia. J Neurochem (1975) 1.17
Brain alpha-ketoglutarate dehydrogenase complex: kinetic properties, regional distribution, and effects of inhibitors. J Neurochem (1986) 1.16
Perfusion of colorectal hepatic metastases. Relative distribution of flow from the hepatic artery and portal vein. Cancer (1987) 1.16
Zn2+ inhibits alpha-ketoglutarate-stimulated mitochondrial respiration and the isolated alpha-ketoglutarate dehydrogenase complex. J Biol Chem (2000) 1.16
Short-term metabolic fate of [13N]ammonia in rat liver in vivo. J Biol Chem (1987) 1.15
The selective vulnerability of striatopallidal neurons. Prog Neurobiol (1999) 1.13
Energy-dependent calcium transport in endoplasmic reticulum of adipocytes. J Biol Chem (1976) 1.13
Pattern of remyelination in the CNS. Nature (1973) 1.13
Insulin effect on protein phosphorylation of plasma membranes and mitochondria in a subcellular system from rat adipocytes. I. Identification of insulin-sensitive phosphoproteins. J Biol Chem (1979) 1.12
Demyelination and remyelination after acute spinal cord compression. Exp Neurol (1973) 1.12
Regional energy balance in rat brain after transient forebrain ischemia. J Neurochem (1983) 1.11
Cerebral energy metabolism during experimental status epilepticus. J Neurochem (1975) 1.11
Regional protein synthesis in rat brain following acute hemispheric ischemia. J Neurochem (1980) 1.11
Depression of immunological responses due to surgery. A model in the guinea-pig. Immunology (1974) 1.10
Modification of insulin and sulfonylurea hypoglycemia by monoamine-oxidase inhibitor drugs. Diabetes (1967) 1.09
Insulin stimulates the phosphorylation of calmodulin in intact adipocytes. J Biol Chem (1987) 1.09
Effect of acute ammonia intoxication on cerebral metabolism in rats with portacaval shunts. J Clin Invest (1977) 1.09
Spasms of amputation stumps: a report of 2 cases. Mov Disord (1989) 1.08
M.A.O. inhibitors and headache. Br Med J (1967) 1.08
Factors in male sexual inadequacy: a review. J Nerv Ment Dis (1969) 1.07
Polymerase chain reaction to detect cytomegalovirus DNA in the cerebrospinal fluid of neonates with congenital infection. J Infect Dis (1994) 1.06
Reference laboratory administrative reengineering. Am J Clin Pathol (1997) 1.06
Clonazepam and branchial myoclonus. Ann Neurol (1977) 1.06
Tandem repeat of C/EBP binding sites mediates PPARgamma2 gene transcription in glucocorticoid-induced adipocyte differentiation. J Cell Biochem (2000) 1.05
Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate. Anal Biochem (1978) 1.05
Apoptosis and tumorigenesis in human cholangiocarcinoma cells. Involvement of Fas/APO-1 (CD95) and calmodulin. Am J Pathol (1999) 1.05
Magnetic resonance imaging in central pontine myelinolysis. J Neurol Neurosurg Psychiatry (1989) 1.04
N(epsilon)-(gamma-L-glutamyl)-L-lysine (GGEL) is increased in cerebrospinal fluid of patients with Huntington's disease. J Neurochem (2001) 1.04
Acute hyperammonemia in the young primate: physiologic and neuropathologic correlates. Pediatr Res (1983) 1.04
A high-performance liquid chromatography method for hemoglobin A1c. Diabetes (1978) 1.04
Brain dysfunction in mild to moderate hypoxia. Am J Med (1981) 1.04
Gap junctions are required for the propagation of spreading depression. J Neurobiol (1995) 1.03
Saturated fatty acid-induced insulin resistance in rat adipocytes. Diabetes (1994) 1.03
Impaired synthesis of acetylcholine by mild hypoxic hypoxia or nitrous oxide. J Neurochem (1981) 1.03
Cerebral ammonia metabolism in hyperammonemic rats. J Neurochem (1985) 1.02
The insulin receptor and calmodulin. Calmodulin enhances insulin-mediated receptor kinase activity and insulin stimulates phosphorylation of calmodulin. J Biol Chem (1986) 1.02
Addison's disease presenting with psychiatric symptoms. Am J Psychiatry (1986) 1.02
Metabolic effects of seizures. Res Publ Assoc Res Nerv Ment Dis (1974) 1.01
Regulation of osteoclastic bone resorption by glucose. Biochem Biophys Res Commun (1997) 1.00
Insulin-stimulated phosphorylation of calmodulin by rat liver insulin receptor preparations. J Biol Chem (1988) 1.00
Calmodulin and HIV type 1: interactions with Gag and Gag products. AIDS Res Hum Retroviruses (2000) 1.00
Requirement of calmodulin binding by HIV-1 gp160 for enhanced FAS-mediated apoptosis. J Biol Chem (2000) 0.99
Relationship of free and total calcium in hypercalcemic conditions. J Clin Endocrinol Metab (1979) 0.99
Calmodulin-activated protein kinase activity in rat pancreatic islet cell membranes. Arch Biochem Biophys (1982) 0.99
Alpha-ketoglutaramate: increased concentrations in the cerebrospinal fluid of patients in hepatic coma. Science (1974) 0.99
Comparison of disinfectants for biofilm, protozoa and Legionella control. J Water Health (2005) 0.99
[13N]cisplatin PET to assess pharmacokinetics of intra-arterial versus intravenous chemotherapy for malignant brain tumors. J Nucl Med (1987) 0.99
Substrate proton exchange catalyzed by gamma-cystathionase. Biochemistry (1977) 0.98
Effects of oral and transdermal 17beta-estradiol with cyclical oral norethindrone acetate on insulin sensitivity, secretion, and elimination in postmenopausal women. Metabolism (2000) 0.98
Hematologic malignancies occurring in patients with urticaria pigmentosa. J Am Acad Dermatol (1982) 0.97
Blood transfusion and recurrence of colorectal cancer: the role of platelet derived growth factors. Br J Surg (1990) 0.97
The effects of clomiphene in impotence. A clinical and endocrine study. Br J Psychiatry (1972) 0.97
Guide to treatment and short-term prognosis of male potency disorders in hospital and general practice. Br Med J (1970) 0.97
Washington University Case Conference. Multiple myeloma and hypercalcemia? Clin Chem (1979) 0.97
Calmodulin-sensitive ATP-dependent Ca2+ transport across adipocyte plasma membranes. J Biol Chem (1980) 0.97
Fluctuations in deoxycytidine monophosphate deaminase activity during the cell cycle in synchronous populations of HeLa cells. Biochim Biophys Acta (1969) 0.97
Treatment of male potency disorders: the present status. Psychosomatics (1974) 0.97
Prostatic cancer, acid phosphatase, creatine kinase-BB and race: a prospective study. J Urol (1982) 0.97
Dysfunction of sensory nerves during attacks of hypokalemic periodic paralysis. Neuromuscul Disord (1999) 0.97
Smoking and cardiovascular disease. Clin Chest Med (2000) 0.96