Published in Exp Cell Res on January 10, 2007
Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase. Mol Cell Biol (2007) 1.75
APLF (C2orf13) is a novel component of poly(ADP-ribose) signaling in mammalian cells. Mol Cell Biol (2008) 1.41
Global analysis of transcriptional regulation by poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem (2009) 1.32
Structure of mammalian poly(ADP-ribose) glycohydrolase reveals a flexible tyrosine clasp as a substrate-binding element. Nat Struct Mol Biol (2012) 1.16
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp Cell Res (2007) 1.15
Hydrolase regulates NAD+ metabolites and modulates cellular redox. J Biol Chem (2009) 1.13
Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase. Biochemistry (2010) 0.94
PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways. Cell Death Dis (2013) 0.90
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod (2009) 0.90
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res (2009) 0.88
The rise and fall of poly(ADP-ribose): An enzymatic perspective. DNA Repair (Amst) (2015) 0.87
Arsenic biotransformation as a cancer promoting factor by inducing DNA damage and disruption of repair mechanisms. Mol Biol Int (2011) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
Discovery and structure-activity relationships of modified salicylanilides as cell permeable inhibitors of poly(ADP-ribose) glycohydrolase (PARG). J Med Chem (2011) 0.83
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. PLoS One (2009) 0.82
New players to the field of ADP-ribosylation make the final cut. EMBO J (2013) 0.82
Visible light may directly induce nuclear DNA damage triggering the death pathway in RGC-5 cells. Mol Vis (2011) 0.80
PARP1 gene expression is downregulated by knockdown of PARG gene. Oncol Rep (2013) 0.80
Structure/function analysis of PARP-1 in oxidative and nitrosative stress-induced monomeric ADPR formation. PLoS One (2009) 0.80
Extremely high intracellular concentration of glucose-6-phosphate and NAD(H) in Deinococcus radiodurans. Extremophiles (2017) 0.75
Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev (2004) 6.08
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks. Nat Cell Biol (2005) 5.11
Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair. Proc Natl Acad Sci U S A (2005) 3.93
Poly(ADP-ribose) is required for spindle assembly and structure. Nature (2004) 3.11
An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat Med (2005) 2.06
Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling. Mol Biol Cell (2002) 2.05
Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1. Mol Endocrinol (2003) 1.81
Ablation of PARP-1 does not interfere with the repair of DNA double-strand breaks, but compromises the reactivation of stalled replication forks. Oncogene (2004) 1.79
MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway. Nat Cell Biol (2011) 1.69
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp Cell Res (2004) 1.66
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol (2004) 1.61
Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice. Cancer Res (2003) 1.54
Nbn heterozygosity renders mice susceptible to tumor formation and ionizing radiation-induced tumorigenesis. Cancer Res (2003) 1.45
Involvement of poly(ADP-Ribose) polymerase 1 and poly(ADP-Ribosyl)ation in regulation of centrosome function. Mol Cell Biol (2003) 1.43
Nibrin functions in Ig class-switch recombination. Proc Natl Acad Sci U S A (2005) 1.41
Conditional deletion of Nbs1 in murine cells reveals its role in branching repair pathways of DNA double-strand breaks. EMBO J (2006) 1.36
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection. Photochem Photobiol Sci (2005) 1.30
Identification of three critical acidic residues of poly(ADP-ribose) glycohydrolase involved in catalysis: determining the PARG catalytic domain. Biochem J (2005) 1.28
Null mutation of DNA strand break-binding molecule poly(ADP-ribose) polymerase causes medulloblastomas in p53(-/-) mice. Am J Pathol (2003) 1.28
Mice deficient in the X-linked lymphoproliferative disease gene sap exhibit increased susceptibility to murine gammaherpesvirus-68 and hypo-gammaglobulinemia. J Med Virol (2003) 1.24
Poly(ADP-ribose) polymerase (PARP) inhibition or PARP-1 gene deletion reduces angiogenesis. Eur J Cancer (2007) 1.22
Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs. Mech Dev (2003) 1.22
PARP1 Val762Ala polymorphism reduces enzymatic activity. Biochem Biophys Res Commun (2006) 1.22
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005) 1.21
Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res (2002) 1.20
Noncleavable poly(ADP-ribose) polymerase-1 regulates the inflammation response in mice. J Clin Invest (2004) 1.17
An inducible null mutant murine model of Nijmegen breakage syndrome proves the essential function of NBS1 in chromosomal stability and cell viability. Hum Mol Genet (2004) 1.16
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp Cell Res (2007) 1.15
Poly(ADP-ribose) polymerases: managing genome stability. Int J Biochem Cell Biol (2004) 1.14
Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap. Blood (2005) 1.09
Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice. Curr Gerontol Geriatr Res (2008) 1.06
Proteins of the extracellular matrix are sensitizers of photo-oxidative stress in human skin cells. J Invest Dermatol (2003) 1.06
Poly(ADP-ribose) polymerase-1, a novel partner of progesterone receptors in endometrial cancer and its precursors. Int J Cancer (2004) 1.04
Identification of an inhibitor binding site of poly(ADP-ribose) glycohydrolase. Biochemistry (2003) 1.03
UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations. Int J Pharm (2007) 1.03
Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential. Front Biosci (Landmark Ed) (2009) 1.02
Requirement for DNA ligase IV during embryonic neuronal development. J Neurosci (2011) 1.01
Poly(ADP-ribose) accumulation and enhancement of postischemic brain damage in 110-kDa poly(ADP-ribose) glycohydrolase null mice. J Cereb Blood Flow Metab (2006) 1.01
Analysis of genetic variants of the poly(ADP-ribose) polymerase-1 gene in breast cancer in French patients. Mutat Res (2007) 0.99
Skin hyperproliferation and susceptibility to chemical carcinogenesis in transgenic mice expressing E6 and E7 of human papillomavirus type 38. J Virol (2005) 0.99
A rapid HPLC method for simultaneous determination of tretinoin and isotretinoin in dermatological formulations. J Pharm Biomed Anal (2006) 0.99
Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma (2005) 0.97
Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell Rep (2012) 0.96
Identification of quenchers of photoexcited States as novel agents for skin photoprotection. J Pharmacol Exp Ther (2004) 0.96
PARP-1 regulates expression of TGF-β receptors in T cells. Blood (2013) 0.95
Identification of a regulatory segment of poly(ADP-ribose) glycohydrolase. Biochemistry (2010) 0.94
HAT cofactor Trrap regulates the mitotic checkpoint by modulation of Mad1 and Mad2 expression. EMBO J (2004) 0.93
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
DNA damage by carbonyl stress in human skin cells. Mutat Res (2003) 0.93
Antimelanoma activity of apoptogenic carbonyl scavengers. J Pharmacol Exp Ther (2005) 0.93
Epigenetic information in chromatin: the code of entry for DNA repair. Cell Cycle (2006) 0.92
A novel function of DNA repair molecule Nbs1 in terminal differentiation of the lens fibre cells and cataractogenesis. DNA Repair (Amst) (2006) 0.92
Deletion of the nuclear isoform of poly(ADP-ribose) glycohydrolase (PARG) reveals its function in DNA repair, genomic stability and tumorigenesis. Carcinogenesis (2010) 0.92
Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23). Gene (2003) 0.92
Inhibition of advanced glycation end product formation on collagen by rutin and its metabolites. J Nutr Biochem (2005) 0.91
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod (2009) 0.90
3-hydroxypyridine chromophores are endogenous sensitizers of photooxidative stress in human skin cells. J Biol Chem (2004) 0.90
Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance. Exp Ther Med (2012) 0.89
Haploinsufficiency of poly(ADP-ribose) polymerase-1-mediated poly(ADP-ribosyl)ation for centrosome duplication. Biochem Biophys Res Commun (2007) 0.89
Aflatoxin-B exposure does not lead to p53 mutations but results in enhanced liver cancer of Hupki (human p53 knock-in) mice. Int J Cancer (2006) 0.89
Progress in the function and regulation of ADP-Ribosylation. Sci Signal (2011) 0.89
Mice lacking the 110-kD isoform of poly(ADP-ribose) glycohydrolase are protected against renal ischemia/reperfusion injury. J Am Soc Nephrol (2005) 0.89
Tumour suppressor menin is essential for development of the pancreatic endocrine cells. J Endocrinol (2008) 0.88
An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence. PLoS Genet (2013) 0.88
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res (2009) 0.88
A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin. Exp Dermatol (2007) 0.88
MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome. Exp Neurol (2007) 0.87
PARG activity mediates intestinal injury induced by splanchnic artery occlusion and reperfusion. FASEB J (2005) 0.87
Genome-wide analysis of gene expression regulated by the HAT cofactor Trrap in conditional knockout cells. Nucleic Acids Res (2003) 0.87
Photosensitized growth inhibition of cultured human skin cells: mechanism and suppression of oxidative stress from solar irradiation of glycated proteins. J Invest Dermatol (2002) 0.87
A novel role of human holliday junction resolvase GEN1 in the maintenance of centrosome integrity. PLoS One (2012) 0.87
Vitamin B6: beyond coenzyme functions. Subcell Biochem (2012) 0.87