Published in Proc Natl Acad Sci U S A on January 13, 2005
53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks. Cell (2010) 8.70
Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science (2007) 6.77
Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair. Cell (2007) 6.68
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol (2010) 5.35
How the fanconi anemia pathway guards the genome. Annu Rev Genet (2009) 4.94
Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. Cell (2010) 3.43
Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway. Genes Dev (2012) 3.42
Expanded roles of the Fanconi anemia pathway in preserving genomic stability. Genes Dev (2010) 3.33
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors. Mol Cell (2010) 3.27
Inhibition of homologous recombination by the PCNA-interacting protein PARI. Mol Cell (2011) 2.61
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Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype. Dev Cell (2009) 2.12
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Rad18 E3 ubiquitin ligase activity mediates Fanconi anemia pathway activation and cell survival following DNA Topoisomerase 1 inhibition. Cell Cycle (2011) 1.87
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks. Proc Natl Acad Sci U S A (2008) 1.84
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The Fanconi anemia core complex is required for efficient point mutagenesis and Rev1 foci assembly. DNA Repair (Amst) (2008) 1.74
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Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype. Am J Hum Genet (2007) 1.67
Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability. EMBO J (2007) 1.65
Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance. Mol Cell Biol (2006) 1.65
Differential usage of alternative pathways of double-strand break repair in Drosophila. Genetics (2005) 1.63
BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair. Mol Cell Biol (2011) 1.52
DNA polymerase POLN participates in cross-link repair and homologous recombination. Mol Cell Biol (2009) 1.47
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Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis. Leukemia (2011) 1.43
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The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol (2007) 1.29
Regulation of the Fanconi anemia pathway by a SUMO-like delivery network. Genes Dev (2011) 1.28
An ATR- and BRCA1-mediated Fanconi anemia pathway is required for activating the G2/M checkpoint and DNA damage repair upon rereplication. Mol Cell Biol (2006) 1.27
Regulated degradation of FANCM in the Fanconi anemia pathway during mitosis. Genes Dev (2009) 1.25
A role for monoubiquitinated FANCD2 at telomeres in ALT cells. Nucleic Acids Res (2009) 1.24
DNA2 and EXO1 in replication-coupled, homology-directed repair and in the interplay between HDR and the FA/BRCA network. Cell Cycle (2012) 1.23
Breast cancer-associated missense mutants of the PALB2 WD40 domain, which directly binds RAD51C, RAD51 and BRCA2, disrupt DNA repair. Oncogene (2013) 1.20
Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. Oncogene (2008) 1.20
Chromatin recruitment of DNA repair proteins: lessons from the fanconi anemia and double-strand break repair pathways. Mol Cell (2008) 1.19
ATR-dependent phosphorylation of FANCA on serine 1449 after DNA damage is important for FA pathway function. Blood (2008) 1.19
DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2. Mol Cell Biol (2007) 1.17
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The Fanconi anemia pathway and ubiquitin. BMC Biochem (2007) 1.10
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Targeting and processing of site-specific DNA interstrand crosslinks. Environ Mol Mutagen (2010) 1.05
Non-specific chemical inhibition of the Fanconi anemia pathway sensitizes cancer cells to cisplatin. Mol Cancer (2012) 1.04
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol Cell (2012) 1.04
Histone deacetylases 9 and 10 are required for homologous recombination. J Biol Chem (2011) 1.03
DNA damage response factors from diverse pathways, including DNA crosslink repair, mediate alternative end joining. PLoS Genet (2015) 1.02
CtIP mediates replication fork recovery in a FANCD2-regulated manner. Hum Mol Genet (2014) 1.01
RECQ1 plays a distinct role in cellular response to oxidative DNA damage. DNA Repair (Amst) (2012) 1.00
DNA damage induced by alkylating agents and repair pathways. J Nucleic Acids (2010) 1.00
DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange. PLoS One (2011) 1.00
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The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability. Mutat Res (2012) 0.99
MRE11-RAD50-NBS1 is a critical regulator of FANCD2 stability and function during DNA double-strand break repair. EMBO J (2009) 0.98
MicroRNAs down-regulate homologous recombination in the G1 phase of cycling cells to maintain genomic stability. Elife (2014) 0.95
Targeted gene therapy and cell reprogramming in Fanconi anemia. EMBO Mol Med (2014) 0.95
Homologous recombination assay for interstrand cross-link repair. Methods Mol Biol (2011) 0.95
Rad5-dependent DNA repair functions of the Saccharomyces cerevisiae FANCM protein homolog Mph1. J Biol Chem (2012) 0.95
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry. Mol Cell (2015) 0.94
Epstein-Barr virus BPLF1 deubiquitinates PCNA and attenuates polymerase η recruitment to DNA damage sites. J Virol (2012) 0.94
UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Mol Cells (2010) 0.93
Disparate contributions of the Fanconi anemia pathway and homologous recombination in preventing spontaneous mutagenesis. Nucleic Acids Res (2007) 0.93
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol (2015) 0.93
Regulation and roles of Cdc7 kinase under replication stress. Cell Cycle (2014) 0.92
Functional connection between Rad51 and PML in homology-directed repair. PLoS One (2011) 0.92
Interplay between Fanconi anemia and homologous recombination pathways in genome integrity. EMBO J (2016) 0.92
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The Fanconi anemia pathway and ICL repair: implications for cancer therapy. Crit Rev Biochem Mol Biol (2010) 0.90
Male fertility defect associated with disrupted BRCA1-PALB2 interaction in mice. J Biol Chem (2014) 0.89
Biomarkers and mechanisms of FANCD2 function. J Biomed Biotechnol (2008) 0.89
Reduced proficiency in homologous recombination underlies the high sensitivity of embryonal carcinoma testicular germ cell tumors to Cisplatin and poly (adp-ribose) polymerase inhibition. PLoS One (2012) 0.89
USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation. Hum Mol Genet (2011) 0.89
Akt-mediated phosphorylation of XLF impairs non-homologous end-joining DNA repair. Mol Cell (2015) 0.88
Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex. Nucleic Acids Res (2015) 0.88
Inhibition of BRCT(BRCA1)-phosphoprotein interaction enhances the cytotoxic effect of olaparib in breast cancer cells: a proof of concept study for synthetic lethal therapeutic option. Breast Cancer Res Treat (2012) 0.88
Regulation of the activation of the Fanconi anemia pathway by the p21 cyclin-dependent kinase inhibitor. Oncogene (2011) 0.87
FANCD1/BRCA2 plays predominant role in the repair of DNA damage induced by ACNU or TMZ. PLoS One (2011) 0.87
The Fanconi anemia ID2 complex: dueling saxes at the crossroads. Cell Cycle (2014) 0.87
Snm1B/Apollo functions in the Fanconi anemia pathway in response to DNA interstrand crosslinks. Hum Mol Genet (2011) 0.86
Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance. Mutat Res Rev Mutat Res (2014) 0.86
Histone deacetylase inhibitors selectively target homology dependent DNA repair defective cells and elevate non-homologous endjoining activity. PLoS One (2014) 0.85
EGFR-activating mutations correlate with a Fanconi anemia-like cellular phenotype that includes PARP inhibitor sensitivity. Cancer Res (2013) 0.85
Attenuating homologous recombination stimulates an AID-induced antileukemic effect. J Exp Med (2013) 0.85
DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27. Nucleic Acids Res (2015) 0.84
Genomic instability in mice is greater in Fanconi anemia caused by deficiency of Fancd2 than Fancg. Cancer Res (2010) 0.84
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