Published in Structure on February 01, 2007
Structural basis of membrane invagination by F-BAR domains. Cell (2008) 5.41
Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism. J Cell Biol (2007) 3.05
Amphipathic motifs in BAR domains are essential for membrane curvature sensing. EMBO J (2009) 2.20
MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell (2010) 2.11
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J (2007) 1.93
miR-23a promotes the transition from indolent to invasive colorectal cancer. Cancer Discov (2012) 1.49
Regulation of actin cytoskeleton dynamics in cells. Mol Cells (2010) 1.46
Coordination of membrane and actin cytoskeleton dynamics during filopodia protrusion. PLoS One (2009) 1.41
Downregulation of metastasis suppressor 1(MTSS1) is associated with nodal metastasis and poor outcome in Chinese patients with gastric cancer. BMC Cancer (2010) 1.28
The C terminus of formin FMNL3 accelerates actin polymerization and contains a WH2 domain-like sequence that binds both monomers and filament barbed ends. J Biol Chem (2011) 1.24
Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping. PLoS Biol (2010) 1.15
Dissecting BAR domain function in the yeast Amphiphysins Rvs161 and Rvs167 during endocytosis. Mol Biol Cell (2010) 1.14
Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. PLoS Genet (2009) 1.14
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nat Struct Mol Biol (2011) 1.12
MIM: a multifunctional scaffold protein. J Mol Med (Berl) (2007) 1.07
Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1. J Cell Biol (2009) 1.02
Toxofilin from Toxoplasma gondii forms a ternary complex with an antiparallel actin dimer. Proc Natl Acad Sci U S A (2007) 1.02
The F-BAR domains from srGAP1, srGAP2 and srGAP3 regulate membrane deformation differently. J Cell Sci (2012) 1.00
I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol (2010) 1.00
Structures of actin-bound Wiskott-Aldrich syndrome protein homology 2 (WH2) domains of Spire and the implication for filament nucleation. Proc Natl Acad Sci U S A (2010) 1.00
Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation. J Mol Biol (2010) 0.98
Mtss1 regulates epidermal growth factor signaling in head and neck squamous carcinoma cells. Oncogene (2011) 0.97
Structure and mechanism in membrane trafficking. Curr Opin Cell Biol (2010) 0.97
Phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) specifically induces membrane penetration and deformation by Bin/amphiphysin/Rvs (BAR) domains. J Biol Chem (2012) 0.96
Yersinia effector YopO uses actin as bait to phosphorylate proteins that regulate actin polymerization. Nat Struct Mol Biol (2015) 0.95
The F-BAR domain of SRGP-1 facilitates cell-cell adhesion during C. elegans morphogenesis. J Cell Biol (2010) 0.95
Evolution of the eukaryotic ARP2/3 activators of the WASP family: WASP, WAVE, WASH, and WHAMM, and the proposed new family members WAWH and WAML. BMC Res Notes (2012) 0.94
Structural analysis of the transitional state of Arp2/3 complex activation by two actin-bound WCAs. Nat Commun (2014) 0.94
Mice deficient in MIM expression are predisposed to lymphomagenesis. Oncogene (2011) 0.94
How a single residue in individual β-thymosin/WH2 domains controls their functions in actin assembly. EMBO J (2011) 0.93
Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J Biol Chem (2012) 0.92
Murine missing in metastasis (MIM) mediates cell polarity and regulates the motility response to growth factors. PLoS One (2011) 0.92
PICK1 is implicated in organelle motility in an Arp2/3 complex-independent manner. Mol Biol Cell (2015) 0.91
Mechanism of IRSp53 inhibition and combinatorial activation by Cdc42 and downstream effectors. Nat Struct Mol Biol (2014) 0.90
MIM regulates the trafficking of bone marrow cells via modulating surface expression of CXCR4. Leukemia (2016) 0.88
Downregulation of MTSS1 expression is an independent prognosticator in squamous cell carcinoma of the lung. Br J Cancer (2015) 0.88
MIM regulates vertebrate neural tube closure. Development (2011) 0.87
The WH2 Domain and Actin Nucleation: Necessary but Insufficient. Trends Biochem Sci (2016) 0.87
Mtss1 is a critical epigenetically regulated tumor suppressor in CML. Leukemia (2015) 0.87
Structural basis for complex formation between human IRSp53 and the translocated intimin receptor Tir of enterohemorrhagic E. coli. Structure (2011) 0.85
Regulation of membrane-shape transitions induced by I-BAR domains. Biophys J (2015) 0.85
Developmental expression and differentiation-related neuron-specific splicing of metastasis suppressor 1 (Mtss1) in normal and transformed cerebellar cells. BMC Dev Biol (2007) 0.83
F-BAR domain proteins: Families and function. Commun Integr Biol (2010) 0.83
Dimerization is necessary for MIM-mediated membrane deformation and endocytosis. Biochem J (2012) 0.81
Filament assembly by Spire: key residues and concerted actin binding. J Mol Biol (2014) 0.80
BAR proteins in cancer and blood disorders. Int J Biochem Mol Biol (2012) 0.79
The BAR Domain Superfamily Proteins from Subcellular Structures to Human Diseases. Membranes (Basel) (2012) 0.79
IRSp53 mediates podosome formation via VASP in NIH-Src cells. PLoS One (2013) 0.79
How cations can assist DNase I in DNA binding and hydrolysis. PLoS Comput Biol (2010) 0.79
Salt Bridge Formation between the I-BAR Domain and Lipids Increases Lipid Density and Membrane Curvature. Sci Rep (2017) 0.75
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases. J Cell Sci (2017) 0.75
Purification, crystallization and preliminary X-ray analysis of the inverse F-BAR domain of the human srGAP2 protein. Acta Crystallogr F Struct Biol Commun (2013) 0.75
The Role of BAR Domain Proteins in the Regulation of Membrane Dynamics. Acta Naturae (2017) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Electrostatics of nanosystems: application to microtubules and the ribosome. Proc Natl Acad Sci U S A (2001) 42.14
Automated MAD and MIR structure solution. Acta Crystallogr D Biol Crystallogr (1999) 41.65
Principles of protein-protein interactions. Proc Natl Acad Sci U S A (1996) 14.51
BAR domains as sensors of membrane curvature: the amphiphysin BAR structure. Science (2003) 12.60
ARP/wARP and automatic interpretation of protein electron density maps. Methods Enzymol (2003) 6.37
Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol (2001) 4.38
Cortactin promotes and stabilizes Arp2/3-induced actin filament network formation. Curr Biol (2001) 4.16
Drosophila Spire is an actin nucleation factor. Nature (2005) 3.64
IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling. Nature (2000) 3.56
WH2 domain: a small, versatile adapter for actin monomers. FEBS Lett (2002) 2.85
Deciphering protein sequence information through hydrophobic cluster analysis (HCA): current status and perspectives. Cell Mol Life Sci (1997) 2.83
The BAR-domain family of proteins: a case of bending and binding? EMBO Rep (2004) 2.77
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. Proc Natl Acad Sci U S A (2005) 2.75
Socket: a program for identifying and analysing coiled-coil motifs within protein structures. J Mol Biol (2001) 2.57
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol (2001) 2.54
The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways. Nature (2001) 2.46
Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics. J Biol Chem (2003) 2.27
Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53. EMBO J (2005) 2.08
MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription. Genes Dev (2004) 2.07
Crystal structure of the endophilin-A1 BAR domain. J Mol Biol (2005) 2.00
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem (2004) 1.96
Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain. J Biol Chem (2002) 1.80
MIM, a potential metastasis suppressor gene in bladder cancer. Neoplasia (2002) 1.71
The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem (2006) 1.56
MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta. Biochem J (2003) 1.54
Structural basis of actin sequestration by thymosin-beta4: implications for WH2 proteins. EMBO J (2004) 1.49
Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B. J Cell Sci (2005) 1.43
Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein. Oncogene (2005) 1.42
Understanding the role of the G-actin-binding domain of Ena/VASP in actin assembly. J Struct Biol (2006) 1.32
IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness. Cancer Res (2004) 1.27
Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4. J Cell Biol (2005) 1.13
Insulin receptor substrate of 53 kDa links postsynaptic shank to PSD-95. J Neurochem (2004) 1.11
From the first to the second domain of gelsolin: a common path on the surface of actin? FEBS Lett (2003) 1.03
Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines. Cancer Lett (2004) 1.02
Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly. Proc Natl Acad Sci U S A (2005) 2.75
Structural basis of protein phosphatase 1 regulation. Nature (2004) 2.31
Crystal structure of monomeric actin in the ATP state. Structural basis of nucleotide-dependent actin dynamics. J Biol Chem (2003) 2.27
Leiomodin is an actin filament nucleator in muscle cells. Science (2008) 2.05
Structural basis for the recruitment of profilin-actin complexes during filament elongation by Ena/VASP. EMBO J (2007) 1.93
Role of changes in the L3 loop of the active site in the evolution of enzymatic activity of VIM-type metallo-beta-lactamases. J Antimicrob Chemother (2010) 1.81
X-ray scattering study of activated Arp2/3 complex with bound actin-WCA. Structure (2008) 1.75
Structural and functional analysis of methylation and 5'-RNA sequence requirements of short capped RNAs by the methyltransferase domain of dengue virus NS5. J Mol Biol (2007) 1.69
A second, non-canonical RNA-dependent RNA polymerase in SARS coronavirus. EMBO J (2006) 1.69
Conventional and unconventional mechanisms for capping viral mRNA. Nat Rev Microbiol (2011) 1.61
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A (2004) 1.61
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog (2010) 1.57
Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system. J Biol Chem (2008) 1.54
Regulation of actin cytoskeleton dynamics in cells. Mol Cells (2010) 1.46
Two distinct myosin light chain structures are induced by specific variations within the bound IQ motifs-functional implications. EMBO J (2003) 1.40
Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system. Proc Natl Acad Sci U S A (2002) 1.39
Structural disorder and modular organization in Paramyxovirinae N and P. J Gen Virol (2003) 1.35
Structure of the light chain-binding domain of myosin V. Proc Natl Acad Sci U S A (2005) 1.33
Understanding the role of the G-actin-binding domain of Ena/VASP in actin assembly. J Struct Biol (2006) 1.32
Mechanism of actin filament nucleation by Vibrio VopL and implications for tandem W domain nucleation. Nat Struct Mol Biol (2011) 1.22
Mechanism of actin filament bundling by fascin. J Biol Chem (2011) 1.18
Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Structure (2002) 1.16
Crystal structure and functional analysis of the SARS-coronavirus RNA cap 2'-O-methyltransferase nsp10/nsp16 complex. PLoS Pathog (2011) 1.13
Essential amino acids of the hantaan virus N protein in its interaction with RNA. J Virol (2005) 1.13
Pinkbar is an epithelial-specific BAR domain protein that generates planar membrane structures. Nat Struct Mol Biol (2011) 1.12
Mechanisms of plasma membrane targeting of formin mDia2 through its amino terminal domains. Mol Biol Cell (2010) 1.10
Oogenesis in adult mammals, including humans: a review. Endocrine (2005) 1.07
Crystal structure of the actin-binding domain of alpha-actinin 1: evaluating two competing actin-binding models. J Struct Biol (2006) 1.03
X-ray scattering study of actin polymerization nuclei assembled by tandem W domains. Proc Natl Acad Sci U S A (2008) 1.03
Toxofilin from Toxoplasma gondii forms a ternary complex with an antiparallel actin dimer. Proc Natl Acad Sci U S A (2007) 1.02
Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein. Am J Physiol Cell Physiol (2009) 1.01
Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein. Acta Crystallogr D Biol Crystallogr (2003) 1.01
Structure of a longitudinal actin dimer assembled by tandem w domains: implications for actin filament nucleation. J Mol Biol (2010) 0.98
Different localizations and cellular behaviors of leiomodin and tropomodulin in mature cardiomyocyte sarcomeres. Mol Biol Cell (2010) 0.95
Modulation of actin structure and function by phosphorylation of Tyr-53 and profilin binding. Proc Natl Acad Sci U S A (2008) 0.94
CDC42 switches IRSp53 from inhibition of actin growth to elongation by clustering of VASP. EMBO J (2013) 0.93
Crystal structure of the actin-binding domain of alpha-actinin-4 Lys255Glu mutant implicated in focal segmental glomerulosclerosis. J Mol Biol (2007) 0.93
Structural analysis of smooth muscle tropomyosin α and β isoforms. J Biol Chem (2011) 0.93
Structure-function study of the N-terminal domain of exocyst subunit Sec3. J Biol Chem (2010) 0.92
Cortactin binding to F-actin revealed by electron microscopy and 3D reconstruction. J Mol Biol (2006) 0.91
Principles for defining adverse events in behavioral intervention research: lessons from a family-focused adolescent drug abuse trial. Clin Trials (2010) 0.90
Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein. J Mol Biol (2011) 0.89
Rickettsia Sca2 has evolved formin-like activity through a different molecular mechanism. Proc Natl Acad Sci U S A (2013) 0.89
Glia maturation factor (GMF) interacts with Arp2/3 complex in a nucleotide state-dependent manner. J Biol Chem (2013) 0.89
CARMIL leading edge localization depends on a non-canonical PH domain and dimerization. Nat Commun (2013) 0.88
Large nucleotide-dependent conformational change in Rab28. FEBS Lett (2008) 0.85
Mammalian neo-oogenesis and expression of meiosis-specific protein SCP3 in adult human and monkey ovaries. Cell Cycle (2007) 0.85
The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain. Mol Microbiol (2013) 0.84
Bone marrow derived cells and alternative pathways of oogenesis in adult rodents. Cell Cycle (2007) 0.84
A vertebrate myosin-I structure reveals unique insights into myosin mechanochemical tuning. Proc Natl Acad Sci U S A (2014) 0.84
The actin-binding domain of cortactin is dynamic and unstructured and affects lateral and longitudinal contacts in F-actin. Cell Motil Cytoskeleton (2009) 0.84
Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration. Bioorg Med Chem Lett (2010) 0.83
Changes of ovarian interstitial cell hormone receptors and behavior of resident mesenchymal cells in developing and adult rats with steroid-induced sterility. Steroids (2002) 0.83
Crystallization, X-ray characterization and selenomethionine phasing of Mlc1p bound to IQ motifs from myosin V. Acta Crystallogr D Biol Crystallogr (2002) 0.83
Immune physiology and oogenesis in fetal and adult humans, ovarian infertility, and totipotency of adult ovarian stem cells. Birth Defects Res C Embryo Today (2009) 0.83
Multiple luteinizing hormone receptor (LHR) protein variants, interspecies reactivity of anti-LHR mAb clone 3B5, subcellular localization of LHR in human placenta, pelvic floor and brain, and possible role for LHR in the development of abnormal pregnancy, pelvic floor disorders and Alzheimer's disease. Reprod Biol Endocrinol (2003) 0.83
Expression of p53 in luminal and glandular epithelium during the growth and regression of rat uterus during the estrous cycle. Mol Reprod Dev (2002) 0.82
Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.82
Arp you ready for actin in the nucleus? EMBO J (2011) 0.81
Dengue virus replicons: production of an interserotypic chimera and cell lines from different species, and establishment of a cell-based fluorescent assay to screen inhibitors, validated by the evaluation of ribavirin's activity. Antiviral Res (2010) 0.81
Solution properties of TMR-actin: when biochemical and crystal data agree. Biophys J (2003) 0.80
Protein engineering. Methods Mol Biol (2007) 0.78
Study origin of germ cells and formation of new primary follicles in adult human and rat ovaries. Methods Mol Biol (2008) 0.78
Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement. Bioorg Med Chem Lett (2011) 0.77
[Capping strategies in RNA viruses]. Med Sci (Paris) (2012) 0.77
Subunit Rtt102 controls the conformation of the Arp7/9 heterodimer and its interactions with nucleotide and the catalytic subunit of SWI/SNF remodelers. J Biol Chem (2013) 0.77
Dystrophin's tandem calponin-homology domains: is the case closed? Biophys J (2012) 0.75
The conformational state of actin filaments regulates branching by actin-related protein 2/3 (Arp2/3) complex. J Biol Chem (2012) 0.75