Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction.

PubWeight™: 3.98‹?› | Rank: Top 1%

🔗 View Article (PMID 17298974)

Published in Eur Heart J on February 13, 2007

Authors

Florian H Seeger1, Torsten Tonn, Nicola Krzossok, Andreas M Zeiher, Stefanie Dimmeler

Author Affiliations

1: Department of Molecular Cardiology, University of Frankfurt, Theodor-Stern-Kai 7, Frankfurt am Main, Germany.

Articles citing this

Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation (2012) 4.56

Effect of intracoronary delivery of autologous bone marrow mononuclear cells 2 to 3 weeks following acute myocardial infarction on left ventricular function: the LateTIME randomized trial. JAMA (2011) 4.52

Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06

Detailed analysis of bone marrow from patients with ischemic heart disease and left ventricular dysfunction: BM CD34, CD11b, and clonogenic capacity as biomarkers for clinical outcomes. Circ Res (2014) 2.46

Rationale and design for TIME: A phase II, randomized, double-blind, placebo-controlled pilot trial evaluating the safety and effect of timing of administration of bone marrow mononuclear cells after acute myocardial infarction. Am Heart J (2009) 2.29

Cardiac cell therapy: where we've been, where we are, and where we should be headed. Br Med Bull (2011) 2.26

Adult Bone Marrow Cell Therapy for Ischemic Heart Disease: Evidence and Insights From Randomized Controlled Trials. Circ Res (2015) 1.80

Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation (2008) 1.77

Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol (2010) 1.69

Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62

Multicenter cell processing for cardiovascular regenerative medicine applications: the Cardiovascular Cell Therapy Research Network (CCTRN) experience. Cytotherapy (2010) 1.55

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy. Clin Res Cardiol (2011) 1.54

Aging is not associated with bone marrow-resident progenitor cell depletion. J Gerontol A Biol Sci Med Sci (2010) 1.54

Role of paracrine factors in stem and progenitor cell mediated cardiac repair and tissue fibrosis. Fibrogenesis Tissue Repair (2008) 1.37

Intramyocardial injection of autologous bone marrow mononuclear cells for patients with chronic ischemic heart disease and left ventricular dysfunction (First Mononuclear Cells injected in the US [FOCUS]): Rationale and design. Am Heart J (2010) 1.28

Results of a phase 1, randomized, double-blind, placebo-controlled trial of bone marrow mononuclear stem cell administration in patients following ST-elevation myocardial infarction. Am Heart J (2010) 1.27

Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study. Am J Physiol Heart Circ Physiol (2008) 1.22

Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19

Generation of mature murine monocytes from heterogeneous bone marrow and description of their properties. J Histochem Cytochem (2011) 1.18

Synergistic effects of SDF-1α chemokine and hyaluronic acid release from degradable hydrogels on directing bone marrow derived cell homing to the myocardium. Biomaterials (2012) 1.18

Bone marrow cell therapy after acute myocardial infarction: the HEBE trial in perspective, first results. Neth Heart J (2008) 1.16

Angiogenesis in the infarcted myocardium. Antioxid Redox Signal (2012) 1.15

Developing mechanistic insights into cardiovascular cell therapy: Cardiovascular Cell Therapy Research Network Biorepository Core Laboratory rationale. Am Heart J (2011) 1.13

Mesenchymal stem/stromal cells: a new ''cells as drugs'' paradigm. Efficacy and critical aspects in cell therapy. Curr Pharm Des (2013) 1.13

Uncultured marrow mononuclear cells delivered within fibrin glue hydrogels to porous scaffolds enhance bone regeneration within critical-sized rat cranial defects. Tissue Eng Part A (2010) 1.12

Comparison of human bone marrow mononuclear cell isolation methods for creating tissue-engineered vascular grafts: novel filter system versus traditional density centrifugation method. Tissue Eng Part C Methods (2011) 1.08

Peripheral blood derived mononuclear cells enhance osteoarthritic human chondrocyte migration. Arthritis Res Ther (2015) 1.07

Cell-based therapy for heart disease: a clinically oriented perspective. Mol Ther (2009) 1.00

Density gradient centrifugation compromises bone marrow mononuclear cell yield. PLoS One (2012) 0.99

In vivo therapeutic potential of mesenchymal stromal cells depends on the source and the isolation procedure. Stem Cell Reports (2015) 0.97

A practical approach for the validation of sterility, endotoxin and potency testing of bone marrow mononucleated cells used in cardiac regeneration in compliance with good manufacturing practice. J Transl Med (2009) 0.95

Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis. J Biol Chem (2013) 0.94

Bone marrow for cardiac repair: the importance of characterizing the phenotype and function of injected cells. Eur Heart J (2007) 0.94

The Oncogenic Potential of Mesenchymal Stem Cells in the Treatment of Cancer: Directions for Future Research. Curr Immunol Rev (2010) 0.93

Mesenchymal Progenitor Cells and Their Orthopedic Applications: Forging a Path towards Clinical Trials. Stem Cells Int (2010) 0.91

Functional impairment of human resident cardiac stem cells by the cardiotoxic antineoplastic agent trastuzumab. Stem Cells Transl Med (2012) 0.89

The REPAIR-AMI and ASTAMI trials: cell isolation procedures. Eur Heart J (2007) 0.89

Aortic implantation of mesenchymal stem cells after aneurysm injury in a porcine model. J Surg Res (2011) 0.89

Bone marrow mononuclear cells and acute myocardial infarction. Stem Cell Res Ther (2012) 0.88

Impact of intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction on left ventricular perfusion and function: a 6-month follow-up gated 99mTc-MIBI single-photon emission computed tomography study. Eur J Nucl Med Mol Imaging (2008) 0.87

Apoptotic endothelial cells demonstrate increased adhesiveness for human mesenchymal stem cells. J Cell Physiol (2009) 0.86

Stem Cell Therapy in Acute Myocardial Infarction: A Pot of Gold or Pandora's Box. Stem Cells Int (2011) 0.86

Oxygen and oxygenation in stem-cell therapy for myocardial infarction. Life Sci (2010) 0.86

GMP-based CD133(+) cells isolation maintains progenitor angiogenic properties and enhances standardization in cardiovascular cell therapy. J Cell Mol Med (2009) 0.86

The Clinical Status of Stem Cell Therapy for Ischemic Cardiomyopathy. Stem Cells Int (2015) 0.86

Bone marrow derived stem cells in regenerative medicine as advanced therapy medicinal products. Am J Transl Res (2010) 0.85

Stem cells therapy for cardiovascular repair in ischemic heart disease: How to predict and secure optimal outcome? EPMA J (2011) 0.85

Emerging roles for integrated imaging modalities in cardiovascular cell-based therapeutics: a clinical perspective. Eur J Nucl Med Mol Imaging (2011) 0.85

Recent advances in the diagnosis and treatment of acute myocardial infarction. World J Cardiol (2015) 0.85

The Evolution of the Stem Cell Theory for Heart Failure. EBioMedicine (2015) 0.82

Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells. Br J Pharmacol (2011) 0.82

Empowering Adult Stem Cells for Myocardial Regeneration V2.0: Success in Small Steps. Circ Res (2016) 0.81

Regenerative cell therapy and pharmacotherapeutic intervention in heart failure: Part 2: Pharmacological targets, agents and intervention perspectives. Neth Heart J (2008) 0.81

Stem cell-based therapies to promote angiogenesis in ischemic cardiovascular disease. Am J Physiol Heart Circ Physiol (2015) 0.81

Combination of miRNA499 and miRNA133 exerts a synergic effect on cardiac differentiation. Stem Cells (2015) 0.81

Personalized cardiac regeneration by stem cells-Hype or hope? EPMA J (2011) 0.80

α1AMP-activated protein kinase mediates vascular protective effects of exercise. Arterioscler Thromb Vasc Biol (2012) 0.80

Human cardiosphere-derived cells from patients with chronic ischaemic heart disease can be routinely expanded from atrial but not epicardial ventricular biopsies. J Cardiovasc Transl Res (2012) 0.79

Optimizing stem cells for cardiac repair: Current status and new frontiers in regenerative cardiology. World J Stem Cells (2017) 0.78

Isolation of equine multipotent mesenchymal stromal cells by enzymatic tissue digestion or explant technique: comparison of cellular properties. BMC Vet Res (2013) 0.78

Migration towards SDF-1 selects angiogenin-expressing bone marrow monocytes endowed with cardiac reparative activity in patients with previous myocardial infarction. Stem Cell Res Ther (2015) 0.77

Progenitor Cell Therapy to Treat Acute Myocardial Infarction: The Promise of High-Dose Autologous CD34(+) Bone Marrow Mononuclear Cells. Stem Cells Int (2013) 0.77

Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. Open Cardiovasc Med J (2012) 0.77

Clinical trials of cardiac repair with adult bone marrow- derived cells. Methods Mol Biol (2013) 0.77

Heart failure management: the present and the future. Antioxid Redox Signal (2009) 0.77

Selective Migration of Subpopulations of Bone Marrow Cells along an SDF-1α and ATP Gradient. Bone Marrow Res (2014) 0.77

Mass production of early-stage bone-marrow-derived mesenchymal stem cells of rat using gelatin-coated matrix. Biomed Res Int (2013) 0.77

The influence of autologous bone marrow stem cell transplantation on matrix metalloproteinases in patients treated for acute ST-elevation myocardial infarction. Mediators Inflamm (2014) 0.75

Comparison of isolation and expansion techniques for equine osteogenic progenitor cells from periosteal tissue. Can J Vet Res (2012) 0.75

Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic heart disease. BMC Res Notes (2012) 0.75

Bone marrow-derived cells for cardiovascular cell therapy: an optimized GMP method based on low-density gradient improves cell purity and function. J Transl Med (2014) 0.75

Cellular Therapy for Heart Failure. Curr Cardiol Rev (2016) 0.75

Glycogen synthase kinase 3β inhibition enhanced proliferation, migration and functional re-endothelialization of endothelial progenitor cells in hypercholesterolemia microenvironment. Exp Biol Med (Maywood) (2015) 0.75

Isolation and intravenous injection of murine bone marrow derived monocytes. J Vis Exp (2014) 0.75

Single-step enrichment of basophils from human peripheral blood by a novel method using a Percoll density gradient. J Sep Sci (2016) 0.75

Fifteen years of bone marrow mononuclear cell therapy in acute myocardial infarction. World J Stem Cells (2017) 0.75

Quantitative Assessment of Optimal Bone Marrow Site for the Isolation of Porcine Mesenchymal Stem Cells. Stem Cells Int (2017) 0.75

Leukemia cells detection based on electroporation assisted surface-enhanced Raman scattering. Biomed Opt Express (2017) 0.75

Articles by these authors

Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med (2006) 11.66

Endothelial progenitor cells: characterization and role in vascular biology. Circ Res (2004) 7.91

Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med (2006) 6.77

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation (2002) 6.50

Circulating microRNAs in patients with coronary artery disease. Circ Res (2010) 6.28

Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med (2003) 6.09

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol (2012) 5.12

Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res (2007) 5.09

MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science (2009) 5.07

Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res (2008) 4.95

Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J (2006) 4.69

Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol (2005) 4.67

Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation (2005) 4.49

Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation (2003) 4.36

Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25

Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res (2012) 4.19

Soluble CD40 ligand in acute coronary syndromes. N Engl J Med (2003) 4.06

MicroRNA-34a regulates cardiac ageing and function. Nature (2013) 4.03

Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol (2004) 3.84

Endothelial function: cardiac events. Circulation (2005) 3.80

Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66

CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation (2002) 3.38

SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34

Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation (2004) 3.26

Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol (2008) 3.15

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization. Blood (2003) 2.93

Members of the microRNA-17-92 cluster exhibit a cell-intrinsic antiangiogenic function in endothelial cells. Blood (2010) 2.80

Critical reevaluation of endothelial progenitor cell phenotypes for therapeutic and diagnostic use. Circ Res (2012) 2.78

Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ Res (2007) 2.71

Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 2.69

Assessment of the tissue distribution of transplanted human endothelial progenitor cells by radioactive labeling. Circulation (2003) 2.63

CD14+CD34low cells with stem cell phenotypic and functional features are the major source of circulating endothelial progenitors. Circ Res (2005) 2.62

Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth. Circ Res (2014) 2.60

Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: results of the TOPCARE-CHD Registry. Circ Res (2007) 2.52

Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation (2003) 2.52

Therapeutic angiogenesis and vasculogenesis for ischemic disease: part II: cell-based therapies. Circulation (2004) 2.51

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase. Nature (2011) 2.47

Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease. Circ Res (2005) 2.47

Selective functional exhaustion of hematopoietic progenitor cells in the bone marrow of patients with postinfarction heart failure. J Am Coll Cardiol (2007) 2.43

Cell-based therapy of myocardial infarction. Arterioscler Thromb Vasc Biol (2007) 2.31

Circulating microRNAs: biomarkers or mediators of cardiovascular diseases? Arterioscler Thromb Vasc Biol (2011) 2.31

Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res (2004) 2.27

Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci U S A (2009) 2.23

A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. J Clin Invest (2002) 2.19

Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA). Circ Cardiovasc Interv (2011) 2.18

Homing and engraftment of progenitor cells: a prerequisite for cell therapy. J Mol Cell Cardiol (2008) 2.13

Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Science (2008) 2.10

Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis. J Am Coll Cardiol (2005) 2.07

Role of beta2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J Exp Med (2004) 2.04

Recent molecular discoveries in angiogenesis and antiangiogenic therapies in cancer. J Clin Invest (2013) 2.03

Intracoronary administration of bone marrow-derived progenitor cells improves left ventricular function in patients at risk for adverse remodeling after acute ST-segment elevation myocardial infarction: results of the Reinfusion of Enriched Progenitor cells And Infarct Remodeling in Acute Myocardial Infarction study (REPAIR-AMI) cardiac magnetic resonance imaging substudy. Am Heart J (2009) 2.01

Clinical outcome 2 years after intracoronary administration of bone marrow-derived progenitor cells in acute myocardial infarction. Circ Heart Fail (2009) 2.01

MicroRNA-29 in aortic dilation: implications for aneurysm formation. Circ Res (2011) 2.01

Nicotine strongly activates dendritic cell-mediated adaptive immunity: potential role for progression of atherosclerotic lesions. Circulation (2003) 1.98

Antioxidative stress-associated genes in circulating progenitor cells: evidence for enhanced resistance against oxidative stress. Blood (2004) 1.96

Cell-to-cell connection of endothelial progenitor cells with cardiac myocytes by nanotubes: a novel mechanism for cell fate changes? Circ Res (2005) 1.95