Published in Genes Dev on October 15, 2007
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res (2008) 2.97
Systematic discovery of nonobvious human disease models through orthologous phenotypes. Proc Natl Acad Sci U S A (2010) 2.61
Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol (2012) 2.12
AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J (2009) 2.09
Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev (2012) 1.99
Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol (1985) (2008) 1.87
Calorie restriction and sirtuins revisited. Genes Dev (2013) 1.79
SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence. Cardiovasc Res (2012) 1.74
MicroRNA-34a induces endothelial progenitor cell senescence and impedes its angiogenesis via suppressing silent information regulator 1. Am J Physiol Endocrinol Metab (2010) 1.73
SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene (2012) 1.70
The intersection between aging and cardiovascular disease. Circ Res (2012) 1.61
Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol (2008) 1.57
Targeting tumor angiogenesis with histone deacetylase inhibitors. Cancer Lett (2008) 1.53
Sorting out functions of sirtuins in cancer. Oncogene (2013) 1.47
The dual role of sirtuins in cancer. Genes Cancer (2011) 1.45
Antisclerotic effect of Trekrezan and its possible mechanisms. Dokl Biochem Biophys (2010) 1.43
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Resveratrol improves myocardial perfusion in a swine model of hypercholesterolemia and chronic myocardial ischemia. Circulation (2010) 1.37
Sirtuins: guardians of mammalian healthspan. Trends Genet (2014) 1.36
SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse. Blood (2010) 1.36
The FoxO family in cardiac function and dysfunction. Annu Rev Physiol (2010) 1.33
Rapid temporal control of Foxp3 protein degradation by sirtuin-1. PLoS One (2011) 1.31
Anti-inflammatory therapies for cardiovascular disease. Eur Heart J (2014) 1.28
Forkhead transcription factors and cardiovascular biology. Circ Res (2008) 1.28
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle (2008) 1.28
Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation. Mol Cells (2009) 1.27
FoxO1 mediates an autofeedback loop regulating SIRT1 expression. J Biol Chem (2010) 1.27
Mitochondria and endothelial function. Circ Res (2013) 1.27
Effect of nitroxoline on angiogenesis and growth of human bladder cancer. J Natl Cancer Inst (2010) 1.22
Critical role of the nitric oxide/reactive oxygen species balance in endothelial progenitor dysfunction. Antioxid Redox Signal (2010) 1.22
MicroRNA Regulation of SIRT1. Front Physiol (2012) 1.21
MicroRNAs in age-related diseases. EMBO Mol Med (2013) 1.20
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab (2011) 1.18
Vascular aging: chronic oxidative stress and impairment of redox signaling-consequences for vascular homeostasis and disease. Ann Med (2012) 1.18
Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1. Proc Natl Acad Sci U S A (2011) 1.16
Protective effects of sirtuins in cardiovascular diseases: from bench to bedside. Eur Heart J (2015) 1.11
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1. Br J Pharmacol (2014) 1.07
Regulation of Akt signaling by sirtuins: its implication in cardiac hypertrophy and aging. Circ Res (2014) 1.06
Perspectives on translational and therapeutic aspects of SIRT1 in inflammaging and senescence. Biochem Pharmacol (2012) 1.06
SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: Role of resveratrol. Biochem Biophys Res Commun (2010) 1.04
Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy. J Mol Cell Cardiol (2011) 1.03
Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1. PLoS One (2012) 1.02
Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions. PLoS One (2012) 1.01
Endothelial sirtuin 1 deficiency perpetrates nephrosclerosis through downregulation of matrix metalloproteinase-14: relevance to fibrosis of vascular senescence. J Am Soc Nephrol (2013) 1.01
Protein deacetylation by sirtuins: delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cell Mol Life Sci (2010) 1.00
SIRT1 enhances matrix metalloproteinase-2 expression and tumor cell invasion in prostate cancer cells. Prostate (2012) 1.00
Potential mechanisms linking atherosclerosis and increased cardiovascular risk in COPD: focus on Sirtuins. Int J Mol Sci (2013) 1.00
Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers. Int J Clin Exp Pathol (2010) 0.99
miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn (2011) 0.98
Anti-angiogenic effect of high-dose resveratrol in a swine model of metabolic syndrome. Surgery (2010) 0.98
Human vascular tissue models formed from human induced pluripotent stem cell derived endothelial cells. Stem Cell Rev (2015) 0.98
Mammalian Sirt1: insights on its biological functions. Cell Commun Signal (2011) 0.98
Emerging Roles of SIRT1 in Cancer Drug Resistance. Genes Cancer (2013) 0.97
Inhibition of the p110α isoform of PI 3-kinase stimulates nonfunctional tumor angiogenesis. J Exp Med (2013) 0.97
SirT1 in muscle physiology and disease: lessons from mouse models. Dis Model Mech (2010) 0.97
SPRY2 loss enhances ErbB trafficking and PI3K/AKT signalling to drive human and mouse prostate carcinogenesis. EMBO Mol Med (2012) 0.96
Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. Am J Pathol (2010) 0.96
Sirt3 is essential for apelin-induced angiogenesis in post-myocardial infarction of diabetes. J Cell Mol Med (2014) 0.96
Resveratrol attenuates ischemia/reperfusion injury in neonatal cardiomyocytes and its underlying mechanism. PLoS One (2012) 0.95
SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1α complex. Antioxid Redox Signal (2013) 0.94
The Role of FoxC2 Transcription Factor in Tumor Angiogenesis. J Oncol (2011) 0.94
Anti-inflammatory properties of sirtuin 6 in human umbilical vein endothelial cells. Mediators Inflamm (2012) 0.93
Endothelial cell metabolism and implications for cancer therapy. Br J Cancer (2012) 0.93
Histone deacetylase inhibition enhances self renewal and cardioprotection by human cord blood-derived CD34 cells. PLoS One (2011) 0.93
Genetics, epigenetics and pharmaco-(epi)genomics in angiogenesis. J Cell Mol Med (2008) 0.93
Endothelial cell metabolism: parallels and divergences with cancer cell metabolism. Cancer Metab (2014) 0.92
Circulating factors induced by caloric restriction in the nonhuman primate Macaca mulatta activate angiogenic processes in endothelial cells. J Gerontol A Biol Sci Med Sci (2012) 0.92
Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol (2011) 0.91
SIRT1 regulates endothelial Notch signaling in lung cancer. PLoS One (2012) 0.91
Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice. Endocrinology (2012) 0.91
SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence. Aging Cell (2014) 0.90
The role of sirtuins in cardiac disease. Am J Physiol Heart Circ Physiol (2015) 0.89
SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress. Genes Cancer (2013) 0.89
Sirtuin-3 (SIRT3) and the Hallmarks of Cancer. Genes Cancer (2013) 0.88
Sirtuins in epigenetic regulation. Chem Rev (2015) 0.88
SIRT1 regulates lamellipodium extension and migration of melanoma cells. J Invest Dermatol (2014) 0.88
Ca2+/calmodulin-dependent protein kinase kinase β phosphorylation of Sirtuin 1 in endothelium is atheroprotective. Proc Natl Acad Sci U S A (2013) 0.88
Androgen depletion in humans leads to cavernous tissue reorganization and upregulation of Sirt1-eNOS axis. Age (Dordr) (2011) 0.87
Sirtinol treatment reduces inflammation in human dermal microvascular endothelial cells. PLoS One (2011) 0.87
Sirtuins, Cell Senescence, and Vascular Aging. Can J Cardiol (2015) 0.87
Testosterone deficiency accelerates neuronal and vascular aging of SAMP8 mice: protective role of eNOS and SIRT1. PLoS One (2012) 0.86
Global Gene Expression Profiling Reveals Functional Importance of Sirt2 in Endothelial Cells under Oxidative Stress. Int J Mol Sci (2013) 0.86
Expression of SIRT1 and DBC1 in Developing and Adult Retinas. Stem Cells Int (2012) 0.86
Sirtuins and pyridine nucleotides. Circ Res (2012) 0.86
Embelin inhibits endothelial mitochondrial respiration and impairs neoangiogenesis during tumor growth and wound healing. EMBO Mol Med (2014) 0.85
On the epigenetics of vascular regulation and disease. Clin Epigenetics (2012) 0.85
Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One (2013) 0.85
The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer's Disease. Proteomes (2016) 0.85
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A (2013) 0.84
tRNA synthetase counteracts c-Myc to develop functional vasculature. Elife (2014) 0.84
Caspase-1 mediates hyperlipidemia-weakened progenitor cell vessel repair. Front Biosci (Landmark Ed) (2016) 0.83
Histone deacetylase modulators provided by Mother Nature. Genes Nutr (2012) 0.83
Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis (2013) 0.83
Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives. PLoS One (2012) 0.83
Resveratrol, an activator of SIRT1, restores erectile function in streptozotocin-induced diabetic rats. Asian J Androl (2013) 0.83
Vascular Smooth Muscle Sirtuin-1 Protects Against Aortic Dissection During Angiotensin II-Induced Hypertension. J Am Heart Assoc (2015) 0.83
Translating the histone code. Science (2001) 56.77
The language of covalent histone modifications. Nature (2000) 44.92
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell (2001) 15.97
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
In vivo imaging of embryonic vascular development using transgenic zebrafish. Dev Biol (2002) 11.62
Histone deacetylases (HDACs): characterization of the classical HDAC family. Biochem J (2003) 11.27
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature (2004) 10.32
The Sir2 family of protein deacetylases. Annu Rev Biochem (2004) 9.28
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun (2000) 9.09
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell (2003) 8.34
FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene (2005) 7.50
Calorie restriction--the SIR2 connection. Cell (2005) 6.51
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A (2000) 6.49
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol (2005) 6.34
Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow. J Exp Med (2001) 5.97
Signaling to chromatin through histone modifications. Cell (2000) 5.36
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev (2004) 4.41
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc Natl Acad Sci U S A (2004) 4.25
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes. J Biol Chem (2005) 4.13
Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A (2003) 3.98
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity. Proc Natl Acad Sci U S A (2004) 3.93
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell (1998) 3.72
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1). J Biol Chem (2004) 3.39
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Nat Med (2001) 3.07
Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell (2006) 3.07
Sirtuins: Sir2-related NAD-dependent protein deacetylases. Genome Biol (2004) 3.00
Lysine acetylation and the bromodomain: a new partnership for signaling. Bioessays (2004) 2.84
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J Biol Chem (2004) 2.73
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun (2000) 2.65
The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol (2004) 2.33
Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Genes Dev (2004) 2.32
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation. EMBO J (2005) 2.30
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun (2003) 2.27
Histone deacetylases inhibitors as anti-angiogenic agents altering vascular endothelial growth factor signaling. Oncogene (2002) 2.02
Role of PECAM-1 in the shear-stress-induced activation of Akt and the endothelial nitric oxide synthase (eNOS) in endothelial cells. J Cell Sci (2005) 1.95
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell (2002) 1.81
Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells. J Cell Sci (2007) 1.57
Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells. J Exp Med (2005) 1.56
Inhibitors of histone deacetylation downregulate the expression of endothelial nitric oxide synthase and compromise endothelial cell function in vasorelaxation and angiogenesis. Circ Res (2002) 1.37
Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress. Circ Res (2005) 1.29
Shear stress-mediated chromatin remodeling provides molecular basis for flow-dependent regulation of gene expression. Circ Res (2003) 1.22
Conserved and divergent patterns of Reelin expression in the zebrafish central nervous system. J Comp Neurol (2002) 1.04
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med (2006) 11.66
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci U S A (2003) 9.14
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell (2006) 8.48
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol (2007) 7.97
Endothelial progenitor cells: characterization and role in vascular biology. Circ Res (2004) 7.91
Recent progress in the biology and physiology of sirtuins. Nature (2009) 7.73
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J (2007) 7.30
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med (2006) 6.77
Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation (2002) 6.50
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
The mechanism and regulation of chromosomal V(D)J recombination. Cell (2002) 6.28
Circulating microRNAs in patients with coronary artery disease. Circ Res (2010) 6.28
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell (2006) 6.09
Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med (2003) 6.09
IgH class switching and translocations use a robust non-classical end-joining pathway. Nature (2007) 6.05
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell (2008) 5.76
SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell (2008) 5.68
DNA repair, genome stability, and aging. Cell (2005) 5.52
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy. Proc Natl Acad Sci U S A (2008) 5.48
Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell (2003) 5.26
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell (2002) 5.19
Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs. Nat Cell Biol (2012) 5.12
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell (2010) 5.11
Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis. Circ Res (2007) 5.09
MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice. Science (2009) 5.07
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc Natl Acad Sci U S A (2002) 5.07
Role of microRNAs in vascular diseases, inflammation, and angiogenesis. Cardiovasc Res (2008) 4.95
Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial. Eur Heart J (2006) 4.69
Soluble factors released by endothelial progenitor cells promote migration of endothelial cells and cardiac resident progenitor cells. J Mol Cell Cardiol (2005) 4.67
Class II histone deacetylases: versatile regulators. Trends Genet (2003) 4.63
Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation (2005) 4.49
Endocytic trafficking of Rac is required for the spatial restriction of signaling in cell migration. Cell (2008) 4.47
Myeloperoxidase serum levels predict risk in patients with acute coronary syndromes. Circulation (2003) 4.36
Mechanism and control of V(D)J recombination at the immunoglobulin heavy chain locus. Annu Rev Immunol (2006) 4.32
Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell (2002) 4.29
Unchain my heart: the scientific foundations of cardiac repair. J Clin Invest (2005) 4.25
Nox4 is a protective reactive oxygen species generating vascular NADPH oxidase. Circ Res (2012) 4.19
Fate tracing reveals the endothelial origin of hematopoietic stem cells. Cell Stem Cell (2008) 4.17
53BP1 links DNA damage-response pathways to immunoglobulin heavy chain class-switch recombination. Nat Immunol (2004) 4.14
Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev (2004) 4.12
Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
Soluble CD40 ligand in acute coronary syndromes. N Engl J Med (2003) 4.06
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
MicroRNA-34a regulates cardiac ageing and function. Nature (2013) 4.03
Spatial organization of the mouse genome and its role in recurrent chromosomal translocations. Cell (2012) 4.02
Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J (2007) 3.98
Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments. J Cell Biol (2006) 3.95
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI Trial. J Am Coll Cardiol (2004) 3.84
Genome-wide translocation sequencing reveals mechanisms of chromosome breaks and rearrangements in B cells. Cell (2011) 3.81
Endothelial function: cardiac events. Circulation (2005) 3.80
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J Clin Invest (2005) 3.66
H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell (2006) 3.53
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall. Genes Dev (2003) 3.48
Tissue-specific regulation of SIRT1 by calorie restriction. Genes Dev (2008) 3.46
CD40 ligand inhibits endothelial cell migration by increasing production of endothelial reactive oxygen species. Circulation (2002) 3.38
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease. Circulation (2004) 3.26
Wnt/beta-catenin signaling controls development of the blood-brain barrier. J Cell Biol (2008) 3.22
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nat Immunol (2011) 3.21
Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5. Nat Cell Biol (2008) 3.15
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab (2005) 3.15
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
The molecular basis of vascular lumen formation in the developing mouse aorta. Dev Cell (2009) 3.08
Activating Notch1 mutations in mouse models of T-ALL. Blood (2005) 3.08
Live imaging of innate immune cell sensing of transformed cells in zebrafish larvae: parallels between tumor initiation and wound inflammation. PLoS Biol (2010) 2.99