Bone marrow-derived stromal cells home to and remain in the infarcted rat heart but fail to improve function: an in vivo cine-MRI study.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMC 2519197)

Published in Am J Physiol Heart Circ Physiol on June 06, 2008

Authors

Carolyn A Carr1, Daniel J Stuckey, Louise Tatton, Damian J Tyler, Sarah J M Hale, Dominic Sweeney, Jürgen E Schneider, Enca Martin-Rendon, George K Radda, Sian E Harding, Suzanne M Watt, Kieran Clarke

Author Affiliations

1: Cardiac Metabolism Research Group, Dept. of Physiology, Anatomy and Genetics, Sherrington Bldg., Univ. of Oxford, Parks Road Oxford, United Kingdom OX1 3PT. Carolyn.Carr@dpag.ox.ac.uk

Articles citing this

Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci U S A (2009) 4.21

Cardiac lymphatics are heterogeneous in origin and respond to injury. Nature (2015) 1.78

Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation (2009) 1.73

Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev (2012) 1.20

Human endothelial stem/progenitor cells, angiogenic factors and vascular repair. J R Soc Interface (2010) 1.04

Cardiosphere-derived cells improve function in the infarcted rat heart for at least 16 weeks--an MRI study. PLoS One (2011) 1.02

In vivo imaging of stem cells and Beta cells using direct cell labeling and reporter gene methods. Arterioscler Thromb Vasc Biol (2009) 1.00

Bone marrow stromal cells produce long-term pain relief in rat models of persistent pain. Stem Cells (2011) 0.99

In vivo MRI characterization of progressive cardiac dysfunction in the mdx mouse model of muscular dystrophy. PLoS One (2012) 0.98

Imaging approaches for the study of cell-based cardiac therapies. Nat Rev Cardiol (2009) 0.96

Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2010) 0.94

Concise review: Nanoparticles and cellular carriers-allies in cancer imaging and cellular gene therapy? Stem Cells (2010) 0.92

Mesenchymal stem cells and cardiovascular disease: a bench to bedside roadmap. Stem Cells Int (2012) 0.92

Magnetic resonance imaging with superparamagnetic iron oxide fails to track the long-term fate of mesenchymal stem cells transplanted into heart. Sci Rep (2015) 0.87

Cardiovascular magnetic resonance imaging in experimental models. Open Cardiovasc Med J (2010) 0.87

Dual-modal tracking of transplanted mesenchymal stem cells after myocardial infarction. Int J Nanomedicine (2011) 0.85

Emerging MRI methods in translational cardiovascular research. J Cardiovasc Transl Res (2011) 0.84

First-pass perfusion CMR two days after infarction predicts severity of functional impairment six weeks later in the rat heart. J Cardiovasc Magn Reson (2011) 0.82

Recent developments and future challenges on imaging for stem cell research. J Cardiovasc Transl Res (2010) 0.82

Murine cardiosphere-derived cells are impaired by age but not by cardiac dystrophic dysfunction. Stem Cells Dev (2014) 0.81

Long-term left ventricular remodelling in rat model of nonreperfused myocardial infarction: sequential MR imaging using a 3T clinical scanner. J Biomed Biotechnol (2012) 0.81

Hypoxic preconditioning increases the protective effect of bone marrow mesenchymal stem cells on spinal cord ischemia/reperfusion injury. Mol Med Rep (2016) 0.80

Autologous cardiomyotissue implantation promotes myocardial regeneration, decreases infarct size, and improves left ventricular function. Circulation (2010) 0.80

Discrepant Results of Experimental Human Mesenchymal Stromal Cell Therapy after Myocardial Infarction: Are Animal Models Robust Enough? PLoS One (2016) 0.79

Extraembryonic origin of circulating endothelial cells. PLoS One (2011) 0.77

Value of MR contrast media in image-guided body interventions. World J Radiol (2012) 0.76

Dynamic Tracking of Injected Mesenchymal Stem Cells after Myocardial Infarction in Rats: A Serial 7T MRI Study. Stem Cells Int (2016) 0.75

Articles cited by this

Bone marrow cells regenerate infarcted myocardium. Nature (2001) 21.24

Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med (2006) 11.66

Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med (2001) 10.36

Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet (2004) 9.35

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 8.87

Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med (2003) 8.46

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation (2002) 7.97

Autologous bone marrow-derived stem-cell transfer in patients with ST-segment elevation myocardial infarction: double-blind, randomised controlled trial. Lancet (2006) 7.33

Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med (2006) 7.28

Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med (2006) 6.77

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI). Circulation (2002) 6.50

Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res (2004) 6.34

Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial. Circulation (2006) 5.99

Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol (2002) 5.74

Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury. Circulation (2004) 4.79

Monolayered mesenchymal stem cells repair scarred myocardium after myocardial infarction. Nat Med (2006) 4.53

Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res (2006) 4.14

Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation (2005) 4.03

Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction. Eur Heart J (2007) 3.98

Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance. Am J Physiol Heart Circ Physiol (2006) 3.78

Clonally expanded novel multipotent stem cells from human bone marrow regenerate myocardium after myocardial infarction. J Clin Invest (2005) 3.61

Autologous transplantation of bone marrow cells improves damaged heart function. Circulation (1999) 3.17

Iron-oxide labeling and outcome of transplanted mesenchymal stem cells in the infarcted myocardium. Circulation (2007) 2.99

Serial cardiac magnetic resonance imaging of injected mesenchymal stem cells. Circulation (2003) 2.75

Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol (2004) 2.69

Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev (2004) 2.60

Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept (2004) 2.56

Highly efficient endosomal labeling of progenitor and stem cells with large magnetic particles allows magnetic resonance imaging of single cells. Blood (2003) 2.50

Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem Biophys Res Commun (2007) 2.35

Regeneration gaps: observations on stem cells and cardiac repair. J Am Coll Cardiol (2006) 2.13

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging (2003) 1.97

Survival after an experimental myocardial infarction: beneficial effects of long-term therapy with captopril. Circulation (1985) 1.92

Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction. Circulation (2004) 1.86

Ex vivo activated human macrophages improve healing, remodeling, and function of the infarcted heart. Circulation (2006) 1.77

Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction. Circ Res (2004) 1.65

Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair. J Mol Cell Cardiol (2006) 1.58

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia. Stem Cells (2006) 1.47

Serial cine-magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats. J Magn Reson Imaging (2001) 1.35

Role of imaging in cardiac stem cell therapy. J Am Coll Cardiol (2007) 1.32

Myocardial neovascularization by bone marrow angioblasts results in cardiomyocyte regeneration. Am J Physiol Heart Circ Physiol (2004) 1.31

Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart. Stem Cells (2006) 1.30

Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Magn Reson Med (2006) 1.25

The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur Heart J (2006) 1.20

Impact of intracoronary bone marrow cell transfer on diastolic function in patients after acute myocardial infarction: results from the BOOST trial. Eur Heart J (2006) 1.16

Tomographic three-dimensional echocardiographic determination of chamber size and systolic function in patients with left ventricular aneurysm: comparison to magnetic resonance imaging, cineventriculography, and two-dimensional echocardiography. Circulation (1997) 1.16

Cine-MRI versus two-dimensional echocardiography to measure in vivo left ventricular function in rat heart. NMR Biomed (2008) 1.15

Mesenchymal stem cells from rat visceral fat exhibit multipotential differentiation in vitro. Anat Rec A Discov Mol Cell Evol Biol (2003) 1.14

CINE-MR imaging of the normal and infarcted rat heart using an 11.7 T vertical bore MR system. J Cardiovasc Magn Reson (2006) 1.13

Comparison of various kinds of bone marrow stem cells for the repair of infarcted myocardium: single clonally purified non-hematopoietic mesenchymal stem cells serve as a superior source. J Cell Biochem (2006) 1.13

Hematopoietic stem cells do not repair the infarcted mouse heart. Cardiovasc Res (2005) 1.08

Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction. Am J Physiol Heart Circ Physiol (2007) 0.97

New methods to titrate EIAV-based lentiviral vectors. Mol Ther (2002) 0.91

The utility of magnetic resonance imaging in cardiac tissue regeneration trials. Nat Clin Pract Cardiovasc Med (2006) 0.87

Haematopoietic stem cells improve cardiac function after infarction without permanent cardiac engraftment. Eur J Heart Fail (2005) 0.85

Cellular cardiomyoplasty in large myocardial infarction: can the beneficial effect be enhanced by ACE-inhibitor therapy? Eur J Heart Fail (2007) 0.81

New concepts in characterization of ischemically injured myocardium by MRI. Exp Biol Med (Maywood) (2001) 0.80

Magnetic resonance imaging in myocardial ischemia. Curr Opin Cardiol (2004) 0.78

Stem cells to repair the broken heart: much ado about nothing? Heart (2006) 0.77

Letter to the editor: infarct size measurements are critically important when comparing interventions affecting ventricular remodeling. Am J Physiol Heart Circ Physiol (2007) 0.76

Articles by these authors

Cyclin E ablation in the mouse. Cell (2003) 5.58

Stress (Takotsubo) cardiomyopathy--a novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. Nat Clin Pract Cardiovasc Med (2008) 4.91

Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science (2010) 2.99

Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J (2008) 2.99

Uncoupling proteins in human heart. Lancet (2004) 2.85

Stem cell treatment for acute myocardial infarction. Cochrane Database Syst Rev (2012) 2.78

In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance. Proc Natl Acad Sci U S A (2008) 2.69

Loss of T-tubules and other changes to surface topography in ventricular myocytes from failing human and rat heart. Proc Natl Acad Sci U S A (2009) 2.61

Beneficial cardiovascular effects of bariatric surgical and dietary weight loss in obesity. J Am Coll Cardiol (2009) 2.57

The effect of obesity and weight loss on aortic pulse wave velocity as assessed by magnetic resonance imaging. Obesity (Silver Spring) (2010) 2.43

Generation of histo-anatomically representative models of the individual heart: tools and application. Philos Trans A Math Phys Eng Sci (2009) 2.37

Rapid identification and 3D reconstruction of complex cardiac malformations in transgenic mouse embryos using fast gradient echo sequence magnetic resonance imaging. J Mol Cell Cardiol (2003) 2.24

Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment. Circulation (2005) 2.23

Automatically generated, anatomically accurate meshes for cardiac electrophysiology problems. IEEE Trans Biomed Eng (2009) 2.15

Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy. FASEB J (2009) 2.05

Identification of cardiac malformations in mice lacking Ptdsr using a novel high-throughput magnetic resonance imaging technique. BMC Dev Biol (2004) 2.01

Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes. Circulation (2003) 2.01

Effects of Na(+)/Ca(2+)-exchanger overexpression on excitation-contraction coupling in adult rabbit ventricular myocytes. J Mol Cell Cardiol (2002) 2.00

Fast, high-resolution in vivo cine magnetic resonance imaging in normal and failing mouse hearts on a vertical 11.7 T system. J Magn Reson Imaging (2003) 1.97

Assessment of motion gating strategies for mouse magnetic resonance at high magnetic fields. J Magn Reson Imaging (2004) 1.92

Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy. Nat Med (2013) 1.89

The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. Circ Cardiovasc Imaging (2012) 1.86

Development of an anatomically detailed MRI-derived rabbit ventricular model and assessment of its impact on simulations of electrophysiological function. Am J Physiol Heart Circ Physiol (2009) 1.84

Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy. J Am Coll Cardiol (2003) 1.84

Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo. Blood (2006) 1.83

Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail (2012) 1.82

Quantitative 3-dimensional echocardiography for accurate and rapid cardiac phenotype characterization in mice. Circulation (2004) 1.79

Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients. Circulation (2013) 1.71

Loss of beta-adrenoceptor response in myocytes overexpressing the Na+/Ca(2+)-exchanger. J Mol Cell Cardiol (2004) 1.68

Ventricular hypertrophy and cavity dilatation in relation to body mass index in women with uncomplicated obesity. Heart (2010) 1.68

Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice. Proc Natl Acad Sci U S A (2008) 1.68

Three-dimensional models of individual cardiac histoanatomy: tools and challenges. Ann N Y Acad Sci (2006) 1.66

Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Nat Genet (2004) 1.61

Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current. Cardiovasc Res (2013) 1.57

Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet (2004) 1.56

Regulation of human metabolism by hypoxia-inducible factor. Proc Natl Acad Sci U S A (2010) 1.56

Targeting phospholamban by gene transfer in human heart failure. Circulation (2002) 1.55

Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med (2002) 1.50

Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia. Stem Cells (2006) 1.47

SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ Arrhythm Electrophysiol (2011) 1.40

NOS substrate during cardioplegic arrest and cold storage decreases stunning after heart transplantation in a rat model. J Heart Lung Transplant (2003) 1.39

Fumarate is cardioprotective via activation of the Nrf2 antioxidant pathway. Cell Metab (2012) 1.35

Is stress cardiomyopathy the underlying cause of ventricular dysfunction associated with brain death? J Heart Lung Transplant (2010) 1.34

A combined 1H-NMR spectroscopy- and mass spectrometry-based metabolomic study of the PPAR-alpha null mutant mouse defines profound systemic changes in metabolism linked to the metabolic syndrome. Physiol Genomics (2006) 1.34

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol (2009) 1.34

Reduced inotropic reserve and increased susceptibility to cardiac ischemia/reperfusion injury in phosphocreatine-deficient guanidinoacetate-N-methyltransferase-knockout mice. Circulation (2005) 1.33

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism. Hum Mol Genet (2010) 1.33

VACTERL/caudal regression/Currarino syndrome-like malformations in mice with mutation in the proprotein convertase Pcsk5. Genes Dev (2008) 1.32

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease. Neurobiol Aging (2012) 1.32

Iron particles for noninvasive monitoring of bone marrow stromal cell engraftment into, and isolation of viable engrafted donor cells from, the heart. Stem Cells (2006) 1.30

Supranormal myocardial creatine and phosphocreatine concentrations lead to cardiac hypertrophy and heart failure: insights from creatine transporter-overexpressing transgenic mice. Circulation (2005) 1.30

Cerebral venous system and anatomical predisposition to high-altitude headache. Ann Neurol (2013) 1.29

High-resolution, high-throughput magnetic paragraph sign resonance imaging of mouse embryonic paragraph sign anatomy using a fast gradient-echo sequence. MAGMA (2003) 1.28

High-resolution imaging of normal anatomy, and neural and adrenal malformations in mouse embryos using magnetic resonance microscopy. J Anat (2003) 1.26

Role of pyruvate dehydrogenase inhibition in the development of hypertrophy in the hyperthyroid rat heart: a combined magnetic resonance imaging and hyperpolarized magnetic resonance spectroscopy study. Circulation (2011) 1.26

Measuring intracellular pH in the heart using hyperpolarized carbon dioxide and bicarbonate: a 13C and 31P magnetic resonance spectroscopy study. Cardiovasc Res (2009) 1.24

Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Circulation (2011) 1.24

Plasticity of surface structures and β(2)-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ Heart Fail (2012) 1.23

Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. J Neurosci (2002) 1.22

Modulation of human embryonic stem cell-derived cardiomyocyte growth: a testbed for studying human cardiac hypertrophy? J Mol Cell Cardiol (2010) 1.22

Determinants of left ventricular mass in obesity; a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson (2009) 1.22

Systemic inflammatory response reactivates immune-mediated lesions in rat brain. J Neurosci (2009) 1.21

Functional requirements for fukutin-related protein in the Golgi apparatus. Hum Mol Genet (2002) 1.21

Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev (2012) 1.20

High-resolution scanning patch-clamp: new insights into cell function. FASEB J (2002) 1.20

Modification of myocardial substrate use as a therapy for heart failure. Nat Clin Pract Cardiovasc Med (2006) 1.19

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart. J Mol Cell Cardiol (2008) 1.19

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice. Hum Mol Genet (2010) 1.19

A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart. Basic Res Cardiol (2011) 1.19