Published in J Biol Chem on January 15, 1992
Signal transduction via the MAP kinases: proceed at your own RSK. Proc Natl Acad Sci U S A (1993) 6.19
Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase. Mol Cell Biol (1993) 3.13
The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway. EMBO J (1994) 2.06
Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro. Mol Cell Biol (1993) 1.99
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A (1992) 1.83
Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1993) 1.46
Bombesin and epidermal growth factor stimulate the mitogen-activated protein kinase through different pathways in Swiss 3T3 cells. Biochem J (1993) 1.34
The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras. Mol Cell Biol (1994) 1.29
The pool of map kinase associated with microtubules is small but constitutively active. Mol Biol Cell (1996) 1.19
Insulin-stimulated disassociation of the SOS-Grb2 complex. Mol Cell Biol (1995) 1.11
Basal extracellular signal-regulated kinase activity modulates cell-cell and cell-matrix interactions. Mol Cell Biol (1998) 1.07
Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells. Biochem J (1995) 1.06
Mixed lineage kinases (MLKs): a role in dendritic cells, inflammation and immunity? Int J Exp Pathol (2007) 1.03
Protein kinase A acts at multiple points to inhibit Xenopus oocyte maturation. Mol Cell Biol (1994) 0.99
The ERK 1 and 2 pathway in the nervous system: from basic aspects to possible clinical applications in pain and visceral dysfunction. Curr Neuropharmacol (2007) 0.94
Networking with mitogen-activated protein kinases. Mol Cell Biochem (1993) 0.92
Protein-tyrosine-phosphatase 2C is phosphorylated and inhibited by 44-kDa mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1994) 0.90
Expression and activity of mitogen activated protein kinases in human colorectal carcinoma. Gut (1999) 0.85
The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol Cell Biochem (1993) 0.84
Rapid stimulation of mitogen-activated protein kinase of rat liver by prolactin. Biochem J (1994) 0.82
The mammalian mitogen activated protein kinase network. Clin Mol Pathol (1995) 0.75
Effects of tanshinone VI on insulin-like growth factor-1-induced hypertrophy of isolated cardiomyocytes from neonatal rats. Exp Clin Cardiol (2004) 0.75
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev (2001) 14.02
ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell (1991) 9.54
Mitogen-activated protein kinase pathways. Curr Opin Cell Biol (1997) 9.10
Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science (1998) 8.55
Differential regulation and properties of MAPKs. Oncogene (2007) 6.36
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity (1996) 5.64
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Mol Cell Biol (1999) 5.55
Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell (1992) 5.11
Atomic structure of the MAP kinase ERK2 at 2.3 A resolution. Nature (1994) 4.97
MAP kinases. Chem Rev (2001) 4.70
An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science (1990) 4.63
Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Cell (1997) 4.26
WNK1, a novel mammalian serine/threonine protein kinase lacking the catalytic lysine in subdomain II. J Biol Chem (2000) 3.97
Phosphorylation activates the insulin receptor tyrosine protein kinase. Proc Natl Acad Sci U S A (1983) 3.94
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation. EMBO J (1995) 3.86
Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood (2000) 3.86
Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation. Cell (1998) 3.80
Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro. J Biol Chem (1993) 3.57
Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. J Biol Chem (2000) 3.50
Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: implications for their mechanism of activation. Proc Natl Acad Sci U S A (1991) 3.31
Identification of multiple extracellular signal-regulated kinases (ERKs) with antipeptide antibodies. Cell Regul (1991) 2.88
Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem (1995) 2.83
Rapid insulin-stimulated accumulation of an mRNA encoding a proline-rich protein. J Biol Chem (1990) 2.65
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J (1997) 2.57
Cloning and characterization of RECQL, a potential human homologue of the Escherichia coli DNA helicase RecQ. J Biol Chem (1994) 2.54
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
New insights into the control of MAP kinase pathways. Exp Cell Res (1999) 2.39
Shk1, a homolog of the Saccharomyces cerevisiae Ste20 and mammalian p65PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1995) 2.33
Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J Biol Chem (1992) 2.29
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways. J Biol Chem (1985) 2.24
Isolation of MEK5 and differential expression of alternatively spliced forms. J Biol Chem (1995) 2.23
Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation. J Biol Chem (1982) 2.21
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation. Curr Biol (1998) 2.20
Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta. Nature (1998) 2.20
Molecular cloning, characterization, and expression of a cDNA encoding the "80- to 87-kDa" myristoylated alanine-rich C kinase substrate: a major cellular substrate for protein kinase C. Proc Natl Acad Sci U S A (1989) 2.16
Systems for polyacrylamide gel electrophoresis. Methods Enzymol (1984) 2.08
HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation. Cell (1998) 2.07
Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases. J Biol Chem (1997) 2.03
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. J Biol Chem (2001) 2.03
Purification and properties of extracellular signal-regulated kinase 1, an insulin-stimulated microtubule-associated protein 2 kinase. Biochemistry (1991) 2.01
MARCKS deficiency in mice leads to abnormal brain development and perinatal death. Proc Natl Acad Sci U S A (1995) 2.01
Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members. Mol Cell Biol (1996) 2.00
Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO J (2001) 1.93
Structural basis of inhibitor selectivity in MAP kinases. Structure (1998) 1.89
Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation. J Biol Chem (1998) 1.86
Evidence for a Ras-dependent extracellular signal-regulated protein kinase (ERK) cascade. Proc Natl Acad Sci U S A (1992) 1.83
The structure of mitogen-activated protein kinase p38 at 2.1-A resolution. Proc Natl Acad Sci U S A (1997) 1.83
ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine-31 in situ. Proc Natl Acad Sci U S A (1992) 1.83
IL-1 receptor-associated kinase modulates host responsiveness to endotoxin. J Immunol (2000) 1.82
Identification of c-fos sequences involved in induction by insulin and phorbol esters. J Biol Chem (1988) 1.78
Bone marrow transplantation reproduces the tristetraprolin-deficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction. J Clin Invest (1997) 1.78
Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. J Biol Chem (1995) 1.75
Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc Natl Acad Sci U S A (1994) 1.67
MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1995) 1.65
Phosphorylation reverses the membrane association of peptides that correspond to the basic domains of MARCKS and neuromodulin. Biophys J (1994) 1.64
Identification of substrates and regulators of the mitogen-activated protein kinase ERK5 using chimeric protein kinases. J Biol Chem (1998) 1.64
Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly(A) tail. J Biol Chem (2001) 1.63
Contribution of the ERK5/MEK5 pathway to Ras/Raf signaling and growth control. J Biol Chem (1999) 1.63
Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zinc-finger transcription factor. Mol Endocrinol (1996) 1.61
Regulation of rat ornithine decarboxylase mRNA translation by its 5'-untranslated region. J Biol Chem (1990) 1.61
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol (2000) 1.60
Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. J Biol Chem (1983) 1.59
Dual MAP kinase pathways mediate opposing forms of long-term plasticity at CA3-CA1 synapses. Nat Neurosci (2000) 1.57
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci U S A (1996) 1.57
Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E. J Biol Chem (1991) 1.56
A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc Natl Acad Sci U S A (1994) 1.53
The metabolic effects of sodium dichloroacetate in the starved rat. Biochem J (1974) 1.52
Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C. J Biol Chem (1989) 1.52
MAP kinase becomes stably activated at metaphase and is associated with microtubule-organizing centers during meiotic maturation of mouse oocytes. Dev Biol (1993) 1.51
Mutation of position 52 in ERK2 creates a nonproductive binding mode for adenosine 5'-triphosphate. Biochemistry (1996) 1.51
Stimulation of NFkappa B activity by multiple signaling pathways requires PAK1. J Biol Chem (2000) 1.49
Roles of tumor necrosis factor-alpha receptor subtypes in the pathogenesis of the tristetraprolin-deficiency syndrome. Blood (2001) 1.49
Purification of casein kinase I and isolation of cDNAs encoding multiple casein kinase I-like enzymes. Proc Natl Acad Sci U S A (1991) 1.47
An insulin-stimulated ribosomal protein S6 kinase from rabbit liver. J Biol Chem (1989) 1.47
Activation of mitogen-activated protein kinase cascades by p21-activated protein kinases in cell-free extracts of Xenopus oocytes. J Biol Chem (1995) 1.45
The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes. Oncogene (2010) 1.43
Experimental diabetic ketoacidosis. Sequential changes of metabolic intermediates in blood, liver, cerebrospinal fluid and brain after acute insulin deprivation in the streptozotocin-diabetic rat. Biochem J (1974) 1.42
The effects of inhibition of gluconeogenesis on ketogenesis in starved and diabetic rats. Biochem J (1975) 1.38
Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion. Proc Natl Acad Sci U S A (1997) 1.36
The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. Nucleic Acids Res (1991) 1.35
The N-terminal ERK-binding site of MEK1 is required for efficient feedback phosphorylation by ERK2 in vitro and ERK activation in vivo. J Biol Chem (1999) 1.33
Insulin and growth factor effects on c-fos expression in normal and protein kinase C-deficient 3T3-L1 fibroblasts and adipocytes. Proc Natl Acad Sci U S A (1986) 1.31
ERK5 and ERK2 cooperate to regulate NF-kappaB and cell transformation. J Biol Chem (2000) 1.30
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J Biol Chem (1998) 1.30
MEKK1 binds directly to the c-Jun N-terminal kinases/stress-activated protein kinases. J Biol Chem (1997) 1.28
Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1. Mol Cell Biol (1993) 1.28
The highly conserved skb1 gene encodes a protein that interacts with Shk1, a fission yeast Ste20/PAK homolog. Proc Natl Acad Sci U S A (1996) 1.28
ERK3 is a constitutively nuclear protein kinase. J Biol Chem (1996) 1.27
Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens. J Biol Chem (1987) 1.27
Role of insulin-stimulated protein phosphorylation in insulin action. Fed Proc (1982) 1.26
Promoter analysis of Zfp-36, the mitogen-inducible gene encoding the zinc finger protein tristetraprolin. J Biol Chem (1995) 1.25
MEKK1 binds raf-1 and the ERK2 cascade components. J Biol Chem (2000) 1.25
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity (2000) 1.25
Down-regulation of protein kinase C and of an endogenous 80-kDa substrate in transformed fibroblasts. J Biol Chem (1987) 1.24
Uncoupling Raf1 from MEK1/2 impairs only a subset of cellular responses to Raf activation. J Biol Chem (2000) 1.22
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop. Structure (1995) 1.22
Characteristics of the intron involvement in the mitogen-induced expression of Zfp-36. J Biol Chem (1998) 1.21