Published in Am J Physiol Lung Cell Mol Physiol on February 16, 2007
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation (2008) 1.57
Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov (2009) 1.45
TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation. J Exp Med (2012) 1.24
Myosin light chain kinase: pulling the strings of epithelial tight junction function. Ann N Y Acad Sci (2012) 1.19
Myosin light chain kinase signaling in endothelial barrier dysfunction. Med Res Rev (2012) 0.98
Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.92
Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation. Am J Respir Cell Mol Biol (2014) 0.91
Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase. J Neurosci Res (2011) 0.91
Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injury. Respir Res (2012) 0.86
TRPV4 calcium entry and surface expression attenuated by inhibition of myosin light chain kinase in rat pulmonary microvascular endothelial cells. Physiol Rep (2013) 0.82
Modulation of factors affecting optic nerve head astrocyte migration. Invest Ophthalmol Vis Sci (2010) 0.80
Inhibition of Myosin light-chain kinase attenuates cerebral edema after traumatic brain injury in postnatal mice. J Neurotrauma (2013) 0.80
Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice. Pharmaceuticals (Basel) (2014) 0.77
Sp1-mediated nonmuscle myosin light chain kinase expression and enhanced activity in vascular endothelial growth factor-induced vascular permeability. Pulm Circ (2015) 0.77
Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100% O2. PLoS One (2015) 0.76
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet (2003) 4.63
Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo. J Clin Invest (2005) 3.15
Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury. Crit Care Med (2014) 2.04
Nonconvulsive seizures are common in children treated with extracorporeal cardiac life support. Pediatr Crit Care Med (2013) 1.74
A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. J Neuroinflammation (2007) 1.70
Guideline Adherence and Hospital Costs in Pediatric Severe Traumatic Brain Injury. Pediatr Crit Care Med (2016) 1.69
Protein kinase involved in lung injury susceptibility: evidence from enzyme isoform genetic knockout and in vivo inhibitor treatment. Proc Natl Acad Sci U S A (2003) 1.62
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation (2008) 1.57
Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med (2012) 1.51
The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restor Neurol Neurosci (2003) 1.49
Analogues of 2-aminopyridine-based selective inhibitors of neuronal nitric oxide synthase with increased bioavailability. Bioorg Med Chem (2009) 1.49
National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery (2013) 1.48
Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov (2009) 1.45
Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci (2006) 1.39
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. J Pediatr Gastroenterol Nutr (2014) 1.38
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia (2007) 1.32
Inhibition of glial cell activation ameliorates the severity of experimental autoimmune encephalomyelitis. Neurosci Res (2007) 1.27
Clinical trial design--effect of prone positioning on clinical outcomes in infants and children with acute respiratory distress syndrome. J Crit Care (2006) 1.25
Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ). J Neuroinflammation (2011) 1.25
Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration. Glia (2006) 1.22
Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol (2010) 1.19
Aminopyridazines inhibit beta-amyloid-induced glial activation and neuronal damage in vivo. Neurobiol Aging (2004) 1.18
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits. Bioorg Med Chem Lett (2006) 1.18
Common data elements for pediatric traumatic brain injury: recommendations from the working group on demographics and clinical assessment. J Neurotrauma (2011) 1.17
Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway. J Biol Chem (2007) 1.17
Neuroinflammation: a potential therapeutic target. Expert Opin Ther Targets (2005) 1.16
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation (2010) 1.15
Association of apolipoprotein E genotype and cerebral palsy in children. Pediatrics (2007) 1.12
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorg Med Chem Lett (2003) 1.11
A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLoS One (2010) 1.10
Human herpes virus 6B: a possible role in epilepsy? Epilepsia (2008) 1.10
A role for long chain myosin light chain kinase (MLCK-210) in microvascular hyperpermeability during severe burns. Shock (2007) 1.05
Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures. Free Radic Biol Med (2012) 1.02
Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human beta-amyloid in a murine model of neuroinflammation. J Mol Neurosci (2004) 1.02
Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Res (2009) 1.01
Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid. J Neuroinflammation (2005) 1.01
A calmodulin-regulated protein kinase linked to neuron survival is a substrate for the calmodulin-regulated death-associated protein kinase. Biochemistry (2004) 1.00
Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis. Bioorg Med Chem (2010) 0.99
Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures. J Neurotrauma (2010) 0.98
Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. PLoS One (2013) 0.97
DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury. Biochim Biophys Acta (2002) 0.96
Validation of the neuroinflammation cycle as a drug discovery target using integrative chemical biology and lead compound development with an Alzheimer's disease-related mouse model. Curr Alzheimer Res (2005) 0.95
Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways. J Neuroinflammation (2012) 0.95
Myosin light chain kinase (210 kDa) is a potential cytoskeleton integrator through its unique N-terminal domain. Exp Cell Res (2004) 0.92
Abnormal neuroimaging is associated with early in-hospital seizures in pediatric abusive head trauma. Neurocrit Care (2011) 0.92
Discovery of a 3-amino-6-phenyl-pyridazine derivative as a new synthetic antineuroinflammatory compound. J Med Chem (2002) 0.92
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Pediatr Crit Care Med (2012) 0.92
Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase. J Neurosci Res (2011) 0.91
Nonmuscle myosin light chain kinase regulates murine asthmatic inflammation. Am J Respir Cell Mol Biol (2014) 0.91
A Step-up Approach for Cell Therapy in Stroke: Translational Hurdles of Bone Marrow-Derived Stem Cells. Transl Stroke Res (2011) 0.91
Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. Pediatr Crit Care Med (2003) 0.91
Mild stretch-induced injury increases susceptibility to interleukin-1β-induced release of matrix metalloproteinase-9 from astrocytes. J Neurotrauma (2011) 0.90
Albumin activates the canonical TGF receptor-smad signaling pathway but this is not required for activation of astrocytes. Exp Neurol (2010) 0.90
Death-associated protein kinase as a potential therapeutic target. Expert Opin Ther Targets (2002) 0.90
Death-associated protein kinase phosphorylates mammalian ribosomal protein S6 and reduces protein synthesis. Biochemistry (2006) 0.90
Mechanism of interleukin-1β induced-increase in mouse intestinal permeability in vivo. J Interferon Cytokine Res (2012) 0.89
De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders. Curr Alzheimer Res (2006) 0.88
Structural insight into nucleotide recognition by human death-associated protein kinase. Acta Crystallogr D Biol Crystallogr (2009) 0.88
Inhibition of experimental autoimmune encephalomyelitis by a novel small molecular weight proinflammatory cytokine suppressing drug. J Neuroimmunol (2008) 0.88
Deletion of MLCK210 induces subtle changes in vascular reactivity but does not affect cardiac function. Am J Physiol Heart Circ Physiol (2005) 0.88
Protection against endotoxic shock as a consequence of reduced nitrosative stress in MLCK210-null mice. Am J Pathol (2007) 0.87
Effect of potential amine prodrugs of selective neuronal nitric oxide synthase inhibitors on blood-brain barrier penetration. Bioorg Med Chem (2009) 0.87
Lack of irrefutable validation does not negate clinical utility of near-infrared spectroscopy monitoring: learning to trust new technology. J Crit Care (2008) 0.86
Oxygen glucose deprivation in rat hippocampal slice cultures results in alterations in carnitine homeostasis and mitochondrial dysfunction. PLoS One (2012) 0.86
Pediatric End-of-Life Issues and Palliative Care. Clin Pediatr Emerg Med (2007) 0.86
Pediatric super-refractory status epilepticus treated with allopregnanolone. Ann Neurol (2014) 0.85
Triage of children with moderate and severe traumatic brain injury to trauma centers. J Neurotrauma (2013) 0.85
Conventional mechanical ventilation in pediatrics. J Pediatr (Rio J) (2007) 0.85
Structure, activity, regulation, and inhibitor discovery for a protein kinase associated with apoptosis and neuronal death. Pharmacol Ther (2002) 0.85
Albumin activates astrocytes and microglia through mitogen-activated protein kinase pathways. Brain Res (2009) 0.84
Percutaneous, ultrasound-guided stellate ganglion nerve block suppresses recurrent ventricular fibrillation in an infant awaiting heart transplant. Circ Arrhythm Electrophysiol (2012) 0.84
Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors. J Neuroimmune Pharmacol (2014) 0.84
Application of NMR spectroscopy in medicinal chemistry and drug discovery. Curr Top Med Chem (2011) 0.83
Successful treatment of recurrent basilar artery occlusion with intra-arterial thrombolysis and vertebral artery coiling in a child. Neurocrit Care (2012) 0.82
Development of a novel bioavailable inhibitor of the calmodulin-regulated protein kinase MLCK: a lead compound that attenuates vascular leak. Biochim Biophys Acta (2006) 0.82
Smooth muscle myosin filament assembly under control of a kinase-related protein (KRP) and caldesmon. J Muscle Res Cell Motil (2002) 0.82
Ictal asystole and anti-N-methyl-D-aspartate receptor antibody encephalitis. Pediatrics (2011) 0.81
Homodimerization of the death-associated protein kinase catalytic domain: development of a new small molecule fluorescent reporter. PLoS One (2010) 0.81
Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration. PLoS One (2013) 0.81
Neurological complications of respiratory syncytial virus infection: case series and review of literature. J Child Neurol (2009) 0.81
Optimizing the use of CROs by academia and small companies. Nat Rev Drug Discov (2013) 0.80
Pilot study of the association of the DDAH2 -449G polymorphism with asymmetric dimethylarginine and hemodynamic shock in pediatric sepsis. PLoS One (2012) 0.79
Massage therapy in outpatient pediatric chronic pain patients: do they facilitate significant reductions in levels of distress, pain, tension, discomfort, and mood alterations? Paediatr Anaesth (2008) 0.79
Molecular properties and CYP2D6 substrates: central nervous system therapeutics case study and pattern analysis of a substrate database. Drug Metab Dispos (2009) 0.79
The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. BMC Neurosci (2008) 0.79