Published in PLoS One on March 12, 2012
Pathophysiology and management of septic acute kidney injury. Pediatr Nephrol (2013) 1.05
Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. J Infect Dis (2014) 0.86
Dimethylarginine Dimethylaminohydrolase 2 (DDAH 2) Gene Polymorphism, Asymmetric Dimethylarginine (ADMA) Concentrations, and Risk of Coronary Artery Disease: A Case-Control Study. Sci Rep (2016) 0.75
Markers of nitric oxide are associated with sepsis severity: an observational study. Crit Care (2017) 0.75
Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med (2008) 31.57
Genetic dissection of complex traits. Science (1994) 29.54
International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics. Pediatr Crit Care Med (2005) 13.40
Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine. Crit Care Med (2009) 7.55
Validation of the paediatric logistic organ dysfunction (PELOD) score: prospective, observational, multicentre study. Lancet (2003) 5.40
PIM2: a revised version of the Paediatric Index of Mortality. Intensive Care Med (2003) 4.09
Vasoactive-inotropic score as a predictor of morbidity and mortality in infants after cardiopulmonary bypass. Pediatr Crit Care Med (2010) 3.72
Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol (2007) 2.05
Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis. Crit Care Med (1987) 1.89
Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Circulation (2003) 1.84
Arginine and nitric oxide metabolism in critically ill septic pediatric patients. Crit Care Med (2003) 1.74
The DDAH/ADMA/NOS pathway. Atheroscler Suppl (2003) 1.68
Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase. Br J Pharmacol (1996) 1.68
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase. Proc Natl Acad Sci U S A (2002) 1.64
Circulating methemoglobin and nitrite/nitrate concentrations as indicators of nitric oxide overproduction in critically ill children with septic shock. Crit Care Med (1997) 1.61
Time course of endogenous nitric oxide inhibitors in severe sepsis in humans. Minerva Anestesiol (2010) 1.56
Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations: comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia. Crit Care Med (1997) 1.50
Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr (2003) 1.37
Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. PLoS Pathog (2010) 1.37
Hemodynamic support in fluid-refractory pediatric septic shock. Pediatrics (1998) 1.29
Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circ Res (2007) 1.29
Effects of nitric oxide in septic shock. Am J Respir Crit Care Med (2000) 1.27
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. Arterioscler Thromb Vasc Biol (2011) 1.19
Asymmetric dimethylarginine, endothelial nitric oxide bioavailability and mortality in sepsis. PLoS One (2011) 1.15
Distributions of cardiopulmonary variables in pediatric survivors and nonsurvivors of septic shock. Crit Care Med (1985) 1.06
Distinct hemodynamic patterns of septic shock at presentation to pediatric intensive care. Pediatrics (2008) 1.05
Asymmetric dimethylarginine (ADMA) in vascular, renal and hepatic disease and the regulatory role of L-arginine on its metabolism. Mol Genet Metab (2007) 1.02
Sequence variation in DDAH1 and DDAH2 genes is strongly and additively associated with serum ADMA concentrations in individuals with type 2 diabetes. PLoS One (2010) 1.01
DDAH gene and cardiovascular risk. Vasc Med (2005) 0.97
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells. Cell Mol Life Sci (2006) 0.96
Increased serum nitrite and nitrate concentrations in children with the sepsis syndrome. Crit Care Med (1995) 0.96
Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochem Biophys Res Commun (2003) 0.92
Evaluation of asymmetric dimethylarginine, arginine, and carnitine metabolism in pediatric sepsis. Pediatr Crit Care Med (2012) 0.92
Measurement of arginine derivatives in pediatric patients with chronic kidney disease using high-performance liquid chromatography-tandem mass spectrometry. Clin Chem Lab Med (2007) 0.91
Elevated levels of asymmetric dimethylarginine (ADMA) as a marker of cardiovascular disease and mortality. Clin Chem Lab Med (2005) 0.90
Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Arterioscler Thromb Vasc Biol (2000) 0.89
Haplotypic association of DDAH1 with susceptibility to pre-eclampsia. Mol Hum Reprod (2004) 0.88
Methylated arginine derivatives in children and adolescents with chronic kidney disease. Pediatr Nephrol (2008) 0.87
Gene polymorphism and requirement for vasopressor infusion after cardiac surgery. Ann Thorac Surg (2006) 0.83
Common genetic variation in DDAH2 is associated with intracerebral haemorrhage in a Chinese population: a multi-centre case-control study in China. Clin Sci (Lond) (2009) 0.83
Dimethylarginine dimethylaminohydrolase-2 overexpression improves impaired nitric oxide synthesis of endothelial cells induced by glycated protein. Nitric Oxide (2006) 0.80
Polymorphisms in the promoter region of the dimethylarginine dimethylaminohydrolase 2 gene are associated with prevalence of hypertension. Pharmacol Res (2009) 0.78
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip. Proc Natl Acad Sci U S A (2010) 7.77
Inertial focusing for tumor antigen-dependent and -independent sorting of rare circulating tumor cells. Sci Transl Med (2013) 4.74
Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents--second edition. Pediatr Crit Care Med (2012) 4.65
Synonymous mutations in the human dopamine receptor D2 (DRD2) affect mRNA stability and synthesis of the receptor. Hum Mol Genet (2003) 4.63
Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer. Sci Transl Med (2010) 3.90
Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell (2008) 3.43
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
Pharmaceutical supply chain in China: current issues and implications for health system reform. Health Policy (2010) 2.63
TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers. Cell (2012) 2.08
Acute care clinical indicators associated with discharge outcomes in children with severe traumatic brain injury. Crit Care Med (2014) 2.04
The NPro product of bovine viral diarrhea virus inhibits DNA binding by interferon regulatory factor 3 and targets it for proteasomal degradation. J Virol (2006) 1.84
Nonconvulsive seizures are common in children treated with extracorporeal cardiac life support. Pediatr Crit Care Med (2013) 1.74
Molecular characterization of Brassica napus NAC domain transcriptional activators induced in response to biotic and abiotic stress. Plant Mol Biol (2003) 1.73
Diagnostic considerations in the measurement of human chorionic gonadotropin in aging women. Clin Chem (2005) 1.71
Axon loss in the spinal cord determines permanent neurological disability in an animal model of multiple sclerosis. J Neuropathol Exp Neurol (2002) 1.70
Guideline Adherence and Hospital Costs in Pediatric Severe Traumatic Brain Injury. Pediatr Crit Care Med (2016) 1.69
Predictive power of serum cystatin C to detect acute kidney injury and pediatric-modified RIFLE class in children undergoing cardiac surgery. Pediatr Crit Care Med (2012) 1.57
Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation (2008) 1.57
Inhibition of beta interferon transcription by noncytopathogenic bovine viral diarrhea virus is through an interferon regulatory factor 3-dependent mechanism. J Virol (2002) 1.56
Associations of ACE gene insertion/deletion polymorphism, ACE activity, and ACE mRNA expression with hypertension in a Chinese population. PLoS One (2013) 1.52
Dysfunction of nodes of Ranvier: a mechanism for anti-ganglioside antibody-mediated neuropathies. Exp Neurol (2011) 1.51
Defining pediatric sepsis by different criteria: discrepancies in populations and implications for clinical practice. Pediatr Crit Care Med (2012) 1.51
Aryl Hydrocarbon Receptor Activation Down-Regulates IL-7 and Reduces Inflammation in a Mouse Model of DSS-Induced Colitis. Dig Dis Sci (2015) 1.50
The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain. Restor Neurol Neurosci (2003) 1.49
National variability in intracranial pressure monitoring and craniotomy for children with moderate to severe traumatic brain injury. Neurosurgery (2013) 1.48
The survey of birth defects rate based on birth registration system. Chin Med J (Engl) (2015) 1.47
Mutations in TUBB8 and Human Oocyte Meiotic Arrest. N Engl J Med (2016) 1.46
Association of TLR4 gene non-missense single nucleotide polymorphisms with rheumatoid arthritis in Chinese Han population. Rheumatol Int (2012) 1.45
Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res (2011) 1.44
Dynamic simulation and preliminary finite element analysis of gunshot wounds to the human mandible. Injury (2011) 1.43
Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression. J Cell Sci (2013) 1.42
The influence of RAMP1 overexpression on CGRP-induced osteogenic differentiation in MG-63 cells in vitro: an experimental study. J Cell Biochem (2013) 1.42
Extraordinary photoluminescence and strong temperature/angle-dependent Raman responses in few-layer phosphorene. ACS Nano (2014) 1.38
EEG abnormalities are associated with increased risk of transplant or poor outcome in children with acute liver failure. J Pediatr Gastroenterol Nutr (2014) 1.38
Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A (2008) 1.36
Glial activation links early-life seizures and long-term neurologic dysfunction: evidence using a small molecule inhibitor of proinflammatory cytokine upregulation. Epilepsia (2007) 1.32
Critical role for scaffolding adapter Gab2 in Fc gamma R-mediated phagocytosis. J Cell Biol (2003) 1.28
Noggin is required for normal lobe patterning and ductal budding in the mouse prostate. Dev Biol (2007) 1.26
Quantitative fitness analysis shows that NMD proteins and many other protein complexes suppress or enhance distinct telomere cap defects. PLoS Genet (2011) 1.26
Preparation of high-quality next-generation sequencing libraries from picogram quantities of target DNA. Genome Res (2011) 1.24
A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration. Genes Dev (2010) 1.21
DNA sensing by silicon nanowire: charge layer distance dependence. Nano Lett (2008) 1.20
Biopolymer system for cell recovery from microfluidic cell capture devices. Anal Chem (2012) 1.20
Alcohol consumption in 0.5 million people from 10 diverse regions of China: prevalence, patterns and socio-demographic and health-related correlates. Int J Epidemiol (2013) 1.20
Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study. Neoplasia (2012) 1.19
Common data elements for pediatric traumatic brain injury: recommendations from the working group on demographics and clinical assessment. J Neurotrauma (2011) 1.17
A novel solid-state thermal rectifier based on reduced graphene oxide. Sci Rep (2012) 1.17
Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway. J Biol Chem (2007) 1.17
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury. J Neuroinflammation (2010) 1.15
Expression of anthocyanins and proanthocyanidins after transformation of alfalfa with maize Lc. Plant Physiol (2003) 1.14
Characterization of a novel wheat NAC transcription factor gene involved in defense response against stripe rust pathogen infection and abiotic stresses. Mol Biol Rep (2010) 1.12
Association of apolipoprotein E genotype and cerebral palsy in children. Pediatrics (2007) 1.12
Moving towards universal health insurance in China: performance, issues and lessons from Thailand. Soc Sci Med (2011) 1.12
An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorg Med Chem Lett (2003) 1.11
A rapid murine coma and behavior scale for quantitative assessment of murine cerebral malaria. PLoS One (2010) 1.10
Association between socioeconomic status and obesity in a Chinese adult population. BMC Public Health (2013) 1.10
Human herpes virus 6B: a possible role in epilepsy? Epilepsia (2008) 1.10
Polarity-reversed robust carrier mobility in monolayer MoS₂ nanoribbons. J Am Chem Soc (2014) 1.08
Quantification of human immunodeficiency virus type 1 proviral DNA by using TaqMan technology. J Clin Microbiol (2002) 1.08
An archived activation tagged population of Arabidopsis thaliana to facilitate forward genetics approaches. BMC Plant Biol (2009) 1.08
X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy. J Biol Chem (2007) 1.07
Passive immunization with anti-ganglioside antibodies directly inhibits axon regeneration in an animal model. J Neurosci (2007) 1.07
Prevalence of major chronic conditions among older Chinese adults: the Study on Global AGEing and adult health (SAGE) wave 1. PLoS One (2013) 1.05
Ultralow thermal conductivity of isotope-doped silicon nanowires. Nano Lett (2007) 1.05
[Epidemiological survey of mental illnesses in the people aged 15 and older in Zhejiang Province, China]. Zhonghua Yu Fang Yi Xue Za Zhi (2005) 1.04
Increased NADPH oxidase-derived superoxide is involved in the neuronal cell death induced by hypoxia-ischemia in neonatal hippocampal slice cultures. Free Radic Biol Med (2012) 1.02
Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorg Med Chem Lett (2005) 1.02
CD8+ T cell immunity to 2009 pandemic and seasonal H1N1 influenza viruses. Vaccine (2011) 1.02
Magnetic resonance imaging of mouse skeletal muscle to measure denervation atrophy. Exp Neurol (2008) 1.02
Enhanced microglial activation and proinflammatory cytokine upregulation are linked to increased susceptibility to seizures and neurologic injury in a 'two-hit' seizure model. Brain Res (2009) 1.01
Pentoxifylline attenuates the development of hyperalgesia in a rat model of neuropathic pain. Neurosci Lett (2006) 1.00
Predictors and outcome of patients with acute respiratory distress syndrome caused by miliary tuberculosis: a retrospective study in Chongqing, China. BMC Infect Dis (2012) 1.00
An anti-ganglioside antibody-secreting hybridoma induces neuropathy in mice. Ann Neurol (2004) 1.00
Structure function analysis of an ADP-ribosyltransferase type III effector and its RNA-binding target in plant immunity. J Biol Chem (2011) 0.99
trans-Diaqua-bis[5-carb-oxy-2-(3-pyrid-yl)-1H-imidazole-4-carboxyl-ato-κN,O]iron(II). Acta Crystallogr Sect E Struct Rep Online (2009) 0.98
Systematic review and meta-analysis of comparative studies reporting early outcomes after robot-assisted radical cystectomy versus open radical cystectomy. Cancer Treat Rev (2012) 0.98
Comparison of PHOX2B testing methods in the diagnosis of congenital central hypoventilation syndrome and mosaic carriers. Diagn Mol Pathol (2010) 0.98
Minozac treatment prevents increased seizure susceptibility in a mouse "two-hit" model of closed skull traumatic brain injury and electroconvulsive shock-induced seizures. J Neurotrauma (2010) 0.98
Protection against oxidant-induced apoptosis by mitochondrial thioredoxin in SH-SY5Y neuroblastoma cells. Toxicol Appl Pharmacol (2006) 0.98
The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis. Genes Dev (2013) 0.98
Cytotoxicity and cellular uptake of iron nanowires. Biomaterials (2009) 0.97
Genetic and clinical determinants influencing warfarin dosing in children with heart disease. Pediatr Cardiol (2012) 0.97
Monodisperse and core-shell-structured SiO2@YBO3:Eu3+ spherical particles: synthesis and characterization. Inorg Chem (2007) 0.97
Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer. Proc Natl Acad Sci U S A (2009) 0.97
Neisseria species identification assay for the confirmation of Neisseria gonorrhoeae-positive results of the COBAS Amplicor PCR. J Clin Microbiol (2007) 0.97
ESTs analysis reveals putative genes involved in symbiotic seed germination in Dendrobium officinale. PLoS One (2013) 0.96
MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2007) 0.96
DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic-ischemic injury. Biochim Biophys Acta (2002) 0.96
Kinetics and template nucleation of self-assembled hydroxyapatite nanocrystallites by chondroitin sulfate. J Biol Chem (2005) 0.96
[Investigation on the changes of dependent signal on the amplitude of low frequency fluctuations at blood oxygen level in brain after acupuncture Neiguan (PC 6)]. Zhongguo Zhen Jiu (2009) 0.96
cDNA-AFLP analysis reveals differential gene expression in compatible interaction of wheat challenged with Puccinia striiformis f. sp. tritici. BMC Genomics (2009) 0.95
Catenovulum agarivorans gen. nov., sp. nov., a peritrichously flagellated, chain-forming, agar-hydrolysing gammaproteobacterium from seawater. Int J Syst Evol Microbiol (2011) 0.95
Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways. J Neuroinflammation (2012) 0.95
Synthesis and biological activity of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 2: 2'-substituted triclosan derivatives. Bioorg Med Chem Lett (2006) 0.94
Serum miR-210 and miR-30a expressions tend to revert to fetal levels in Chinese adult patients with chronic heart failure. Cardiovasc Pathol (2013) 0.94
Transmembrane TNF-α promotes suppressive activities of myeloid-derived suppressor cells via TNFR2. J Immunol (2013) 0.94
Functional conservation of HIV-1 Vpr and variability in a mother-child pair of long-term non-progressors. Virus Res (2002) 0.93
Modeling analysis and experimental study on the optical fiber hydrogen sensor based on Pd-Y alloy thin film. Rev Sci Instrum (2012) 0.93
Thin films of Ag nanoparticles prepared from the reduction of AgI nanoparticles in self-assembled films. J Colloid Interface Sci (2002) 0.93
Abnormal neuroimaging is associated with early in-hospital seizures in pediatric abusive head trauma. Neurocrit Care (2011) 0.92