Mitochondrial Targeted Endonuclease III DNA Repair Enzyme Protects against Ventilator Induced Lung Injury in Mice.

PubWeight™: 0.77‹?›

🔗 View Article (PMC 4167202)

Published in Pharmaceuticals (Basel) on August 22, 2014

Authors

Masahiro Hashizume1, Marc Mouner1, Joshua M Chouteau2, Olena M Gorodnya3, Mykhaylo V Ruchko2, Glenn L Wilson4, Mark N Gillespie2, James C Parker5

Author Affiliations

1: Department of Physiology, University of South Alabama, Mobile, AL 36688, USA.
2: Center for Lung Biology, University of South Alabama, Mobile, AL 36688, USA.
3: Department of Pharmacology, University of South Alabama, Mobile, AL 36688, USA.
4: Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, AL 36688, USA.
5: Department of Physiology, University of South Alabama, Mobile, AL 36688, USA. jparker@southalabama.edu.

Articles cited by this

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03

Mitochondrial formation of reactive oxygen species. J Physiol (2003) 10.73

Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A (1997) 5.95

Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management. Am J Respir Cell Mol Biol (2005) 2.93

Cross talk between mitochondria and NADPH oxidases. Free Radic Biol Med (2011) 2.63

Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells. Circ Res (2006) 2.14

Mitochondrial requirement for endothelial responses to cyclic strain: implications for mechanotransduction. Am J Physiol Lung Cell Mol Physiol (2004) 2.12

Outcome measures for clinical research in sepsis: a report of the 2nd Cambridge Colloquium of the International Sepsis Forum. Crit Care Med (2005) 1.77

Sepsis-induced lung injury in rats increases alveolar epithelial vulnerability to stretch. Crit Care Med (2006) 1.64

The redox environment in the mitochondrial intermembrane space is maintained separately from the cytosol and matrix. J Biol Chem (2008) 1.63

High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury. J Appl Physiol (1985) (2003) 1.62

Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia. Lab Invest (2006) 1.60

Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol (2005) 1.56

Lack of phosphoinositide 3-kinase-gamma attenuates ventilator-induced lung injury. Crit Care Med (2006) 1.52

The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury. Semin Respir Crit Care Med (2006) 1.44

Treatment of ARDS. Chest (2001) 1.37

Enhanced mtDNA repair capacity protects pulmonary artery endothelial cells from oxidant-mediated death. Am J Physiol Lung Cell Mol Physiol (2002) 1.32

Minimizing the damage: repair pathways keep mitochondrial DNA intact. Nat Rev Mol Cell Biol (2012) 1.30

Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. J Biol Chem (2012) 1.30

Differential lung mechanics are genetically determined in inbred murine strains. J Appl Physiol (1985) (1999) 1.29

Actin and myosin contribute to mammalian mitochondrial DNA maintenance. Nucleic Acids Res (2011) 1.27

Targeting human 8-oxoguanine glycosylase to mitochondria of oligodendrocytes protects against menadione-induced oxidative stress. Glia (2003) 1.27

Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.22

Non-muscle myosin light chain kinase isoform is a viable molecular target in acute inflammatory lung injury. Am J Respir Cell Mol Biol (2010) 1.19

Inhibitors of myosin light chain kinase and phosphodiesterase reduce ventilator-induced lung injury. J Appl Physiol (1985) (2000) 1.17

Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs. Am J Physiol Lung Cell Mol Physiol (2011) 1.14

Phosphoinositide 3-kinase, Src, and Akt modulate acute ventilation-induced vascular permeability increases in mouse lungs. Am J Physiol Lung Cell Mol Physiol (2007) 1.11

The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells. Free Radic Biol Med (2010) 1.11

Redox imbalance and ventilator-induced lung injury. Antioxid Redox Signal (2007) 1.10

Sequence-specific oxidative base modifications in hypoxia-inducible genes. Free Radic Biol Med (2007) 1.10

Antioxidants that protect mitochondria reduce interleukin-6 and oxidative stress, improve mitochondrial function, and reduce biochemical markers of organ dysfunction in a rat model of acute sepsis. Br J Anaesth (2013) 1.00

Endonuclease III and endonuclease VIII conditionally targeted into mitochondria enhance mitochondrial DNA repair and cell survival following oxidative stress. Nucleic Acids Res (2004) 0.97

MLCK210 gene knockout or kinase inhibition preserves lung function following endotoxin-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol (2007) 0.96

Mechanical ventilation increases microvascular permeability in oleic acid-injured lungs. J Appl Physiol (1985) (1990) 0.94

Targeting repair proteins to the mitochondria of mammalian cells through stable transfection, transient transfection, viral transduction, and TAT-mediated protein transduction. Methods Mol Biol (2009) 0.93

Mitochondrial-targeted DNA repair enzyme 8-oxoguanine DNA glycosylase 1 protects against ventilator-induced lung injury in intact mice. Am J Physiol Lung Cell Mol Physiol (2012) 0.92

Pulmonary-derived phosphoinositide 3-kinase gamma (PI3Kγ) contributes to ventilator-induced lung injury and edema. Intensive Care Med (2010) 0.88

Acute lung injury and pulmonary vascular permeability: use of transgenic models. Compr Physiol (2011) 0.78