The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities.

PubWeight™: 1.39‹?› | Rank: Top 5%

🔗 View Article (PMC 2859178)

Published in Cancer Res on February 15, 2007

Authors

Anny Shai1, Tiffany Brake, Chamorro Somoza, Paul F Lambert

Author Affiliations

1: McArdle Laboratory for Cancer Research, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA.

Associated clinical trials:

A Trial of Tamoxifen and Letrozole in Recurrent and Persistent Squamous Cell Carcinoma of the Cervix (TGOG1005) | NCT02482740

Articles citing this

Molecular mechanisms of human papillomavirus-induced carcinogenesis. Public Health Genomics (2009) 1.45

Early age at first sexual intercourse and early pregnancy are risk factors for cervical cancer in developing countries. Br J Cancer (2009) 1.40

Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta (2011) 1.40

Estrogen and ERalpha: culprits in cervical cancer? Trends Endocrinol Metab (2010) 1.33

microRNAs are biomarkers of oncogenic human papillomavirus infections. Proc Natl Acad Sci U S A (2014) 1.25

Cellular transformation by human papillomaviruses: lessons learned by comparing high- and low-risk viruses. Virology (2012) 1.23

Cell polarity proteins: common targets for tumorigenic human viruses. Oncogene (2008) 1.22

Cellular binding partners of the human papillomavirus E6 protein. Arch Virol (2008) 1.21

Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res (2008) 1.21

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer. Cancer Res (2007) 1.13

Emerging theme: cellular PDZ proteins as common targets of pathogenic viruses. J Virol (2011) 1.12

Human papillomavirus 16 E5 modulates the expression of host microRNAs. PLoS One (2011) 1.11

p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers. Cancer Res (2008) 1.06

Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists. Proc Natl Acad Sci U S A (2009) 1.04

Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines. Virology (2008) 1.04

A role for HPV16 E5 in cervical carcinogenesis. Cancer Res (2010) 1.03

Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice. Virology (2010) 1.00

Requirement for stromal estrogen receptor alpha in cervical neoplasia. Horm Cancer (2012) 1.00

A mouse model for human anal cancer. Cancer Prev Res (Phila) (2010) 0.96

High-risk human papillomavirus E6 oncoproteins interact with 14-3-3ζ in a PDZ binding motif-dependent manner. J Virol (2012) 0.96

The role of protein kinase A regulation of the E6 PDZ-binding domain during the differentiation-dependent life cycle of human papillomavirus type 18. J Virol (2013) 0.94

NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol (2009) 0.93

Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein. Cancer Res (2012) 0.92

Human tumour viruses and the deregulation of cell polarity in cancer. Nat Rev Cancer (2012) 0.90

E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice. Cancer Res (2010) 0.90

The Hippo/YAP pathway interacts with EGFR signaling and HPV oncoproteins to regulate cervical cancer progression. EMBO Mol Med (2015) 0.90

Dominant role of HPV16 E7 in anal carcinogenesis. Virology (2011) 0.88

Combined oral contraceptive use increases HPV persistence but not new HPV detection in a cohort of women from Thailand. J Infect Dis (2011) 0.87

Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis. J Virol (2014) 0.87

High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins. Oncogene (2013) 0.86

Deregulation of the miRNAs expression in cervical cancer: human papillomavirus implications. Biomed Res Int (2013) 0.85

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy. Viruses (2015) 0.84

The transcriptional regulator gene E2 of the Human Papillomavirus (HPV) 16 influences the radiosensitivity of cervical keratinocytes. Radiat Oncol (2012) 0.84

Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83

Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain. PLoS One (2013) 0.82

Homologous Recombination Repair Factors Rad51 and BRCA1 Are Necessary for Productive Replication of Human Papillomavirus 31. J Virol (2015) 0.82

Gene expression profile of cervical and skin tissues from human papillomavirus type 16 E6 transgenic mice. BMC Cancer (2008) 0.82

The p53-estrogen receptor loop in cancer. Curr Mol Med (2013) 0.82

Cancer-causing human papillomavirus E6 proteins display major differences in the phospho-regulation of their PDZ interactions. J Virol (2014) 0.81

Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue. Virology (2013) 0.80

HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS. Expert Opin Med Diagn (2008) 0.80

Viral Interactions with PDZ Domain-Containing Proteins-An Oncogenic Trait? Pathogens (2016) 0.78

Large-scale analysis of protein expression changes in human keratinocytes immortalized by human papilloma virus type 16 E6 and E7 oncogenes. Proteome Sci (2009) 0.78

IGF axis and other factors in HPV-related and HPV-unrelated carcinogenesis (review). Oncol Rep (2014) 0.78

Differential gene expression between skin and cervix induced by the E7 oncoprotein in a transgenic mouse model. Virology (2012) 0.76

Potential anti-HPV and related cancer agents from marine resources: an overview. Mar Drugs (2014) 0.76

Mitotic control of human papillomavirus genome-containing cells is regulated by the function of the PDZ-binding motif of the E6 oncoprotein. Oncotarget (2017) 0.75

miR-2861 acts as a tumor suppressor via targeting EGFR/AKT2/CCND1 pathway in cervical cancer induced by human papillomavirus virus 16 E6. Sci Rep (2016) 0.75

Articles cited by this

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. J Pathol (1999) 40.46

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell (1990) 20.60

The causal relation between human papillomavirus and cervical cancer. J Clin Pathol (2002) 14.73

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell (1993) 12.41

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature (1998) 7.81

Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science (2000) 6.44

UBE3A/E6-AP mutations cause Angelman syndrome. Nat Genet (1997) 5.97

Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature (2000) 4.80

Overexpression of p16(INK4A) as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri. Int J Cancer (2001) 3.61

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proc Natl Acad Sci U S A (1997) 3.37

Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet (2001) 3.22

Worldwide burden of gynaecological cancer: the size of the problem. Best Pract Res Clin Obstet Gynaecol (2005) 3.16

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase. Mol Cell Biol (2000) 2.79

Expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. Am J Pathol (1998) 2.62

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer. Bioessays (2003) 2.49

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res (2003) 2.32

Inhibition of cyclin D-CDK4/CDK6 activity is associated with an E2F-mediated induction of cyclin kinase inhibitor activity. Proc Natl Acad Sci U S A (1996) 2.30

Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology (1997) 2.29

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation. Oncogene (1999) 2.25

A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8. Int J Cancer (2003) 2.24

Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene. J Virol (1996) 2.12

Multiple functions of human papillomavirus type 16 E6 contribute to the immortalization of mammary epithelial cells. J Virol (1999) 2.09

The human papillomavirus type 16 E6 gene alone is sufficient to induce carcinomas in transgenic animals. J Virol (1999) 2.01

The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol (2003) 1.91

Ki-67, cyclin E, and p16INK4 are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia. Am J Surg Pathol (2001) 1.89

Human papillomavirus types 16 E6 and E7 contribute differently to carcinogenesis. Virology (2000) 1.83

Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res (2003) 1.81

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc Natl Acad Sci U S A (1995) 1.81

Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation. Oncogene (2002) 1.71

Elevated p16 at senescence and loss of p16 at immortalization in human papillomavirus 16 E6, but not E7, transformed human uroepithelial cells. Cancer Res (1996) 1.65

The expressions of the Rb pathway in cervical intraepithelial neoplasia; predictive and prognostic significance. Gynecol Oncol (2006) 1.60

Human papillomaviruses: targeting differentiating epithelial cells for malignant transformation. Oncogene (2003) 1.59

Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model. Proc Natl Acad Sci U S A (2005) 1.50

Cell-cycle-dependent regulation of DNA replication and its relevance to cancer pathology. J Pathol (2005) 1.44

Imprinting analysis of three genes in the Prader-Willi/Angelman region: SNRPN, E6-associated protein, and PAR-2 (D15S225E). Hum Mol Genet (1994) 1.44

Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix. Br J Cancer (2004) 1.30

Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27

Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential. Cancer Res (2005) 1.15

A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo. J Virol (2002) 1.15

Both conserved region 1 (CR1) and CR2 of the human papillomavirus type 16 E7 oncogene are required for induction of epidermal hyperplasia and tumor formation in transgenic mice. J Virol (1997) 1.13

Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein. Virology (2002) 1.12

Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy. Int J Cancer (2004) 1.03

Human papillomavirus type 16 E6 promotes retinoblastoma protein phosphorylation and cell cycle progression. J Virol (2004) 0.94

Differential expression of human Dlg in cervical intraepithelial neoplasias. Gynecol Oncol (2004) 0.93

Targetting of the N-terminal domain of the human papillomavirus type 16 E6 oncoprotein with monomeric ScFvs blocks the E6-mediated degradation of cellular p53. J Mol Recognit (2000) 0.89

Association of p16(INK4a) and pRb inactivation with immortalization of human cells. Carcinogenesis (2002) 0.88

Expression of cyclin E and p27(KIP1) in cervical carcinoma. Cancer Lett (2000) 0.87

Parallel cyclin E and cyclin A expression in neoplastic lesions of the uterine cervix. Br J Cancer (2006) 0.86

Immortalization of normal human embryonic fibroblasts by introduction of either the human papillomavirus type 16 E6 or E7 gene alone. Int J Cancer (2003) 0.85

Articles by these authors

Fundamental differences in cell cycle deregulation in human papillomavirus-positive and human papillomavirus-negative head/neck and cervical cancers. Cancer Res (2007) 2.93

Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood (2005) 2.64

Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res (2003) 2.32

Establishment of human papillomavirus infection requires cell cycle progression. PLoS Pathog (2009) 1.94

The PDZ ligand domain of the human papillomavirus type 16 E6 protein is required for E6's induction of epithelial hyperplasia in vivo. J Virol (2003) 1.91

Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. J Biol Chem (2002) 1.90

Enhanced radiation sensitivity in HPV-positive head and neck cancer. Cancer Res (2013) 1.87

Comparative analysis of cervical cancer in women and in a human papillomavirus-transgenic mouse model: identification of minichromosome maintenance protein 7 as an informative biomarker for human cervical cancer. Cancer Res (2003) 1.81

Structural and functional consequences of glutamine tract variation in the androgen receptor. Hum Mol Genet (2004) 1.74

Production of infectious human papillomavirus independently of viral replication and epithelial cell differentiation. Proc Natl Acad Sci U S A (2005) 1.72

Identification of biomarkers that distinguish human papillomavirus (HPV)-positive versus HPV-negative head and neck cancers in a mouse model. Proc Natl Acad Sci U S A (2006) 1.57

The minor capsid protein L2 contributes to two steps in the human papillomavirus type 31 life cycle. J Virol (2005) 1.53

Estrogen contributes to the onset, persistence, and malignant progression of cervical cancer in a human papillomavirus-transgenic mouse model. Proc Natl Acad Sci U S A (2005) 1.50

Quantitative role of the human papillomavirus type 16 E5 gene during the productive stage of the viral life cycle. J Virol (2003) 1.49

Recapitulation of the effects of the human papillomavirus type 16 E7 oncogene on mouse epithelium by somatic Rb deletion and detection of pRb-independent effects of E7 in vivo. Mol Cell Biol (2003) 1.43

Methylation patterns of papillomavirus DNA, its influence on E2 function, and implications in viral infection. J Virol (2003) 1.37

Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene. Cancer Res (2005) 1.34

Estrogen and ERalpha: culprits in cervical cancer? Trends Endocrinol Metab (2010) 1.33

Human papillomavirus type 16 E1circumflexE4 contributes to multiple facets of the papillomavirus life cycle. J Virol (2005) 1.32

The human papillomavirus type 16 E7 oncoprotein activates the Fanconi anemia (FA) pathway and causes accelerated chromosomal instability in FA cells. J Virol (2007) 1.29

Impaired antigen presentation and effectiveness of combined active/passive immunotherapy for epithelial tumors. J Natl Cancer Inst (2004) 1.28

Requirement of PDZ-containing proteins for cell cycle regulation and differentiation in the mouse lens epithelium. Mol Cell Biol (2003) 1.27

Merkel cell polyomavirus: a newly discovered human virus with oncogenic potential. Virology (2013) 1.27

Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res (2010) 1.26

Cyclin G2 is a centrosome-associated nucleocytoplasmic shuttling protein that influences microtubule stability and induces a p53-dependent cell cycle arrest. Exp Cell Res (2006) 1.22

Requirement for estrogen receptor alpha in a mouse model for human papillomavirus-associated cervical cancer. Cancer Res (2008) 1.21

Critical roles for non-pRb targets of human papillomavirus type 16 E7 in cervical carcinogenesis. Cancer Res (2006) 1.21

Development and characterization of HPV-positive and HPV-negative head and neck squamous cell carcinoma tumorgrafts. Clin Cancer Res (2012) 1.20

Interactions with pocket proteins contribute to the role of human papillomavirus type 16 E7 in the papillomavirus life cycle. J Virol (2005) 1.16

Two distinct activities contribute to human papillomavirus 16 E6's oncogenic potential. Cancer Res (2005) 1.15

DEK proto-oncogene expression interferes with the normal epithelial differentiation program. Am J Pathol (2008) 1.15

A mutant of human papillomavirus type 16 E6 deficient in binding alpha-helix partners displays reduced oncogenic potential in vivo. J Virol (2002) 1.15

Role of Rb-dependent and Rb-independent functions of papillomavirus E7 oncogene in head and neck cancer. Cancer Res (2007) 1.13

Human papillomavirus type 16 E1 E4-induced G2 arrest is associated with cytoplasmic retention of active Cdk1/cyclin B1 complexes. J Virol (2005) 1.10

Induction of ovarian leiomyosarcomas in mice by conditional inactivation of Brca1 and p53. PLoS One (2009) 1.09

Stable replication of papillomavirus genomes in Saccharomyces cerevisiae. J Virol (2002) 1.07

p53 Loss synergizes with estrogen and papillomaviral oncogenes to induce cervical and breast cancers. Cancer Res (2008) 1.06

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis. Environ Health Perspect (2015) 1.05

Examination of the pRb-dependent and pRb-independent functions of E7 in vivo. J Virol (2005) 1.05

Persistence of high-grade cervical dysplasia and cervical cancer requires the continuous expression of the human papillomavirus type 16 E7 oncogene. Cancer Res (2009) 1.04

Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists. Proc Natl Acad Sci U S A (2009) 1.04

Effects of cellular differentiation, chromosomal integration and 5-aza-2'-deoxycytidine treatment on human papillomavirus-16 DNA methylation in cultured cell lines. Virology (2008) 1.04

A role for HPV16 E5 in cervical carcinogenesis. Cancer Res (2010) 1.03

Human papillomavirus E7 oncoprotein overrides the tumor suppressor activity of p21Cip1 in cervical carcinogenesis. Cancer Res (2009) 1.02

The fanconi anemia pathway limits human papillomavirus replication. J Virol (2012) 1.01

Epigenetics of human papillomaviruses. Virology (2013) 1.00

Human papillomavirus type 16 E6 and E7 oncoproteins act synergistically to cause head and neck cancer in mice. Virology (2010) 1.00

Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage. Oncogene (2004) 1.00

Requirement for stromal estrogen receptor alpha in cervical neoplasia. Horm Cancer (2012) 1.00

Human papillomavirus 16 E5 oncogene contributes to two stages of skin carcinogenesis. Cancer Res (2007) 0.98

Rapamycin inhibits anal carcinogenesis in two preclinical animal models. Cancer Prev Res (Phila) (2010) 0.96

Prevalence of human papillomavirus in oropharyngeal squamous cell carcinoma in the United States across time. Chem Res Toxicol (2014) 0.96

A mouse model for human anal cancer. Cancer Prev Res (Phila) (2010) 0.96

Human papillomavirus 16 E6 variants differ in their dysregulation of human keratinocyte differentiation and apoptosis. Virology (2008) 0.95

Inhibition of gamma secretase blocks HPV infection. Virology (2010) 0.94

Identification of cis-acting elements that mediate the replication and maintenance of human papillomavirus type 16 genomes in Saccharomyces cerevisiae. J Virol (2005) 0.94

Rare human papillomavirus 16 E6 variants reveal significant oncogenic potential. Mol Cancer (2011) 0.93

Inactivating all three rb family pocket proteins is insufficient to initiate cervical cancer. Cancer Res (2012) 0.93

Cervical cancers require the continuous expression of the human papillomavirus type 16 E7 oncoprotein even in the presence of the viral E6 oncoprotein. Cancer Res (2012) 0.92

E1 protein of bovine papillomavirus 1 is not required for the maintenance of viral plasmid DNA replication. Virology (2002) 0.92

Down-regulation of transforming growth factor-beta type II receptor (TGF-betaRII) protein and mRNA expression in cervical cancer. Mol Cancer (2008) 0.91

Induction of promyelocytic leukemia (PML) oncogenic domains (PODs) by papillomavirus. Virology (2007) 0.91

High incidence of HPV-associated head and neck cancers in FA deficient mice is associated with E7's induction of DNA damage through its inactivation of pocket proteins. PLoS One (2013) 0.90

Inactivation of p53 rescues the maintenance of high risk HPV DNA genomes deficient in expression of E6. PLoS Pathog (2013) 0.90

E6-associated protein is required for human papillomavirus type 16 E6 to cause cervical cancer in mice. Cancer Res (2010) 0.90

Expression of a single, viral oncoprotein in skin epithelium is sufficient to recruit lymphocytes. PLoS One (2013) 0.89

Pocket proteins suppress head and neck cancer. Cancer Res (2012) 0.89

E6 and E7 oncoproteins induce distinct patterns of chromosomal aneuploidy in skin tumors from transgenic mice. Cancer Res (2004) 0.89

Dominant role of HPV16 E7 in anal carcinogenesis. Virology (2011) 0.88

The E6 oncoprotein from HPV16 enhances the canonical Wnt/β-catenin pathway in skin epidermis in vivo. Mol Cancer Res (2011) 0.87

Use of an in vivo animal model for assessing the role of integrin α(6)β(4) and syndecan-1 in early steps in papillomavirus infection. Virology (2012) 0.87

IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes. Lab Invest (2010) 0.84

Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. PLoS One (2013) 0.83

Prevalence of Human Papillomavirus in Oropharyngeal Cancer: A Systematic Review. Cancer J (2015) 0.83

A magnetic immunochromatographic strip test for detection of human papillomavirus 16 E6. Clin Chem (2006) 0.83

Sonoporation delivery of monoclonal antibodies against human papillomavirus 16 E6 restores p53 expression in transformed cervical keratinocytes. PLoS One (2012) 0.83

The HPV16 oncogenes cause aberrant stem cell mobilization. Virology (2013) 0.81

Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. Carcinogenesis (2013) 0.81

Gene expression profile regulated by the HPV16 E7 oncoprotein and estradiol in cervical tissue. Virology (2013) 0.80

Gene expression analysis of interferon kappa in laser capture microdissected cervical epithelium. Anal Biochem (2008) 0.80

HUMAN PAPILLOMAVIRUS ASSOCIATION WITH HEAD AND NECK CANCERS: UNDERSTANDING VIRUS BIOLOGY AND USING IT IN THE DEVELOPMENT OF CANCER DIAGNOSTICS. Expert Opin Med Diagn (2008) 0.80

TGFβ signaling regulates lipogenesis in human sebaceous glands cells. BMC Dermatol (2013) 0.79

Vulnerable elderly patients and overactive bladder syndrome. Drugs Aging (2010) 0.79

Papillomavirus E6 oncoprotein up-regulates occludin and ZO-2 expression in ovariectomized mice epidermis. Exp Cell Res (2013) 0.78

Novel antivirals inhibit early steps in HPV infection. Antiviral Res (2011) 0.77

Characterization of interactions between transcription factors and a regulatory region spanning nt -320 to -281 of the HIV-1 LTR in T-lymphoid and non-T-lymphoid cells. J Biomed Sci (2002) 0.75

The interwoven story of the small DNA tumor viruses. Virology (2009) 0.75