Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

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Published in Science on July 07, 2000

Authors

D Bilder1, M Li, N Perrimon

Author Affiliations

1: Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA. bilder@rascal.med.harvard.edu

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Hemorrhagic shock induces bacterial translocation from the gut. J Trauma (1988) 1.77

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Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR). FEBS Lett (1998) 1.72

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