Published in Pain on February 20, 2007
TNF-alpha and neuropathic pain--a review. J Neuroinflammation (2010) 1.68
Roles of reactive oxygen and nitrogen species in pain. Free Radic Biol Med (2011) 1.32
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. J Neurosci (2011) 1.31
Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A (2009) 1.25
NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A (2010) 1.22
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. Pain (2011) 1.14
Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radic Biol Med (2008) 1.10
Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. J Neurophysiol (2009) 1.10
Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice. Br J Pharmacol (2008) 1.08
Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy. PLoS One (2011) 1.08
Pain modulation by nitric oxide in the spinal cord. Front Neurosci (2009) 0.97
Supraspinal inactivation of mitochondrial superoxide dismutase is a source of peroxynitrite in the development of morphine antinociceptive tolerance. Neuroscience (2009) 0.97
Antinociceptive effects of intraperitoneal and intrathecal vitamin e in the rat formalin test. Korean J Pain (2012) 0.94
Magnesium attenuates chronic hypersensitivity and spinal cord NMDA receptor phosphorylation in a rat model of diabetic neuropathic pain. J Physiol (2010) 0.94
Reactive oxygen species are involved in group I mGluR-mediated facilitation of nociceptive processing in amygdala neurons. J Neurophysiol (2010) 0.94
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br J Pharmacol (2012) 0.91
Redox regulation of neuronal voltage-gated calcium channels. Antioxid Redox Signal (2013) 0.91
Free radical signalling underlies inhibition of CaV3.2 T-type calcium channels by nitrous oxide in the pain pathway. J Physiol (2010) 0.91
Reactive oxygen species mediate TNFR1 increase after TRPV1 activation in mouse DRG neurons. Mol Pain (2009) 0.88
NMDA-receptor activation and nitroxidative regulation of the glutamatergic pathway during nociceptive processing. Pain (2010) 0.87
Spinal NADPH oxidase is a source of superoxide in the development of morphine-induced hyperalgesia and antinociceptive tolerance. Neurosci Lett (2010) 0.86
Antioxidant, anti-inflammatory and analgesic potential of the Citrus decumana L. peel extract. Inflammopharmacology (2009) 0.86
Peroxynitrite and opiate antinociceptive tolerance: a painful reality. Arch Biochem Biophys (2008) 0.86
Anti-superoxide and anti-peroxynitrite strategies in pain suppression. Biochim Biophys Acta (2011) 0.85
Intrathecal Administration of Tempol Reduces Chronic Constriction Injury-Induced Neuropathic Pain in Rats by Increasing SOD Activity and Inhibiting NGF Expression. Cell Mol Neurobiol (2015) 0.82
Reactive oxygen species mediate visceral pain-related amygdala plasticity and behaviors. Pain (2015) 0.82
Antinociceptive effect of phenyl N-tert-butylnitrone, a free radical scavenger, on the rat formalin test. Korean J Anesthesiol (2012) 0.81
Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects. BMC Complement Altern Med (2011) 0.79
The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia. Neuroscience (2015) 0.78
Potential role of nitric oxide synthase isoforms in pathophysiology of neuropathic pain. Inflammopharmacology (2014) 0.78
Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity. J Exp Neurosci (2016) 0.77
Antiallodynic effects of vitamin C and vitamin E in chronic post-ischemia pain rat model. Korean J Anesthesiol (2013) 0.77
Superoxide and Nitric Oxide Involvement in Enhancing of N-methyl-D-aspartate Receptor-Mediated Central Sensitization in the Chronic Post-ischemia Pain Model. Korean J Pain (2010) 0.77
Distinct contributions of reactive oxygen species in amygdala to bee venom-induced spontaneous pain-related behaviors. Neurosci Lett (2016) 0.77
Enhanced NMDA receptor NR1 phosphorylation and neuronal activity in the arcuate nucleus of hypothalamus following peripheral inflammation. Acta Pharmacol Sin (2011) 0.76
Neuroprotective activity of thioctic acid in central nervous system lesions consequent to peripheral nerve injury. Biomed Res Int (2013) 0.76
Pharmacological activation of heme oxygenase (HO)-1/carbon monoxide pathway prevents the development of peripheral neuropathic pain in Wistar rats. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.76
A peroxynitrite decomposition catalyst prevents mechanical allodynia and NMDA receptor activation in the hind-paw ischemia reperfusion injury rats. Exp Ther Med (2013) 0.76
Blockade of Glutamine Synthetase Enhances Inflammatory Response in Microglial Cells. Antioxid Redox Signal (2016) 0.75
A Novel Nitronyl Nitroxide with Salicylic Acid Framework Attenuates Pain Hypersensitivity and Ectopic Neuronal Discharges in Radicular Low Back Pain. Neural Plast (2015) 0.75
Peripheral NMDA Receptors Mediate Antidromic Nerve Stimulation-Induced Tactile Hypersensitivity in the Rat. Mediators Inflamm (2015) 0.75
Coadministration of Resveratrol and Rice Oil Mitigates Nociception and Oxidative State in a Mouse Fibromyalgia-Like Model. Pain Res Treat (2016) 0.75
Effect of superoxide on the development and maintenance of mechanical allodynia in a rat model of chronic post-ischemia pain. Korean J Anesthesiol (2012) 0.75
Antiallodynic effect of intrathecal epigallocatechin-3-gallate due to suppression of reactive oxygen species. Korean J Anesthesiol (2014) 0.75
Nitroxidative Signaling Mechanisms in Pathological Pain. Trends Neurosci (2016) 0.75
Supression of chronic central pain by superoxide dismutase in rats with spinal cord injury: Inhibition of the NMDA receptor implicated. Exp Ther Med (2014) 0.75
Innovations in the Management of Musculoskeletal Pain With Alpha-Lipoic Acid (IMPALA Trial): Study protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Alpha-Lipoic Acid for the Treatment of Fibromyalgia Pain. JMIR Res Protoc (2017) 0.75
Activation of the nuclear factor E2-related factor 2/anitioxidant response element alleviates the nitroglycerin-induced hyperalgesia in rats. J Headache Pain (2016) 0.75
AMPKα1 knockout enhances nociceptive behaviors and spinal glutamatergic synaptic activities via production of reactive oxygen species in the spinal dorsal horn. Neuroscience (2016) 0.75
Monomethyl fumarate (MMF) inhibits pain behaviors and amygdala activity in a rat arthritis model. Pain (2017) 0.75
Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods (1994) 23.05
Oxidative stress, glutamate, and neurodegenerative disorders. Science (1993) 7.96
Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol (1980) 6.82
Evidence for a central component of post-injury pain hypersensitivity. Nature (1984) 4.41
Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. J Neurosci (1996) 3.50
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats. Science (1999) 2.68
Free radical pathways in CNS injury. J Neurotrauma (2000) 2.52
Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci (1992) 2.36
Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain (2004) 2.26
Characterization of protein kinase A and protein kinase C phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit using phosphorylation site-specific antibodies. J Biol Chem (1997) 2.25
Structure and function of the NMDA receptor channel. Neuropharmacology (1995) 2.22
A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21
Oxidative damage in neurodegenerative disease. Lancet (1994) 2.16
The contribution of excitatory amino acids to central sensitization and persistent nociception after formalin-induced tissue injury. J Neurosci (1992) 1.93
Progressive tactile hypersensitivity: an inflammation-induced incremental increase in the excitability of the spinal cord. Pain (1996) 1.85
Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. J Neurophysiol (1991) 1.72
Exercise and hormesis: activation of cellular antioxidant signaling pathway. Ann N Y Acad Sci (2006) 1.65
NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity. Curr Opin Neurobiol (2001) 1.58
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat. Brain Res (1990) 1.55
Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain (2006) 1.54
Silent glutamatergic synapses and nociception in mammalian spinal cord. Nature (1998) 1.46
Altered brain metabolism of iron as a cause of neurodegenerative diseases? J Neurochem (1994) 1.46
Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. J Neurosci (2000) 1.42
Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain (2005) 1.40
Cell-permeable scavengers of superoxide prevent long-term potentiation in hippocampal area CA1. J Neurophysiol (1998) 1.34
A role for superoxide in protein kinase C activation and induction of long-term potentiation. J Biol Chem (1998) 1.31
Signaling by reactive oxygen species in the nervous system. Cell Mol Life Sci (2000) 1.27
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons. Eur J Neurosci (2004) 1.27
An introduction to the free radical hypothesis in Parkinson's disease. Ann Neurol (1992) 1.22
A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport (1996) 1.20
Cells in laminae III and IV of the rat spinal cord that possess the neurokinin-1 receptor and have dorsally directed dendrites receive a major synaptic input from tachykinin-containing primary afferents. J Neurosci (1997) 1.19
Long-term potentiation in spinothalamic neurons. Brain Res Brain Res Rev (2002) 1.17
Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats. Neuroscience (2002) 1.15
Modulation of protein kinases and protein phosphatases by reactive oxygen species: implications for hippocampal synaptic plasticity. Prog Neuropsychopharmacol Biol Psychiatry (1999) 1.13
Positive role of reactive oxygen species in mammalian sperm capacitation: triggering and modulation of phosphorylation events. Free Radic Biol Med (2006) 1.03
Pharmacologic properties of phenyl N-tert-butylnitrone. Antioxid Redox Signal (1999) 1.03
Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in rats. Brain Res (2004) 0.99
Phosphorylation of the Arginine-X-X-(Serine/Threonine) motif in human sperm proteins during capacitation: modulation and protein kinase A dependency. Mol Hum Reprod (2004) 0.98
Evidence of an oxidative challenge in the Alzheimer's brain. Neurochem Res (1994) 0.95
Insulin causes a transient tyrosine phosphorylation of NR2A and NR2B NMDA receptor subunits in rat hippocampus. J Neurochem (1999) 0.95
The effects of protein phosphatase inhibitors on nociceptive behavioral responses of rats following intradermal injection of capsaicin. Pain (2003) 0.90
Molecular characterization of NMDA and metabotropic glutamate receptors. Ann N Y Acad Sci (1993) 0.90
Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors. Toxicol Appl Pharmacol (2001) 0.86
Cyclic adenosine 3'5'-monophosphate potentiates excitatory amino acid and synaptic responses of rat spinal dorsal horn neurons. Brain Res (1992) 0.84
The effect of lumbar sympathectomy in the spinal nerve ligation model of neuropathic pain. J Pain (2001) 0.84
Effects of purinergic and adrenergic antagonists in a rat model of painful peripheral neuropathy. Pain (2000) 0.81
Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain (2004) 2.26
Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett (2005) 1.58
Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain (2006) 1.54
The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain (2007) 1.41
Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats. Pain (2005) 1.40
Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci (2009) 1.36
Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain (2008) 1.30
Two variables that can be used as pain indices in experimental animal models of arthritis. J Neurosci Methods (2002) 1.29
Acupuncture analgesia in a new rat model of ankle sprain pain. Pain (2002) 1.24
Segmental spinal nerve ligation model of neuropathic pain. Methods Mol Med (2004) 1.24
Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. Pain (2011) 1.14
Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn. J Neurophysiol (2009) 1.10
Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal alpha-adrenoceptors. Pain (2007) 1.10
Importance of hyperexcitability of DRG neurons in neuropathic pain. Pain Pract (2002) 1.06
Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain. Pain (2008) 1.02
Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci Lett (2008) 1.01
Proteomics study of neuropathic and nonneuropathic dorsal root ganglia: altered protein regulation following segmental spinal nerve ligation injury. Physiol Genomics (2007) 0.98
Mitochondrial Ca(2+) uptake is essential for synaptic plasticity in pain. J Neurosci (2011) 0.98
Electroacupuncture suppresses capsaicin-induced secondary hyperalgesia through an endogenous spinal opioid mechanism. Pain (2009) 0.96
Changes in three subtypes of tetrodotoxin sensitive sodium channel expression in the axotomized dorsal root ganglion in the rat. Neurosci Lett (2002) 0.92
Superoxide signaling in pain is independent of nitric oxide signaling. Neuroreport (2009) 0.90
Regulation of Wnt signaling by nociceptive input in animal models. Mol Pain (2012) 0.90
Models of neuropathic pain in the rat. Curr Protoc Neurosci (2003) 0.89
Effect of antioxidant treatment on spinal GABA neurons in a neuropathic pain model in the mouse. Pain (2013) 0.89
Ionotropic glutamate receptors contribute to maintained neuronal hyperexcitability following spinal cord injury in rats. Exp Neurol (2010) 0.87
Electroacupuncture analgesia in rat ankle sprain pain model: neural mechanisms. Neurol Res (2010) 0.87
Phenyl N-t-butylnitrone, a reactive oxygen species scavenger, reduces zymosan-induced visceral pain in rats. Neurosci Lett (2008) 0.86
Peripheral norepinephrine exacerbates neuritis-induced hyperalgesia. J Pain (2003) 0.86
Electroacupuncture reduces the evoked responses of the spinal dorsal horn neurons in ankle-sprained rats. J Neurophysiol (2011) 0.85
Peripheral acid-sensing ion channels and P2X receptors contribute to mechanical allodynia in a rodent thrombus-induced ischemic pain model. J Pain (2010) 0.85
Functional motoneurons develop from human neural stem cell transplants in adult rats. Neuroreport (2007) 0.83
Reactive oxygen species (ROS) modulate AMPA receptor phosphorylation and cell-surface localization in concert with pain-related behavior. Pain (2012) 0.81
Changes in the gene expression of six subtypes of P2X receptors in rat dorsal root ganglion after spinal nerve ligation. Neurosci Lett (2003) 0.81
Inhibition of renal Na+/H+ exchange in cadmium-intoxicated rats. Toxicol Appl Pharmacol (2005) 0.81
A new rat model for thrombus-induced ischemic pain (TIIP); development of bilateral mechanical allodynia. Pain (2008) 0.80
Responses of spinal dorsal horn neurons to foot movements in rats with a sprained ankle. J Neurophysiol (2011) 0.79
Induction of long-term potentiation and long-term depression is cell-type specific in the spinal cord. Pain (2015) 0.79
Bilateral hyperexcitability of thalamic VPL neurons following unilateral spinal injury in rats. J Physiol Sci (2009) 0.79
A surgical ankle sprain pain model in the rat: effects of morphine and indomethacin. Neurosci Lett (2008) 0.79
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. Pain (2006) 0.77
Brief review: chemotherapy-induced painful peripheral neuropathy (CIPPN): current status and future directions. Can J Anaesth (2014) 0.76
Models of neuropathic pain in the rat. Curr Protoc Pharmacol (2003) 0.76
Reactive oxygen species affect spinal cell type-specific synaptic plasticity in a model of neuropathic pain. Pain (2017) 0.75
Peripheral afferents and spinal inhibitory system in dynamic and static mechanical allodynia. Pain (2017) 0.75
Sodium channels and neuropathic pain. Novartis Found Symp (2004) 0.75
Postinjury stimulation triggers a transition to nociplastic pain in mice. Pain (2022) 0.75