Published in Antioxid Redox Signal on November 02, 2016
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem (1982) 27.26
Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med (1999) 5.08
Oxidative stress and neurodegenerative diseases: a review of upstream and downstream antioxidant therapeutic options. Curr Neuropharmacol (2009) 4.52
Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med (2005) 4.42
Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A (1991) 3.85
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis (2005) 3.78
Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest (2012) 3.65
Glutamine synthetase: glial localization in brain. Science (1977) 3.14
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med (Berl) (1997) 2.55
Signal regulatory proteins in the immune system. J Immunol (2005) 2.48
The role of oxidative stress in the pathogenesis of multiple sclerosis: the need for effective antioxidant therapy. J Neurol (2004) 2.40
Biochemistry and physiology of brain ammonia. Physiol Rev (1987) 2.30
Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener (2009) 2.23
Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull (2011) 2.22
The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J Exp Med (2007) 2.16
Structure-function relationships of glutamine synthetases. Biochim Biophys Acta (2000) 2.13
Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part I: creatine kinase BB, glutamine synthase, and ubiquitin carboxy-terminal hydrolase L-1. Free Radic Biol Med (2002) 2.10
Glutamine synthetase is a genetic determinant of cell type-specific glutamine independence in breast epithelia. PLoS Genet (2011) 1.90
Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem (1995) 1.84
Neuroinflammation and M2 microglia: the good, the bad, and the inflamed. J Neuroinflammation (2014) 1.83
Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system. J Biol Chem (1983) 1.78
Microglia as liaisons between the immune and central nervous systems: functional implications for multiple sclerosis. Glia (2002) 1.74
Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J Neuroinflammation (2008) 1.65
Modulation of glutamine metabolism by the PI(3)K-PKB-FOXO network regulates autophagy. Nat Cell Biol (2012) 1.63
Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: correlation of structural and functional changes. Arch Biochem Biophys (1990) 1.57
Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain (2007) 1.44
Quinolinic acid, the inescapable neurotoxin. FEBS J (2012) 1.42
Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators Inflamm (2014) 1.35
Microglia and multiple sclerosis. J Neurosci Res (2005) 1.34
Neurodegeneration in multiple sclerosis: the role of oxidative stress and excitotoxicity. J Neurol Sci (2008) 1.25
Local nitric oxide production in viral and autoimmune diseases of the central nervous system. Proc Natl Acad Sci U S A (1995) 1.21
Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome. Mol Genet Metab (2010) 1.18
Role of glutamate transporters in the regulation of glutathione levels in human macrophages. Am J Physiol Cell Physiol (2001) 1.10
Neurotoxic effects of tumor necrosis factor alpha in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis. Dev Neurosci (1993) 1.10
Reactive oxygen species are required for the phagocytosis of myelin by macrophages. J Neuroimmunol (1998) 1.09
Loss of blood-brain barrier integrity in the spinal cord is common to experimental allergic encephalomyelitis in knockout mouse models. Proc Natl Acad Sci U S A (2007) 1.05
Insulin restores metabolic function in cultured cortical neurons subjected to oxidative stress. Diabetes (2006) 1.04
An amino acid shuffle activates mTORC1. Cell (2009) 1.01
System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate. Cereb Cortex (2008) 1.01
Quinolinic acid: an endogenous neurotoxin with multiple targets. Oxid Med Cell Longev (2013) 1.00
Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: relevance to Alzheimer's disease. J Neurochem (1997) 0.95
Glutamine synthetase deficiency in murine astrocytes results in neonatal death. Glia (2010) 0.95
Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: morphology. Glia (1994) 0.94
Characterization of human monocyte-derived microglia-like cells. Glia (2006) 0.93
Glutamine and interleukin-1beta interact at the level of Sp1 and nuclear factor-kappaB to regulate argininosuccinate synthetase gene expression. FEBS J (2007) 0.93
Regulation of astrocyte glutamine synthetase in epilepsy. Neurochem Int (2013) 0.90
Early expression of glutamate transporter proteins in ramified microglia after controlled cortical impact injury in the rat. Glia (2001) 0.90
The glutamate-glutamine cycle as an inducible, protective face of macrophage activation. J Leukoc Biol (2006) 0.89
SOD1 overexpression alters ROS production and reduces neurotoxic inflammatory signaling in microglial cells. J Neuroimmunol (2006) 0.89
Oxidative modification of Escherichia coli glutamine synthetase. Decreases in the thermodynamic stability of protein structure and specific changes in the active site conformation. J Biol Chem (1992) 0.89
Glutamate transporter GLT-1 is highly expressed in activated microglia following facial nerve axotomy. Brain Res Mol Brain Res (2000) 0.88
Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis. Neuroscience (2011) 0.87
Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. J Biol Chem (2012) 0.87
Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun (2010) 0.86
Expression of excitatory amino acid transporter-2 (EAAT-2) and glutamine synthetase (GS) in brain macrophages and microglia of SIVmac251-infected macaques. Neuropathol Appl Neurobiol (2002) 0.86
Identification of mitochondrial coenzyme a transporters from maize and Arabidopsis. Plant Physiol (2013) 0.86
Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons. Invest Ophthalmol Vis Sci (2008) 0.85
From theory to therapy: implications from an in vitro model of ramified microglia. Microsc Res Tech (2001) 0.85
Glutamine activates peroxisome proliferator-activated receptor-γ in intestinal epithelial cells via 15-S-HETE and 13-OXO-ODE: a novel mechanism. Am J Physiol Gastrointest Liver Physiol (2011) 0.84
N9 microglial cells polarized by LPS and IL4 show differential responses to secondary environmental stimuli. Cell Immunol (2012) 0.83
Misoprostol elevates intracellular calcium in Neuro-2a cells via protein kinase A. Biochem Biophys Res Commun (2010) 0.83
Expression of excitatory amino acid transporter-1 in brain macrophages and microglia of HIV-infected patients. A neuroprotective role for activated microglia? J Neuropathol Exp Neurol (2003) 0.81
Regulated expression of sodium-dependent glutamate transporters and synthetase: a neuroprotective role for activated microglia and macrophages in HIV infection? Brain Pathol (2003) 0.80
Expression of excitatory amino acid transporter-1 (EAAT-1) in brain macrophages and microglia of patients with prion diseases. J Neuropathol Exp Neurol (2004) 0.80
Prostaglandin E2 alters Wnt-dependent migration and proliferation in neuroectodermal stem cells: implications for autism spectrum disorders. Cell Commun Signal (2014) 0.80
Insulin affects synaptosomal GABA and glutamate transport under oxidative stress conditions. Brain Res (2003) 0.79
Microglial glutamate uptake is coupled to glutathione synthesis and glutamate release. Eur J Neurosci (2006) 0.79
The involvement of neuroinflammation and kynurenine pathway in Parkinson's disease. Parkinsons Dis (2011) 0.79
Effects of various nitric oxide synthase inhibitors on NMDA-induced neuronal injury in rat cortical neurons. Chin J Physiol (1996) 0.79
Blood monocytes and spleen macrophages differentiate into microglia-like cells on monolayers of astrocytes: membrane currents. Glia (1994) 0.79
Acetylation of human mitochondrial citrate carrier modulates mitochondrial citrate/malate exchange activity to sustain NADPH production during macrophage activation. Biochim Biophys Acta (2015) 0.79
Up-regulation of glutamine synthesis in microglia activated with endotoxin. Neurosci Lett (2015) 0.78
Glutamine induces nuclear degradation of the NF-κB p65 subunit in Caco-2/TC7 cells. Biochimie (2011) 0.77
Glutamine synthetase desensitizes differentiated adipocytes to proinflammatory stimuli by raising intracellular glutamine levels. FEBS Lett (2014) 0.76
Prostaglandin E2 elevates calcium in differentiated neuroectodermal stem cells. Mol Cell Neurosci (2016) 0.76
Identification of a chronic non-neurodegenerative microglia activation state in a mouse model of peroxisomal β-oxidation deficiency. Glia (2015) 0.76