Nitroxidative Signaling Mechanisms in Pathological Pain.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 27842920)

Published in Trends Neurosci on November 12, 2016

Authors

Peter M Grace1, Andrew D Gaudet2, Vasiliki Staikopoulos3, Steven F Maier2, Mark R Hutchinson3, Daniela Salvemini4, Linda R Watkins2

Author Affiliations

1: Department of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO, USA; Current address: Department of Critical Care Research, University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: pgrace@mdanderson.org.
2: Department of Psychology and Neuroscience, and the Center for Neuroscience, University of Colorado, Boulder, CO, USA.
3: Discipline of Physiology, School of Medicine, and the Australian Research Council (ARC) Centre for Nanoscale BioPhotonics (CNBP), University of Adelaide, Adelaide, SA, Australia.
4: Department of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.

Articles cited by this

(truncated to the top 100)

Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain (2005) 13.45

A role for mitochondria in NLRP3 inflammasome activation. Nature (2010) 13.21

Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature (2010) 11.24

TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell (2006) 11.01

Cellular and molecular mechanisms of pain. Cell (2009) 9.36

Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2009) 9.24

Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell (2005) 9.16

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol (2010) 9.02

Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 7.23

Central sensitization: a generator of pain hypersensitivity by central neural plasticity. J Pain (2009) 7.11

Activation and regulation of the inflammasomes. Nat Rev Immunol (2013) 5.71

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity (2012) 5.08

Physiological roles of mitochondrial reactive oxygen species. Mol Cell (2012) 5.05

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol (2005) 4.32

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10

Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med (2002) 3.91

Chronic pain in Australia: a prevalence study. Pain (2001) 3.83

Cutting edge: direct interaction of TLR4 with NAD(P)H oxidase 4 isozyme is essential for lipopolysaccharide-induced production of reactive oxygen species and activation of NF-kappa B. J Immunol (2004) 3.27

TRP channels and pain. Annu Rev Cell Dev Biol (2013) 2.94

Interactions between the immune and nervous systems in pain. Nat Med (2010) 2.91

Cellular mechanisms and physiological consequences of redox-dependent signalling. Nat Rev Mol Cell Biol (2014) 2.83

Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med (2006) 2.77

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nat Med (2008) 2.77

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Trends Biochem Sci (2014) 2.53

The neuro-immune balance in neuropathic pain: involvement of inflammatory immune cells, immune-like glial cells and cytokines. J Neuroimmunol (2010) 2.39

Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. J Biol Chem (2009) 2.33

Antioxidants in Translational Medicine. Antioxid Redox Signal (2015) 2.32

Mitochondria: master regulators of danger signalling. Nat Rev Mol Cell Biol (2012) 2.28

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med (2012) 2.25

A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther (2004) 2.21

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis. Arch Toxicol (2013) 2.18

Nociceptor sensitization in pain pathogenesis. Nat Med (2010) 2.13

Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels. J Biol Chem (2004) 2.08

Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury. J Neuroinflammation (2011) 2.02

NF-kappaB regulates phagocytic NADPH oxidase by inducing the expression of gp91phox. J Biol Chem (2006) 2.00

Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci U S A (2009) 1.94

Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93

P2X7 mediates superoxide production in primary microglia and is up-regulated in a transgenic mouse model of Alzheimer's disease. J Biol Chem (2003) 1.87

Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest (2010) 1.85

Mitochondrial fission is an upstream and required event for bax foci formation in response to nitric oxide in cortical neurons. Cell Death Differ (2006) 1.77

Pathological pain and the neuroimmune interface. Nat Rev Immunol (2014) 1.73

Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia. Pharmacol Rev (2011) 1.66

Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer. Am J Physiol Regul Integr Comp Physiol (2003) 1.62

Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. J Biol Chem (2011) 1.59

Multiple PKCε-dependent mechanisms mediating mechanical hyperalgesia. Pain (2010) 1.55

P2X7R blockade prevents NLRP3 inflammasome activation and brain injury in a rat model of intracerebral hemorrhage: involvement of peroxynitrite. J Neuroinflammation (2015) 1.48

Alleviating suffering 101--pain relief in the United States. N Engl J Med (2012) 1.47

Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain (2007) 1.44

Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models. Neuroscience (2009) 1.44

The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain (2007) 1.41

Caspase signalling in neuropathic and inflammatory pain in the rat. Eur J Neurosci (2004) 1.39

Peroxynitrite is an essential component of cytokines production mechanism in human monocytes through modulation of nuclear factor-kappa B DNA binding activity. J Biol Chem (2001) 1.39

Reactive oxygen species in the regulation of synaptic plasticity and memory. Antioxid Redox Signal (2010) 1.37

Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice. J Clin Invest (2007) 1.37

Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci (2009) 1.36

Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol (2009) 1.34

Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol (2009) 1.33

Roles of reactive oxygen and nitrogen species in pain. Free Radic Biol Med (2011) 1.32

TRPM2 links oxidative stress to NLRP3 inflammasome activation. Nat Commun (2013) 1.32

SOD mimetics are coming of age. Nat Rev Drug Discov (2002) 1.32

Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain (2008) 1.30

ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling. Cell Microbiol (2007) 1.29

NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression. J Immunol (2009) 1.29

Nox4 is a novel inducible source of reactive oxygen species in monocytes and macrophages and mediates oxidized low density lipoprotein-induced macrophage death. Circ Res (2010) 1.29

Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model. Anesthesiology (2007) 1.29

The PSD95-nNOS interface: a target for inhibition of excitotoxic p38 stress-activated protein kinase activation and cell death. J Cell Biol (2005) 1.26

Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys (1999) 1.26

Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A (2009) 1.25

Interleukin-10 protects lipopolysaccharide-induced neurotoxicity in primary midbrain cultures by inhibiting the function of NADPH oxidase. J Pharmacol Exp Ther (2006) 1.25

Functional deficits in peripheral nerve mitochondria in rats with paclitaxel- and oxaliplatin-evoked painful peripheral neuropathy. Exp Neurol (2011) 1.24

Neurogenic neuroinflammation: inflammatory CNS reactions in response to neuronal activity. Nat Rev Neurosci (2013) 1.24

NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain. Proc Natl Acad Sci U S A (2010) 1.22

Endogenous adenosine A3 receptor activation selectively alleviates persistent pain states. Brain (2014) 1.21

Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology (2008) 1.21

Targeting the overproduction of peroxynitrite for the prevention and reversal of paclitaxel-induced neuropathic pain. J Neurosci (2012) 1.21

Pain and analgesia: The dual effect of nitric oxide in the nociceptive system. Nitric Oxide (2011) 1.20

Reactive oxygen species contribute to neuropathic pain by reducing spinal GABA release. Pain (2011) 1.14

Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol (2008) 1.13

Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current. Mol Pharmacol (2006) 1.12

Lipophilicity is a critical parameter that dominates the efficacy of metalloporphyrins in blocking the development of morphine antinociceptive tolerance through peroxynitrite-mediated pathways. Free Radic Biol Med (2008) 1.10

Reactive oxygen species derived from NOX1/NADPH oxidase enhance inflammatory pain. J Neurosci (2008) 1.09

Mitochondrial electron transport in models of neuropathic and inflammatory pain. Pain (2006) 1.08

Cyclooxygenases 1 and 2 contribute to peroxynitrite-mediated inflammatory pain hypersensitivity. FASEB J (2008) 1.08

Role of oxidative stress in pathophysiology of peripheral neuropathy and modulation by N-acetyl-L-cysteine in rats. Eur J Pain (2005) 1.08

Mechanism of concentration-dependent induction of heme oxygenase-1 by resveratrol in human aortic smooth muscle cells. Biochem Pharmacol (2005) 1.08

Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr Neurovasc Res (2011) 1.06

New insights on NOX enzymes in the central nervous system. Antioxid Redox Signal (2014) 1.06

Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain. Sci Transl Med (2014) 1.06

Oxidative stress-inducible proteins in macrophages. Free Radic Res (1999) 1.05

Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. Eur J Pharmacol (2011) 1.05

Peripheral immune contributions to the maintenance of central glial activation underlying neuropathic pain. Brain Behav Immun (2011) 1.05

Sensory neurons and schwann cells respond to oxidative stress by increasing antioxidant defense mechanisms. Antioxid Redox Signal (2009) 1.04

The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats. J Pharmacol Exp Ther (2013) 1.02

Redox regulation of FoxO transcription factors. Redox Biol (2015) 1.01

Enduring reversal of neuropathic pain by a single intrathecal injection of adenosine 2A receptor agonists: a novel therapy for neuropathic pain. J Neurosci (2009) 1.01

TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice. J Neurosci (2012) 1.00

Protective role of reactive oxygen species in endotoxin-induced lung inflammation through modulation of IL-10 expression. J Immunol (2012) 1.00

Biological and physiological role of reactive oxygen species--the good, the bad and the ugly. Acta Physiol (Oxf) (2015) 0.99

Novel therapeutic strategy to prevent chemotherapy-induced persistent sensory neuropathy by TRPA1 blockade. Cancer Res (2013) 0.99

The therapeutic potential of interleukin-10 in neuroimmune diseases. Neuropharmacology (2014) 0.98