Inflammatory bowel disease: past, present, and future.

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Published in J Gastroenterol on February 16, 2007

Authors

Bruce E Sands1

Author Affiliations

1: MGH Crohn's and Colitis Center and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, 165 Cambridge Street, 9th Floor, Boston, MA 02114, USA.

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The role of intestinal bacteria in the metabolism of salicylazosulfapyridine. J Pharmacol Exp Ther (1972) 2.37

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Appendectomy and subsequent risk of inflammatory bowel diseases. Surgery (2001) 2.35

Sargramostim for active Crohn's disease. N Engl J Med (2005) 2.24

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Tumour-necrosis-factor antibody treatment in Crohn's disease. Lancet (1993) 2.00

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Smoking cessation and the course of Crohn's disease: an intervention study. Gastroenterology (2001) 1.73

Straight ileoanal anastomosis v ileal pouch--anal anastomosis after colectomy and mucosal proctectomy. Arch Surg (1983) 1.63

Time relationships between cessation of smoking and onset of ulcerative colitis. Digestion (1987) 1.60

Probiotics and the management of inflammatory bowel disease. Inflamm Bowel Dis (2004) 1.36

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Effect of resection margins on the recurrence of Crohn's disease in the small bowel. A randomized controlled trial. Ann Surg (1996) 1.30

Review article: the genetics of inflammatory bowel disease. Aliment Pharmacol Ther (2001) 1.25

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Long-term outcome of treatment with intravenous cyclosporin in patients with severe ulcerative colitis. Inflamm Bowel Dis (2004) 1.22

Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol (2003) 1.22

Are 100,000 "SNPs" useless? Science (2002) 1.20

Effects of cigarette smoking on the clinical course of ulcerative colitis. Scand J Gastroenterol (1988) 1.18

Regional ileitis: a pathologic and clinical entity. 1932. Mt Sinai J Med (2000) 1.18

Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology (2004) 1.17

An open-labelled study of granulocyte colony-stimulating factor in the treatment of active Crohn's disease. Aliment Pharmacol Ther (2005) 1.11

Historical origins of current IBD concepts. World J Gastroenterol (2001) 1.10

Transdermal nicotine for induction of remission in ulcerative colitis. Cochrane Database Syst Rev (2004) 1.08

A controlled evaluation of intravenous adrenocorticotropic hormone and hydrocortisone in the treatment of acute colitis. Gastroenterology (1975) 1.07

Microbial pattern recognition receptors mediate M-cell uptake of a gram-negative bacterium. Infect Immun (2006) 1.05

Favorable effect of 6-mercaptopurine on fistulae of Crohn's disease. Dig Dis Sci (1985) 1.05

Is Crohn's disease an immunodeficiency? A hypothesis suggesting possible early events in the pathogenesis of Crohn's disease. Dig Dis Sci (2000) 1.05

Antibiotics and azathioprine for the treatment of perianal fistulas in Crohn's disease. Aliment Pharmacol Ther (2003) 1.03

Probiotics in the treatment of inflammatory bowel disease. J Clin Gastroenterol (2006) 0.96

Effects of current cigarette smoking on clinical course of Crohn's disease and ulcerative colitis. Dig Dis Sci (2001) 0.96

Experimental models of inflammatory bowel disease. Arch Immunol Ther Exp (Warsz) (2003) 0.91

Update in medical therapy of ulcerative colitis: newer concepts and therapies. J Clin Gastroenterol (2005) 0.91

Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling. Pediatr Res (2005) 0.86

The role of antibiotics in the management of Crohn's disease. Inflamm Bowel Dis (2004) 0.84

Stapler stricturoplasty for Crohn's disease. Surg Gynecol Obstet (1989) 0.78