Published in Immunol Rev on August 01, 2001
Checkpoint blockade in cancer immunotherapy. Adv Immunol (2006) 4.09
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med (2005) 3.70
Mechanisms of impaired regulation by CD4(+)CD25(+)FOXP3(+) regulatory T cells in human autoimmune diseases. Nat Rev Immunol (2010) 3.69
Induction of immune tolerance to coagulation factor IX antigen by in vivo hepatic gene transfer. J Clin Invest (2003) 3.52
The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin Exp Immunol (2007) 3.51
Human CD25+CD4+ T suppressor cell clones produce transforming growth factor beta, but not interleukin 10, and are distinct from type 1 T regulatory cells. J Exp Med (2002) 3.49
Heterogeneity and plasticity of T helper cells. Cell Res (2009) 3.09
Myasthenia gravis: past, present, and future. J Clin Invest (2006) 3.06
Reversing the defective induction of IL-10-secreting regulatory T cells in glucocorticoid-resistant asthma patients. J Clin Invest (2005) 2.94
CD4+ Tregs and immune control. J Clin Invest (2004) 2.85
Two functional subsets of FOXP3+ regulatory T cells in human thymus and periphery. Immunity (2008) 2.78
Amplification of tumor-specific regulatory T cells following therapeutic cancer vaccines. Blood (2005) 2.60
The immune paradox of sarcoidosis and regulatory T cells. J Exp Med (2006) 2.35
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology (2006) 2.03
Shifting the equilibrium in cancer immunoediting: from tumor tolerance to eradication. Immunol Rev (2011) 2.02
'Yin-Yang' functions of transforming growth factor-beta and T regulatory cells in immune regulation. Immunol Rev (2007) 1.98
Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy. J Exp Med (2004) 1.96
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1. J Exp Med (2006) 1.84
Inflammatory bowel disease: past, present, and future. J Gastroenterol (2007) 1.83
The development and function of regulatory T cells. Cell Mol Life Sci (2009) 1.66
The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? Immunology (2004) 1.65
Imbalance of regulatory T cells in human autoimmune diseases. Immunology (2006) 1.64
T regulatory type 1 cells in squamous cell carcinoma of the head and neck: mechanisms of suppression and expansion in advanced disease. Clin Cancer Res (2008) 1.63
Sensitization to brain antigens after stroke is augmented by lipopolysaccharide. J Cereb Blood Flow Metab (2005) 1.63
T-cell responses to survivin in cancer patients undergoing radiation therapy. Clin Cancer Res (2008) 1.61
Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion. Cell Death Differ (2006) 1.55
The complex and evolving story of T cell activation to AAV vector-encoded transgene products. Mol Ther (2010) 1.55
IL-35 stimulation of CD39+ regulatory T cells confers protection against collagen II-induced arthritis via the production of IL-10. J Immunol (2010) 1.53
Programming CD8+ T cells for effective immunotherapy. Curr Opin Immunol (2006) 1.51
TGF-beta and regulatory T cell in immunity and autoimmunity. J Clin Immunol (2008) 1.49
How diverse--CD4 effector T cells and their functions. J Mol Cell Biol (2009) 1.44
Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment? Hum Reprod Update (2009) 1.43
Increased hepatitis C virus (HCV)-specific CD4+CD25+ regulatory T lymphocytes and reduced HCV-specific CD4+ T cell response in HCV-infected patients with normal versus abnormal alanine aminotransferase levels. Clin Exp Immunol (2006) 1.43
Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke. Stroke (2008) 1.43
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation tolerance. J Exp Med (2011) 1.43
Functional characterization and gene expression analysis of CD4+ CD25+ regulatory T cells generated in mice treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Immunol (2008) 1.38
Translational mini-review series on Th17 cells: induction of interleukin-17 production by regulatory T cells. Clin Exp Immunol (2009) 1.37
Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease. Am J Gastroenterol (2005) 1.34
The anti-inflammatory mechanisms of Hsp70. Front Immunol (2012) 1.31
Inducible costimulator-dependent IL-10 production by regulatory T cells specific for self-antigen. Proc Natl Acad Sci U S A (2004) 1.27
Latency-associated peptide identifies a novel CD4+CD25+ regulatory T cell subset with TGFbeta-mediated function and enhanced suppression of experimental autoimmune encephalomyelitis. J Immunol (2008) 1.26
Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood (2006) 1.25
Immune deviation by mucosal antigen administration suppresses gene-transfer-induced inhibitor formation to factor IX. Blood (2006) 1.24
Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells. Clin Exp Immunol (2008) 1.23
Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. Immunity (2012) 1.21
Modulating the intestinal immune system: the role of lymphotoxin and GALT organs. Gut (2004) 1.17
Astrovirus induces diarrhea in the absence of inflammation and cell death. J Virol (2003) 1.15
Epithelia: lymphocyte interactions in the gut. Immunol Rev (2007) 1.15
Combination of rapamycin and IL-2 increases de novo induction of human CD4(+)CD25(+)FOXP3(+) T cells. J Autoimmun (2008) 1.14
Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer. PLoS One (2013) 1.13
CD27 expression discriminates between regulatory and non-regulatory cells after expansion of human peripheral blood CD4+ CD25+ cells. Immunology (2007) 1.13
Regulatory T cells in human disease and their potential for therapeutic manipulation. Immunology (2006) 1.12
Chronic inhaled ovalbumin exposure induces antigen-dependent but not antigen-specific inhalational tolerance in a murine model of allergic airway disease. Am J Pathol (2004) 1.12
Comparative study of clinical grade human tolerogenic dendritic cells. J Transl Med (2011) 1.12
MCAM-expressing CD4(+) T cells in peripheral blood secrete IL-17A and are significantly elevated in inflammatory autoimmune diseases. J Autoimmun (2011) 1.10
Regulatory T cells negatively affect IL-2 production of effector T cells through CD39/adenosine pathway in HIV infection. PLoS Pathog (2013) 1.10
Human dendritic cell subsets for vaccination. J Clin Immunol (2005) 1.09
Cells with regulatory function of the innate and adaptive immune system in primary Sjögren's syndrome. Clin Exp Immunol (2009) 1.07
FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. J Virol (2007) 1.06
Foxp3+ regulatory T cells promote lung epithelial proliferation. Mucosal Immunol (2014) 1.06
Clonal regulatory T cells specific for a red blood cell autoantigen in human autoimmune hemolytic anemia. Blood (2007) 1.05
FoxP3(+)CD4(+)CD25(+) T cells with regulatory properties can be cultured from colonic mucosa of patients with Crohn's disease. Clin Exp Immunol (2005) 1.04
Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice. Proc Natl Acad Sci U S A (2008) 1.04
Induced and natural regulatory T cells in the development of inflammatory bowel disease. Inflamm Bowel Dis (2013) 1.03
Th17 cells and Tregs: unlikely allies. J Leukoc Biol (2014) 1.03
Interleukin 35: a key mediator of suppression and the propagation of infectious tolerance. Front Immunol (2013) 1.03
Pathways of major histocompatibility complex allorecognition. Curr Opin Organ Transplant (2008) 1.02
Making sense of regulatory T cell suppressive function. Semin Immunol (2011) 1.00
Ovalbumin-protein sigma 1 M-cell targeting facilitates oral tolerance with reduction of antigen-specific CD4+ T cells. Gastroenterology (2008) 1.00
Regulatory T cells and innate immune regulation in tumor immunity. Springer Semin Immunopathol (2006) 0.99
Resolving the identity myth: key markers of functional CD4+FoxP3+ regulatory T cells. Int Immunopharmacol (2011) 0.99
Dendritic cells: a critical player in cancer therapy? J Immunother (2008) 0.99
Segregated regulatory CD39+CD4+ T cell function: TGF-β-producing Foxp3- and IL-10-producing Foxp3+ cells are interdependent for protection against collagen-induced arthritis. J Immunol (2011) 0.99
The role of tregs in glioma-mediated immunosuppression: potential target for intervention. Neurosurg Clin N Am (2010) 0.98
Myasthenia gravis: a review. Autoimmune Dis (2012) 0.98
Thymic versus induced regulatory T cells - who regulates the regulators? Front Immunol (2013) 0.98
NKT cells play critical roles in the induction of oral tolerance by inducing regulatory T cells producing IL-10 and transforming growth factor beta, and by clonally deleting antigen-specific T cells. Immunology (2006) 0.98
Th2 mediated regulation in RA and the spondyloarthropathies. Ann Rheum Dis (2002) 0.96
Treating atherosclerosis with regulatory T cells. Arterioscler Thromb Vasc Biol (2014) 0.95
Natural regulatory T cells in autoimmunity. Autoimmunity (2010) 0.94
A nasal proteosome adjuvant activates microglia and prevents amyloid deposition. Ann Neurol (2008) 0.94
Imbalance in distribution of functional autologous regulatory T cells in rheumatoid arthritis. Ann Rheum Dis (2007) 0.93
T regulatory cells: aid or hindrance in the clearance of disease? J Cell Mol Med (2008) 0.93
Loss of ileal IgA+ plasma cells and of CD4+ lymphocytes in ileal Peyer's patches of vitamin A deficient rats. Clin Exp Immunol (2002) 0.92
Development of thymically derived natural regulatory T cells. Ann N Y Acad Sci (2010) 0.91
Modification of the tumor microenvironment as a novel target of renal cell carcinoma therapeutics. Cancer J (2013) 0.90
The phenotypic and functional consequences of tumour necrosis factor receptor type 2 expression on CD4(+) FoxP3(+) regulatory T cells. Immunology (2011) 0.90
Regulatory T cell subsets in filarial infection and their function. Front Immunol (2013) 0.90
CD4+ regulatory cells as a potential immunotherapy. Philos Trans R Soc Lond B Biol Sci (2005) 0.90
Elimination of CD4(+)CD25(+) T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZB x NZW F mice. Int J Exp Pathol (2005) 0.90
T regulatory cells: an overview and intervention techniques to modulate allergy outcome. Clin Mol Allergy (2009) 0.89
HIV-specific TGF-beta-positive CD4+ T cells do not express regulatory surface markers and are regulated by CTLA-4. AIDS Res Hum Retroviruses (2010) 0.88
Role of apoptosis in autoimmunity. J Clin Immunol (2004) 0.88
Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go? Purinergic Signal (2012) 0.88
Forkhead transcription factors in chronic inflammation. Int J Biochem Cell Biol (2009) 0.87
Curcumin induces maturation-arrested dendritic cells that expand regulatory T cells in vitro and in vivo. Clin Exp Immunol (2010) 0.87
Suppression of lymphocyte proliferation and regulation of dendritic cell phenotype by soluble mediators from rat lacrimal epithelial cells. Scand J Immunol (2009) 0.87
Mucosal tolerance induced by an immunodominant peptide from rat alpha3(IV)NC1 in established experimental autoimmune glomerulonephritis. Am J Pathol (2009) 0.87
Large-scale expansion of rat CD4+ CD25+ T(reg) cells in the absence of T-cell receptor stimulation. Immunology (2006) 0.87