Published in Development on February 28, 2007
Alterations of the Notch pathway in lung cancer. Proc Natl Acad Sci U S A (2009) 3.10
Notch signaling controls liver development by regulating biliary differentiation. Development (2009) 2.93
The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19
Lineage tracing reveals the dynamic contribution of Hes1+ cells to the developing and adult pancreas. Development (2011) 1.89
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1). Proc Natl Acad Sci U S A (2012) 1.83
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation. Proc Natl Acad Sci U S A (2008) 1.62
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell (2015) 1.50
Notch and the skeleton. Mol Cell Biol (2009) 1.49
Transcriptional control of stem cell maintenance in the Drosophila intestine. Development (2010) 1.48
Notch signaling augments the canonical Wnt pathway to specify the size of the otic placode. Development (2008) 1.42
Stabilized beta-catenin functions through TCF/LEF proteins and the Notch/RBP-Jkappa complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol (2008) 1.42
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Complex interplay between β-catenin signalling and Notch effectors in intestinal tumorigenesis. Gut (2011) 1.33
Prox1 regulates the notch1-mediated inhibition of neurogenesis. PLoS Biol (2010) 1.23
Molecular evolution of the vertebrate mechanosensory cell and ear. Int J Dev Biol (2007) 1.23
Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum (2008) 1.20
Notch2 activation in the embryonic kidney depletes nephron progenitors. J Am Soc Nephrol (2010) 1.18
A role for the transcription factor HEY1 in glioblastoma. J Cell Mol Med (2008) 1.16
Notch signaling maintains Leydig progenitor cells in the mouse testis. Development (2008) 1.14
Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling. J Exp Med (2012) 1.13
Neurod1 regulates survival and formation of connections in mouse ear and brain. Cell Tissue Res (2010) 1.12
HES1 is a novel interactor of the Fanconi anemia core complex. Blood (2008) 1.10
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development. BMC Dev Biol (2008) 1.07
T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1. Nat Immunol (2013) 1.07
Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas. Dev Biol (2011) 1.06
Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme. Development (2013) 1.06
Dynamic expression of notch signaling genes in neural stem/progenitor cells. Front Neurosci (2011) 1.06
Distinct effects of Hedgehog signaling on neuronal fate specification and cell cycle progression in the embryonic mouse retina. J Neurosci (2009) 1.04
Functional roles of Notch signaling in the cnidarian Nematostella vectensis. Dev Biol (2011) 1.03
Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression. Breast Dis (2008) 1.03
NOTCH1 is required for regeneration of Clara cells during repair of airway injury. Stem Cells (2012) 1.02
The role of bHLH genes in ear development and evolution: revisiting a 10-year-old hypothesis. Cell Mol Life Sci (2010) 1.02
Hes1 is expressed in the second heart field and is required for outflow tract development. PLoS One (2009) 1.01
Detection of selective sweeps in cattle using genome-wide SNP data. BMC Genomics (2013) 1.01
Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1. PLoS One (2011) 1.01
Notch and bone morphogenetic protein differentially act on dermomyotome cells to generate endothelium, smooth, and striated muscle. J Cell Biol (2008) 1.01
Hes1 regulates embryonic stem cell differentiation by suppressing Notch signaling. Genes Cells (2010) 1.00
Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus. Proc Natl Acad Sci U S A (2009) 0.98
Comprehensive transcriptome analysis of mouse embryonic stem cell adipogenesis unravels new processes of adipocyte development. Genome Biol (2010) 0.98
Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation. J Biol Chem (2008) 0.98
Defects in the cerebella of conditional Neurod1 null mice correlate with effective Tg(Atoh1-cre) recombination and granule cell requirements for Neurod1 for differentiation. Cell Tissue Res (2009) 0.97
Notch signaling during cell fate determination in the inner ear. Semin Cell Dev Biol (2013) 0.97
Transcription factor Hes1 modulates osteoarthritis development in cooperation with calcium/calmodulin-dependent protein kinase 2. Proc Natl Acad Sci U S A (2015) 0.95
Inhibition of Notch signaling prevents experimental fibrosis and induces regression of established fibrosis. Arthritis Rheum (2011) 0.94
The role of dimerisation and nuclear transport in the Hes1 gene regulatory network. Bull Math Biol (2013) 0.94
HES1 (hairy and enhancer of split 1) is a determinant of bone mass. J Biol Chem (2010) 0.92
Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions. Development (2014) 0.92
Hes1 mediates the different responses of hematopoietic stem and progenitor cells to T cell leukemic environment. Cell Cycle (2012) 0.92
Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. J Biol Chem (2013) 0.91
Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome. Dev Biol (2010) 0.91
Jagged 1 is necessary for normal mouse lens formation. Dev Biol (2009) 0.91
The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis. Development (2011) 0.90
Notch1 is required in newly postmitotic cells to inhibit the rod photoreceptor fate. Development (2013) 0.89
The molecular biology of ear development - "Twenty years are nothing". Int J Dev Biol (2007) 0.89
Lunatic fringe promotes the lateral inhibition of neurogenesis. Development (2009) 0.88
Hes4 controls proliferative properties of neural stem cells during retinal ontogenesis. Stem Cells (2012) 0.88
Hes1: a key role in stemness, metastasis and multidrug resistance. Cancer Biol Ther (2015) 0.88
An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer. Oncogene (2013) 0.87
Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination. Dev Biol (2008) 0.87
Evolution of a genomic regulatory domain: the role of gene co-option and gene duplication in the Enhancer of split complex. Genome Res (2010) 0.87
Biphasic recruitment of transcriptional repressors to the murine cytomegalovirus major immediate-early promoter during the course of infection in vivo. J Virol (2010) 0.87
Sox2, Tlx, Gli3, and Her9 converge on Rx2 to define retinal stem cells in vivo. EMBO J (2015) 0.87
Comparison and optimization of hiPSC forebrain cortical differentiation protocols. PLoS One (2014) 0.86
Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. PLoS One (2010) 0.86
Development of the choroid plexus and blood-CSF barrier. Front Neurosci (2015) 0.86
ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. J Biol Chem (2010) 0.86
Non-canonical Notch signaling represents an ancestral mechanism to regulate neural differentiation. Evodevo (2014) 0.86
On the functional diversity of dynamical behaviour in genetic and metabolic feedback systems. BMC Syst Biol (2009) 0.85
Monocyte activation in HIV/HCV coinfection correlates with cognitive impairment. PLoS One (2013) 0.84
Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex. BMC Dev Biol (2007) 0.83
Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development. PLoS One (2011) 0.83
Mamld1 knockdown reduces testosterone production and Cyp17a1 expression in mouse Leydig tumor cells. PLoS One (2011) 0.83
microRNA input into a neural ultradian oscillator controls emergence and timing of alternative cell states. Nat Commun (2014) 0.83
The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub. Development (2012) 0.83
Hairy and Enhancer of Split-related with YRPW motif (HEY)2 regulates bone remodeling in mice. J Biol Chem (2013) 0.82
Notch Signaling and the Skeleton. Endocr Rev (2016) 0.82
The MEK/ERK pathway promotes NOTCH signalling in pancreatic cancer cells. PLoS One (2013) 0.82
The roof plate boundary is a bi-directional organiser of dorsal neural tube and choroid plexus development. Development (2012) 0.82
An expanded Notch-Delta model exhibiting long-range patterning and incorporating MicroRNA regulation. PLoS Comput Biol (2014) 0.81
Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity. Stem Cells (2013) 0.81
Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors. Neural Dev (2008) 0.81
The fanconi anemia core complex acts as a transcriptional co-regulator in hairy enhancer of split 1 signaling. J Biol Chem (2009) 0.81
γ-Secretase-regulated mechanisms similar to notch signaling may play a role in signaling events, including APP signaling, which leads to Alzheimer's disease. Cell Mol Neurobiol (2011) 0.81
HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. Biol Open (2012) 0.80
A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome. Dev Biol (2014) 0.80
The bHLH factors Dpn and members of the E(spl) complex mediate the function of Notch signalling regulating cell proliferation during wing disc development. Biol Open (2012) 0.80
Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering. Genes Dis (2015) 0.80
BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development. Elife (2016) 0.80
Functions of huntingtin in germ layer specification and organogenesis. PLoS One (2013) 0.80
Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation. Neuro Oncol (2013) 0.79
Mechanoregulation of h2-calponin gene expression and the role of Notch signaling. J Biol Chem (2013) 0.79
Hes1 oscillations contribute to heterogeneous differentiation responses in embryonic stem cells. Genes (Basel) (2011) 0.79
History of a prolific family: the Hes/Hey-related genes of the annelid Platynereis. Evodevo (2014) 0.79
Dynamics of BMP and Hes1/Hairy1 signaling in the dorsal neural tube underlies the transition from neural crest to definitive roof plate. BMC Biol (2016) 0.78
The Id-protein family in developmental and cancer-associated pathways. Cell Commun Signal (2017) 0.78
Integration of Signaling Pathways with the Epigenetic Machinery in the Maintenance of Stem Cells. Stem Cells Int (2015) 0.78
Heterogeneous generation of new cells in the adult echinoderm nervous system. Front Neuroanat (2015) 0.78
A novel transcriptional factor Nkapl is a germ cell-specific suppressor of Notch signaling and is indispensable for spermatogenesis. PLoS One (2015) 0.78
HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci (2016) 0.78
Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci (2008) 6.13
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop. Science (2002) 3.93
Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron (2008) 3.51
Roles of bHLH genes in neural stem cell differentiation. Exp Cell Res (2005) 2.73
Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability. J Biol Chem (2005) 2.33
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition. Nat Neurosci (2008) 2.13
Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells. Proc Natl Acad Sci U S A (2006) 2.10
Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol (2006) 1.86
Roles of Hes genes in neural development. Dev Growth Differ (2008) 1.76
Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline. Development (2008) 1.50
Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development (2006) 1.48
Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A (2007) 1.47
The basic helix-loop-helix genes Hesr1/Hey1 and Hesr2/Hey2 regulate maintenance of neural precursor cells in the brain. J Biol Chem (2003) 1.41
Intronic delay is essential for oscillatory expression in the segmentation clock. Proc Natl Acad Sci U S A (2011) 1.37
Temporal regulation of Cre recombinase activity in neural stem cells. Genesis (2006) 1.36
RECK modulates Notch signaling during cortical neurogenesis by regulating ADAM10 activity. Nat Neurosci (2007) 1.26
Hes1 and Hes5 control the progenitor pool, intermediate lobe specification, and posterior lobe formation in the pituitary development. Mol Endocrinol (2007) 1.25
Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc Natl Acad Sci U S A (2011) 1.24
The role of Hes genes in intestinal development, homeostasis and tumor formation. Development (2012) 1.16
Dynamic regulation of Notch signaling in neural progenitor cells. Curr Opin Cell Biol (2009) 1.16
MicroRNA9 regulates neural stem cell differentiation by controlling Hes1 expression dynamics in the developing brain. Genes Cells (2012) 1.10
Ecosystem development and carbon cycle on a glacier foreland in the high Arctic, Ny-Alesund, Svalbard. J Plant Res (2005) 1.09
Hes1 regulates corneal development and the function of corneal epithelial stem/progenitor cells. Stem Cells (2008) 1.08
Ultradian oscillations in Notch signaling regulate dynamic biological events. Curr Top Dev Biol (2010) 1.07
Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. Cell Rep (2012) 1.07
Dynamic expression of notch signaling genes in neural stem/progenitor cells. Front Neurosci (2011) 1.06
Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development. Development (2012) 1.04
Notch-Hes1 pathway contributes to the cochlear prosensory formation potentially through the transcriptional down-regulation of p27Kip1. J Neurosci Res (2009) 1.03
Mash1 and Math3 are required for development of branchiomotor neurons and maintenance of neural progenitors. J Neurosci (2005) 0.96
Continuous neurogenesis in the adult brain. Dev Growth Differ (2009) 0.93
Photosynthetic characteristics and biomass distribution of the dominant vascular plant species in a high Arctic tundra ecosystem, Ny-Alesund, Svalbard: implications for their role in ecosystem carbon gain. J Plant Res (2008) 0.90
Mash1 is required for neuroendocrine cell development in the glandular stomach. Genes Cells (2008) 0.88
Genetic visualization of notch signaling in mammalian neurogenesis. Cell Mol Life Sci (2012) 0.87
Requirement of multiple lysine residues for the transcriptional activity and the instability of Hes7. Biochem Biophys Res Commun (2008) 0.84
Biometric-based estimation of net ecosystem production in a mature Japanese cedar (Cryptomeria japonica) plantation beneath a flux tower. J Plant Res (2010) 0.83
Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development. Mech Dev (2013) 0.80
Novel and robust transplantation reveals the acquisition of polarized processes by cortical cells derived from mouse and human pluripotent stem cells. Stem Cells Dev (2014) 0.79
Hes1 oscillation: making variable choices for stem cell differentiation. Cell Cycle (2010) 0.79
The identification of transcriptional targets of Ascl1 in oligodendrocyte development. Glia (2012) 0.79
The first Hes1 dimer inhibitors from natural products. Bioorg Med Chem Lett (2009) 0.78
Carbon dynamics and budget in a Zoysia japonica grassland, central Japan. J Plant Res (2009) 0.75
An outbreak of food poisoning caused by an enteropathogeic Escherichia coli O115:H19 in Miyagi Prefecture. Jpn J Infect Dis (2005) 0.75
[Regulation of neural development by the bHLH factor Hes1]. Tanpakushitsu Kakusan Koso (2008) 0.75