Hes1 desynchronizes differentiation of pluripotent cells by modulating STAT3 activity.

PubWeight™: 0.81‹?›

🔗 View Article (PMC 4063271)

Published in Stem Cells on August 01, 2013

Authors

Xinzhi Zhou1, Andrew J H Smith, Anna Waterhouse, Guillaume Blin, Mattias Malaguti, Chia-Yi Lin, Rodrigo Osorno, Ian Chambers, Sally Lowell

Author Affiliations

1: MRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.

Articles cited by this

Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene (1991) 38.64

Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell (2003) 20.16

The ground state of embryonic stem cell self-renewal. Nature (2008) 19.44

New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature (2007) 13.54

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47

Nanog safeguards pluripotency and mediates germline development. Nature (2007) 13.01

Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature (2007) 11.72

Signalling downstream of activated mammalian Notch. Nature (1995) 11.08

Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cells. Proc Natl Acad Sci U S A (1997) 8.35

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature (1988) 7.61

A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell (2006) 7.07

Changing potency by spontaneous fusion. Nature (2002) 6.46

Exploring the sequence space for tetracycline-dependent transcriptional activators: novel mutations yield expanded range and sensitivity. Proc Natl Acad Sci U S A (2000) 5.99

Identification and characterization of subpopulations in undifferentiated ES cell culture. Development (2008) 5.55

Notch signalling regulates stem cell numbers in vitro and in vivo. Nature (2006) 5.49

A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells. Nature (2009) 5.46

Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNA-Seq analysis. Cell Stem Cell (2010) 4.97

Self-renewal of teratocarcinoma and embryonic stem cells. Oncogene (2004) 4.40

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A (1996) 4.13

Progressive lineage analysis by cell sorting and culture identifies FLK1+VE-cadherin+ cells at a diverging point of endothelial and hemopoietic lineages. Development (1998) 3.94

Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell (2010) 3.42

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects. Genes Dev (1995) 3.29

Oct4 and LIF/Stat3 additively induce Krüppel factors to sustain embryonic stem cell self-renewal. Cell Stem Cell (2009) 3.27

Conservation of the Notch signalling pathway in mammalian neurogenesis. Development (1997) 3.13

Notch signaling: simplicity in design, versatility in function. Development (2011) 3.13

The Hes gene family: repressors and oscillators that orchestrate embryogenesis. Development (2007) 2.92

Notch promotes neural lineage entry by pluripotent embryonic stem cells. PLoS Biol (2006) 2.91

Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling. Nat Cell Biol (2004) 2.75

Basic helix-loop-helix transcription factors regulate the neuroendocrine differentiation of fetal mouse pulmonary epithelium. Development (2000) 2.73

3D cell nuclei segmentation based on gradient flow tracking. BMC Cell Biol (2007) 2.41

Functional heterogeneity of embryonic stem cells revealed through translational amplification of an early endodermal transcript. PLoS Biol (2010) 2.38

The cyclic gene Hes1 contributes to diverse differentiation responses of embryonic stem cells. Genes Dev (2009) 2.19

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell (2007) 2.06

Induction of cardiogenesis in embryonic stem cells via downregulation of Notch1 signaling. Circ Res (2006) 1.75

Defining a developmental path to neural fate by global expression profiling of mouse embryonic stem cells and adult neural stem/progenitor cells. Stem Cells (2005) 1.53

Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum. Proc Natl Acad Sci U S A (2007) 1.47

Recombination signal sequence-binding protein Jkappa alters mesodermal cell fate decisions by suppressing cardiomyogenesis. Proc Natl Acad Sci U S A (2003) 1.45

The lipopolysaccharide-binding protein is a secretory class 1 acute-phase protein whose gene is transcriptionally activated by APRF/STAT/3 and other cytokine-inducible nuclear proteins. Mol Cell Biol (1996) 1.38

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer. Int J Oncol (2007) 1.36

Distinct functions of BMP4 during different stages of mouse ES cell neural commitment. Development (2010) 1.36

Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development. Mech Dev (2006) 1.35

Spatial organization of embryonic stem cell responsiveness to autocrine gp130 ligands reveals an autoregulatory stem cell niche. Stem Cells (2006) 1.24

Neural stem cells, neurons, and glia. Methods Enzymol (2006) 1.24

Regulation of mouse mast cell protease 6 gene expression by transcription factor encoded by the mi locus. Blood (1996) 1.15

The homeodomain protein Nanog and pluripotency in mouse embryonic stem cells. Biochem Soc Trans (2005) 1.11

Manipulation of signaling thresholds in "engineered stem cell niches" identifies design criteria for pluripotent stem cell screens. PLoS One (2009) 1.03

Neural induction intermediates exhibit distinct roles of Fgf signaling. Stem Cells (2010) 0.97

Notch1 expression is spatiotemporally correlated with neurogenesis and negatively regulated by Notch1-independent Hes genes in the developing nervous system. Cereb Cortex (2006) 0.94

Wnt-Notch signalling: an integrated mechanism regulating transitions between cell states. Bioessays (2012) 0.89

Evolution of the mechanisms that establish the embryonic axes. Curr Opin Genet Dev (2006) 0.81

Articles by these authors

BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell (2003) 13.47

Nanog is the gateway to the pluripotent ground state. Cell (2009) 7.27

Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science (2002) 6.01

An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell (2010) 5.00

Nanog promotes transfer of pluripotency after cell fusion. Nature (2006) 4.38

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med (2012) 3.96

Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature (2006) 3.71

Deregulation of dorsoventral patterning by FGF confers trilineage differentiation capacity on CNS stem cells in vitro. Neuron (2003) 3.27

Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19

Association between active genes occurs at nuclear speckles and is modulated by chromatin environment. J Cell Biol (2008) 3.13

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell (2012) 2.93

The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A (2008) 2.81

Molecular coupling of Xist regulation and pluripotency. Science (2008) 2.74

Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Mol Cell Biol (2002) 2.68

Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol (2002) 2.64

Neurofascins are required to establish axonal domains for saltatory conduction. Neuron (2005) 2.41

Essential role for proteinase-activated receptor-2 in arthritis. J Clin Invest (2003) 2.22

Multiple functionalities of polyelectrolyte multilayer films: new biomedical applications. Adv Mater (2010) 2.22

Manipulating the mouse genome to engineer precise functional syntenic replacements with human sequence. Cell (2007) 2.06

The pluripotency rheostat Nanog functions as a dimer. Biochem J (2008) 1.97

Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol (2008) 1.95

The pluripotent genome in three dimensions is shaped around pluripotency factors. Nature (2013) 1.82

Molecular coupling of Tsix regulation and pluripotency. Nature (2010) 1.69

Decorin prevents metastatic spreading of breast cancer. Oncogene (2005) 1.69

Loss of Atrx affects trophoblast development and the pattern of X-inactivation in extraembryonic tissues. PLoS Genet (2006) 1.64

Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Hepatology (2006) 1.61

Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons. Cell Metab (2009) 1.59

Engineering the mouse genome with bacterial artificial chromosomes to create multipurpose alleles. Nat Biotechnol (2003) 1.57

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment. EMBO J (2011) 1.55

Epidermal stem cells. J Pathol (2002) 1.54

In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation. Cell Rep (2012) 1.45

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog. Cell Stem Cell (2013) 1.42

Inhibition of vascular endothelial growth factor-induced angiogenesis by resveratrol through interruption of Src-dependent vascular endothelial cadherin tyrosine phosphorylation. Mol Pharmacol (2003) 1.39

Foxn1 regulates lineage progression in cortical and medullary thymic epithelial cells but is dispensable for medullary sublineage divergence. PLoS Genet (2011) 1.38

Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A (2004) 1.35

The developmental dismantling of pluripotency is reversed by ectopic Oct4 expression. Development (2012) 1.33

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40). Blood (2009) 1.27

Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development (2014) 1.26

Neural stem cells, neurons, and glia. Methods Enzymol (2006) 1.24

OCT4/SOX2-independent Nanog autorepression modulates heterogeneous Nanog gene expression in mouse ES cells. EMBO J (2012) 1.23

Distribution of the lipolysis stimulated receptor in adult and embryonic murine tissues and lethality of LSR-/- embryos at 12.5 to 14.5 days of gestation. Eur J Biochem (2004) 1.23

Transposon-mediated BAC transgenesis in human ES cells. Nucleic Acids Res (2012) 1.21

A mouse model of tuberous sclerosis 1 showing background specific early post-natal mortality and metastatic renal cell carcinoma. Hum Mol Genet (2005) 1.21

Targeted homozygous deletion of M-band titin in cardiomyocytes prevents sarcomere formation. J Cell Sci (2006) 1.18

Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. PLoS One (2007) 1.18

Genomically humanized mice: technologies and promises. Nat Rev Genet (2011) 1.18

Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. Diabetes (2003) 1.18

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal. EMBO J (2013) 1.16

Thrombospondin type I domain containing 7A (THSD7A) mediates endothelial cell migration and tube formation. J Cell Physiol (2010) 1.12

Polycomb eviction as a new distant enhancer function. Genes Dev (2011) 1.12

Experimental acute pancreatitis in PAP/HIP knock-out mice. Gut (2007) 1.08

Metalloprotease-disintegrin ADAM8: expression analysis and targeted deletion in mice. Dev Dyn (2005) 1.08

Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn J Pharmacol (2002) 1.08

A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties. Acta Biomater (2010) 1.06

Elastin-based materials. Chem Soc Rev (2010) 1.04

The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells. Hum Genet (2011) 1.04

A conserved truncated isoform of the ATR-X syndrome protein lacking the SWI/SNF-homology domain. Gene (2004) 1.04

Covalent immobilisation of tropoelastin on a plasma deposited interface for enhancement of endothelialisation on metal surfaces. Biomaterials (2009) 0.97

Tcf15 primes pluripotent cells for differentiation. Cell Rep (2013) 0.95

The role of pluripotency gene regulatory network components in mediating transitions between pluripotent cell states. Curr Opin Genet Dev (2013) 0.93

Transcription factor heterogeneity and epiblast pluripotency. Philos Trans R Soc Lond B Biol Sci (2011) 0.92

A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLoS One (2010) 0.89

Bone morphogenic protein signalling suppresses differentiation of pluripotent cells by maintaining expression of E-Cadherin. Elife (2013) 0.89

Bmi1 facilitates primitive endoderm formation by stabilizing Gata6 during early mouse development. Genes Dev (2012) 0.87

AKT/mTOR as Novel Targets of Polyphenol Piceatannol Possibly Contributing to Inhibition of Proliferation of Cultured Prostate Cancer Cells. ISRN Urol (2012) 0.86

Free radical functionalization of surfaces to prevent adverse responses to biomedical devices. Proc Natl Acad Sci U S A (2011) 0.86

Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. Nucleic Acids Res (2009) 0.84

Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells. Carcinogenesis (2012) 0.82

The optimal time for early burn wound excision to reduce pro-inflammatory cytokine production in a murine burn injury model. Burns (2010) 0.82

NRIP, a novel calmodulin binding protein, activates calcineurin to dephosphorylate human papillomavirus E2 protein. J Virol (2011) 0.82

The evolving biology of cell reprogramming. Philos Trans R Soc Lond B Biol Sci (2011) 0.81

Nanog retrotransposed genes with functionally conserved open reading frames. Mamm Genome (2006) 0.81

Brainstem excitability is increased in subjects with palmomental reflex. J Formos Med Assoc (2007) 0.81

National prevalence of breastfeeding in Taiwan. J Hum Lact (2005) 0.81

Mentalis muscle responses to median nerve stimulation. Chin J Physiol (2006) 0.80

The use of plasma-activated covalent attachment of early domains of tropoelastin to enhance vascular compatibility of surfaces. Biomaterials (2013) 0.80

A CMOS-compatible poly-Si nanowire device with hybrid sensor/memory characteristics for System-on-Chip applications. Sensors (Basel) (2012) 0.80

Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors. Development (2015) 0.78

Transcranial magnetic stimulation after conditioning stimulation in two adrenomyeloneuropathy patients: delayed but facilitated motor-evoked potentials. Funct Neurol (2006) 0.77

Plasma-based biofunctionalization of vascular implants. Nanomedicine (Lond) (2012) 0.77

Magnetic-composite-modified polycrystalline silicon nanowire field-effect transistor for vascular endothelial growth factor detection and cancer diagnosis. Anal Chem (2014) 0.77

Haematopoietic differentiation is inhibited when Notch activity is enhanced in FLK1(+) mesoderm progenitors. Stem Cell Res (2013) 0.77

Quantification of pluripotency transcription factor levels in embryonic stem cells by flow cytometry. Curr Protoc Stem Cell Biol (2011) 0.76

Is the umbilical cord a lifeline for regenerative therapy? Cell Cycle (2010) 0.75

Effect of sacral neuromodulation on the spinal nociceptive reflex of patients with idiopathic overactive bladder. Neuromodulation (2008) 0.75