PubRank

Menelas N Pangalos

Author PubWeight™ 77.26‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A 2006 3.61
2 Rapamycin alleviates toxicity of different aggregate-prone proteins. Hum Mol Genet 2005 3.45
3 Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. J Neurosci 2010 2.78
4 Phospho-dependent functional modulation of GABA(B) receptors by the metabolic sensor AMP-dependent protein kinase. Neuron 2007 2.38
5 Activation of estrogen receptor-beta regulates hippocampal synaptic plasticity and improves memory. Nat Neurosci 2008 2.29
6 Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 2005 2.05
7 mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res Mol Brain Res 2002 1.98
8 Impact of apolipoprotein E (ApoE) polymorphism on brain ApoE levels. J Neurosci 2008 1.92
9 The clustering of GABA(A) receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor alpha 2 subunits to gephyrin. J Neurosci 2008 1.83
10 Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system. Mol Pharmacol 2010 1.81
11 The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease. Mol Cell Neurosci 2007 1.66
12 Phospho-dependent binding of the clathrin AP2 adaptor complex to GABAA receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A 2005 1.56
13 BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci 2003 1.52
14 Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J Pharmacol Exp Ther 2009 1.51
15 Activity-dependent ubiquitination of GABA(A) receptors regulates their accumulation at synaptic sites. J Neurosci 2007 1.49
16 Phosphorylation and chronic agonist treatment atypically modulate GABAB receptor cell surface stability. J Biol Chem 2004 1.40
17 Treatment strategies targeting amyloid β-protein. Cold Spring Harb Perspect Med 2012 1.37
18 A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner. Mol Cell Neurosci 2008 1.30
19 Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke. J Cereb Blood Flow Metab 2007 1.26
20 Binding of rapamycin analogs to calcium channels and FKBP52 contributes to their neuroprotective activities. Proc Natl Acad Sci U S A 2007 1.23
21 Discovery of begacestat, a Notch-1-sparing gamma-secretase inhibitor for the treatment of Alzheimer's disease. J Med Chem 2008 1.22
22 Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx. J Biol Chem 2002 1.19
23 Prolonged activation of NMDA receptors promotes dephosphorylation and alters postendocytic sorting of GABAB receptors. Proc Natl Acad Sci U S A 2010 1.14
24 Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis. Neurobiol Dis 2006 1.12
25 Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A 2008 1.12
26 Marlin-1, a novel RNA-binding protein associates with GABA receptors. J Biol Chem 2004 1.12
27 The availability of surface GABA B receptors is independent of gamma-aminobutyric acid but controlled by glutamate in central neurons. J Biol Chem 2008 1.12
28 The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition. J Biol Chem 2006 1.11
29 Unravelling the unusual signalling properties of the GABA(B) receptor. Biochem Pharmacol 2004 1.09
30 Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease. Neurobiol Aging 2011 1.02
31 Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. Neuron 2012 1.01
32 Multiple motifs regulate the trafficking of GABA(B) receptors at distinct checkpoints within the secretory pathway. Mol Cell Neurosci 2005 0.99
33 Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists. J Biol Chem 2008 0.98
34 GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses. J Neurosci 2009 0.97
35 The development of stroke therapeutics: promising mechanisms and translational challenges. Neuropharmacology 2008 0.96
36 GABA(A) receptor membrane trafficking regulates spine maturity. Proc Natl Acad Sci U S A 2009 0.96
37 Structural correlates of antibodies associated with acute reversal of amyloid beta-related behavioral deficits in a mouse model of Alzheimer disease. J Biol Chem 2009 0.94
38 Gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB receptor (GABABR) binding sites are distinctive from one another: molecular evidence. Neuropharmacology 2004 0.90
39 Functional modulation of GABAB receptors by protein kinases and receptor trafficking. Adv Pharmacol 2010 0.90
40 Sodium channel cleavage is associated with aberrant neuronal activity and cognitive deficits in a mouse model of Alzheimer's disease. J Neurosci 2013 0.90
41 Postsynaptic GABAB receptor activity regulates excitatory neuronal architecture and spatial memory. J Neurosci 2014 0.90
42 A beam-walking apparatus to assess behavioural impairments in MPTP-treated mice: pharmacological validation with R-(-)-deprenyl. J Neurosci Methods 2007 0.88
43 Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders. Curr Mol Pharmacol 2009 0.88
44 Prodrugs of perzinfotel with improved oral bioavailability. J Med Chem 2009 0.87
45 Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J Med Chem 2010 0.87
46 Characterization of vabicaserin (SCA-136), a selective 5-hydroxytryptamine 2C receptor agonist. J Pharmacol Exp Ther 2011 0.86
47 Neuroprotective profile of novel SRC kinase inhibitors in rodent models of cerebral ischemia. J Pharmacol Exp Ther 2009 0.86
48 Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer's disease. NeuroRx 2005 0.85
49 Localisation of the GPRC5B receptor in the rat brain and spinal cord. Brain Res Mol Brain Res 2002 0.85
50 Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice. Epilepsy Res 2003 0.84
51 The GABA(B2) subunit is critical for the trafficking and function of native GABA(B) receptors. Biochem Pharmacol 2004 0.84
52 Overcoming the inhibitors of myelin with a novel neurotrophin strategy. J Biol Chem 2004 0.82
53 Temporal proteomic profile of memory consolidation in the rat hippocampal dentate gyrus. Proteomics 2011 0.82
54 Highly potent, selective, and orally active phosphodiesterase 10A inhibitors. J Med Chem 2011 0.81
55 AAV-mediated chronic over-expression of SNAP-25 in adult rat dorsal hippocampus impairs memory-associated synaptic plasticity. J Neurochem 2009 0.80
56 GABAB receptor subunits, R1 and R2, in brainstem catecholamine and serotonin neurons. Brain Res 2003 0.78
57 Social odor recognition: a novel behavioral model for cognitive dysfunction in Parkinson's disease. Neurodegener Dis 2010 0.78
58 New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: exploring the S2' region. Bioorg Med Chem Lett 2011 0.78
59 Temporal dysregulation of cortical gene expression in the isolation reared Wistar rat. J Neurochem 2010 0.77
60 Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits. Biochem Pharmacol 2003 0.77
61 Novel pyrrolyl 2-aminopyridines as potent and selective human beta-secretase (BACE1) inhibitors. Bioorg Med Chem Lett 2010 0.77
62 Drug development and Alzheimer disease. Am J Geriatr Psychiatry 2003 0.76
63 Reduced reelin protein synthesis in ventral hippocampus of isolation reared Wistar rats accompanies impaired avoidance conditioning. Behav Brain Res 2010 0.76
64 Multimodal magnetic resonance imaging for assessing evolution of ischemic penumbra: a key translational medicine strategy to manage the risk of developing novel therapies for acute ischemic stroke. J Cereb Blood Flow Metab 2008 0.76
65 Novel triazines as potent and selective phosphodiesterase 10A inhibitors. Bioorg Med Chem Lett 2012 0.75
66 Application of TaqMan RT-PCR for real-time semiquantitative analysis of gene expression in the striatum. Methods Mol Med 2003 0.75
67 Introduction to the special issue on Alzheimer's disease. Neuropharmacology 2010 0.75