Published in Dev Cell on March 01, 2007
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The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men. Nat Rev Mol Cell Biol (2008) 6.90
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A (2007) 3.62
Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development. Nat Med (2010) 3.59
Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest (2007) 3.19
Sox9 directs hypertrophic maturation and blocks osteoblast differentiation of growth plate chondrocytes. Dev Cell (2012) 2.28
The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest (2008) 2.24
MicroRNA directly enhances mitochondrial translation during muscle differentiation. Cell (2014) 2.14
Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain. J Biol Chem (2008) 2.09
MEF2C, a transcription factor that facilitates learning and memory by negative regulation of synapse numbers and function. Proc Natl Acad Sci U S A (2008) 2.09
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HDAC4 regulates neuronal survival in normal and diseased retinas. Science (2009) 1.86
Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Mol Cell Biol (2007) 1.79
Targeted deletion of Sost distal enhancer increases bone formation and bone mass. Proc Natl Acad Sci U S A (2012) 1.78
Control of the SOST bone enhancer by PTH using MEF2 transcription factors. J Bone Miner Res (2007) 1.74
Haploinsufficiency of HDAC4 causes brachydactyly mental retardation syndrome, with brachydactyly type E, developmental delays, and behavioral problems. Am J Hum Genet (2010) 1.65
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nat Immunol (2008) 1.51
Regulation of lymphoid versus myeloid fate 'choice' by the transcription factor Mef2c. Nat Immunol (2009) 1.49
Fragile X mental retardation protein is required for synapse elimination by the activity-dependent transcription factor MEF2. Neuron (2010) 1.46
Nonhistone protein acetylation as cancer therapy targets. Expert Rev Anticancer Ther (2010) 1.45
Genome-Wide Association Identifies TBX5 as Candidate Gene for Osteochondrosis Providing a Functional Link to Cartilage Perfusion as Initial Factor. Front Genet (2013) 1.43
MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development. PLoS Genet (2013) 1.42
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci (2012) 1.35
Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway. Mol Cell Biol (2009) 1.31
Vertebrate skeletogenesis. Curr Top Dev Biol (2010) 1.30
Requirement of MEF2A, C, and D for skeletal muscle regeneration. Proc Natl Acad Sci U S A (2014) 1.21
Zfp521 is a target gene and key effector of parathyroid hormone-related peptide signaling in growth plate chondrocytes. Dev Cell (2010) 1.21
Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification. Pediatr Nephrol (2009) 1.19
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Histone deacetylases in skeletal development and bone mass maintenance. Gene (2010) 1.16
SOX9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression. PLoS Genet (2011) 1.16
Proteoglycan 4 expression protects against the development of osteoarthritis. Sci Transl Med (2013) 1.14
Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol (2010) 1.12
Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr (2009) 1.11
Genetic syndromes caused by mutations in epigenetic genes. Hum Genet (2013) 1.11
RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels. Mol Cell Biol (2014) 1.07
Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cells. BMC Immunol (2009) 1.06
Runx2 contributes to murine Col10a1 gene regulation through direct interaction with its cis-enhancer. J Bone Miner Res (2011) 1.06
Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development. Dev Dyn (2008) 1.05
Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes (2011) 1.04
Regulation of facial morphogenesis by endothelin signaling: insights from mice and fish. Am J Med Genet A (2010) 1.04
Histone deacetylase inhibitors in cell pluripotency, differentiation, and reprogramming. Stem Cells Int (2012) 1.02
Spatial and temporal regulation of gene expression in the mammalian growth plate. Bone (2010) 1.01
Hdac-mediated control of endochondral and intramembranous ossification. Crit Rev Eukaryot Gene Expr (2011) 1.00
Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation. Dev Biol (2012) 0.98
High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res (2014) 0.98
A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes. FASEB J (2009) 0.96
Myocyte enhancer factor 2 and microphthalmia-associated transcription factor cooperate with NFATc1 to transactivate the V-ATPase d2 promoter during RANKL-induced osteoclastogenesis. J Biol Chem (2009) 0.96
The transcription factor Mef2 is required for normal circadian behavior in Drosophila. J Neurosci (2010) 0.94
Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders. Biochim Biophys Acta (2013) 0.93
The histone deacetylase inhibitor, vorinostat, reduces tumor growth at the metastatic bone site and associated osteolysis, but promotes normal bone loss. Mol Cancer Ther (2010) 0.93
The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro. J Biol Chem (2015) 0.93
MicroRNAs involved in bone formation. Cell Mol Life Sci (2014) 0.92
Functional and mechanistic exploration of an adult neurogenesis-promoting small molecule. FASEB J (2012) 0.92
Loss of the putative catalytic domain of HDAC4 leads to reduced thermal nociception and seizures while allowing normal bone development. PLoS One (2009) 0.91
MHCI requires MEF2 transcription factors to negatively regulate synapse density during development and in disease. J Neurosci (2013) 0.91
Lack of oxygen in articular cartilage: consequences for chondrocyte biology. Int J Exp Pathol (2010) 0.88
FoxA family members are crucial regulators of the hypertrophic chondrocyte differentiation program. Dev Cell (2012) 0.88
Mef2C is a lineage-restricted target of Scl/Tal1 and regulates megakaryopoiesis and B-cell homeostasis. Blood (2009) 0.88
Histone Deacetylases in Bone Development and Skeletal Disorders. Physiol Rev (2015) 0.87
HDAC4 integrates PTH and sympathetic signaling in osteoblasts. J Cell Biol (2014) 0.87
SOXC Transcription Factors Induce Cartilage Growth Plate Formation in Mouse Embryos by Promoting Noncanonical WNT Signaling. J Bone Miner Res (2015) 0.87
Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity. Mol Cell Neurosci (2013) 0.87
Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch. Dev Biol (2012) 0.86
The genetic pleiotropy of musculoskeletal aging. Front Physiol (2012) 0.85
Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton. BMC Dev Biol (2012) 0.85
Involvement of SOX-9 and FGF-23 in RUNX-2 regulation in osteoarthritic chondrocytes. J Cell Mol Med (2009) 0.84
Morphological and molecular characterization of developing vertebral fusions using a teleost model. BMC Physiol (2010) 0.84
Tumor suppressor maspin as a rheostat in HDAC regulation to achieve the fine-tuning of epithelial homeostasis. Crit Rev Eukaryot Gene Expr (2012) 0.84
The central nervous system (CNS)-independent anti-bone-resorptive activity of muscle contraction and the underlying molecular and cellular signatures. J Biol Chem (2013) 0.84
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells. PLoS One (2014) 0.84
Bone marrow-induced Mef2c deficiency delays B-cell development and alters the expression of key B-cell regulatory proteins. Int Immunol (2012) 0.83
Class I and IIa histone deacetylases have opposite effects on sclerostin gene regulation. J Biol Chem (2014) 0.83
Identification and characterization of the novel Col10a1 regulatory mechanism during chondrocyte hypertrophic differentiation. Cell Death Dis (2014) 0.83
G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun (2014) 0.83
The control operated by the cell cycle machinery on MEF2 stability contributes to the downregulation of CDKN1A and entry into S phase. Mol Cell Biol (2015) 0.83
Myocyte enhancer factor 2c, an osteoblast transcription factor identified by dimethyl sulfoxide (DMSO)-enhanced mineralization. J Biol Chem (2011) 0.83
Vertebrate paralogous MEF2 genes: origin, conservation, and evolution. PLoS One (2011) 0.82
Developmental cues for bone formation from parathyroid hormone and parathyroid hormone-related protein in an ex vivo organotypic culture system of embryonic chick femora. Tissue Eng Part C Methods (2012) 0.82
Molecular pathology of vertebral deformities in hyperthermic Atlantic salmon (Salmo salar). BMC Physiol (2010) 0.82
The histone deacetylase HDAC4 regulates long-term memory in Drosophila. PLoS One (2013) 0.81
Replication of Caucasian loci associated with bone mineral density in Koreans. Osteoporos Int (2013) 0.81
MEF2 transcription factors: developmental regulators and emerging cancer genes. Oncotarget (2016) 0.81
Indian hedgehog signaling regulates transcription and expression of collagen type X via Runx2/Smads interactions. J Biol Chem (2014) 0.81
Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation. Nucleic Acids Res (2013) 0.81
Focus on the p38 MAPK signaling pathway in bone development and maintenance. Bonekey Rep (2015) 0.81
Postnatal Loss of Mef2c Results in Dissociation of Effects on Synapse Number and Learning and Memory. Biol Psychiatry (2015) 0.81
The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis. Cell Cycle (2013) 0.81
Mef2c regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart. PLoS One (2013) 0.81
Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun (2016) 0.80
Mitogen-activated protein kinase p38 induces HDAC4 degradation in hypertrophic chondrocytes. Biochim Biophys Acta (2014) 0.80
Role of G-proteins in the differentiation of epiphyseal chondrocytes. J Mol Endocrinol (2014) 0.80
Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus laevis. PLoS One (2014) 0.79
Relating the chondrocyte gene network to growth plate morphology: from genes to phenotype. PLoS One (2012) 0.79
Functional gene expression analysis of tissue-specific isoforms of Mef2c. Cell Mol Neurobiol (2011) 0.79
Strategies to minimize hypertrophy in cartilage engineering and regeneration. Genes Dis (2015) 0.78
MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway. J Bone Miner Res (2015) 0.78
In vivo impact of Dlx3 conditional inactivation in neural crest-derived craniofacial bones. J Cell Physiol (2013) 0.78
MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Elife (2016) 0.78
Expression characterization and the promoter activity analysis of zebrafish hdac4. Fish Physiol Biochem (2011) 0.77
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
Control of stress-dependent cardiac growth and gene expression by a microRNA. Science (2007) 12.08
A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A (2006) 10.09
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci U S A (2008) 9.86
The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet (2009) 9.68
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab (2005) 9.14
Transient regenerative potential of the neonatal mouse heart. Science (2011) 9.02
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell (2002) 7.10
MicroRNAs in stress signaling and human disease. Cell (2012) 6.93
Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65
Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med (2007) 6.61
Cardiac plasticity. N Engl J Med (2008) 6.29
Expression of Cre Recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis (2002) 6.11
Pervasive roles of microRNAs in cardiovascular biology. Nature (2011) 6.08
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80
A twist code determines the onset of osteoblast differentiation. Dev Cell (2004) 5.40
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance. Dev Cell (2009) 5.28
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science (2009) 5.17
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche. Cell Stem Cell (2010) 5.07
Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest (2004) 4.97
MEF2: a calcium-dependent regulator of cell division, differentiation and death. Trends Biochem Sci (2002) 4.96
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84
Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. Nature (2004) 4.76
MicroRNAs: powerful new regulators of heart disease and provocative therapeutic targets. J Clin Invest (2007) 4.76
Signaling pathways in skeletal muscle remodeling. Annu Rev Biochem (2006) 4.75
Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal (2009) 4.73
MEF2: a central regulator of diverse developmental programs. Development (2007) 4.70
Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metab (2005) 4.65
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development (2003) 4.63
HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes. Cell (2009) 4.63
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility. Genes Dev (2007) 4.50
Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol (2004) 4.49
Hypertrophy of the heart: a new therapeutic target? Circulation (2004) 4.45
Myocardin is a master regulator of smooth muscle gene expression. Proc Natl Acad Sci U S A (2003) 4.35
Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development. Mol Cell Biol (2004) 4.24
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science (2002) 4.18
The myocardin family of transcriptional coactivators: versatile regulators of cell growth, migration, and myogenesis. Genes Dev (2006) 4.18
Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes. Circ Res (2003) 3.99
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
MicroRNA1 influences cardiac differentiation in Drosophila and regulates Notch signaling. Proc Natl Acad Sci U S A (2005) 3.78
Potentiation of serum response factor activity by a family of myocardin-related transcription factors. Proc Natl Acad Sci U S A (2002) 3.74
Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72
MicroRNAs add a new dimension to cardiovascular disease. Circulation (2010) 3.64
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A (2007) 3.62
Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo. Nature (2002) 3.60
CaM kinase II selectively signals to histone deacetylase 4 during cardiomyocyte hypertrophy. J Clin Invest (2006) 3.53
Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. J Biol Chem (2002) 3.52
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity. Cell (2003) 3.40