Published in Cell Metab on April 01, 2005
PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J Clin Invest (2006) 6.85
PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. Sci Transl Med (2010) 3.48
Role of mitochondrial dysfunction in insulin resistance. Circ Res (2008) 3.45
Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. J Clin Invest (2007) 3.02
PGC-1alpha coactivates PDK4 gene expression via the orphan nuclear receptor ERRalpha: a mechanism for transcriptional control of muscle glucose metabolism. Mol Cell Biol (2005) 2.93
Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance. PLoS Biol (2006) 2.86
Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proc Natl Acad Sci U S A (2006) 2.71
Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network. Biochim Biophys Acta (2010) 2.70
Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity. Cell Metab (2010) 2.63
The role of mitochondria in the pathogenesis of type 2 diabetes. Endocr Rev (2010) 2.59
Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metab (2006) 2.37
Energy metabolism in heart failure and remodelling. Cardiovasc Res (2008) 2.37
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Cardiac angiogenic imbalance leads to peripartum cardiomyopathy. Nature (2012) 2.27
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res (2008) 2.19
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Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies. Proc Natl Acad Sci U S A (2011) 2.07
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) (2010) 1.90
A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension (2011) 1.90
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev (2008) 1.80
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Reciprocal transcriptional regulation of metabolic and signaling pathways correlates with disease severity in heart failure. Circ Cardiovasc Genet (2011) 1.68
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol (2008) 1.63
Impaired PGC-1alpha function in muscle in Huntington's disease. Hum Mol Genet (2009) 1.63
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab (2010) 1.56
Defective DNA replication impairs mitochondrial biogenesis in human failing hearts. Circ Res (2010) 1.55
The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis. Am J Physiol Heart Circ Physiol (2008) 1.51
Mitochondria in the diabetic heart. Cardiovasc Res (2010) 1.50
Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS One (2008) 1.50
PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal (2010) 1.48
Age-dependent cardiomyopathy in mitochondrial mutator mice is attenuated by overexpression of catalase targeted to mitochondria. Aging Cell (2010) 1.47
Deletion of the metabolic transcriptional coactivator PGC1β induces cardiac arrhythmia. Cardiovasc Res (2011) 1.46
Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proc Natl Acad Sci U S A (2008) 1.45
O-linked β-N-acetylglucosamine transferase is indispensable in the failing heart. Proc Natl Acad Sci U S A (2010) 1.43
Orphan nuclear receptor Errγ induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PLoS One (2014) 1.42
Calsarcin-2 deficiency increases exercise capacity in mice through calcineurin/NFAT activation. J Clin Invest (2008) 1.40
Minireview: the PGC-1 coactivator networks: chromatin-remodeling and mitochondrial energy metabolism. Mol Endocrinol (2008) 1.37
PGC-1 coactivators in the control of energy metabolism. Acta Biochim Biophys Sin (Shanghai) (2011) 1.35
AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. PLoS One (2008) 1.32
PGC-1β deficiency accelerates the transition to heart failure in pressure overload hypertrophy. Circ Res (2011) 1.31
Novel role of NADPH oxidase in angiogenesis and stem/progenitor cell function. Antioxid Redox Signal (2009) 1.30
PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch (2010) 1.29
Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency. Proc Natl Acad Sci U S A (2008) 1.29
Myc controls transcriptional regulation of cardiac metabolism and mitochondrial biogenesis in response to pathological stress in mice. J Clin Invest (2010) 1.28
Glucose metabolism and cardiac hypertrophy. Cardiovasc Res (2011) 1.28
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circ Heart Fail (2012) 1.23
Peroxisome proliferator activator receptor gamma coactivator-1alpha (PGC-1α) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener (2011) 1.23
Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise. Biol Rev Camb Philos Soc (2010) 1.23
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3. Nat Commun (2015) 1.21
The Pim protein kinases regulate energy metabolism and cell growth. Proc Natl Acad Sci U S A (2010) 1.20
Pathways for ischemic cytoprotection: role of sirtuins in caloric restriction, resveratrol, and ischemic preconditioning. J Cereb Blood Flow Metab (2011) 1.18
Regulation of mitochondrial oxidative metabolism by tumor suppressor FLCN. J Natl Cancer Inst (2012) 1.16
Redox modification of cell signaling in the cardiovascular system. J Mol Cell Cardiol (2011) 1.15
Nucleus-encoded regulators of mitochondrial function: integration of respiratory chain expression, nutrient sensing and metabolic stress. Biochim Biophys Acta (2011) 1.14
Thioredoxin and ventricular remodeling. J Mol Cell Cardiol (2006) 1.14
Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on fatty acid esterification and oxidation in rat skeletal muscle. J Biol Chem (2009) 1.13
Mitochondrial dysfunction in diabetic cardiomyopathy. Biochim Biophys Acta (2011) 1.12
PGC-1alpha down-regulation affects the antioxidant response in Friedreich's ataxia. PLoS One (2010) 1.11
Effects of aging on angiogenesis. Circ Res (2012) 1.10
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem (2011) 1.10
Mitochondrial SIRT3 and heart disease. Cardiovasc Res (2010) 1.09
Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? J Aging Res (2012) 1.08
Transition from obesity to metabolic syndrome is associated with altered myocardial autophagy and apoptosis. Arterioscler Thromb Vasc Biol (2012) 1.07
PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy. J Biol Chem (2009) 1.05
Mitochondria and PGC-1α in Aging and Age-Associated Diseases. J Aging Res (2011) 1.04
Coactivators in PPAR-Regulated Gene Expression. PPAR Res (2010) 1.04
Sex-specific pathways in early cardiac response to pressure overload in mice. J Mol Med (Berl) (2008) 1.04
The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol (2010) 1.04
Type 2 diabetes, mitochondrial biology and the heart. J Mol Cell Cardiol (2009) 1.03
p53-PGC-1α pathway mediates oxidative mitochondrial damage and cardiomyocyte necrosis induced by monoamine oxidase-A upregulation: role in chronic left ventricular dysfunction in mice. Antioxid Redox Signal (2012) 1.02
The Mitochondrial Basis of Aging. Mol Cell (2016) 1.02
Endothelial PGC-1α mediates vascular dysfunction in diabetes. Cell Metab (2014) 1.02
Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Hum Mol Genet (2012) 1.02
AMP activated protein kinase-α2 regulates expression of estrogen-related receptor-α, a metabolic transcription factor related to heart failure development. Hypertension (2011) 1.01
Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Circ Res (2008) 1.01
Dual modulation of both lipid oxidation and synthesis by peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in cultured myotubes. FASEB J (2009) 1.01
The role of PGC-1 coactivators in aging skeletal muscle and heart. IUBMB Life (2012) 1.00
Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization? Trends Cardiovasc Med (2009) 0.99
Nitrite activates AMP kinase to stimulate mitochondrial biogenesis independent of soluble guanylate cyclase. Free Radic Biol Med (2012) 0.99
Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome. Cardiorenal Med (2012) 0.98
Role of cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 3 (CRTC3) in the initiation of mitochondrial biogenesis and stress response in liver cells. J Biol Chem (2011) 0.98
Neuronal inactivation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) protects mice from diet-induced obesity and leads to degenerative lesions. J Biol Chem (2010) 0.98
Perturbations in the gene regulatory pathways controlling mitochondrial energy production in the failing heart. Biochim Biophys Acta (2012) 0.98
Telomeres and mitochondria in the aging heart. Circ Res (2012) 0.98
Targeting the mitochondria to augment myocardial protection. Curr Opin Pharmacol (2008) 0.97
Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. J Biol Chem (2014) 0.97
The genetic contribution to heart rate and heart rate variability in quiescent mice. Am J Physiol Heart Circ Physiol (2008) 0.96
Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women. J Gerontol A Biol Sci Med Sci (2010) 0.96
AKT3 controls mitochondrial biogenesis and autophagy via regulation of the major nuclear export protein CRM-1. FASEB J (2013) 0.96
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS One (2013) 0.96
Maternal cardiac metabolism in pregnancy. Cardiovasc Res (2014) 0.94
The role of transcriptional regulators in central control of appetite and body weight. Nat Clin Pract Endocrinol Metab (2009) 0.94
CREB-1alpha is recruited to and mediates upregulation of the cytochrome c promoter during enhanced mitochondrial biogenesis accompanying skeletal muscle differentiation. Mol Cell Biol (2008) 0.94
The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation. Am J Physiol Heart Circ Physiol (2011) 0.94
PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells. PLoS One (2012) 0.93
The interplay of neuronal mitochondrial dynamics and bioenergetics: implications for Parkinson's disease. Neurobiol Dis (2012) 0.93
Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology. Semin Immunopathol (2013) 0.93
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature (2005) 18.41
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature (2012) 14.67
Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature (2002) 14.37
PRDM16 controls a brown fat/skeletal muscle switch. Nature (2008) 13.08
Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab (2005) 11.66
Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell (2012) 11.03
Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell (2006) 10.18
Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev (2003) 9.93
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature (2003) 9.77
Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem (2008) 9.56
Adipocytes as regulators of energy balance and glucose homeostasis. Nature (2006) 9.52
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med (2006) 9.07
Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell (2004) 8.58
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med (2003) 8.46
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med (2005) 7.66
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis. Dev Cell (2008) 7.26
Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest (2010) 6.96
Transcriptional control of brown fat determination by PRDM16. Cell Metab (2007) 6.79
Cardiotoxicity associated with tyrosine kinase inhibitor sunitinib. Lancet (2007) 6.76
Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev (2006) 6.68
Heart repair by reprogramming non-myocytes with cardiac transcription factors. Nature (2012) 6.65
Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc Natl Acad Sci U S A (2004) 6.53
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell (2007) 6.47
C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev (2002) 6.46
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J (2006) 5.93
HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature (2008) 5.85
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell (2004) 5.80
FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev (2012) 5.71
Reduction of macrophage infiltration and chemoattractant gene expression changes in white adipose tissue of morbidly obese subjects after surgery-induced weight loss. Diabetes (2005) 5.68
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (2005) 5.56
microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev (2008) 5.39
The role of exercise and PGC1alpha in inflammation and chronic disease. Nature (2008) 5.31
PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proc Natl Acad Sci U S A (2006) 5.28
Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest (2007) 5.17
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science (2009) 5.17
Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metab (2006) 5.01
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature (2010) 5.01
Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature (2009) 4.98
Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron (2007) 4.96
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature (2012) 4.84
The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue. FASEB J (2009) 4.78
MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury. Genes Dev (2009) 4.62
Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. J Biol Chem (2007) 4.58
betaAR signaling required for diet-induced thermogenesis and obesity resistance. Science (2002) 4.47
Retracted Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proc Natl Acad Sci U S A (2009) 4.37
Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A (2003) 4.34
An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A (2003) 4.31
Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature (2011) 4.23
Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem (2001) 4.20
Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science (2002) 4.18
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res (2004) 4.13
Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds. Proc Natl Acad Sci U S A (2004) 4.13
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment. Neuron (2008) 4.00
ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1. Nat Med (2011) 3.96
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev (2008) 3.90
Multiple organ pathology, metabolic abnormalities and impaired homeostasis of reactive oxygen species in Epas1-/- mice. Nat Genet (2003) 3.78
Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev (2013) 3.74
Modulation of K-Ras-dependent lung tumorigenesis by MicroRNA-21. Cancer Cell (2010) 3.72
PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell (2013) 3.71
Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban. Science (2003) 3.71
Molecular mechanisms of cancer development in obesity. Nat Rev Cancer (2011) 3.65
An intragenic MEF2-dependent enhancer directs muscle-specific expression of microRNAs 1 and 133. Proc Natl Acad Sci U S A (2007) 3.62
Transcriptional control of preadipocyte determination by Zfp423. Nature (2010) 3.55
Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell (2005) 3.54
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. J Appl Physiol (1985) (2008) 3.54
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