Published in Proc Natl Acad Sci U S A on February 27, 2004
Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs. Front Neuroendocrinol (2006) 1.60
Expression of urocortin peptides in canine myocardium and plasma. Vet J (2010) 1.37
Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J Physiol (2009) 1.32
Prion-induced amyloid heart disease with high blood infectivity in transgenic mice. Science (2006) 1.23
Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proc Natl Acad Sci U S A (2008) 1.05
erbB2 is required for G protein-coupled receptor signaling in the heart. Proc Natl Acad Sci U S A (2006) 0.95
New targets of urocortin-mediated cardioprotection. J Mol Endocrinol (2010) 0.91
cAMP- and Ca²(+) /calmodulin-dependent protein kinases mediate inotropic, lusitropic and arrhythmogenic effects of urocortin 2 in mouse ventricular myocytes. Br J Pharmacol (2011) 0.86
Intravenous adeno-associated virus serotype 8 encoding urocortin-2 provides sustained augmentation of left ventricular function in mice. Hum Gene Ther (2013) 0.84
Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk. Peptides (2014) 0.82
Impaired exercise capacity and skeletal muscle function in a mouse model of pulmonary inflammation. J Appl Physiol (1985) (2013) 0.81
Central urocortin 3 and type 2 corticotropin-releasing factor receptor in the regulation of energy homeostasis: critical involvement of the ventromedial hypothalamus. Front Endocrinol (Lausanne) (2013) 0.80
Minireview: CRF and Wylie Vale: a story of 41 amino acids and a Texan with grit. Endocrinology (2012) 0.80
Distribution of urocortins and corticotropin-releasing factor receptors in the cardiovascular system. Int J Endocrinol (2012) 0.80
The Modulation of Cardiac Contractile Function by the Pharmacological and Toxicological Effects of Urocortin2. Toxicol Sci (2015) 0.79
Differentiation dependent expression of urocortin's mRNA and peptide in human osteoprogenitor cells: influence of BMP-2, TGF-beta-1 and dexamethasone. J Mol Histol (2009) 0.79
Intravenous AAV8 Encoding Urocortin-2 Increases Function of the Failing Heart in Mice. Hum Gene Ther (2015) 0.79
Urocortin 2 stimulates nitric oxide production in ventricular myocytes via Akt- and PKA-mediated phosphorylation of eNOS at serine 1177. Am J Physiol Heart Circ Physiol (2014) 0.79
The impact of stress on tumor growth: peripheral CRF mediates tumor-promoting effects of stress. Mol Cancer (2010) 0.79
Variation in the maternal corticotrophin releasing hormone-binding protein (CRH-BP) gene and birth weight in Blacks, Hispanics and Whites. PLoS One (2012) 0.78
Clinical perspectives of urocortin and related agents for the treatment of cardiovascular disease. Int J Endocrinol (2012) 0.77
Effect of Urocortin on strength and microarchitecture of osteopenic rat femur. J Bone Miner Metab (2014) 0.77
Urocortin ameliorates diabetic cardiomyopathy in rats via the Akt/GSK-3β signaling pathway. Exp Ther Med (2015) 0.76
Urocortin 2 lowers blood pressure and reduces plasma catecholamine levels in mice with hyperadrenergic activity. Endocrinology (2010) 0.76
Comparative pharmacokinetics and pharmacodynamics of urocortins 1, 2 and 3 in healthy sheep. Br J Pharmacol (2012) 0.76
Cardiac CRFR1 Expression Is Elevated in Human Heart Failure and Modulated by Genetic Variation and Alternative Splicing. Endocrinology (2016) 0.75
Cardiovascular effects of urocortin 2 and urocortin 3 in patients with chronic heart failure. Br J Clin Pharmacol (2016) 0.75
Urocortin Treatment Improves Acute Hemodynamic Instability and Reduces Myocardial Damage in Post-Cardiac Arrest Myocardial Dysfunction. PLoS One (2016) 0.75
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science (1981) 9.64
Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med (1982) 6.79
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Cell (1997) 4.67
Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature (1995) 4.24
Effective arterial elastance as index of arterial vascular load in humans. Circulation (1992) 3.42
Transthoracic echocardiography in models of cardiac disease in the mouse. Circulation (1996) 3.34
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A (2001) 3.23
Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet (2000) 3.04
Left ventricular interaction with arterial load studied in isolated canine ventricle. Am J Physiol (1983) 2.91
Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A (2001) 2.87
Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci U S A (1995) 2.70
Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. Cell (1999) 2.68
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Nat Med (2001) 2.33
Use of echocardiography for the phenotypic assessment of genetically altered mice. Physiol Genomics (2003) 2.26
Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet (2000) 2.24
In vivo murine left ventricular pressure-volume relations by miniaturized conductance micromanometry. Am J Physiol (1998) 2.22
Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ Res (1995) 1.91
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A (1995) 1.86
CRF2 alpha and CRF2 beta receptor mRNAs are differentially distributed between the rat central nervous system and peripheral tissues. Endocrinology (1995) 1.73
A sauvagine/corticotropin-releasing factor receptor expressed in heart and skeletal muscle. Proc Natl Acad Sci U S A (1995) 1.58
Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy. Nat Med (2001) 1.51
Cellular and functional defects in a mouse model of heart failure. Am J Physiol Heart Circ Physiol (2000) 1.49
Long-term hemodynamic effects of prenalterol in patients with severe congestive heart failure. Circulation (1984) 1.39
Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function. Circulation (2002) 1.32
Identification of a novel murine receptor for corticotropin-releasing hormone expressed in the heart. Mol Endocrinol (1995) 1.29
Urocortin protects against ischemic and reperfusion injury via a MAPK-dependent pathway. J Biol Chem (2000) 1.29
Chronic measurement of cardiac output in conscious mice. Am J Physiol Regul Integr Comp Physiol (2002) 1.28
Activation of protein kinase B/Akt by urocortin is essential for its ability to protect cardiac cells against hypoxia/reoxygenation-induced cell death. J Mol Cell Cardiol (2002) 1.09
Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Am J Physiol Heart Circ Physiol (2000) 1.06
Cardiac inotropic actions of urocortin in conscious sheep. Am J Physiol (1997) 1.06
Single-beat estimation of end-systolic elastance using bilinearly approximated time-varying elastance curve. Circulation (2000) 1.06
Long-term outcome of fetal cell transplantation on postinfarction ventricular remodeling and function. J Mol Cell Cardiol (2003) 1.00
Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart. J Endocrinol (2001) 0.98
Beneficial hemodynamic, endocrine, and renal effects of urocortin in experimental heart failure: comparison with normal sheep. J Am Coll Cardiol (2002) 0.96
Effects of corticotropin-releasing factor on isolated rat heart activity. Am J Physiol (1993) 0.94
Force-frequency effect is a powerful determinant of myocardial contractility in the mouse. Am J Physiol (1997) 0.92
Pressure-volume analysis as a method for quantifying simultaneous drug (amrinone) effects on arterial load and contractile state in vivo. J Am Coll Cardiol (1990) 0.79
Hemodynamics as surrogate end points for survival in advanced heart failure: an analysis from FIRST. Am Heart J (2001) 0.78
MicroRNA-133 controls cardiac hypertrophy. Nat Med (2007) 11.68
Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell (2006) 7.21
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03
Marked differences in differentiation propensity among human embryonic stem cell lines. Nat Biotechnol (2008) 6.19
CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol (2004) 5.21
The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell (2002) 4.72
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages. Nature (2009) 4.68
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature (2006) 4.35
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol (2003) 4.25
Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science (2009) 3.78
An Nkx2-5/Bmp2/Smad1 negative feedback loop controls heart progenitor specification and proliferation. Cell (2007) 3.74
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511. Nat Biotechnol (2010) 3.70
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature (2002) 3.67
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity. Nat Med (2004) 3.63
Fibulin-5/DANCE is essential for elastogenesis in vivo. Nature (2002) 3.60
The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell (2007) 3.54
ErbB2 is essential in the prevention of dilated cardiomyopathy. Nat Med (2002) 3.36
Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.18
Epicardial retinoid X receptor alpha is required for myocardial growth and coronary artery formation. Proc Natl Acad Sci U S A (2005) 3.13
Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci U S A (2002) 3.13
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2. EMBO J (2003) 3.02
Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest (2009) 2.98
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure. Development (2002) 2.71
Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell (2008) 2.68
Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
BMP10 is essential for maintaining cardiac growth during murine cardiogenesis. Development (2004) 2.50
Three-dimensional electron microscopy reveals new details of membrane systems for Ca2+ signaling in the heart. J Cell Sci (2009) 2.49
Neurotransmitter acetylcholine negatively regulates neuromuscular synapse formation by a Cdk5-dependent mechanism. Neuron (2005) 2.46
Identification of cardiac-specific myosin light chain kinase. Circ Res (2008) 2.45
Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart. Circ Res (2005) 2.45
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A (2003) 2.44
Islet1 cardiovascular progenitors: a single source for heart lineages? Development (2008) 2.39
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. Nat Med (2002) 2.37
Conditional mutation of the ErbB2 (HER2) receptor in cardiomyocytes leads to dilated cardiomyopathy. Proc Natl Acad Sci U S A (2002) 2.32
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2. J Neurosci (2005) 2.21
An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice. J Clin Invest (2008) 2.19
Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog. J Clin Invest (2005) 2.19
Essential role for mitochondrial thioredoxin reductase in hematopoiesis, heart development, and heart function. Mol Cell Biol (2004) 2.12
Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction. Nat Biotechnol (2013) 2.11
MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J Clin Invest (2010) 2.04
Intracoronary adenovirus encoding adenylyl cyclase VI increases left ventricular function in heart failure. Circulation (2004) 2.01
The cardiac-specific nuclear delta(B) isoform of Ca2+/calmodulin-dependent protein kinase II induces hypertrophy and dilated cardiomyopathy associated with increased protein phosphatase 2A activity. J Biol Chem (2001) 1.99
Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells. Development (2004) 1.98
p75(NTR) mediates ephrin-A reverse signaling required for axon repulsion and mapping. Neuron (2008) 1.97
The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci (2006) 1.96
p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol (2004) 1.95
Regeneration next: toward heart stem cell therapeutics. Cell Stem Cell (2009) 1.92
Structure of the ternary signaling complex of a TGF-beta superfamily member. Proc Natl Acad Sci U S A (2006) 1.88
Mouse PeP: a novel peroxisomal protein linked to myoblast differentiation and development. Dev Dyn (2002) 1.87
Loss of enigma homolog protein results in dilated cardiomyopathy. Circ Res (2010) 1.85
Resident fibroblast lineages mediate pressure overload-induced cardiac fibrosis. J Clin Invest (2014) 1.82
The neurobiology of depression: inroads to treatment and new drug discovery. J Clin Psychiatry (2005) 1.81
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Proc Natl Acad Sci U S A (2004) 1.80
Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy. J Am Coll Cardiol (2004) 1.79
Stem cells: lost in translation. Nature (2004) 1.79
International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands. Pharmacol Rev (2003) 1.79
Cardiac-specific disruption of the c-raf-1 gene induces cardiac dysfunction and apoptosis. J Clin Invest (2004) 1.79
Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron (2005) 1.77
Key role of CRF in the skin stress response system. Endocr Rev (2013) 1.77
Genetically encoding unnatural amino acids for cellular and neuronal studies. Nat Neurosci (2007) 1.76
Urocortin-II and urocortin-III are cardioprotective against ischemia reperfusion injury: an essential endogenous cardioprotective role for corticotropin releasing factor receptor type 2 in the murine heart. Endocrinology (2003) 1.76
Towards regenerative therapy for cardiac disease. Lancet (2012) 1.75
Aberrant patterning of neuromuscular synapses in choline acetyltransferase-deficient mice. J Neurosci (2003) 1.75
Moderate heart dysfunction in mice with inducible cardiomyocyte-specific excision of the Serca2 gene. J Mol Cell Cardiol (2009) 1.72
Adeno-associated virus effectively mediates conditional gene modification in the brain. Proc Natl Acad Sci U S A (2002) 1.72
Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gastroenterology (2011) 1.71
Junctophilin type 2 is associated with caveolin-3 and is down-regulated in the hypertrophic and dilated cardiomyopathies. Biochem Biophys Res Commun (2004) 1.69
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasis. Cancer Res (2004) 1.67
Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology (2009) 1.66
Fibulin-5/DANCE has an elastogenic organizer activity that is abrogated by proteolytic cleavage in vivo. J Cell Biol (2007) 1.60
Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease. J Clin Invest (2012) 1.59
Astressin B, a nonselective corticotropin-releasing hormone receptor antagonist, prevents the inhibitory effect of ghrelin on luteinizing hormone pulse frequency in the ovariectomized rhesus monkey. Endocrinology (2007) 1.59
Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers. Biotechnol Bioeng (2003) 1.58
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
Laminin-alpha4 and integrin-linked kinase mutations cause human cardiomyopathy via simultaneous defects in cardiomyocytes and endothelial cells. Circulation (2007) 1.57
Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Proc Natl Acad Sci U S A (2007) 1.57