Published in BMC Genomics on February 15, 2017
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Clustal W and Clustal X version 2.0. Bioinformatics (2007) 126.47
PAML 4: phylogenetic analysis by maximum likelihood. Mol Biol Evol (2007) 45.68
RAxML version 8: a tool for phylogenetic analysis and post-analysis of large phylogenies. Bioinformatics (2014) 28.04
Lyme disease-a tick-borne spirochetosis? Science (1982) 27.50
FastTree 2--approximately maximum-likelihood trees for large alignments. PLoS One (2010) 26.15
The spirochetal etiology of Lyme disease. N Engl J Med (1983) 21.59
Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature (1997) 19.08
A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Mol Microbiol (2000) 7.60
Changes in infectivity and plasmid profile of the Lyme disease spirochete, Borrelia burgdorferi, as a result of in vitro cultivation. Infect Immun (1988) 6.64
Antigenic variation in Lyme disease borreliae by promiscuous recombination of VMP-like sequence cassettes. Cell (1997) 6.36
Linear plasmids of the bacterium Borrelia burgdorferi have covalently closed ends. Science (1987) 5.80
Plasmid analysis of Borrelia burgdorferi, the Lyme disease agent. J Clin Microbiol (1988) 4.83
Correlation between plasmid content and infectivity in Borrelia burgdorferi. Proc Natl Acad Sci U S A (2000) 4.81
Gepard: a rapid and sensitive tool for creating dotplots on genome scale. Bioinformatics (2007) 4.45
Sequence typing reveals extensive strain diversity of the Lyme borreliosis agents Borrelia burgdorferi in North America and Borrelia afzelii in Europe. Microbiology (2004) 3.82
Analysis of supercoiled circular plasmids in infectious and non-infectious Borrelia burgdorferi. Microb Pathog (1990) 3.24
A plasmid-encoded nicotinamidase (PncA) is essential for infectivity of Borrelia burgdorferi in a mammalian host. Mol Microbiol (2003) 3.17
Experimental Lyme arthritis in rats infected with Borrelia burgdorferi. J Infect Dis (1988) 3.02
Recombination between genes encoding major outer surface proteins A and B of Borrelia burgdorferi. Mol Microbiol (1992) 3.01
Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi. Mol Microbiol (2001) 2.95
The urinary bladder, a consistent source of Borrelia burgdorferi in experimentally infected white-footed mice (Peromyscus leucopus). J Clin Microbiol (1988) 2.85
A 9.0-kilobase-pair circular plasmid of Borrelia burgdorferi encodes an exported protein: evidence for expression only during infection. Infect Immun (1994) 2.74
Polymerase chain reaction analyses identify two distinct classes of Borrelia burgdorferi. J Clin Microbiol (1991) 2.71
Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31. Mol Microbiol (1998) 2.68
MLST of housekeeping genes captures geographic population structure and suggests a European origin of Borrelia burgdorferi. Proc Natl Acad Sci U S A (2008) 2.67
Homology throughout the multiple 32-kilobase circular plasmids present in Lyme disease spirochetes. J Bacteriol (1997) 2.36
Identification of loci critical for replication and compatibility of a Borrelia burgdorferi cp32 plasmid and use of a cp32-based shuttle vector for the expression of fluorescent reporters in the lyme disease spirochaete. Mol Microbiol (2002) 2.28
Linear plasmids of Borrelia burgdorferi have a telomeric structure and sequence similar to those of a eukaryotic virus. J Bacteriol (1991) 2.15
Analysis of the distribution and molecular heterogeneity of the ospD gene among the Lyme disease spirochetes: evidence for lateral gene exchange. J Bacteriol (1994) 2.14
The absence of linear plasmid 25 or 28-1 of Borrelia burgdorferi dramatically alters the kinetics of experimental infection via distinct mechanisms. Infect Immun (2003) 2.06
Borrelia genomes in the year 2000. J Mol Microbiol Biotechnol (2000) 2.03
The Borrelia burgdorferi circular plasmid cp26: conservation of plasmid structure and targeted inactivation of the ospC gene. Mol Microbiol (1997) 1.99
Genetic exchange and plasmid transfers in Borrelia burgdorferi sensu stricto revealed by three-way genome comparisons and multilocus sequence typing. Proc Natl Acad Sci U S A (2004) 1.82
Evidence for lateral transfer and recombination in OspC variation in Lyme disease Borrelia. Mol Microbiol (1995) 1.81
An OspB mutant of Borrelia burgdorferi has reduced invasiveness in vitro and reduced infectivity in vivo. Infect Immun (1993) 1.79
Plasmid analysis and restriction fragment length polymorphisms of chromosomal DNA allow a distinction between Borrelia burgdorferi strains. Zentralbl Bakteriol (1990) 1.77
Phylogeography of Borrelia burgdorferi in the eastern United States reflects multiple independent Lyme disease emergence events. Proc Natl Acad Sci U S A (2009) 1.71
bptA (bbe16) is essential for the persistence of the Lyme disease spirochete, Borrelia burgdorferi, in its natural tick vector. Proc Natl Acad Sci U S A (2005) 1.66
The critical role of the linear plasmid lp36 in the infectious cycle of Borrelia burgdorferi. Mol Microbiol (2007) 1.66
Linear chromosomes of Lyme disease agent spirochetes: genetic diversity and conservation of gene order. J Bacteriol (1995) 1.64
DNA analysis of Borrelia burgdorferi NCH-1, the first northcentral U.S. human Lyme disease isolate. J Clin Microbiol (1992) 1.61
Whole-genome sequences of thirteen isolates of Borrelia burgdorferi. J Bacteriol (2010) 1.60
Borrelia burgdorferi contains repeated DNA sequences that are species specific and plasmid associated. Infect Immun (1990) 1.57
Evolution and distribution of the ospC Gene, a transferable serotype determinant of Borrelia burgdorferi. MBio (2010) 1.55
Experimental assessment of the roles of linear plasmids lp25 and lp28-1 of Borrelia burgdorferi throughout the infectious cycle. Infect Immun (2004) 1.55
Analysis and comparison of plasmid profiles of Borrelia burgdorferi sensu lato strains. J Clin Microbiol (1995) 1.54
Cloning and sequence analysis of linear plasmid telomeres of the bacterium Borrelia burgdorferi. Mol Microbiol (1990) 1.54
The essential nature of the ubiquitous 26-kilobase circular replicon of Borrelia burgdorferi. J Bacteriol (2004) 1.50
Towards understanding the molecular basis of bacterial DNA segregation. Philos Trans R Soc Lond B Biol Sci (2005) 1.50
In vivo expression technology identifies a novel virulence factor critical for Borrelia burgdorferi persistence in mice. PLoS Pathog (2013) 1.49
Whole genome sequence of an unusual Borrelia burgdorferi sensu lato isolate. J Bacteriol (2011) 1.49
Molecular evidence for a new bacteriophage of Borrelia burgdorferi. J Bacteriol (1999) 1.44
Wide distribution of a high-virulence Borrelia burgdorferi clone in Europe and North America. Emerg Infect Dis (2008) 1.43
Plasmid stability during in vitro propagation of Borrelia burgdorferi assessed at a clonal level. Infect Immun (2003) 1.40
Co-evolution of the outer surface protein C gene (ospC) and intraspecific lineages of Borrelia burgdorferi sensu stricto in the northeastern United States. Infect Genet Evol (2006) 1.39
Lyme arthritis resolution with antiserum to a 37-kilodalton Borrelia burgdorferi protein. Infect Immun (2000) 1.36
Fitness variation of Borrelia burgdorferi sensu stricto strains in mice. Appl Environ Microbiol (2007) 1.36
Comparative genome hybridization reveals substantial variation among clinical isolates of Borrelia burgdorferi sensu stricto with different pathogenic properties. J Bacteriol (2006) 1.34
Intra- and interbacterial genetic exchange of Lyme disease spirochete erp genes generates sequence identity amidst diversity. J Mol Evol (2003) 1.34
Linear and circular plasmid content in Borrelia burgdorferi clinical isolates. Infect Immun (2003) 1.33
Transduction by phiBB-1, a bacteriophage of Borrelia burgdorferi. J Bacteriol (2001) 1.31
Telomeres of the linear chromosomes of Lyme disease spirochaetes: nucleotide sequence and possible exchange with linear plasmid telomeres. Mol Microbiol (1997) 1.30
Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids. PLoS One (2012) 1.28
Distribution of twelve linear extrachromosomal DNAs in natural isolates of Lyme disease spirochetes. J Bacteriol (2000) 1.28
Geographic differences in genetic locus linkages for Borrelia burgdorferi. Emerg Infect Dis (2010) 1.26
Whole-genome sequences of two Borrelia afzelii and two Borrelia garinii Lyme disease agent isolates. J Bacteriol (2011) 1.23
Variation in the size of the ospA-containing linear plasmid, but not the linear chromosome, among the three Borrelia species associated with Lyme disease. J Gen Microbiol (1993) 1.20
Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity. PLoS One (2012) 1.19
Comparative analysis of genetic variability among Borrelia burgdorferi isolates from Europe and the United States by restriction enzyme analysis, gene restriction fragment length polymorphism, and pulsed-field gel electrophoresis. J Clin Microbiol (1993) 1.18
Mapping of essential replication functions of the linear plasmid lp17 of B. burgdorferi by targeted deletion walking. Mol Microbiol (2005) 1.17
Plasmid requirements for infection of ticks by Borrelia burgdorferi. Vector Borne Zoonotic Dis (2005) 1.15
A second allele of eppA in Borrelia burgdorferi strain B31 is located on the previously undetected circular plasmid cp9-2. J Bacteriol (2000) 1.13
Analysis of linear plasmid dimers in Borrelia burgdorferi sensu lato isolates: implications concerning the potential mechanism of linear plasmid replication. J Bacteriol (1996) 1.13
A monoclonal antibody generated by antigen inoculation via tick bite is reactive to the Borrelia burgdorferi Rev protein, a member of the 2.9 gene family locus. Infect Immun (1998) 1.12
Defining plasmids required by Borrelia burgdorferi for colonization of tick vector Ixodes scapularis (Acari: Ixodidae). J Med Entomol (2005) 1.12
Evolution of northeastern and midwestern Borrelia burgdorferi, United States. Emerg Infect Dis (2010) 1.12
Identification of potential virulence determinants by Himar1 transposition of infectious Borrelia burgdorferi B31. Infect Immun (2006) 1.08
DNA Strider. A Macintosh program for handling protein and nucleic acid sequences. Methods Mol Biol (1994) 1.06
Whole-genome sequences of Borrelia bissettii, Borrelia valaisiana, and Borrelia spielmanii. J Bacteriol (2012) 1.04
Telomere exchange between linear replicons of Borrelia burgdorferi. J Bacteriol (2004) 1.04
Characterization and in vitro reaction properties of 19 unique hairpin telomeres from the linear plasmids of the lyme disease spirochete. J Biol Chem (2009) 1.00
Pervasive recombination and sympatric genome diversification driven by frequency-dependent selection in Borrelia burgdorferi, the Lyme disease bacterium. Genetics (2011) 0.97
OspC phylogenetic analyses support the feasibility of a broadly protective polyvalent chimeric Lyme disease vaccine. Clin Vaccine Immunol (2007) 0.97
Isolation and characterization of Borrelia burgdorferi from blood of a bird captured in the Saint Croix River Valley. J Clin Microbiol (1993) 0.96
Transcriptional regulation of the Borrelia burgdorferi antigenically variable VlsE surface protein. J Bacteriol (2006) 0.96
The failure of immune response evasion by linear plasmid 28-1-deficient Borrelia burgdorferi is attributable to persistent expression of an outer surface protein. Infect Immun (2008) 0.93
Inter- and intra-specific pan-genomes of Borrelia burgdorferi sensu lato: genome stability and adaptive radiation. BMC Genomics (2013) 0.92
Molecular analysis of decorin-binding protein A (DbpA) reveals five major groups among European Borrelia burgdorferi sensu lato strains with impact for the development of serological assays and indicates lateral gene transfer of the dbpA gene. Int J Med Microbiol (2006) 0.91
Molecular characterization of Borrelia burgdorferi sensu lato strains by pulsed-field gel electrophoresis. Electrophoresis (1995) 0.89
Borrelia burgdorferi complement regulator-acquiring surface protein 2 (CspZ) as a serological marker of human Lyme disease. Clin Vaccine Immunol (2007) 0.88
The cyclic-di-GMP signaling pathway in the Lyme disease spirochete, Borrelia burgdorferi. Front Cell Infect Microbiol (2014) 0.88
Fast, adaptive evolution at a bacterial host-resistance locus: the PFam54 gene array in Borrelia burgdorferi. Gene (2009) 0.86
vls Antigenic Variation Systems of Lyme Disease Borrelia: Eluding Host Immunity through both Random, Segmental Gene Conversion and Framework Heterogeneity. Microbiol Spectr (2014) 0.84
Loss of plasmids of Borrelia burgdorferi sensu lato during prolonged in vitro cultivation. Plasmid (2011) 0.83
Induction of type I and type III interferons by Borrelia burgdorferi correlates with pathogenesis and requires linear plasmid 36. PLoS One (2014) 0.80
Distribution of cp32 prophages among Lyme disease-causing spirochetes and natural diversity of their lipoprotein-encoding erp loci. Appl Environ Microbiol (2013) 0.80
Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family. BMC Microbiol (2015) 0.80
Requirements for Borrelia burgdorferi plasmid maintenance. Plasmid (2012) 0.80