Published in N Engl J Med on March 15, 2007
Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR. Proc Natl Acad Sci U S A (2007) 3.15
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med (2012) 3.03
Energy metabolism in heart failure and remodelling. Cardiovasc Res (2008) 2.37
Role of mitochondrial Ca2+ in the regulation of cellular energetics. Biochemistry (2012) 2.26
Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure. Circulation (2012) 2.17
Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.05
Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation (2009) 2.01
Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature (2013) 2.00
The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res (2010) 1.94
PGC-1 coactivators in cardiac development and disease. Circ Res (2010) 1.86
The cycling of acetyl-coenzyme A through acetylcarnitine buffers cardiac substrate supply: a hyperpolarized 13C magnetic resonance study. Circ Cardiovasc Imaging (2012) 1.86
Quantitative cardiac 31P spectroscopy at 3 Tesla using adiabatic pulses. Magn Reson Med (2009) 1.83
Hyperpolarized (13)C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart. Eur J Heart Fail (2012) 1.82
Mitochondria in heart failure. Cardiovasc Res (2010) 1.75
Mitochondrial complex I deficiency increases protein acetylation and accelerates heart failure. Cell Metab (2013) 1.74
Cardiac metabolism in heart failure: implications beyond ATP production. Circ Res (2013) 1.72
Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease. Circ Heart Fail (2011) 1.72
Induction of manganese superoxide dismutase by nuclear translocation and activation of SIRT1 promotes cell survival in chronic heart failure. J Biol Chem (2010) 1.65
PGC-1alpha and ERRalpha target gene downregulation is a signature of the failing human heart. J Mol Cell Cardiol (2008) 1.63
Adenosine receptors and the heart: role in regulation of coronary blood flow and cardiac electrophysiology. Handb Exp Pharmacol (2009) 1.56
Cardiac metabolism and its interactions with contraction, growth, and survival of cardiomyocytes. Circ Res (2013) 1.56
The cell biology of disease: cellular mechanisms of cardiomyopathy. J Cell Biol (2011) 1.54
Heart failure risk prediction in the Multi-Ethnic Study of Atherosclerosis. Heart (2014) 1.49
Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy. Circ Cardiovasc Imaging (2014) 1.48
The roles of senescence and telomere shortening in cardiovascular disease. Nat Rev Cardiol (2013) 1.48
Cardiovascular remodelling in coronary artery disease and heart failure. Lancet (2014) 1.47
Dysregulation of cardiolipin biosynthesis in pediatric heart failure. J Mol Cell Cardiol (2014) 1.40
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy. Dev Cell (2009) 1.40
No Evidence of Myocardial Oxygen Deprivation in Nonischemic Heart Failure. Circ Heart Fail (2015) 1.39
Mechanisms of altered Ca²⁺ handling in heart failure. Circ Res (2013) 1.37
Modulating fatty acid oxidation in heart failure. Cardiovasc Res (2011) 1.37
Targeting myocardial substrate metabolism in heart failure: potential for new therapies. Eur J Heart Fail (2012) 1.36
Plasma soluble corin in patients with heart failure. Circ Heart Fail (2010) 1.36
Glucose, obesity, metabolic syndrome, and diabetes relevance to incidence of heart failure. J Am Coll Cardiol (2010) 1.36
Cardiac-specific deletion of acetyl CoA carboxylase 2 prevents metabolic remodeling during pressure-overload hypertrophy. Circ Res (2012) 1.35
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest (2010) 1.34
Intrinsic aerobic capacity sets a divide for aging and longevity. Circ Res (2011) 1.33
Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts. Circ Cardiovasc Genet (2009) 1.32
Functional consequences of human induced pluripotent stem cell therapy: myocardial ATP turnover rate in the in vivo swine heart with postinfarction remodeling. Circulation (2013) 1.29
Pathway analysis of dilated cardiomyopathy using global proteomic profiling and enrichment maps. Proteomics (2010) 1.29
Mitochondria in cardiac hypertrophy and heart failure. J Mol Cell Cardiol (2012) 1.29
Cardiac muscle ring finger-1 increases susceptibility to heart failure in vivo. Circ Res (2009) 1.29
Mitochondrial centrality in heart failure. Heart Fail Rev (2008) 1.28
Glucose metabolism and cardiac hypertrophy. Cardiovasc Res (2011) 1.28
The Failing Heart Relies on Ketone Bodies as a Fuel. Circulation (2016) 1.27
Experimentally observed phenomena on cardiac energetics in heart failure emerge from simulations of cardiac metabolism. Proc Natl Acad Sci U S A (2009) 1.25
Hyperpolarized magnetic resonance: a novel technique for the in vivo assessment of cardiovascular disease. Circulation (2011) 1.24
Cardiovascular molecular imaging: focus on clinical translation. Circulation (2011) 1.24
G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia. Circulation (2011) 1.23
Capturing the stem cell paracrine effect using heparin-presenting nanofibres to treat cardiovascular diseases. J Tissue Eng Regen Med (2010) 1.23
Metabolic gene remodeling and mitochondrial dysfunction in failing right ventricular hypertrophy secondary to pulmonary arterial hypertension. Circ Heart Fail (2012) 1.23
Disease prevention--should we target obesity or sedentary lifestyle? Nat Rev Cardiol (2010) 1.22
Regulation of pyruvate metabolism and human disease. Cell Mol Life Sci (2013) 1.21
Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism. PLoS Biol (2013) 1.18
A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. Circ Res (2013) 1.18
Protease corin expression and activity in failing hearts. Am J Physiol Heart Circ Physiol (2010) 1.16
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol (2014) 1.16
Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium. J Pharmacol Exp Ther (2010) 1.15
Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol (2011) 1.14
Monoamine oxidases (MAO) in the pathogenesis of heart failure and ischemia/reperfusion injury. Biochim Biophys Acta (2010) 1.13
Resveratrol improves survival, hemodynamics and energetics in a rat model of hypertension leading to heart failure. PLoS One (2011) 1.13
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathy. PLoS Genet (2010) 1.13
Hepatic dysfunction and survival after orthotopic heart transplantation: application of the MELD scoring system for outcome prediction. J Heart Lung Transplant (2012) 1.13
Cardiolipin biosynthesis and remodeling enzymes are altered during development of heart failure. J Lipid Res (2008) 1.12
Dynamic organization of mitochondria in human heart and in myocardial disease. Int J Biochem Cell Biol (2009) 1.11
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem (2011) 1.10
Cardiac anaplerosis in health and disease: food for thought. Cardiovasc Res (2011) 1.09
Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements. J Magn Reson Imaging (2011) 1.09
Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol (2012) 1.08
ADP compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle. Biophys J (2010) 1.08
Local energetic regulation of sarcoplasmic and myosin ATPase is differently impaired in rats with heart failure. J Physiol (2008) 1.08
Clinical implications of cardiac hyperpolarized magnetic resonance imaging. J Cardiovasc Magn Reson (2013) 1.07
Increased afterload induces pathological cardiac hypertrophy: a new in vitro model. Basic Res Cardiol (2012) 1.06
On improvement in ejection fraction with iron chelation in thalassemia major and the risk of future heart failure. J Cardiovasc Magn Reson (2011) 1.05
The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet. Am J Physiol Heart Circ Physiol (2008) 1.04
PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes. PLoS One (2010) 1.04
Metabonomic profiles delineate the effect of traditional Chinese medicine sini decoction on myocardial infarction in rats. PLoS One (2012) 1.03
Human cardiac 31P magnetic resonance spectroscopy at 7 Tesla. Magn Reson Med (2013) 1.02
G protein-coupled receptor kinase 2: a link between myocardial contractile function and cardiac metabolism. Circ Res (2014) 1.02
Mice over-expressing the myocardial creatine transporter develop progressive heart failure and show decreased glycolytic capacity. J Mol Cell Cardiol (2009) 1.02
Activation of mitochondrial energy metabolism protects against cardiac failure. Aging (Albany NY) (2010) 1.02
Insulin stimulates mitochondrial fusion and function in cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 signaling pathway. Diabetes (2013) 1.01
Metabolic compartmentation - a system level property of muscle cells: real problems of diffusion in living cells. Int J Mol Sci (2008) 1.01
In vivo alterations in cardiac metabolism and function in the spontaneously hypertensive rat heart. Cardiovasc Res (2012) 1.01
Modulation of energy transfer pathways between mitochondria and myofibrils by changes in performance of perfused heart. J Biol Chem (2010) 1.01
Cardiac mitochondrial matrix and respiratory complex protein phosphorylation. Am J Physiol Heart Circ Physiol (2012) 1.01
Electromechanical dyssynchrony and resynchronization of the failing heart. Circ Res (2013) 1.01
Reverse changes in cardiac substrate oxidation in dogs recovering from heart failure. Am J Physiol Heart Circ Physiol (2008) 1.01
Mitochondrial and cellular mechanisms for managing lipid excess. Front Physiol (2014) 1.00
Inhibition of c-Jun-N-terminal kinase increases cardiac peroxisome proliferator-activated receptor alpha expression and fatty acid oxidation and prevents lipopolysaccharide-induced heart dysfunction. J Biol Chem (2011) 1.00
A preferred AMPK phosphorylation site adjacent to the inhibitory loop of cardiac and skeletal troponin I. Protein Sci (2011) 1.00
Metabolic therapy at the crossroad: how to optimize myocardial substrate utilization? Trends Cardiovasc Med (2009) 0.99
Peroxisome proliferator-activated receptor-γ activation prevents sepsis-related cardiac dysfunction and mortality in mice. Circ Heart Fail (2013) 0.99
Alterations in mitochondrial function as a harbinger of cardiomyopathy: lessons from the dystrophic heart. J Mol Cell Cardiol (2009) 0.99
Left ventricular torsion, energetics, and diastolic function in normal human aging. Am J Physiol Heart Circ Physiol (2011) 0.99
Adverse remodeling of the electrophysiological response to ischemia-reperfusion in human heart failure is associated with remodeling of metabolic gene expression. Circ Arrhythm Electrophysiol (2014) 0.98
Matrix revisited: mechanisms linking energy substrate metabolism to the function of the heart. Circ Res (2014) 0.98
Transcriptional control of cardiac fuel metabolism and mitochondrial function. Cold Spring Harb Symp Quant Biol (2011) 0.98
Telomeres and mitochondria in the aging heart. Circ Res (2012) 0.98
Moderate elevation of intracellular creatine by targeting the creatine transporter protects mice from acute myocardial infarction. Cardiovasc Res (2012) 0.97