Published in Circulation on March 23, 2009
Myocardial ischemia induced by rapid atrial pacing causes troponin T release detectable by a highly sensitive assay: insights from a coronary sinus sampling study. J Am Coll Cardiol (2011) 2.83
Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes (2009) 2.68
Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: form and function. Circulation (2012) 1.64
Modulation of mitochondrial proteome and improved mitochondrial function by biventricular pacing of dyssynchronous failing hearts. Circ Cardiovasc Genet (2009) 1.32
Metabolomic profiling reveals mitochondrial-derived lipid biomarkers that drive obesity-associated inflammation. PLoS One (2012) 1.27
Mechanical unloading promotes myocardial energy recovery in human heart failure. Circ Cardiovasc Genet (2014) 0.97
Metabolomic distinction and insights into the pathogenesis of human primary dilated cardiomyopathy. Eur J Clin Invest (2010) 0.97
Energetics and metabolism in the failing heart: important but poorly understood. Curr Opin Clin Nutr Metab Care (2010) 0.94
Metabolomics and atherosclerosis. Curr Atheroscler Rep (2010) 0.93
Metabolomic profiling for identification of novel potential biomarkers in cardiovascular diseases. J Biomed Biotechnol (2011) 0.93
1H-NMR-based metabolic analysis of human serum reveals novel markers of myocardial energy expenditure in heart failure patients. PLoS One (2014) 0.88
Tissue-specific and nutrient regulation of the branched-chain α-keto acid dehydrogenase phosphatase, protein phosphatase 2Cm (PP2Cm). J Biol Chem (2012) 0.84
The emerging role of metabolomics in the development of biomarkers for pulmonary hypertension and other cardiovascular diseases (2013 Grover Conference series). Pulm Circ (2014) 0.83
Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats. Anesthesiology (2016) 0.81
Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. Circulation (2016) 0.81
The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination. Mol Cell Endocrinol (2015) 0.81
Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes. PLoS One (2014) 0.80
CD36 overexpression predisposes to arrhythmias but reduces infarct size in spontaneously hypertensive rats: gene expression profile analysis. Physiol Genomics (2011) 0.79
Low T3 State Is Correlated with Cardiac Mitochondrial Impairments after Ischemia Reperfusion Injury: Evidence from a Proteomic Approach. Int J Mol Sci (2015) 0.78
Imaging and modeling of myocardial metabolism. J Cardiovasc Transl Res (2010) 0.76
Metabolomic profiling of cardiac substrate utilization: fanning the flames of systems biology? Circulation (2009) 0.76
Metabolomic approach to profile functional and metabolic changes in heart failure. J Transl Med (2015) 0.76
Lost in Translation (LiT): IUPHAR Review 6. Br J Pharmacol (2014) 0.76
Identification of metabolic biomarkers in patients with type 2 diabetic coronary heart diseases based on metabolomic approach. Sci Rep (2016) 0.76
Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure. J Card Fail (2015) 0.76
Increases in myocardial workload induced by rapid atrial pacing trigger alterations in global metabolism. PLoS One (2014) 0.76
Defective Branched-Chain Amino Acid Catabolism Disrupts Glucose Metabolism and Sensitizes the Heart to Ischemia-Reperfusion Injury. Cell Metab (2017) 0.75
Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. Integr Comp Biol (2014) 0.75
Metabolic profiles in heart failure due to non-ischemic cardiomyopathy at rest and under exercise. ESC Heart Fail (2017) 0.75
Compound danshen dripping pills modulate the perturbed energy metabolism in a rat model of acute myocardial ischemia. Sci Rep (2016) 0.75
Association between serum N-terminal pro-B-type natriuretic peptide levels and characteristics of coronary atherosclerotic plaque detected by coronary computed tomography angiography. Exp Ther Med (2016) 0.75
Metabotyping Patients' Journeys Reveals Early Predisposition to Lung Injury after Cardiac Surgery. Sci Rep (2017) 0.75
Conceptual Foundations of Systems Biology Explaining Complex Cardiac Diseases. Healthcare (Basel) (2017) 0.75
The failing heart--an engine out of fuel. N Engl J Med (2007) 12.06
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Myocardial substrate metabolism in the normal and failing heart. Physiol Rev (2005) 6.06
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Metabolomic identification of novel biomarkers of myocardial ischemia. Circulation (2005) 3.16
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Mitochondrial DNA damage and dysfunction associated with oxidative stress in failing hearts after myocardial infarction. Circ Res (2001) 2.62
Tandem mass spectrometry: a new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism. J Inherit Metab Dis (1990) 2.53
Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles. J Physiol (2003) 2.32
Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog. Circ Res (1998) 2.16
ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. J Clin Invest (2004) 2.08
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy. J Am Coll Cardiol (2002) 2.07
Improved hemodynamic function and mechanical efficiency in congestive heart failure with sodium dichloroacetate. J Am Coll Cardiol (1994) 1.66
Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure. J Mol Cell Cardiol (2004) 1.49
An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure. J Nucl Med (2001) 1.47
Induction of mitochondrial biogenesis is a maladaptive mechanism in mitochondrial cardiomyopathies. J Am Coll Cardiol (2007) 1.43
Combined metabolomic and proteomic analysis of human atrial fibrillation. J Am Coll Cardiol (2008) 1.38
Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. J Clin Invest (1991) 1.26
Total-body and myocardial substrate oxidation in congestive heart failure. Metabolism (1994) 1.19
Changes in substrate metabolism and effects of excess fatty acids in reperfused myocardium. Circ Res (1988) 1.15
Effects of L-carnitine administration on left ventricular remodeling after acute anterior myocardial infarction: the L-Carnitine Ecocardiografia Digitalizzata Infarto Miocardico (CEDIM) Trial. J Am Coll Cardiol (1995) 1.06
Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters. Am J Physiol (1993) 1.04
Effect of increasing degrees of ischemic injury on myocardial oxidative metabolism early after reperfusion in isolated rat hearts. Circ Res (1991) 0.99
Substrate use in ischemic and reperfused canine myocardium: quantitative considerations. Am J Physiol (1987) 0.98
Metabolic treatment with L-carnitine in acute anterior ST segment elevation myocardial infarction. A randomized controlled trial. Cardiology (2006) 0.95
Myocardial carnitine and carnitine palmitoyltransferase deficiencies in patients with severe heart failure. Biochim Biophys Acta (2000) 0.93
Myocardial metabolism before and after valve replacement for aortic stenosis. J Cardiovasc Surg (Torino) (2006) 0.88
Impaired fatty acid uptake in ischemic but viable myocardium identified by thallium-201 reinjection. Am Heart J (1996) 0.88
Coronary blood flow, metabolism, and function in dysfunctional viable myocardium before and early after surgical revascularisation. Heart (2004) 0.85
Myocardial substrate uptake and oxidation during and after routine cardiac surgery. J Thorac Cardiovasc Surg (1999) 0.85
Effect of hyperglycemia and fatty acid oxidation inhibition during aerobic conditions and demand-induced ischemia. Am J Physiol Heart Circ Physiol (2003) 0.84
Mechanical and metabolic functions in pig hearts after 4 days of chronic coronary stenosis. J Am Coll Cardiol (1995) 0.83
Trauma metabolism and the heart. Uptake of substrates and effects of insulin early after cardiac operations. J Thorac Cardiovasc Surg (1990) 0.82
Effects of moderate repetitive ischemia on myocardial substrate utilization. Am J Physiol (1995) 0.80
Decreased postoperative myocardial fatty acid oxidation. J Surg Res (1988) 0.79
A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab (2009) 11.46
Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab (2008) 9.74
Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science (2013) 8.81
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature (2010) 6.48
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
Percutaneous repair or surgery for mitral regurgitation. N Engl J Med (2011) 5.78
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance. Nat Med (2004) 5.04
Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metab (2007) 4.51
Peroxisome proliferator-activated receptor-gamma co-activator 1alpha-mediated metabolic remodeling of skeletal myocytes mimics exercise training and reverses lipid-induced mitochondrial inefficiency. J Biol Chem (2005) 4.30
The impact of a consortium of fermented milk strains on the gut microbiome of gnotobiotic mice and monozygotic twins. Sci Transl Med (2011) 4.24
Depression as a risk factor for mortality after coronary artery bypass surgery. Lancet (2003) 4.21
Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. J Biol Chem (2003) 4.12
Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell (2005) 4.04
Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women. Diabetes Care (2009) 3.69
Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Leptin therapy in insulin-deficient type I diabetes. Proc Natl Acad Sci U S A (2010) 3.23
A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat Med (2002) 3.22
Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic subjects despite identical weight loss. Sci Transl Med (2011) 3.20
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (2008) 3.17
Obesity-related derangements in metabolic regulation. Annu Rev Biochem (2006) 3.14
Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab (2008) 3.04
Continuous electroencephalographic monitoring in critically ill patients: indications, limitations, and strategies. Crit Care Med (2013) 2.79
Metabolomics applied to diabetes research: moving from information to knowledge. Diabetes (2009) 2.68
Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. PLoS Genet (2008) 2.63
Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. Am J Hum Genet (2010) 2.61
Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. Science (2013) 2.49
Dissecting the in vivo metabolic potential of two human gut acetogens. J Biol Chem (2010) 2.42
Nitric oxide represses the Arabidopsis floral transition. Science (2004) 2.41
Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. Circ Cardiovasc Genet (2010) 2.34
Presence and severity of intensive care unit-acquired paresis at time of awakening are associated with increased intensive care unit and hospital mortality. Crit Care Med (2009) 2.31
Carnitine insufficiency caused by aging and overnutrition compromises mitochondrial performance and metabolic control. J Biol Chem (2009) 2.28
Central nervous system injury associated with cardiac surgery. Lancet (2006) 2.27
Prospective evaluation of pain and analgesic use following major elective intracranial surgery. J Neurosurg (2007) 2.26
Mortality in patients with necrotizing fasciitis. Plast Reconstr Surg (2007) 2.25
Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg? Ophthalmology (2005) 2.22
High heritability of metabolomic profiles in families burdened with premature cardiovascular disease. Mol Syst Biol (2009) 2.21
PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem (2003) 2.20
Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility. Cell Metab (2012) 2.11
Acute lung injury in critical neurological illness. Crit Care Med (2012) 2.09
Intraoperative magnesium administration does not improve neurocognitive function after cardiac surgery. Stroke (2013) 2.05
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci U S A (2002) 2.04
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem (2006) 2.03
Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. Cell Metab (2010) 2.00
Metabolic cycling in control of glucose-stimulated insulin secretion. Am J Physiol Endocrinol Metab (2008) 1.99
Effects of aerobic vs. resistance training on visceral and liver fat stores, liver enzymes, and insulin resistance by HOMA in overweight adults from STRRIDE AT/RT. Am J Physiol Endocrinol Metab (2011) 1.91
Cafeteria diet is a robust model of human metabolic syndrome with liver and adipose inflammation: comparison to high-fat diet. Obesity (Silver Spring) (2011) 1.90
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Outcomes for endocarditis surgery in North America: a simplified risk scoring system. J Thorac Cardiovasc Surg (2011) 1.80
beta-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice. J Clin Invest (2009) 1.79
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem (2006) 1.74
Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance. J Biol Chem (2007) 1.73
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med (2005) 1.70
SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. Cell Metab (2013) 1.70
Impact of early renal recovery on survival after cardiac surgery-associated acute kidney injury. Ann Thorac Surg (2010) 1.68
Cognitive function after major noncardiac surgery, apolipoprotein E4 genotype, and biomarkers of brain injury. Anesthesiology (2010) 1.68
Pulse pressure and risk of adverse outcome in coronary bypass surgery. Anesth Analg (2008) 1.67
Ghrelin concentrations in Prader-Willi syndrome (PWS) infants and children: changes during development. Clin Endocrinol (Oxf) (2008) 1.67
The effect of aprotinin on outcome after coronary-artery bypass grafting. N Engl J Med (2008) 1.66
The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab (2012) 1.66
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Efficacy of intravenous patient-controlled analgesia after supratentorial intracranial surgery: a prospective randomized controlled trial. Clinical article. J Neurosurg (2009) 1.64