Published in Mol Cancer Ther on March 01, 2007
DNA hypomethylation in cancer cells. Epigenomics (2009) 3.71
Integrated analysis of DNA methylation and gene expression reveals specific signaling pathways associated with platinum resistance in ovarian cancer. BMC Med Genomics (2009) 1.91
Sulfatase 2 up-regulates glypican 3, promotes fibroblast growth factor signaling, and decreases survival in hepatocellular carcinoma. Hepatology (2008) 1.87
Identification of hypermethylated genes associated with cisplatin resistance in human cancers. Cancer Res (2010) 1.26
SUV420H2-mediated H4K20 trimethylation enforces RNA polymerase II promoter-proximal pausing by blocking hMOF-dependent H4K16 acetylation. Mol Cell Biol (2011) 1.19
Heparin-degrading sulfatases in hepatocellular carcinoma: roles in pathogenesis and therapy targets. Future Oncol (2008) 1.11
Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells. Mutat Res (2010) 1.10
MicroRNA-mediated drug resistance in breast cancer. Clin Epigenetics (2011) 1.06
Drug resistance and the role of combination chemotherapy in improving patient outcomes. Int J Breast Cancer (2013) 1.05
Tissue transglutaminase as a central mediator in inflammation-induced progression of breast cancer. Breast Cancer Res (2013) 1.00
Wnt5A regulates ABCB1 expression in multidrug-resistant cancer cells through activation of the non-canonical PKA/β-catenin pathway. Oncotarget (2014) 0.91
MicroRNA: a prognostic biomarker and a possible druggable target for circumventing multidrug resistance in cancer chemotherapy. J Biomed Sci (2013) 0.90
Tissue transglutaminase: a new target to reverse cancer drug resistance. Amino Acids (2011) 0.89
Troglitazone reverses the multiple drug resistance phenotype in cancer cells. Drug Des Devel Ther (2009) 0.87
Epigenetic changes associated with inflammation in breast cancer patients treated with chemotherapy. Brain Behav Immun (2014) 0.87
Epigenetic modulation of the biophysical properties of drug-resistant cell lipids to restore drug transport and endocytic functions. Mol Pharm (2012) 0.86
Phase I study of azacitidine and oxaliplatin in patients with advanced cancers that have relapsed or are refractory to any platinum therapy. Clin Epigenetics (2015) 0.85
High-definition DNA methylation profiles from breast and ovarian carcinoma cell lines with differing doxorubicin resistance. PLoS One (2010) 0.80
Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors. Clin Epigenetics (2014) 0.80
DNA Methylation and Flavonoids in Genitourinary Cancers. Curr Pharmacol Rep (2015) 0.80
Heterogeneity in mechanisms of emergent resistance in pediatric T-cell acute lymphoblastic leukemia. Oncotarget (2016) 0.78
Prognostic and predictive significance of long interspersed nucleotide element-1 methylation in advanced-stage colorectal cancer. BMC Cancer (2016) 0.76
The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells. Sci Rep (2017) 0.75
High and low dose radiation effects on mammary adenocarcinoma cells - an epigenetic connection. Oncoscience (2016) 0.75
Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells. Cancer Biol Ther (2013) 0.75
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther (2008) 2.85
Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin. Int J Cancer (2010) 2.10
DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res (2007) 1.79
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer (2010) 1.78
Pathogen-induced systemic plant signal triggers DNA rearrangements. Nature (2003) 1.77
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci U S A (2008) 1.62
Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog (2009) 1.61
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect (2010) 1.59
Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice. Lab Invest (2010) 1.59
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr (2002) 1.47
Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues. Cell Cycle (2009) 1.43
Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr (2003) 1.36
Induction of microRNAome deregulation in rat liver by long-term tamoxifen exposure. Mutat Res (2007) 1.34
S-adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc Natl Acad Sci U S A (2004) 1.32
Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res (2005) 1.31
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis (2007) 1.26
Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environ Mol Mutagen (2009) 1.24
Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. J Hepatol (2009) 1.23
Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat (2011) 1.22
Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther (2006) 1.22
Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle (2007) 1.21
Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis. Mutat Res (2010) 1.19
Dose-dependence, sex- and tissue-specificity, and persistence of radiation-induced genomic DNA methylation changes. Biochem Biophys Res Commun (2004) 1.16
In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen. Int J Radiat Oncol Biol Phys (2008) 1.16
Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol Cancer Res (2005) 1.13
The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women. Nutr Res (2007) 1.10
Molecular aspects of plant adaptation to life in the Chernobyl zone. Plant Physiol (2004) 1.09
The role of miRNA in the direct and indirect effects of ionizing radiation. Radiat Environ Biophys (2011) 1.08
Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle (2008) 1.08
Non-targeted radiation effects-an epigenetic connection. Mutat Res (2011) 1.07
Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet. Brain Res (2008) 1.07
Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats. Carcinogenesis (2006) 1.06
MicroRNA-mediated drug resistance in breast cancer. Clin Epigenetics (2011) 1.06
DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle (2008) 1.05
Epigenetic changes in patients with multiple sclerosis. Nat Rev Neurol (2012) 1.05
Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res (2010) 1.04
Genome stability of vtc1, tt4, and tt5 Arabidopsis thaliana mutants impaired in protection against oxidative stress. Plant J (2004) 1.03
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res (2010) 1.03
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis (2006) 1.03
Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicol Mech Methods (2011) 1.03
Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo. Int J Radiat Oncol Biol Phys (2006) 1.03
Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. Toxicol Appl Pharmacol (2012) 1.02
Maternal stress induces epigenetic signatures of psychiatric and neurological diseases in the offspring. PLoS One (2013) 1.00
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci (2010) 1.00
Interstrain differences in the liver effects of trichloroethylene in a multistrain panel of inbred mice. Toxicol Sci (2010) 0.99
Ancestral exposure to stress epigenetically programs preterm birth risk and adverse maternal and newborn outcomes. BMC Med (2014) 0.99
The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation. Toxicol Appl Pharmacol (2009) 0.99
Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun (2008) 0.99
Mechanisms of epigenetic silencing of the Rassf1a gene during estrogen-induced breast carcinogenesis in ACI rats. Carcinogenesis (2009) 0.98
Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression. Carcinogenesis (2009) 0.98
Sex- and tissue-specific expression of maintenance and de novo DNA methyltransferases upon low dose X-irradiation in mice. Biochem Biophys Res Commun (2004) 0.98
Methyl deficiency, alterations in global histone modifications, and carcinogenesis. J Nutr (2007) 0.98
Global leukocyte DNA methylation is similar in African American and Caucasian women under conditions of controlled folate intake. Epigenetics (2007) 0.98
Epigenetic effects of the continuous exposure to peroxisome proliferator WY-14,643 in mouse liver are dependent upon peroxisome proliferator activated receptor alpha. Mutat Res (2007) 0.98
Systemic plant signal triggers genome instability. Plant J (2004) 0.97
Selective brain responses to acute and chronic low-dose X-ray irradiation in males and females. Biochem Biophys Res Commun (2004) 0.96
Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis (2008) 0.96
Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis? Biochem Biophys Res Commun (2005) 0.96
Oxidative stress and antioxidant defenses in goldfish liver in response to short-term exposure to arsenite. Environ Mol Mutagen (2007) 0.96
Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle (2008) 0.95
Crucial role for early growth response-1 in the transcriptional regulation of miR-20b in breast cancer. Oncotarget (2013) 0.94
Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl-deficient diet. Mol Nutr Food Res (2010) 0.94
Transcriptome profiling reveals similarities and differences in plant responses to cadmium and lead. Mutat Res (2005) 0.94
DNA methylation in Folbp1 knockout mice supplemented with folic acid during gestation. J Nutr (2002) 0.93
An in vitro investigation of metabolically sensitive biomarkers in breast cancer progression. Breast Cancer Res Treat (2011) 0.93
Transcriptome analysis reveals fundamental differences in plant response to acute and chronic exposure to ionizing radiation. Mutat Res (2007) 0.93
Sensitivity of human prostate cancer cells to chemotherapeutic drugs depends on EndoG expression regulated by promoter methylation. Cancer Lett (2008) 0.92
Parental enrichment and offspring development: modifications to brain, behavior and the epigenome. Behav Brain Res (2011) 0.92
Molecular mechanisms of fibrosis-associated promotion of liver carcinogenesis. Toxicol Sci (2013) 0.91
Epigenetic downregulation of the suppressor of cytokine signaling 1 (Socs1) gene is associated with the STAT3 activation and development of hepatocellular carcinoma induced by methyl-deficiency in rats. Cell Cycle (2008) 0.91
Intense THz pulses cause H2AX phosphorylation and activate DNA damage response in human skin tissue. Biomed Opt Express (2013) 0.90
Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals. Aging (Albany NY) (2011) 0.90
Micronuclei in genotoxicity assessment: from genetics to epigenetics and beyond. Front Genet (2013) 0.90
Methyl deficiency causes reduction of the methyl-CpG-binding protein, MeCP2, in rat liver. Carcinogenesis (2003) 0.90
Radiation-induced bystander effects in vivo are sex specific. Mutat Res (2008) 0.90
Role of DNA hypomethylation in the development of the resistance to doxorubicin in human MCF-7 breast adenocarcinoma cells. Cancer Lett (2006) 0.90
Increased incidence of aflatoxin B1-induced liver tumors in hepatitis virus C transgenic mice. Int J Cancer (2011) 0.89
Prenatal bystander stress alters brain, behavior, and the epigenome of developing rat offspring. Dev Neurosci (2011) 0.89
Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol (2006) 0.89
Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice. Hepatology (2012) 0.89
Intense THz pulses down-regulate genes associated with skin cancer and psoriasis: a new therapeutic avenue? Sci Rep (2013) 0.88
Acetaminophen-induced acute liver injury in HCV transgenic mice. Toxicol Appl Pharmacol (2012) 0.88