Published in Proc Natl Acad Sci U S A on March 15, 2004
S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev (2012) 1.82
TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase. Development (2009) 1.28
PRPS1 mutations: four distinct syndromes and potential treatment. Am J Hum Genet (2010) 1.26
Adenosine kinase deficiency disrupts the methionine cycle and causes hypermethioninemia, encephalopathy, and abnormal liver function. Am J Hum Genet (2011) 1.14
The emerging use of zebrafish to model metabolic disease. Dis Model Mech (2013) 1.09
S-Adenosylhomocysteine hydrolase deficiency: a second patient, the younger brother of the index patient, and outcomes during therapy. J Inherit Metab Dis (2005) 1.03
S-adenosylhomocysteine hydrolase deficiency in a 26-year-old man. J Inherit Metab Dis (2006) 1.03
Inherited disorders in the conversion of methionine to homocysteine. J Inherit Metab Dis (2009) 0.97
Alu-mediated 100-kb deletion in the primate genome: the loss of the agouti signaling protein gene in the lesser apes. Genome Res (2006) 0.96
A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase. Genetics (2006) 0.93
Adenosine kinase deficiency: expanding the clinical spectrum and evaluating therapeutic options. J Inherit Metab Dis (2015) 0.90
S-adenosyl-L-homocysteine hydrolase and methylation disorders: yeast as a model system. Biochim Biophys Acta (2012) 0.87
Selective targeting of leukemic cell growth in vivo and in vitro using a gene silencing approach to diminish S-adenosylmethionine synthesis. J Biol Chem (2008) 0.87
A single mutation at Tyr143 of human S-adenosylhomocysteine hydrolase renders the enzyme thermosensitive and affects the oxidation state of bound cofactor nicotinamide-adenine dinucleotide. Biochem J (2006) 0.85
Phenylketonuria as a model for protein misfolding diseases and for the development of next generation orphan drugs for patients with inborn errors of metabolism. J Inherit Metab Dis (2010) 0.84
Protein arginine hypomethylation in a mouse model of cystathionine β-synthase deficiency. FASEB J (2014) 0.84
Transmethylation in immunity and autoimmunity. Clin Immunol (2011) 0.84
Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine. Mol Genet Metab (2011) 0.84
Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA). Nutr Metab Cardiovasc Dis (2013) 0.83
S-adenosylhomocysteine hydrolase deficiency: two siblings with fetal hydrops and fatal outcomes. J Inherit Metab Dis (2010) 0.83
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation. J Biol Chem (2014) 0.82
Screening for primary creatine deficiencies in French patients with unexplained neurological symptoms. Orphanet J Rare Dis (2012) 0.82
Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization. J Neurochem (2009) 0.82
Adult-onset liver disease and hepatocellular carcinoma in S-adenosylhomocysteine hydrolase deficiency. Mol Genet Metab (2015) 0.81
Regulation of homocysteine metabolism by Mycobacterium tuberculosis S-adenosylhomocysteine hydrolase. Sci Rep (2013) 0.79
Multi-tissue computational modeling analyzes pathophysiology of type 2 diabetes in MKR mice. PLoS One (2014) 0.78
Downregulation of genes involved in metabolism and oxidative stress in the peripheral leukocytes of Huntington's disease patients. PLoS One (2012) 0.78
Consensus recommendations for the diagnosis, treatment and follow-up of inherited methylation disorders. J Inherit Metab Dis (2016) 0.78
Cannabinoid receptor signaling regulates liver development and metabolism. Development (2016) 0.78
DNA hypermethylation in hyperhomocysteinemia contributes to abnormal extracellular matrix metabolism in the kidney. FASEB J (2015) 0.77
Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: potential roles in toxicity. Toxicol Appl Pharmacol (2009) 0.77
Daily variation in global and local DNA methylation in mouse livers. PLoS One (2015) 0.77
Determinants for the cAMP-binding site at the S-adenosylhomocysteine-hydrolase. Naunyn Schmiedebergs Arch Pharmacol (2009) 0.77
S-adenosylhomocysteine hydrolase (AHCY) deficiency: two novel mutations with lethal outcome. Hum Mutat (2009) 0.76
Cutting back on the essentials: Can manipulating intake of specific amino acids modulate health and lifespan? Ageing Res Rev (2016) 0.76
Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders? JIMD Rep (2016) 0.76
Adenosine kinase deficiency with neurodevelopemental delay and recurrent hepatic dysfunction: A case report. Adv Rare Dis (2016) 0.75
Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency. PLoS One (2016) 0.75
The biochemical and toxicological significance of hypermethionemia: new insights and clinical relevance. Expert Opin Drug Metab Toxicol (2010) 0.75
Exome sequencing in Jewish and Arab patients with rhabdomyolysis reveals single-gene etiology in 43% of cases. Pediatr Nephrol (2017) 0.75
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation. Nat Commun (2017) 0.75
Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products. Nucleic Acids Res (1991) 9.56
Alterations in DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res (1998) 8.95
The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem (1959) 3.05
DNA methylation: past, present and future directions. Carcinogenesis (2000) 2.58
Labile methyl balances for normal humans on various dietary regimens. Metabolism (1975) 2.53
DNA methylation in early development. Hum Mol Genet (1995) 2.45
Quantitation of choline and its metabolites in tissues and foods by liquid chromatography/electrospray ionization-isotope dilution mass spectrometry. Anal Chem (2002) 2.35
Formation of methylation patterns in the mammalian genome. Mutat Res (1997) 1.88
Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood (1993) 1.80
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem Biophys Res Commun (1999) 1.77
Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism (1993) 1.66
Biological effects of inhibitors of S-adenosylhomocysteine hydrolase. Pharmacol Ther (1998) 1.61
Effect of hyperhomocysteinemia on plasma or tissue adenosine levels and renal function. Circulation (2002) 1.54
Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circ Res (2001) 1.50
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr (2002) 1.47
Creatine deficiency in the brain: a new, treatable inborn error of metabolism. Pediatr Res (1994) 1.47
In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients. J Clin Invest (1979) 1.47
Glycine N -methyltransferase deficiency: a new patient with a novel mutation. J Inherit Metab Dis (2003) 1.44
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia. J Inherit Metab Dis (2001) 1.42
Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem (1998) 1.37
Labile methyl group balances in the human: the role of sarcosine. Metabolism (1980) 1.34
Structure and function of S-adenosylhomocysteine hydrolase. Cell Biochem Biophys (2000) 1.29
Quantitation of total homocysteine, total cysteine, and methionine in normal serum and urine using capillary gas chromatography-mass spectrometry. Anal Biochem (1987) 1.25
The mouse lethal nonagouti (a(x)) mutation deletes the S-adenosylhomocysteine hydrolase (Ahcy) gene. EMBO J (1994) 1.17
Measurement of plasma S-adenosylmethionine and S-adenosylhomocysteine as their fluorescent isoindoles. Anal Biochem (1998) 1.17
Relationship between tissue levels of S-adenosylmethionine, S-adenylhomocysteine, and transmethylation reactions. Can J Biochem (1979) 1.15
Plasma homocysteine is regulated by phospholipid methylation. J Biol Chem (2002) 1.14
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet (2001) 1.12
Isolated persistent hypermethioninemia. Am J Hum Genet (1995) 1.11
Plasma S-adenosylhomocysteine is a more sensitive indicator of cardiovascular disease than plasma homocysteine. Am J Clin Nutr (2001) 1.11
Choline deficiency-induced liver damage is reversible in Pemt(-/-) mice. J Nutr (2002) 1.10
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism (2002) 1.08
Highlights in the development of new antiviral agents. Mini Rev Med Chem (2002) 1.06
Improving treatment of guanidinoacetate methyltransferase deficiency: reduction of guanidinoacetic acid in body fluids by arginine restriction and ornithine supplementation. Mol Genet Metab (2001) 1.05
Creatine deficiency syndromes. Mol Cell Biochem (2003) 1.02
Total homocysteine in pediatric patients. Clin Chem (1997) 0.97
Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals. Metabolism (1992) 0.94
Methioninemia and myopathy: a new disorder. Ann Neurol (1981) 0.91
Copper binding to mouse liver S-adenosylhomocysteine hydrolase and the effects of copper on its levels. J Biol Chem (1995) 0.88
Disturbed ratio of erythrocyte and plasma S-adenosylmethionine/S-adenosylhomocysteine in peripheral arterial occlusive disease. Atherosclerosis (2001) 0.86
Influence of methylenetetrahydrofolate reductase genotype, age, vitamin B-12, and folate status on plasma homocysteine in children. Am J Clin Nutr (2000) 0.84
Familial hypermethioninemia partially responsive to dietary restriction. J Pediatr (1990) 0.84
Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase. J Biol Chem (1995) 0.83
Interrelations between plasma homocysteine and intracellular S-adenosylhomocysteine. Biochem Biophys Res Commun (2000) 0.82
Reference ranges for total homocysteine in children. Clin Chim Acta (1997) 0.80
Isolated hypermethioninemia: measurements of S-adenosylmethionine and choline. Metabolism (2000) 0.80
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (2008) 2.91
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin. Mol Cancer Ther (2008) 2.85
Homocysteine and the risk of ischemic stroke in a triethnic cohort: the NOrthern MAnhattan Study. Stroke (2004) 2.76
Resuscitation of newborn infants with 100% oxygen or air: a systematic review and meta-analysis. Lancet (2004) 2.74
Enlargement of the spinal cord: inflammation or neoplasm? Clin Neurol Neurosurg (2005) 2.27
Median nerve superficial to the transverse carpal ligament. Orthopedics (2015) 1.97
Total homocysteine is associated with white matter hyperintensity volume: the Northern Manhattan Study. Stroke (2005) 1.91
Steroid profiling by tandem mass spectrometry improves the positive predictive value of newborn screening for congenital adrenal hyperplasia. J Clin Endocrinol Metab (2004) 1.91
Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex (2002) 1.89
A mathematical model gives insights into nutritional and genetic aspects of folate-mediated one-carbon metabolism. J Nutr (2006) 1.82
E-cadherin transcriptional down-regulation by epigenetic and microRNA-200 family alterations is related to mesenchymal and drug-resistant phenotypes in human breast cancer cells. Int J Cancer (2010) 1.78
Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr (2007) 1.76
Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice. J Biol Chem (2008) 1.73
Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas. Oncogene (2003) 1.64
Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci U S A (2008) 1.62
Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog (2009) 1.61
Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect (2010) 1.59
Glycine N-methyltransferase and regulation of S-adenosylmethionine levels. J Biol Chem (2009) 1.55
Regulation of methylbenzoate emission after pollination in snapdragon and petunia flowers. Plant Cell (2003) 1.54
Survival and major neonatal complications in infants born between 22 0/7 and 24 6/7 weeks of gestation (1999-2003). Am J Obstet Gynecol (2006) 1.53
Shmt1 and de novo thymidylate biosynthesis underlie folate-responsive neural tube defects in mice. Am J Clin Nutr (2011) 1.53
Hepatitis B virus hepatotropism is mediated by specific receptor recognition in the liver and not restricted to susceptible hosts. Hepatology (2013) 1.52
Homocysteine and methylmalonic acid: markers to predict and avoid toxicity from pemetrexed therapy. Mol Cancer Ther (2002) 1.51
Learning curve and fatigue effect of flicker defined form perimetry. Am J Ophthalmol (2011) 1.49
Elevation in S-adenosylhomocysteine and DNA hypomethylation: potential epigenetic mechanism for homocysteine-related pathology. J Nutr (2002) 1.47
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol (2004) 1.47
Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Ann Neurol (2005) 1.46
Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr (2004) 1.46
Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
Biomarkers of folate status in NHANES: a roundtable summary. Am J Clin Nutr (2011) 1.43
MKS3/TMEM67 mutations are a major cause of COACH Syndrome, a Joubert Syndrome related disorder with liver involvement. Hum Mutat (2009) 1.43
Adenosine kinase deficiency is associated with developmental abnormalities and reduced transmethylation. Plant Physiol (2002) 1.43
Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics (2004) 1.42
Comparing McRoberts' and Rubin's maneuvers for initial management of shoulder dystocia: an objective evaluation. Am J Obstet Gynecol (2005) 1.40
Episiotomy versus fetal manipulation in managing severe shoulder dystocia: a comparison of outcomes. Am J Obstet Gynecol (2004) 1.39
Metabolic imbalance associated with methylation dysregulation and oxidative damage in children with autism. J Autism Dev Disord (2012) 1.38
Increased levels of antimicrobial peptides in tracheal aspirates of newborn infants during infection. Am J Respir Crit Care Med (2002) 1.38
Mechanisms of DNA damage, DNA hypomethylation, and tumor progression in the folate/methyl-deficient rat model of hepatocarcinogenesis. J Nutr (2003) 1.36
Isolated hypoglossal nerve palsy: a diagnostic challenge. Eur Neurol (2007) 1.36
Vitamin B12, homocysteine and carotid plaque in the era of folic acid fortification of enriched cereal grain products. CMAJ (2005) 1.34
Megalencephalic leukoencephalopathy with subcortical cysts: an update and extended mutation analysis of MLC1. Hum Mutat (2006) 1.34
Congenital heart defects and abnormal maternal biomarkers of methionine and homocysteine metabolism. Am J Clin Nutr (2005) 1.33
Methyl balance and transmethylation fluxes in humans. Am J Clin Nutr (2007) 1.33
Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency. Mutat Res (2005) 1.31
A mathematical model of glutathione metabolism. Theor Biol Med Model (2008) 1.30
Liquid chromatography-mass spectrometry-based parallel metabolic profiling of human and mouse model serum reveals putative biomarkers associated with the progression of nonalcoholic fatty liver disease. J Proteome Res (2010) 1.29
High homocysteine and thrombosis without connective tissue disorders are associated with a novel class of cystathionine beta-synthase (CBS) mutations. Hum Mutat (2002) 1.29
Zinc, gravida, infection, and iron, but not vitamin B-12 or folate status, predict hemoglobin during pregnancy in Southern Ethiopia. J Nutr (2008) 1.29
Folate deficiency disturbs hepatic methionine metabolism and promotes liver injury in the ethanol-fed micropig. Proc Natl Acad Sci U S A (2002) 1.28
Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis (2007) 1.26
Role of ferritin alterations in human breast cancer cells. Breast Cancer Res Treat (2011) 1.22
Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyltransferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther (2006) 1.22
Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression. Cell Cycle (2007) 1.21
Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples. Proteomics Clin Appl (2010) 1.21
Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol Endocrinol (2004) 1.21
Quantification of serum and urinary S-adenosylmethionine and S-adenosylhomocysteine by stable-isotope-dilution liquid chromatography-mass spectrometry. Clin Chem (2003) 1.20
Changes in S-adenosylmethionine and GSH homeostasis during endotoxemia in mice. Lab Invest (2008) 1.19
The Arabidopsis HOMOLOGY-DEPENDENT GENE SILENCING1 gene codes for an S-adenosyl-L-homocysteine hydrolase required for DNA methylation-dependent gene silencing. Plant Cell (2005) 1.18
Nutrient intake from food in children with autism. Pediatrics (2012) 1.18
Cancer cachexia syndrome in head and neck cancer patients: part I. Diagnosis, impact on quality of life and survival, and treatment. Head Neck (2007) 1.18
Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr (2012) 1.17
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A (2003) 1.17
Genomic hypomethylation is specific for preneoplastic liver in folate/methyl deficient rats and does not occur in non-target tissues. Mutat Res (2004) 1.16
Transient fulminant liver failure as an initial presentation in citrullinemia type I. Mol Genet Metab (2010) 1.15
Mthfd1 is an essential gene in mice and alters biomarkers of impaired one-carbon metabolism. J Biol Chem (2008) 1.14
Versatility in corrinoid salvaging and remodeling pathways supports corrinoid-dependent metabolism in Dehalococcoides mccartyi. Appl Environ Microbiol (2012) 1.14
Epigenetic profiling of multidrug-resistant human MCF-7 breast adenocarcinoma cells reveals novel hyper- and hypomethylated targets. Mol Cancer Ther (2007) 1.13
Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood (2004) 1.13
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism. Hum Genet (2001) 1.12
Towards high-throughput metabolomics using ultrahigh-field Fourier transform ion cyclotron resonance mass spectrometry. Metabolomics (2008) 1.12
Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency. Mol Genet Metab (2009) 1.12
Structural, immunocytochemical, and mr imaging properties of periventricular crossroads of growing cortical pathways in preterm infants. AJNR Am J Neuroradiol (2005) 1.11
An overview of L-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study. Hum Mutat (2010) 1.11
Long-range allosteric interactions between the folate and methionine cycles stabilize DNA methylation reaction rate. Epigenetics (2006) 1.11
The MTHFR 677TT genotype and folate intake interact to lower global leukocyte DNA methylation in young Mexican American women. Nutr Res (2007) 1.10
Genome hypermethylation in Pinus silvestris of Chernobyl--a mechanism for radiation adaptation? Mutat Res (2003) 1.09
Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency. Metabolism (2002) 1.08
Mathematical modeling of folate metabolism: predicted effects of genetic polymorphisms on mechanisms and biomarkers relevant to carcinogenesis. Cancer Epidemiol Biomarkers Prev (2008) 1.08
Propionyl-CoA and adenosylcobalamin metabolism in Caenorhabditis elegans: evidence for a role of methylmalonyl-CoA epimerase in intermediary metabolism. Mol Genet Metab (2006) 1.06
MicroRNA-mediated drug resistance in breast cancer. Clin Epigenetics (2011) 1.06
Elevation of guanidinoacetate in newborn dried blood spots and impact of early treatment in GAMT deficiency. Mol Genet Metab (2013) 1.05
A revisit to the natural history of homocystinuria due to cystathionine beta-synthase deficiency. Mol Genet Metab (2010) 1.04
HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology (2010) 1.04
Prevention of brain disease from severe 5,10-methylenetetrahydrofolate reductase deficiency. Mol Genet Metab (2007) 1.04
L-2-Hydroxyglutaric aciduria: pattern of MR imaging abnormalities in 56 patients. Radiology (2009) 1.04
Dextromethorphan is effective in the treatment of subacute methotrexate neurotoxicity. Pediatr Hematol Oncol (2002) 1.03
Effect of long-term tamoxifen exposure on genotoxic and epigenetic changes in rat liver: implications for tamoxifen-induced hepatocarcinogenesis. Carcinogenesis (2006) 1.03
Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res (2010) 1.03
Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment. Mol Genet Metab (2010) 1.03
Serum methionine metabolites are risk factors for metastatic prostate cancer progression. PLoS One (2011) 1.03
Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicol Mech Methods (2011) 1.03
Health implications of creatine: can oral creatine supplementation protect against neurological and atherosclerotic disease? Neuroscience (2002) 1.02