Published in Mol Cell Neurosci on February 12, 2007
Substrate-targeting gamma-secretase modulators. Nature (2008) 3.38
Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration. Proc Natl Acad Sci U S A (2011) 3.11
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio. EMBO J (2010) 2.26
Amyloid beta from axons and dendrites reduces local spine number and plasticity. Nat Neurosci (2009) 2.18
Protein aggregation in the brain: the molecular basis for Alzheimer's and Parkinson's diseases. Mol Med (2008) 1.90
Alzheimer's disease: synaptic dysfunction and Abeta. Mol Neurodegener (2009) 1.73
Synapses and Alzheimer's disease. Cold Spring Harb Perspect Biol (2012) 1.57
Toxic fibrillar oligomers of amyloid-β have cross-β structure. Proc Natl Acad Sci U S A (2012) 1.53
Molecular mechanisms of dendrite stability. Nat Rev Neurosci (2013) 1.44
Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility. Mol Neurodegener (2015) 1.40
Synaptic activity reduces intraneuronal Abeta, promotes APP transport to synapses, and protects against Abeta-related synaptic alterations. J Neurosci (2009) 1.37
Beta amyloid oligomers and fibrils stimulate differential activation of primary microglia. J Neuroinflammation (2009) 1.32
Structure-function relationships of pre-fibrillar protein assemblies in Alzheimer's disease and related disorders. Curr Alzheimer Res (2008) 1.26
The PI3K-Akt-mTOR pathway regulates Abeta oligomer induced neuronal cell cycle events. Mol Neurodegener (2009) 1.23
Inconsistencies and controversies surrounding the amyloid hypothesis of Alzheimer's disease. Acta Neuropathol Commun (2014) 1.16
Aβ oligomers inhibit synapse remodelling necessary for memory consolidation. Neurobiol Aging (2010) 1.14
Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci (2012) 1.06
Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS One (2009) 1.05
Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh Migr (2009) 1.05
Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity. Biochemistry (2014) 1.00
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic (2012) 0.98
Seroprevalence of N-methyl-D-aspartate glutamate receptor (NMDA-R) autoantibodies in aging subjects without neuropsychiatric disorders and in dementia patients. Eur Arch Psychiatry Clin Neurosci (2014) 0.97
Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease. J Neurosci (2012) 0.96
Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci (2014) 0.95
New developments on the role of NMDA receptors in Alzheimer's disease. Curr Opin Neurobiol (2011) 0.93
The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models. Exp Brain Res (2011) 0.92
Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet (2012) 0.89
Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits. PLoS One (2014) 0.85
Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction. J Neurosci (2013) 0.85
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PLoS One (2011) 0.84
Advances on the understanding of the origins of synaptic pathology in AD. Curr Genomics (2007) 0.83
Chemical and morphological alterations of spines within the hippocampus and entorhinal cortex precede the onset of Alzheimer's disease pathology in double knock-in mice. J Comp Neurol (2007) 0.82
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci (2012) 0.81
A new player in the "synaptopathy" of Alzheimer's disease - arc/arg 3.1. Front Neurol (2013) 0.81
Impairment of adolescent hippocampal plasticity in a mouse model for Alzheimer's disease precedes disease phenotype. PLoS One (2008) 0.80
Protective effect of tetrahydroxy stilbene glucoside on learning and memory by regulating synaptic plasticity. Neural Regen Res (2016) 0.77
A new Mint1 isoform, but not the conventional Mint1, interacts with the small GTPase Rab6. PLoS One (2013) 0.76
The Emergence of NMDA Receptor Metabotropic Function: Insights from Imaging. Front Synaptic Neurosci (2016) 0.76
Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors. Clin Psychopharmacol Neurosci (2017) 0.75
Phenotypic assays for β-amyloid in mouse embryonic stem cell-derived neurons. Chem Biol (2013) 0.75
Regulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in Disease. Neural Plast (2016) 0.75
Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization. Sci Rep (2017) 0.75
Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature (2002) 19.36
Alzheimer's disease is a synaptic failure. Science (2002) 13.82
Natural oligomers of the amyloid-beta protein specifically disrupt cognitive function. Nat Neurosci (2004) 9.73
Regulation of NMDA receptor trafficking by amyloid-beta. Nat Neurosci (2005) 9.17
AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron (2006) 6.76
Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci (2007) 6.27
Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci (2004) 5.10
Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med (2006) 5.09
Evidence that production and release of amyloid beta-protein involves the endocytic pathway. J Biol Chem (1994) 4.78
Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. Neuron (1996) 4.75
Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci (2005) 4.71
Rapid actin-based plasticity in dendritic spines. Neuron (1998) 4.70
Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol (2006) 3.74
Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci U S A (2006) 3.61
Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Res (2002) 2.88
Aggregation of secreted amyloid beta-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem (1995) 2.68
Plasma and cerebrospinal fluid levels of amyloid beta proteins 1-40 and 1-42 in Alzheimer disease. Arch Neurol (2000) 2.66
Reduction of beta-amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease. Ann Neurol (1995) 2.62
Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition. Biochem Soc Trans (2002) 2.55
Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A (1999) 2.53
Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron (2005) 2.53
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci (2006) 2.47
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease. J Neuropathol Exp Neurol (1997) 2.43
Dendrite and dendritic spine alterations in Alzheimer models. J Neurocytol (2004) 1.99
Detection of single amyloid beta-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat Med (1998) 1.89
Dendritic spine loss in the hippocampus of young PDAPP and Tg2576 mice and its prevention by the ApoE2 genotype. Neurobiol Dis (2003) 1.88
The synaptic Abeta hypothesis of Alzheimer disease. Nat Neurosci (2005) 1.68
Neuritic plaques in senile dementia of Alzheimer type: a Golgi analysis in the hippocampal region. Brain Res (1983) 1.60
Fast, convenient, and effective method to transiently transfect primary hippocampal neurons. J Neurosci Res (1999) 1.50
Current pharmacotherapy for Alzheimer's disease. Annu Rev Med (2006) 1.45
Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease. Biol Psychiatry (2004) 1.45
The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease. CNS Drug Rev (2003) 1.40
Amyloid beta peptide adversely affects spine number and motility in hippocampal neurons. Mol Cell Neurosci (2006) 1.28
Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope. Pharmacol Res (2005) 1.28
Down's syndrome and Alzheimer's disease: dendritic spine counts in the hippocampus. Acta Neuropathol (1990) 1.23
Neurochemical dissection of synaptic pathology in Alzheimer's disease. Int Psychogeriatr (1998) 1.18
The role of nicotinic acetylcholine receptors in Alzheimer's disease. J Physiol Paris (2006) 1.11
The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiol Aging (2005) 1.09
Targeting the alpha 7 nicotinic acetylcholine receptor to reduce amyloid accumulation in Alzheimer's disease pyramidal neurons. Curr Pharm Des (2006) 1.09
The ups and downs of Abeta. Nat Med (2006) 1.04
Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques. J Neurosci (1994) 1.01
Absence of synaptophysin near cortical neurons containing oligomer Abeta in Alzheimer's disease brain. J Neurosci Res (2006) 0.91
The role of synaptic proteins in Alzheimer's disease. Ann N Y Acad Sci (2000) 0.87
Alois Alzheimer and Alzheimer's disease: a centennial perspective. J Neurochem (2006) 0.85
The acoustic cortex in Alzheimer's disease. Acta Otolaryngol Suppl (1992) 0.80
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet (2011) 10.07
Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature (2012) 5.47
Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell (2002) 5.15
Amyloid precursor protein trafficking, processing, and function. J Biol Chem (2008) 4.79
Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med (2009) 4.11
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med (2005) 4.00
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest (2003) 3.50
Substrate-targeting gamma-secretase modulators. Nature (2008) 3.38
The MAP2/Tau family of microtubule-associated proteins. Genome Biol (2004) 2.80
Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron (2011) 2.67
Essential role for the PKC target MARCKS in maintaining dendritic spine morphology. Neuron (2005) 2.53
Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell (2002) 2.37
Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem (2003) 2.31
Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology (2012) 2.08
MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J Cell Biol (2002) 2.04
The amyloid precursor protein: beyond amyloid. Mol Neurodegener (2006) 1.98
Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One (2008) 1.84
The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J (2002) 1.79
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci (2004) 1.79
Development and regulation of dendritic spine synapses. Physiology (Bethesda) (2006) 1.71
Actin and microtubules in neurite initiation: are MAPs the missing link? J Neurobiol (2004) 1.68
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem (2005) 1.61
Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system. Proc Natl Acad Sci U S A (2009) 1.60
Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener (2011) 1.58
Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci (2006) 1.52
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci (2007) 1.48
Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem (2002) 1.46
Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord (2007) 1.44
Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem (2003) 1.40
Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol (2003) 1.36
γ-Secretase inhibitors and modulators. Biochim Biophys Acta (2013) 1.32
The role of microtubule-associated protein 2c in the reorganization of microtubules and lamellipodia during neurite initiation. J Neurosci (2003) 1.26
Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem (2009) 1.25
Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem (2009) 1.25
Mechanosensitivity of N-type calcium channel currents. Biophys J (2002) 1.24
MAP2c, but not tau, binds and bundles F-actin via its microtubule binding domain. Curr Biol (2004) 1.22
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron (2013) 1.21
Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem (2007) 1.20
Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol (2005) 1.17
Insulin causes hyperthermia by direct inhibition of warm-sensitive neurons. Diabetes (2009) 1.16
Ceramide mediates the rapid phase of febrile response to IL-1beta. Proc Natl Acad Sci U S A (2006) 1.16
alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem (2009) 1.15
Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem (2008) 1.13
Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J (2007) 1.12
A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB J (2009) 1.12
Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nat Commun (2010) 1.10
Histamine influences body temperature by acting at H1 and H3 receptors on distinct populations of preoptic neurons. J Neurosci (2010) 1.09
Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem (2008) 1.07
Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci (2012) 1.06
Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem (2003) 1.04
NeuriteQuant: an open source toolkit for high content screens of neuronal morphogenesis. BMC Neurosci (2011) 1.04
A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis (2002) 1.04
Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci (2013) 1.01
The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol (2014) 0.98
Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB J (2012) 0.98
Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic (2012) 0.98
Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. J Biol Chem (2011) 0.97
The protein phosphatase PP2A/Bα binds to the microtubule-associated proteins Tau and MAP2 at a motif also recognized by the kinase Fyn: implications for tauopathies. J Biol Chem (2012) 0.96
A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol (2005) 0.95
Night eating and obesity in the EP3R-deficient mouse. Proc Natl Acad Sci U S A (2007) 0.94
Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem (2005) 0.94
C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis (2008) 0.93
Insulin-like growth factor 1-mediated hyperthermia involves anterior hypothalamic insulin receptors. J Biol Chem (2011) 0.91
Tropomodulins are negative regulators of neurite outgrowth. Eur J Cell Biol (2010) 0.91
The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A (2002) 0.91
Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry (2013) 0.90
Cathepsin B-like proteolysis and MARCKS degradation in sub-lethal NMDA-induced collapse of dendritic spines. Neuropharmacology (2004) 0.90
Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun (2009) 0.89
Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem (2005) 0.89
Kv4.2 mediates histamine modulation of preoptic neuron activity and body temperature. PLoS One (2011) 0.86
Actin in a supporting role. Nat Neurosci (2003) 0.86
The endocytotic pathway is required for increased A beta 42 secretion during apoptosis. Brain Res Mol Brain Res (2004) 0.84
Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol (2015) 0.84
Steroids as γ-secretase modulators. FASEB J (2013) 0.82
Emerging therapeutics for Alzheimer's disease. Annu Rev Pharmacol Toxicol (2014) 0.81
Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c. Cell Motil Cytoskeleton (2007) 0.81
Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci (2012) 0.81
And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A (2010) 0.81
Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry (2014) 0.81
To think or not to think: synaptic activity and Abeta release. Neuron (2005) 0.80
Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. J Neurochem (2012) 0.80
Nascent structure in the kinase anchoring domain of microtubule-associated protein 2. Biochem Biophys Res Commun (2003) 0.79
Neurite outgrowth: a flick of the wrist. Curr Biol (2007) 0.77
Lithium prevents aberrant NMDA-induced F-actin reorganization in neurons. Neuroreport (2014) 0.76
The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis? Bioessays (2013) 0.75