PubRank

Edward H Koo

Author PubWeight™ 107.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 2011 10.07
2 Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature 2012 5.47
3 Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell 2002 5.15
4 Amyloid precursor protein trafficking, processing, and function. J Biol Chem 2008 4.79
5 Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nat Med 2009 4.11
6 Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med 2005 4.00
7 NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 2003 3.50
8 Substrate-targeting gamma-secretase modulators. Nature 2008 3.38
9 Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift. Neuron 2011 2.67
10 Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis. Cell 2002 2.37
11 Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J Biol Chem 2003 2.31
12 Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology 2012 2.08
13 The amyloid precursor protein: beyond amyloid. Mol Neurodegener 2006 1.98
14 The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processing. EMBO J 2002 1.79
15 FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor protein. J Neurosci 2004 1.79
16 Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem 2005 1.61
17 Biology and pathophysiology of the amyloid precursor protein. Mol Neurodegener 2011 1.58
18 Deficits in synaptic transmission and learning in amyloid precursor protein (APP) transgenic mice require C-terminal cleavage of APP. J Neurosci 2006 1.52
19 Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem 2003 1.49
20 Chronic administration of R-flurbiprofen attenuates learning impairments in transgenic amyloid precursor protein mice. BMC Neurosci 2007 1.48
21 Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein. Mol Cell Neurosci 2007 1.48
22 Caspase cleavage of members of the amyloid precursor family of proteins. J Neurochem 2002 1.46
23 Safety, tolerability, pharmacokinetics, and Abeta levels after short-term administration of R-flurbiprofen in healthy elderly individuals. Alzheimer Dis Assoc Disord 2007 1.44
24 Caspase cleavage of the amyloid precursor protein modulates amyloid beta-protein toxicity. J Neurochem 2003 1.40
25 Amyloid beta protein toxicity mediated by the formation of amyloid-beta protein precursor complexes. Ann Neurol 2003 1.36
26 γ-Secretase inhibitors and modulators. Biochim Biophys Acta 2013 1.32
27 Novel role of RanBP9 in BACE1 processing of amyloid precursor protein and amyloid beta peptide generation. J Biol Chem 2009 1.25
28 Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem 2009 1.25
29 Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway. Neuron 2013 1.21
30 Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations. J Biol Chem 2007 1.20
31 Perturbed neurogenesis in the adult hippocampus associated with presenilin-1 A246E mutation. Am J Pathol 2005 1.17
32 alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation. J Neurochem 2009 1.15
33 Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase. J Biol Chem 2008 1.13
34 Low-density lipoprotein receptor-related protein promotes amyloid precursor protein trafficking to lipid rafts in the endocytic pathway. FASEB J 2007 1.12
35 A fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation. FASEB J 2009 1.12
36 Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site. Nat Commun 2010 1.10
37 Formation of Pmel17 amyloid is regulated by juxtamembrane metalloproteinase cleavage, and the resulting C-terminal fragment is a substrate for gamma-secretase. J Biol Chem 2008 1.07
38 Amyloid precursor protein (APP) regulates synaptic structure and function. Mol Cell Neurosci 2012 1.06
39 Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem 2003 1.04
40 A role for presenilin 1 in regulating the delivery of amyloid precursor protein to the cell surface. Neurobiol Dis 2002 1.04
41 Early BDNF treatment ameliorates cell loss in the entorhinal cortex of APP transgenic mice. J Neurosci 2013 1.01
42 Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region. J Biol Chem 2011 1.01
43 Role of RanBP9 on amyloidogenic processing of APP and synaptic protein levels in the mouse brain. FASEB J 2012 0.98
44 The multifaceted nature of amyloid precursor protein and its proteolytic fragments: friends and foes. Acta Neuropathol 2014 0.98
45 Early and selective impairments in axonal transport kinetics of synaptic cargoes induced by soluble amyloid β-protein oligomers. Traffic 2012 0.98
46 Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein. J Biol Chem 2011 0.97
47 A pilot proteomic study of amyloid precursor interactors in Alzheimer's disease. Ann Neurol 2005 0.95
48 Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signaling. J Biol Chem 2005 0.94
49 Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42. J Neurochem 2005 0.94
50 C-terminal cleavage of the amyloid-beta protein precursor at Asp664: a switch associated with Alzheimer's disease. J Alzheimers Dis 2008 0.93
51 The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production. J Biol Chem 2003 0.92
52 The aspartate-257 of presenilin 1 is indispensable for mouse development and production of beta-amyloid peptides through beta-catenin-independent mechanisms. Proc Natl Acad Sci U S A 2002 0.91
53 Prevalence of cognitive impairment in Chinese: epidemiology of dementia in Singapore study. J Neurol Neurosurg Psychiatry 2013 0.90
54 Mechanism of cytotoxicity mediated by the C31 fragment of the amyloid precursor protein. Biochem Biophys Res Commun 2009 0.89
55 Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem 2005 0.89
56 The endocytotic pathway is required for increased A beta 42 secretion during apoptosis. Brain Res Mol Brain Res 2004 0.84
57 Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol 2015 0.84
58 Steroids as γ-secretase modulators. FASEB J 2013 0.82
59 And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A 2010 0.81
60 Complex relationships between substrate sequence and sensitivity to alterations in γ-secretase processivity induced by γ-secretase modulators. Biochemistry 2014 0.81
61 Emerging therapeutics for Alzheimer's disease. Annu Rev Pharmacol Toxicol 2014 0.81
62 Deletion of the amyloid precursor-like protein 2 (APLP2) does not affect hippocampal neuron morphology or function. Mol Cell Neurosci 2012 0.81
63 Asp664 cleavage of amyloid precursor protein induces tau phosphorylation by decreasing protein phosphatase 2A activity. J Neurochem 2012 0.80
64 To think or not to think: synaptic activity and Abeta release. Neuron 2005 0.80
65 The--YENPTY--domain of the amyloid precursor protein: much more than just endocytosis? Bioessays 2013 0.75