Lysine 624 of the amyloid precursor protein (APP) is a critical determinant of amyloid β peptide length: support for a sequential model of γ-secretase intramembrane proteolysis and regulation by the amyloid β precursor protein (APP) juxtamembrane region.

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Published in J Biol Chem on August 25, 2011

Authors

Thomas L Kukar1, Thomas B Ladd, Paul Robertson, Sean A Pintchovski, Brenda Moore, Maralyssa A Bann, Zhao Ren, Karen Jansen-West, Kim Malphrus, Simone Eggert, Hiroko Maruyama, Barbara A Cottrell, Pritam Das, Guriqbal S Basi, Edward H Koo, Todd E Golde

Author Affiliations

1: Emory University, School of Medicine, Department of Pharmacology, Center for Neurodegenerative Disease, Atlanta, Georgia 30322, USA. tkukar@emory.edu

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