Greener approaches to organic synthesis using microreactor technology.

PubWeight™: 1.97‹?› | Rank: Top 2%

🔗 View Article (PMID 17373852)

Published in Chem Rev on March 21, 2007

Authors

Brian P Mason1, Kristin E Price, Jeremy L Steinbacher, Andrew R Bogdan, D Tyler McQuade

Author Affiliations

1: Cornell University, Department of Chemistry and Chemical Biology, Baker Laboratory, Ithaca, New York 14853-1301, USA.

Articles citing this

Flow photochemistry: Old light through new windows. Beilstein J Org Chem (2012) 1.25

Asymmetric reactions in continuous flow. Beilstein J Org Chem (2009) 1.23

Accelerating palladium-catalyzed C-F bond formation: use of a microflow packed-bed reactor. Angew Chem Int Ed Engl (2011) 1.18

The development and evaluation of a continuous flow process for the lipase-mediated oxidation of alkenes. Beilstein J Org Chem (2009) 1.02

Fully automated continuous flow synthesis of highly functionalized imidazo[1,2-a] heterocycles. Org Lett (2010) 0.98

Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis. Beilstein J Org Chem (2012) 0.98

An integrated microfluidic device for large-scale in situ click chemistry screening. Lab Chip (2009) 0.95

Rapid and efficient trifluoromethylation of aromatic and heteroaromatic compounds using potassium trifluoroacetate enabled by a flow system. Angew Chem Int Ed Engl (2013) 0.95

Rapid multistep synthesis of 1,2,4-oxadiazoles in a single continuous microreactor sequence. J Org Chem (2008) 0.89

Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline. Beilstein J Org Chem (2011) 0.86

Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters. Beilstein J Org Chem (2009) 0.86

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions. Beilstein J Org Chem (2011) 0.85

Radicals: Reactive Intermediates with Translational Potential. J Am Chem Soc (2016) 0.83

Triple-channel microreactor for biphasic gas-liquid reactions: Photosensitized oxygenations. Beilstein J Org Chem (2011) 0.82

Rapid catalyst screening by a continuous-flow microreactor interfaced with ultra-high-pressure liquid chromatography. J Org Chem (2010) 0.82

Continuous-flow hydration-condensation reaction: Synthesis of α,β-unsaturated ketones from alkynes and aldehydes by using a heterogeneous solid acid catalyst. Beilstein J Org Chem (2011) 0.82

Flow "Fine" Synthesis: High Yielding and Selective Organic Synthesis by Flow Methods. Chem Asian J (2015) 0.82

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactor. Beilstein J Org Chem (2009) 0.82

Synthesis of homo- and heteromultivalent carbohydrate-functionalized oligo(amidoamines) using novel glyco-building blocks. Beilstein J Org Chem (2013) 0.81

Miniaturization in biocatalysis. Int J Mol Sci (2010) 0.80

Synthesis and immunological evaluation of protein conjugates of Neisseria meningitidis X capsular polysaccharide fragments. Beilstein J Org Chem (2014) 0.80

Coupled chemo(enzymatic) reactions in continuous flow. Beilstein J Org Chem (2011) 0.79

Continuous proline catalysis via leaching of solid proline. Beilstein J Org Chem (2011) 0.79

Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups. Beilstein J Org Chem (2009) 0.79

Homocoupling of aryl halides in flow: Space integration of lithiation and FeCl(3) promoted homocoupling. Beilstein J Org Chem (2011) 0.78

Acid-mediated reactions under microfluidic conditions: a new strategy for practical synthesis of biofunctional natural products. Beilstein J Org Chem (2009) 0.78

Koch-Haaf reaction of adamantanols in an acid-tolerant hastelloy-made microreactor. Beilstein J Org Chem (2011) 0.78

Scaling up of continuous-flow, microwave-assisted, organic reactions by varying the size of Pd-functionalized catalytic monoliths. Beilstein J Org Chem (2011) 0.78

Acid, silver, and solvent-free gold-catalyzed hydrophenoxylation of internal alkynes. Beilstein J Org Chem (2013) 0.78

Continuous flow synthesis of ZSM-5 zeolite on the order of seconds. Proc Natl Acad Sci U S A (2016) 0.77

Continuous preparation of carbon-nanotube-supported platinum catalysts in a flow reactor directly heated by electric current. Beilstein J Org Chem (2011) 0.76

Flow invariant droplet formation for stable parallel microreactors. Nat Commun (2016) 0.76

Controlled synthesis of poly(3-hexylthiophene) in continuous flow. Beilstein J Org Chem (2013) 0.75

Investigating the continuous synthesis of a nicotinonitrile precursor to nevirapine. Beilstein J Org Chem (2013) 0.75

Development of an Intermittent-Flow Enantioselective Aza-Henry Reaction Using an Arylnitromethane and Homogeneous Brønsted Acid-Base Catalyst with Recycle. Org Process Res Dev (2016) 0.75

Continuous-flow reactor-based synthesis of carbohydrate and dihydrolipoic acid-capped quantum dots. Nat Protoc (2011) 0.75

Thermomyces lanuginosus lipase-catalyzed synthesis of natural flavor esters in a continuous flow microreactor. 3 Biotech (2016) 0.75

The application of a monolithic triphenylphosphine reagent for conducting Ramirez gem-dibromoolefination reactions in flow. Beilstein J Org Chem (2013) 0.75

Simple and rapid hydrogenation of p-nitrophenol with aqueous formic acid in catalytic flow reactors. Beilstein J Org Chem (2013) 0.75

C-O bond Formation in a Microfluidic Reactor: High Yield SNAr Substitution of Heteroaryl Chlorides. Tetrahedron Lett (2016) 0.75

Strategic Application of Residence-Time Control in Continuous-Flow Reactors. ChemistryOpen (2015) 0.75

Articles by these authors

Interfacial polymerization within a simplified microfluidic device: capturing capsules. J Am Chem Soc (2005) 1.10

Synthesis and characterization of cross-linked reverse micelles. J Am Chem Soc (2003) 1.03

Increased efficacy of doxorubicin delivered in multifunctional microparticles for mesothelioma therapy. Int J Cancer (2010) 1.02

Stereoconvergent synthesis of chiral allylboronates from an E/Z mixture of allylic aryl ethers using a 6-NHC-Cu(I) catalyst. J Am Chem Soc (2011) 1.01

The continuous-flow synthesis of Ibuprofen. Angew Chem Int Ed Engl (2009) 1.01

Investigating PdEnCat catalysis. J Org Chem (2006) 1.01

Differences in gene expression and cytokine production by crystalline vs. amorphous silica in human lung epithelial cells. Part Fibre Toxicol (2012) 0.98

Improving solid-supported catalyst productivity by using simplified packed-bed microreactors. Angew Chem Int Ed Engl (2007) 0.97

Regioselective catalytic hydroboration of propargylic species using Cu(I)-NHC complexes. Org Lett (2012) 0.90

One-pot multi-step synthesis: a challenge spawning innovation. Org Biomol Chem (2005) 0.89

Organic reaction systems: using microcapsules and microreactors to perform chemical synthesis. Acc Chem Res (2012) 0.87

Rapid self-assembly of core-shell organosilicon microcapsules within a microfluidic device. J Am Chem Soc (2006) 0.87

Crystallization of bacteriorhodopsin solubilized by a tripod amphiphile. Biochim Biophys Acta (2005) 0.86

Continuous synthesis of artemisinin-derived medicines. Chem Commun (Camb) (2014) 0.84

Mechanism and application of a microcapsule enabled multicatalyst reaction. J Am Chem Soc (2007) 0.84

Iterative asymmetric allylic substitutions: syn- and anti-1,2-diols through catalyst control. Angew Chem Int Ed Engl (2012) 0.83

Continuous-flow oxidative cyanation of primary and secondary amines using singlet oxygen. Angew Chem Int Ed Engl (2013) 0.82

A biphasic oxidation of alcohols to aldehydes and ketones using a simplified packed-bed microreactor. Beilstein J Org Chem (2009) 0.82

A new interpretation of the Baylis-Hillman mechanism. J Org Chem (2005) 0.82

A chiral 6-membered N-heterocyclic carbene copper(I) complex that induces high stereoselectivity. Org Lett (2010) 0.82

Thiourea/proline derivative-catalyzed synthesis of tetrahydrofuran derivatives: a mechanistic view. J Org Chem (2011) 0.82

Baylis-Hillman mechanism: a new interpretation in aprotic solvents. Org Lett (2005) 0.82

Flow Heck reactions using extremely low loadings of phosphine-free palladium acetate. Org Lett (2013) 0.82

Enhanced uptake of porous silica microparticles by bifunctional surface modification with a targeting antibody and a biocompatible polymer. ACS Appl Mater Interfaces (2010) 0.81

Continuous synthesis and use of N-heterocyclic carbene copper(I) complexes from insoluble Cu2O. Org Lett (2013) 0.81

A concise flow synthesis of efavirenz. Angew Chem Int Ed Engl (2015) 0.80

Solving the clogging problem: precipitate-forming reactions in flow. Angew Chem Int Ed Engl (2006) 0.80

Microcapsule enabled multicatalyst system. J Am Chem Soc (2006) 0.80

A multifunctional mesothelin antibody-tagged microparticle targets human mesotheliomas. J Histochem Cytochem (2012) 0.79

Continuous photochemical cleavage of linkers for solid-phase synthesis. Org Lett (2014) 0.79

Continuous proline catalysis via leaching of solid proline. Beilstein J Org Chem (2011) 0.79

Use of bifunctional ureas to increase the rate of proline-catalyzed alpha-aminoxylations. J Org Chem (2009) 0.79

A general approach to creating soluble catalytic polymers heterogenized in microcapsules. Org Lett (2007) 0.79

Synthesis of optically active 4-substituted 2-cyclohexenones. Org Lett (2012) 0.79

Microencapsulated linear polymers: "soluble" heterogeneous catalysts. J Am Chem Soc (2006) 0.78

DBU catalysis of N,N'-carbonyldiimidazole-mediated amidations. Org Lett (2010) 0.78

Epitope mapping and competitive binding of HSA drug site II ligands by NMR diffusion measurements. J Am Chem Soc (2004) 0.77

Ylidenemalononitrile enamines as fluorescent "turn-on" indicators for primary amines. J Am Chem Soc (2014) 0.77

Improved synthesis of mono- and disubstituted 2-halonicotinonitriles from alkylidene malononitriles. Org Lett (2013) 0.77

Microcapsules with three orthogonal reactive sites. Org Lett (2009) 0.77

Fluorescent THF-based fructose analogue exhibits fructose-dependent uptake. Chembiochem (2013) 0.77

Structural control in thin layers of poly(p-phenyleneethynylene)s: photophysical studies of Langmuir and Langmuir-Blodgett films. J Am Chem Soc (2002) 0.75

Microspheres targeted with a mesothelin antibody and loaded with doxorubicin reduce tumor volume of human mesotheliomas in xenografts. BMC Cancer (2013) 0.75

Flow synthesis of a versatile fructosamine mimic and quenching studies of a fructose transport probe. Beilstein J Org Chem (2013) 0.75

Removable colored coatings based on calcium alginate hydrogels. Biomacromolecules (2006) 0.75

A comparison of crystalline- and graft polymer-based chemosensors. J Am Chem Soc (2003) 0.75

Thermal isomerization of cis,anti,cis-tricyclo[6.3.0.0(2,7)]undec-3-ene to endo-tricyclo[5.2.2.0(2,6)]undec-8-ene. Org Lett (2005) 0.75

Alkali metal oxides trapped by diethylzinc. Chem Commun (Camb) (2014) 0.75

A cross-linked reverse micelle-encapsulated palladium catalyst. Chem Commun (Camb) (2005) 0.75