Published in Cell on March 23, 2007
Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science (2009) 4.58
The GET complex mediates insertion of tail-anchored proteins into the ER membrane. Cell (2008) 3.51
Interactions between nuclei and the cytoskeleton are mediated by SUN-KASH nuclear-envelope bridges. Annu Rev Cell Dev Biol (2010) 3.04
Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling. Science (2014) 2.78
Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature (2011) 2.54
A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature (2010) 2.51
Distinct targeting pathways for the membrane insertion of tail-anchored (TA) proteins. J Cell Sci (2008) 2.11
A nuclear-envelope bridge positions nuclei and moves chromosomes. J Cell Sci (2009) 2.10
Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. PLoS Biol (2011) 2.04
Delivering proteins for export from the cytosol. Nat Rev Mol Cell Biol (2009) 2.00
Tail-anchored membrane protein insertion into the endoplasmic reticulum. Nat Rev Mol Cell Biol (2011) 1.95
The structural basis of tail-anchored membrane protein recognition by Get3. Nature (2009) 1.94
A chaperone cascade sorts proteins for posttranslational membrane insertion into the endoplasmic reticulum. Mol Cell (2010) 1.85
The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature (2011) 1.84
Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74
Bat3 promotes the membrane integration of tail-anchored proteins. J Cell Sci (2010) 1.71
Signal peptide peptidase (SPP) assembles with substrates and misfolded membrane proteins into distinct oligomeric complexes. Biochem J (2010) 1.68
Structural basis for tail-anchored membrane protein biogenesis by the Get3-receptor complex. Science (2011) 1.68
Biogenesis of tail-anchored proteins: the beginning for the end? J Cell Sci (2009) 1.64
Structural insights into tail-anchored protein binding and membrane insertion by Get3. Proc Natl Acad Sci U S A (2009) 1.63
Model for eukaryotic tail-anchored protein binding based on the structure of Get3. Proc Natl Acad Sci U S A (2009) 1.59
The protein targeting factor Get3 functions as ATP-independent chaperone under oxidative stress conditions. Mol Cell (2014) 1.50
Structural characterization of the Get4/Get5 complex and its interaction with Get3. Proc Natl Acad Sci U S A (2010) 1.49
The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature (2016) 1.47
A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. J Biol Chem (2008) 1.44
Subcellular Partitioning of Protein Tyrosine Phosphatase 1B to the Endoplasmic Reticulum and Mitochondria Depends Sensitively on the Composition of Its Tail Anchor. PLoS One (2015) 1.44
IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses. Nature (2017) 1.43
GRP94: An HSP90-like protein specialized for protein folding and quality control in the endoplasmic reticulum. Biochim Biophys Acta (2011) 1.42
Peroxisomal membrane proteins insert into the endoplasmic reticulum. Mol Biol Cell (2010) 1.41
The crystal structures of yeast Get3 suggest a mechanism for tail-anchored protein membrane insertion. PLoS One (2009) 1.39
Automated identification of pathways from quantitative genetic interaction data. Mol Syst Biol (2010) 1.37
Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol Cell (2013) 1.35
WRB is the receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins into the ER membrane. J Cell Sci (2011) 1.30
Key enzymes of the retinoid (visual) cycle in vertebrate retina. Biochim Biophys Acta (2011) 1.28
The mechanism of tail-anchored protein insertion into the ER membrane. Mol Cell (2011) 1.25
In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods Mol Biol (2010) 1.20
ATP-independent reversal of a membrane protein aggregate by a chloroplast SRP subunit. Nat Struct Mol Biol (2010) 1.16
Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death. J Biol Chem (2009) 1.16
Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors. Mol Cell (2014) 1.15
Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci (2012) 1.15
Nucleotide-dependent mechanism of Get3 as elucidated from free energy calculations. Proc Natl Acad Sci U S A (2012) 1.14
What is moving in the secretory pathway of plants? Plant Physiol (2008) 1.13
Formation and toxicity of soluble polyglutamine oligomers in living cells. PLoS One (2010) 1.12
An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. J Cell Biol (2008) 1.12
Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation. Mol Biol Cell (2008) 1.12
The complex process of GETting tail-anchored membrane proteins to the ER. Curr Opin Struct Biol (2012) 1.12
ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway. Cell (2014) 1.12
Secretory protein biogenesis and traffic in the early secretory pathway. Genetics (2013) 1.11
Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting. Structure (2010) 1.10
The conserved AAA-ATPase Msp1 confers organelle specificity to tail-anchored proteins. Proc Natl Acad Sci U S A (2014) 1.09
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Mol Cell (2014) 1.09
A calmodulin-dependent translocation pathway for small secretory proteins. Cell (2011) 1.09
A portrait of the GET pathway as a surprisingly complicated young man. Trends Biochem Sci (2012) 1.08
UBE2O is a quality control factor for orphans of multiprotein complexes. Science (2017) 1.06
Neutral sphingomyelinase-3 is a DNA damage and nongenotoxic stress-regulated gene that is deregulated in human malignancies. Mol Cancer Res (2008) 1.05
Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins. EMBO J (2014) 1.04
Tail-anchor targeting by a Get3 tetramer: the structure of an archaeal homologue. EMBO J (2011) 1.03
SGTA antagonizes BAG6-mediated protein triage. Proc Natl Acad Sci U S A (2012) 1.03
A biochemical analysis of the constraints of tail-anchored protein biogenesis. Biochem J (2011) 1.02
Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms. Cell Death Differ (2008) 1.02
Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo. Science (2015) 1.01
The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. J Biol Chem (2010) 1.01
Helix insertion into bilayers and the evolution of membrane proteins. Cell Mol Life Sci (2009) 1.00
The nuclear envelope LEM-domain protein emerin. Nucleus (2013) 0.99
Physiological and environmental control of yeast prions. FEMS Microbiol Rev (2013) 0.97
TRC40 can deliver short secretory proteins to the Sec61 translocon. J Cell Sci (2012) 0.97
Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. J Cell Biol (2013) 0.97
Endoplasmic reticulum targeting and insertion of tail-anchored membrane proteins by the GET pathway. Cold Spring Harb Perspect Biol (2013) 0.96
Get3 is a holdase chaperone and moves to deposition sites for aggregated proteins when membrane targeting is blocked. J Cell Sci (2012) 0.95
Ergosterol content specifies targeting of tail-anchored proteins to mitochondrial outer membranes. Mol Biol Cell (2012) 0.94
Tail-anchored membrane proteins: exploring the complex diversity of tail-anchored-protein targeting in plant cells. Plant Cell Rep (2010) 0.94
Precise timing of ATPase activation drives targeting of tail-anchored proteins. Proc Natl Acad Sci U S A (2013) 0.93
WRB and CAML are necessary and sufficient to mediate tail-anchored protein targeting to the ER membrane. PLoS One (2014) 0.93
CDK5 regulatory subunit-associated protein 1-like 1 (CDKAL1) is a tail-anchored protein in the endoplasmic reticulum (ER) of insulinoma cells. J Biol Chem (2012) 0.92
A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic (2011) 0.92
The association of BAG6 with SGTA and tail-anchored proteins. PLoS One (2013) 0.91
Multiple pathways for protein transport to peroxisomes. J Mol Biol (2015) 0.91
Functional Promiscuity of Homologues of the Bacterial ArsA ATPases. Int J Microbiol (2010) 0.91
Evolution and functional diversity of the Calcium Binding Proteins (CaBPs). Front Mol Neurosci (2012) 0.90
A Protein Structure Initiative approach to expression, purification, and in situ delivery of human cytochrome b5 to membrane vesicles. Protein Expr Purif (2007) 0.90
Crystal structure of ATP-bound Get3-Get4-Get5 complex reveals regulation of Get3 by Get4. Nat Struct Mol Biol (2014) 0.89
Characterization of the deubiquitinating activity of USP19 and its role in endoplasmic reticulum-associated degradation. J Biol Chem (2013) 0.89
The Get1/2 transmembrane complex is an endoplasmic-reticulum membrane protein insertase. Nature (2014) 0.88
Structures of the scanning and engaged states of the mammalian SRP-ribosome complex. Elife (2015) 0.87
Targeting and function of the mitochondrial fission factor GDAP1 are dependent on its tail-anchor. PLoS One (2009) 0.87
SGTA regulates the cytosolic quality control of hydrophobic substrates. J Cell Sci (2014) 0.87
The special delivery of a tail-anchored protein: why it pays to use a dedicated courier. Mol Cell (2010) 0.86
WPP-domain proteins mimic the activity of the HSC70-1 chaperone in preventing mistargeting of RanGAP1-anchoring protein WIT1. Plant Physiol (2009) 0.86
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization. Proc Natl Acad Sci U S A (2015) 0.86
Evidence for prenylation-dependent targeting of a Ykt6 SNARE in Plasmodium falciparum. Mol Biochem Parasitol (2010) 0.85
Inter-species complementation of the translocon beta subunit requires only its transmembrane domain. PLoS One (2008) 0.85
Determination of the membrane topology of the small EF-hand Ca2+-sensing proteins CaBP7 and CaBP8. PLoS One (2011) 0.85
Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. J Biol Chem (2011) 0.85
Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain. Proc Natl Acad Sci U S A (2014) 0.84
Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum. J Biol Chem (2011) 0.84
Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation. Mol Cell (2016) 0.84
Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR. J Biol Chem (2016) 0.83
Epstein-Barr viral BNLF2a protein hijacks the tail-anchored protein insertion machinery to block antigen processing by the transport complex TAP. J Biol Chem (2011) 0.83
Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A. PLoS One (2014) 0.82
Formation of stacked ER cisternae by low affinity protein interactions. J Cell Biol (2003) 3.76
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell (2006) 3.26
Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature (2011) 2.54
A ribosome-associating factor chaperones tail-anchored membrane proteins. Nature (2010) 2.51
Regulation of basal cellular physiology by the homeostatic unfolded protein response. J Cell Biol (2010) 2.40
A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature (2005) 2.21
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell (2009) 2.14
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol (2004) 2.07
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. J Cell Biol (2003) 2.07
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
The structural basis of tail-anchored membrane protein recognition by Get3. Nature (2009) 1.94
The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature (2011) 1.84
Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74
The efficiency of protein compartmentalization into the secretory pathway. Mol Biol Cell (2004) 1.74
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Dev Cell (2002) 1.62
Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. EMBO J (2005) 1.57
Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells. Proc Natl Acad Sci U S A (2006) 1.57
Protection from cytosolic prion protein toxicity by modulation of protein translocation. EMBO J (2004) 1.55
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Dev Cell (2008) 1.54
Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc (2007) 1.41
Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel. Mol Biol Cell (2002) 1.38
Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol Cell (2013) 1.35
Regulation of protein compartmentalization expands the diversity of protein function. Dev Cell (2005) 1.28
Selective processing and metabolism of disease-causing mutant prion proteins. PLoS Pathog (2009) 1.22
In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods Mol Biol (2010) 1.20
The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells. J Cell Biol (2004) 1.17
Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation. Mol Biol Cell (2008) 1.12
A calmodulin-dependent translocation pathway for small secretory proteins. Cell (2011) 1.09
Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store. J Biol Chem (2007) 1.06
Design principles of protein biosynthesis-coupled quality control. Dev Cell (2012) 1.06
Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER. Cell (2013) 1.06
Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein. J Cell Biol (2010) 1.04
Ribosome-associated protein quality control. Nat Struct Mol Biol (2016) 1.00
Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry. Pflugers Arch (2006) 0.98
Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators. Chem Biol (2011) 0.97
Prion protein biosynthesis and its emerging role in neurodegeneration. Trends Biochem Sci (2009) 0.97
Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo. Mol Biol Cell (2010) 0.94
An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate. Elife (2014) 0.92
A conserved archaeal pathway for tail-anchored membrane protein insertion. Traffic (2011) 0.92
Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii. J Biol Chem (2004) 0.89
Arginine 383 is a crucial residue in ABCG2 biogenesis. Biochim Biophys Acta (2009) 0.88
Rational design and evaluation of FRET experiments to measure protein proximities in cells. Curr Protoc Cell Biol (2006) 0.86
Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins. Mol Biol Cell (2011) 0.85
The life of proteins: the good, the mostly good and the ugly. Nat Struct Mol Biol (2011) 0.84
Histone deacetylase inhibitors influence chemotherapy transport by modulating expression and trafficking of a common polymorphic variant of the ABCG2 efflux transporter. Cancer Res (2012) 0.79
Lighting up the stressed ER. Cell (2008) 0.78
Prions and retroviruses: an endosomal rendezvous? EMBO Rep (2006) 0.78
Conformational control through translocational regulation: a new view of secretory and membrane protein folding. Bioessays (2002) 0.77
A flip turn for membrane protein insertion. Cell (2011) 0.76