Published in J Biol Chem on February 12, 2007
Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol (2010) 5.11
STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol (2009) 2.15
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STIM and Orai: the long-awaited constituents of store-operated calcium entry. Trends Pharmacol Sci (2009) 1.20
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1. Proc Natl Acad Sci U S A (2009) 1.20
Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. J Biol Chem (2009) 1.07
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Helminth induced suppression of macrophage activation is correlated with inhibition of calcium channel activity. PLoS One (2014) 0.81
Ca2+ influx via TRPC channels induces NF-kappaB-dependent A20 expression to prevent thrombin-induced apoptosis in endothelial cells. Am J Physiol Cell Physiol (2009) 0.79
The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning. BMC Dev Biol (2008) 0.79
STIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions. Sci Signal (2015) 0.78
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Induced expression of STIM1 sensitizes intestinal epithelial cells to apoptosis by modulating store-operated Ca2+ influx. J Gastrointest Surg (2012) 0.75
Interruption of progerin-lamin A/C binding ameliorates Hutchinson-Gilford progeria syndrome phenotype. J Clin Invest (2016) 0.75
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The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions. J Cell Biol (2006) 5.58
Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. J Biol Chem (2006) 5.32
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Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
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Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem (2004) 1.23
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TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. J Biol Chem (2004) 1.18
Refill status of the agonist-sensitive Ca2+ pool regulates Mn2+ influx into parotid acini. J Biol Chem (1990) 1.16
Conformational coupling: a physiological calcium entry mechanism. Sci STKE (2004) 1.11
Distinct Ca(2+)-permeable cation currents are activated by internal Ca(2+)-store depletion in RBL-2H3 cells and human salivary gland cells, HSG and HSY. J Membr Biol (2004) 1.08
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Measurement of Ca2+ signaling dynamics in exocrine cells with total internal reflection microscopy. Am J Physiol Gastrointest Liver Physiol (2006) 0.94
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Subpopulation of store-operated Ca2+ channels regulate Ca2+-induced Ca2+ release in non-excitable cells. J Biol Chem (2004) 0.79
Identification of a targeting factor for posttranslational membrane protein insertion into the ER. Cell (2007) 4.53
Formation of stacked ER cisternae by low affinity protein interactions. J Cell Biol (2003) 3.76
Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway. Cell (2006) 3.26
Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Evidence for similarities in store-operated and calcium release-activated calcium channel components. J Biol Chem (2007) 2.63
Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature (2011) 2.54
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A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum. Nature (2005) 2.21
The role of p58IPK in protecting the stressed endoplasmic reticulum. Mol Biol Cell (2007) 2.20
Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. Proc Natl Acad Sci U S A (2007) 2.17
Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration. Cell (2009) 2.14
Functional reactivity of cerebral capillaries. J Cereb Blood Flow Metab (2007) 2.10
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet (2007) 2.09
Mutant PrPSc conformers induced by a synthetic peptide and several prion strains. J Virol (2004) 2.07
Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane. J Cell Biol (2003) 2.07
Architecture of the ribosome-channel complex derived from native membranes. J Mol Biol (2005) 1.97
The structural basis of tail-anchored membrane protein recognition by Get3. Nature (2009) 1.94
A mathematical model of metabolic insulin signaling pathways. Am J Physiol Endocrinol Metab (2002) 1.86
The mechanism of membrane-associated steps in tail-anchored protein insertion. Nature (2011) 1.84
TRPC1: the link between functionally distinct store-operated calcium channels. Cell Calcium (2007) 1.79
Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion. Am J Physiol Endocrinol Metab (2007) 1.77
Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74
Functional requirement for Orai1 in store-operated TRPC1-STIM1 channels. J Biol Chem (2008) 1.74
The efficiency of protein compartmentalization into the secretory pathway. Mol Biol Cell (2004) 1.74
Loss of TRPC1-mediated Ca2+ influx contributes to impaired degranulation in Fyn-deficient mouse bone marrow-derived mast cells. J Leukoc Biol (2010) 1.73
Lipid rafts determine clustering of STIM1 in endoplasmic reticulum-plasma membrane junctions and regulation of store-operated Ca2+ entry (SOCE). J Biol Chem (2008) 1.71
A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. J Biol Chem (2006) 1.70
Calcium and glycolysis mediate multiple bursting modes in pancreatic islets. Biophys J (2004) 1.68
Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome. Structure (2008) 1.68
Interleukin-12 induces salivary gland dysfunction in transgenic mice, providing a new model of Sjögren's syndrome. Arthritis Rheum (2009) 1.67
Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium (2009) 1.65
Signal sequences control gating of the protein translocation channel in a substrate-specific manner. Dev Cell (2002) 1.62
The Ca2+ dynamics of isolated mouse beta-cells and islets: implications for mathematical models. Biophys J (2003) 1.59
Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition. EMBO J (2005) 1.57
Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells. Proc Natl Acad Sci U S A (2006) 1.57
STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. Proc Natl Acad Sci U S A (2012) 1.55
Protection from cytosolic prion protein toxicity by modulation of protein translocation. EMBO J (2004) 1.55
Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration. Dev Cell (2008) 1.54
Molecular analysis of a store-operated and 2-acetyl-sn-glycerol-sensitive non-selective cation channel. Heteromeric assembly of TRPC1-TRPC3. J Biol Chem (2005) 1.51
VAMP2-dependent exocytosis regulates plasma membrane insertion of TRPC3 channels and contributes to agonist-stimulated Ca2+ influx. Mol Cell (2004) 1.49
Caveolin-1 contributes to assembly of store-operated Ca2+ influx channels by regulating plasma membrane localization of TRPC1. J Biol Chem (2003) 1.46
Local Ca²+ entry via Orai1 regulates plasma membrane recruitment of TRPC1 and controls cytosolic Ca²+ signals required for specific cell functions. PLoS Biol (2011) 1.45
Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc (2007) 1.41
Synaptically released zinc triggers metabotropic signaling via a zinc-sensing receptor in the hippocampus. J Neurosci (2009) 1.41
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Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel. Mol Biol Cell (2002) 1.38
Human immunodeficiency virus type 1-induced macrophage gene expression includes the p21 gene, a target for viral regulation. J Virol (2005) 1.37
TRPC1 is required for functional store-operated Ca2+ channels. Role of acidic amino acid residues in the S5-S6 region. J Biol Chem (2003) 1.37
Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation. Mol Cell (2013) 1.35
Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis. Diabetes (2010) 1.35
Glucose modulates [Ca2+]i oscillations in pancreatic islets via ionic and glycolytic mechanisms. Biophys J (2006) 1.35
Astrocytes in adult rat brain express type 2 inositol 1,4,5-trisphosphate receptors. Glia (2002) 1.33
Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1. Mol Cell (2002) 1.32
Elevated inflammatory response in caveolin-1-deficient mice with Pseudomonas aeruginosa infection is mediated by STAT3 protein and nuclear factor kappaB (NF-kappaB). J Biol Chem (2011) 1.31
Individual mice can be distinguished by the period of their islet calcium oscillations: is there an intrinsic islet period that is imprinted in vivo? Diabetes (2005) 1.30
Regulation of protein compartmentalization expands the diversity of protein function. Dev Cell (2005) 1.28
A calcium-based phantom bursting model for pancreatic islets. Bull Math Biol (2004) 1.28
Canonical transient receptor potential 1 plays a role in basic fibroblast growth factor (bFGF)/FGF receptor-1-induced Ca2+ entry and embryonic rat neural stem cell proliferation. J Neurosci (2005) 1.27
Experimental characterization and mathematical modeling of P2X7 receptor channel gating. J Neurosci (2010) 1.25
Interaction of glycolysis and mitochondrial respiration in metabolic oscillations of pancreatic islets. Biophys J (2006) 1.23
Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem (2004) 1.23
Selective processing and metabolism of disease-causing mutant prion proteins. PLoS Pathog (2009) 1.22
Neurotoxin-induced ER stress in mouse dopaminergic neurons involves downregulation of TRPC1 and inhibition of AKT/mTOR signaling. J Clin Invest (2012) 1.21
Polarized but differential localization and recruitment of STIM1, Orai1 and TRPC channels in secretory cells. Traffic (2010) 1.20
In vitro dissection of protein translocation into the mammalian endoplasmic reticulum. Methods Mol Biol (2010) 1.20
Activation of TRPC1 by STIM1 in ER-PM microdomains involves release of the channel from its scaffold caveolin-1. Proc Natl Acad Sci U S A (2009) 1.20
Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Blood (2009) 1.20
Mechanism of spontaneous and receptor-controlled electrical activity in pituitary somatotrophs: experiments and theory. J Neurophysiol (2007) 1.19
Intra- and inter-islet synchronization of metabolically driven insulin secretion. Biophys J (2005) 1.19
A simplified model for mitochondrial ATP production. J Theor Biol (2006) 1.19
Store-operated Ca2+ entry is remodelled and controls in vitro angiogenesis in endothelial progenitor cells isolated from tumoral patients. PLoS One (2012) 1.18
TRPC1-mediated inhibition of 1-methyl-4-phenylpyridinium ion neurotoxicity in human SH-SY5Y neuroblastoma cells. J Biol Chem (2004) 1.18
Up-regulation of transient receptor potential canonical 1 (TRPC1) following sarco(endo)plasmic reticulum Ca2+ ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease. Mol Biol Cell (2006) 1.17