PubRank

Lihong Hu

Author PubWeight™ 37.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Sexually transmitted disease prevalence and characteristics of market vendors in eastern China. Sex Transm Dis 2003 2.02
2 Identification of influenza A nucleoprotein as an antiviral target. Nat Biotechnol 2010 1.71
3 Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers. J Am Chem Soc 2011 1.20
4 Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance. J Neurosci 2013 1.10
5 Identification of novel small-molecule inhibitors of severe acute respiratory syndrome-associated coronavirus by chemical genetics. Chem Biol 2004 1.05
6 An approach to 3,6-disubstituted 2,5-dioxybenzoquinones via two sequential Suzuki couplings. three-step synthesis of leucomelone. Org Lett 2009 1.00
7 Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS J 2006 0.98
8 Danshen extract 15,16-dihydrotanshinone I functions as a potential modulator against metabolic syndrome through multi-target pathways. J Steroid Biochem Mol Biol 2010 0.97
9 Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay. Protein Sci 2008 0.94
10 D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin. Int J Antimicrob Agents 2008 0.94
11 Molecular determinants of magnolol targeting both RXRα and PPARγ. PLoS One 2011 0.93
12 Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol 2005 0.91
13 Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem 2010 0.91
14 Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori. FEBS Lett 2006 0.89
15 Structure basis of bigelovin as a selective RXR agonist with a distinct binding mode. J Mol Biol 2011 0.88
16 Structural insight into inactivation of plasminogen activator inhibitor-1 by a small-molecule antagonist. Chem Biol 2013 0.87
17 Arctigenin preferentially induces tumor cell death under glucose deprivation by inhibiting cellular energy metabolism. Biochem Pharmacol 2012 0.87
18 Reversal of P-gp and MRP1-mediated multidrug resistance by H6, a gypenoside aglycon from Gynostemma pentaphyllum, in vincristine-resistant human oral cancer (KB/VCR) cells. Eur J Pharmacol 2012 0.87
19 BM6, a new semi-synthetic vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles. Cancer Biol Ther 2007 0.86
20 Small molecules from natural sources, targeting signaling pathways in diabetes. Biochim Biophys Acta 2010 0.86
21 Instability of St. John's wort (Hypericum perforatum L.) and degradation of hyperforin in aqueous solutions and functional beverage. J Agric Food Chem 2004 0.85
22 2,2',4'-trihydroxychalcone from Glycyrrhiza glabra as a new specific BACE1 inhibitor efficiently ameliorates memory impairment in mice. J Neurochem 2010 0.84
23 (+)-Rutamarin as a dual inducer of both GLUT4 translocation and expression efficiently ameliorates glucose homeostasis in insulin-resistant mice. PLoS One 2012 0.83
24 Discovery of inhibitors to block interactions of HIV-1 integrase with human LEDGF/p75 via structure-based virtual screening and bioassays. J Med Chem 2012 0.81
25 In vitro metabolism of hyperforin in rat liver microsomal systems. Drug Metab Dispos 2004 0.81
26 Synthesis and biological evaluation of arctigenin ester and ether derivatives as activators of AMPK. Bioorg Med Chem 2013 0.81
27 Enzymatic characterization and inhibitor discovery of a new cystathionine {gamma}-synthase from Helicobacter pylori. J Biochem 2007 0.81
28 Arctigenin efficiently enhanced sedentary mice treadmill endurance. PLoS One 2011 0.81
29 20(S)-Protopanaxadiol (PPD) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Bioorg Med Chem 2013 0.80
30 Dammarane-type glycosides from Gynostemma pentaphyllum. J Nat Prod 2004 0.80
31 Investigation of the immunosuppressive activity of Physalin H on T lymphocytes. Int Immunopharmacol 2009 0.79
32 Alternating and random copolymerization of isoprene and ethylene catalyzed by cationic half-sandwich scandium alkyls. J Am Chem Soc 2009 0.78
33 Terpenoids from roots of Chloranthus henryi. Planta Med 2009 0.78
34 Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. J Cell Biochem 2010 0.78
35 Synthesis and structure-activity relationships study of novel anti-tumor carbamate anhydrovinblastine analogues. Bioorg Med Chem 2007 0.77
36 Cytotoxic cardenolides from the root bark of Calotropis gigantea. Steroids 2013 0.77
37 Novel dammarane-type glycosides from Gynostemma pentaphyllum. Chem Pharm Bull (Tokyo) 2004 0.76
38 Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism. Biochem Pharmacol 2008 0.76
39 Design, synthesis and SAR study of hydroxychalcone inhibitors of human β-secretase (BACE1). J Enzyme Inhib Med Chem 2011 0.76
40 Activation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosis. PLoS One 2010 0.76
41 Natural product vindoline stimulates insulin secretion and efficiently ameliorates glucose homeostasis in diabetic murine models. J Ethnopharmacol 2013 0.75
42 Biomimetic synthesis: discovery of xanthanolide dimers. Angew Chem Int Ed Engl 2014 0.75
43 Ceric ammonium nitrate-promoted oxidative coupling reaction for the synthesis and evaluation of a series of anti-tumor amide anhydrovinblastine analogs. Bioorg Med Chem Lett 2011 0.75
44 The effect of vindoline C-16 substituents on the biomimetic coupling reaction: synthesis and cytotoxicity evaluation of the corresponding vinorelbine analogues. Bioorg Med Chem Lett 2012 0.75
45 Isoprenylated naphthoquinone dimers firmianones A, B, and C from Firmiana platanifolia. J Nat Prod 2005 0.75
46 Synthesis and structure-activity relationship studies of cytotoxic vinorelbine amide analogues. Bioorg Med Chem Lett 2012 0.75
47 Structure, assembly, and topology of the G185R mutant of the fourth transmembrane domain of divalent metal transporter. J Am Chem Soc 2005 0.75
48 Composite films of lecithin and heme proteins with electrochemical and electrocatalytic activities. J Colloid Interface Sci 2007 0.75
49 Triterpene saponins from Gynostemma cardiospermum. J Nat Prod 2006 0.75
50 Dammarane-type glycosides from Gynostemma pubescens. Phytochemistry 2007 0.75
51 QSAR analyses on ginkgolides and their analogues using CoMFA, CoMSIA, and HQSAR. Bioorg Med Chem 2005 0.75