Published in J Cell Biol on March 26, 2007
Tubulin modifications and their cellular functions. Curr Opin Cell Biol (2008) 3.52
Hereditary spastic paraplegias: membrane traffic and the motor pathway. Nat Rev Neurosci (2011) 2.30
Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23
Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion. Traffic (2008) 2.16
Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin. Nature (2008) 2.15
The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches. Mol Biol Cell (2008) 2.11
Microtubule-severing enzymes. Curr Opin Cell Biol (2009) 1.84
Katanin regulates dynamics of microtubules and biogenesis of motile cilia. J Cell Biol (2007) 1.54
No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50
Tubulin polyglutamylation stimulates spastin-mediated microtubule severing. J Cell Biol (2010) 1.49
Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia. J Neurosci (2008) 1.32
ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics. Proc Natl Acad Sci U S A (2009) 1.30
Microtubule-severing enzymes at the cutting edge. J Cell Sci (2012) 1.29
Hereditary spastic paraplegia SPG4: what is known and not known about the disease. Brain (2015) 1.28
Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3. EMBO Rep (2012) 1.20
Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia. Eur J Hum Genet (2008) 1.20
Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15
The ESCRT machinery: from the plasma membrane to endosomes and back again. Crit Rev Biochem Mol Biol (2014) 1.12
Activation of human VPS4A by ESCRT-III proteins reveals ability of substrates to relieve enzyme autoinhibition. J Biol Chem (2010) 1.08
Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta (2011) 1.07
Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice. Dis Model Mech (2012) 1.01
Molecular basis for class V beta-tubulin effects on microtubule assembly and paclitaxel resistance. J Biol Chem (2009) 0.92
A common substrate recognition mode conserved between katanin p60 and VPS4 governs microtubule severing and membrane skeleton reorganization. J Biol Chem (2010) 0.92
Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia. Hum Mol Genet (2010) 0.91
The nuclear envelope localization of DYT1 dystonia torsinA-ΔE requires the SUN1 LINC complex component. BMC Cell Biol (2011) 0.90
Congenital bovine spinal dysmyelination is caused by a missense mutation in the SPAST gene. Neurogenetics (2009) 0.86
Spastin's microtubule-binding properties and comparison to katanin. PLoS One (2012) 0.85
Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia. Hum Mol Genet (2010) 0.84
Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem (2015) 0.83
Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia. PLoS One (2012) 0.83
Crystal structure of the human spastin AAA domain. J Struct Biol (2012) 0.82
Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol (2015) 0.82
Subunit Interactions and cooperativity in the microtubule-severing AAA ATPase spastin. J Biol Chem (2012) 0.82
The C terminus of tubulin, a versatile partner for cationic molecules: binding of Tau, polyamines, and calcium. J Biol Chem (2010) 0.82
Microtubule-severing ATPase spastin in glioblastoma: increased expression in human glioblastoma cell lines and inverse roles in cell motility and proliferation. J Neuropathol Exp Neurol (2011) 0.81
Pathogenic mutation of spastin has gain-of-function effects on microtubule dynamics. J Neurosci (2014) 0.80
Computer simulation of assembly and co-operativity of hexameric AAA ATPases. PLoS One (2013) 0.79
Microtubule severing by katanin p60 AAA+ ATPase requires the C-terminal acidic tails of both α- and β-tubulins and basic amino acid residues in the AAA+ ring pore. J Biol Chem (2015) 0.78
Katanin Severing and Binding Microtubules Are Inhibited by Tubulin Carboxy Tails. Biophys J (2015) 0.76
Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin. PLoS One (2016) 0.76
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol (2017) 0.75
The mitotic tensegrity guardian tau protects mammary epithelia from katanin-like1-induced aneuploidy. Oncotarget (2016) 0.75
Microtubule motors involved in nuclear movement during skeletal muscle differentiation. Mol Biol Cell (2017) 0.75
Structure of the alpha beta tubulin dimer by electron crystallography. Nature (1998) 11.07
A protein assembly-disassembly pathway in vitro that may correspond to sequential steps of synaptic vesicle docking, activation, and fusion. Cell (1993) 10.66
High-resolution model of the microtubule. Cell (1999) 9.04
AAA+ proteins: have engine, will work. Nat Rev Mol Cell Biol (2005) 7.73
The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J (1998) 7.68
The ClpXP and ClpAP proteases degrade proteins with carboxy-terminal peptide tails added by the SsrA-tagging system. Genes Dev (1998) 6.73
Boundary analysis in sedimentation transport experiments: a procedure for obtaining sedimentation coefficient distributions using the time derivative of the concentration profile. Anal Biochem (1992) 4.94
Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat Genet (1999) 4.74
Central pore residues mediate the p97/VCP activity required for ERAD. Mol Cell (2006) 4.56
Identification of katanin, an ATPase that severs and disassembles stable microtubules. Cell (1993) 3.95
Global unfolding of a substrate protein by the Hsp100 chaperone ClpA. Nature (1999) 3.84
The oncoprotein 18/stathmin family of microtubule destabilizers. Curr Opin Cell Biol (2002) 3.11
A method for directly fitting the time derivative of sedimentation velocity data and an alternative algorithm for calculating sedimentation coefficient distribution functions. Anal Biochem (2000) 2.79
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation. Cell (2005) 2.69
Crystal structures of the HslVU peptidase-ATPase complex reveal an ATP-dependent proteolysis mechanism. Structure (2001) 2.63
Structural and mechanistic studies of VPS4 proteins. EMBO J (2005) 2.58
Interaction of brain cytoplasmic dynein and MAP2 with a common sequence at the C terminus of tubulin. Nature (1989) 2.41
Improved methods for fitting sedimentation coefficient distributions derived by time-derivative techniques. Anal Biochem (2006) 2.36
Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. Hum Mol Genet (2002) 2.20
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
Microtubule disassembly by ATP-dependent oligomerization of the AAA enzyme katanin. Science (1999) 2.15
Role of the processing pore of the ClpX AAA+ ATPase in the recognition and engagement of specific protein substrates. Genes Dev (2004) 2.11
The 4 A X-ray structure of a tubulin:stathmin-like domain complex. Cell (2000) 2.09
Distinct roles for the AAA ATPases NSF and p97 in the secretory pathway. Mol Biol Cell (2003) 2.09
Spastin and atlastin, two proteins mutated in autosomal-dominant hereditary spastic paraplegia, are binding partners. Hum Mol Genet (2005) 2.01
Dissecting the role of a conserved motif (the second region of homology) in the AAA family of ATPases. Site-directed mutagenesis of the ATP-dependent protease FtsH. J Biol Chem (1999) 1.97
The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules. Curr Biol (2005) 1.93
Atomic snapshots of an RNA packaging motor reveal conformational changes linking ATP hydrolysis to RNA translocation. Cell (2004) 1.86
Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. J Cell Biol (2005) 1.80
Tau protects microtubules in the axon from severing by katanin. J Neurosci (2006) 1.69
The role of the ClpA chaperone in proteolysis by ClpAP. Proc Natl Acad Sci U S A (1998) 1.65
Conserved pore residues in the AAA protease FtsH are important for proteolysis and its coupling to ATP hydrolysis. J Biol Chem (2003) 1.61
Microtubules cut and run. Trends Cell Biol (2005) 1.60
Microtubule-depolymerizing kinesins. Curr Opin Cell Biol (2005) 1.60
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance. Proc Natl Acad Sci U S A (2006) 1.56
Role of the GYVG pore motif of HslU ATPase in protein unfolding and translocation for degradation by HslV peptidase. J Biol Chem (2005) 1.53
ClpA mediates directional translocation of substrate proteins into the ClpP protease. Proc Natl Acad Sci U S A (2001) 1.51
Translocation pathway of protein substrates in ClpAP protease. Proc Natl Acad Sci U S A (2001) 1.47
Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus. Hum Mol Genet (2003) 1.18
Tubulin rings: which way do they curve? Curr Opin Struct Biol (2003) 1.17
Hereditary spastic paraplegia. Neurol Clin (2002) 1.08
An AAA family tree. J Cell Sci (2001) 1.08
Substrate specific consequences of central pore mutations in the i-AAA protease Yme1 on substrate engagement. J Struct Biol (2006) 1.03
Preparation and functional assay of pure populations of tyrosinated and detyrosinated tubulin. Methods Enzymol (1991) 0.93
AAA+ ATPases: achieving diversity of function with conserved machinery. Traffic (2007) 2.12
T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-binding surface. Immunity (2007) 1.92
Inhibition of HIV-1 ribonuclease H by a novel diketo acid, 4-[5-(benzoylamino)thien-2-yl]-2,4-dioxobutanoic acid. J Biol Chem (2002) 1.80
Structure of the s5a:k48-linked diubiquitin complex and its interactions with rpn13. Mol Cell (2009) 1.57
Interaction of two hereditary spastic paraplegia gene products, spastin and atlastin, suggests a common pathway for axonal maintenance. Proc Natl Acad Sci U S A (2006) 1.56
Mechanism of PKR activation: dimerization and kinase activation in the absence of double-stranded RNA. J Mol Biol (2005) 1.44
Mechanism of PKR Activation by dsRNA. J Mol Biol (2008) 1.42
NTB-A receptor crystal structure: insights into homophilic interactions in the signaling lymphocytic activation molecule receptor family. Immunity (2006) 1.27
Domain architecture and biochemical characterization of vertebrate Mcm10. J Biol Chem (2007) 1.19
Structure of CD84 provides insight into SLAM family function. Proc Natl Acad Sci U S A (2007) 1.17
RNA dimerization promotes PKR dimerization and activation. J Mol Biol (2009) 1.16
Global analysis of non-specific protein-nucleic interactions by sedimentation equilibrium. Biophys Chem (2004) 1.14
Analysis of PKR structure by small-angle scattering. J Mol Biol (2009) 1.14
Climp-63-mediated binding of microtubules to the ER affects the lateral mobility of translocon complexes. J Cell Sci (2007) 1.10
Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin. J Mol Biol (2007) 1.09
Mechanism of interaction of the double-stranded RNA (dsRNA) binding domain of protein kinase R with short dsRNA sequences. Biochemistry (2007) 1.08
Unactivated PKR exists in an open conformation capable of binding nucleotides. Biochemistry (2006) 1.06
Interaction of the trp RNA-binding attenuation protein (TRAP) with anti-TRAP. J Mol Biol (2004) 1.05
The role of human Dicer-dsRBD in processing small regulatory RNAs. PLoS One (2012) 0.97
Domain stabilities in protein kinase R (PKR): evidence for weak interdomain interactions. Biochemistry (2008) 0.97
Parkinson's disease-associated alpha-synuclein is a calmodulin substrate. J Biol Chem (2003) 0.96
Are fluorescence-detected sedimentation velocity data reliable? Anal Biochem (2013) 0.92
Energetics of SecA dimerization. J Mol Biol (2011) 0.92
Analysis of high-affinity binding of protein kinase R to double-stranded RNA. Biochemistry (2012) 0.90
Magnesium-dependent interaction of PKR with adenovirus VAI. J Mol Biol (2010) 0.89
Conformational dynamics of the Rpt6 ATPase in proteasome assembly and Rpn14 binding. Structure (2013) 0.87
Heparin activates PKR by inducing dimerization. J Mol Biol (2011) 0.87
Analysis of PKR-RNA interactions by sedimentation velocity. Methods Enzymol (2011) 0.83
Defining the Escherichia coli SecA dimer interface residues through in vivo site-specific photo-cross-linking. J Bacteriol (2013) 0.82
A Phase II trial of topotecan and gemcitabine in patients with previously treated, advanced nonsmall cell lung carcinoma. Cancer (2002) 0.82
Crystal structure of the human spastin AAA domain. J Struct Biol (2012) 0.82
Characterization of the neuron-specific L1-CAM cytoplasmic tail: naturally disordered in solution it exercises different binding modes for different adaptor proteins. Biochemistry (2008) 0.82
Role of the PAS sensor domains in the Bacillus subtilis sporulation kinase KinA. J Bacteriol (2013) 0.81
Analysis of monomeric and dimeric phosphorylated forms of protein kinase R. Biochemistry (2010) 0.80
Cholesterol and steroid synthesizing smooth endoplasmic reticulum of adrenocortical cells contains high levels of proteins associated with the translocation channel. Endocrinology (2005) 0.79
Identification of new inhibitors of protein kinase R guided by statistical modeling. Bioorg Med Chem Lett (2011) 0.78
Analysis of SecA dimerization in solution. Biochemistry (2014) 0.78
(1aR,5aR)1a,3,5,5a-Tetrahydro-1H-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid (MK-1903): a potent GPR109a agonist that lowers free fatty acids in humans. J Med Chem (2012) 0.77
Preface. Methods Enzymol (2015) 0.75
Phase I trial of gemcitabine, administered as a standard and constant dose-rate infusion, in combination with paclitaxel in patients with advanced solid tumors (LOA-2). Am J Clin Oncol (2002) 0.75