AAA+ proteins: have engine, will work.

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66

Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding. Nat Struct Mol Biol (2008) 3.41

Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev (2009) 3.20

Remodelling of VipA/VipB tubules by ClpV-mediated threading is crucial for type VI protein secretion. EMBO J (2009) 3.19

ACF7 regulates cytoskeletal-focal adhesion dynamics and migration and has ATPase activity. Cell (2008) 2.94

The clinical continuum of cryopyrinopathies: novel CIAS1 mutations in North American patients and a new cryopyrin model. Arthritis Rheum (2007) 2.88

Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell (2009) 2.87

Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet (2010) 2.66

Single-molecule protein unfolding and translocation by an ATP-fueled proteolytic machine. Cell (2011) 2.40

The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev (2009) 2.29

Chaperone machines for protein folding, unfolding and disaggregation. Nat Rev Mol Cell Biol (2013) 2.24

Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1. J Cell Biol (2006) 2.18

ClpXP, an ATP-powered unfolding and protein-degradation machine. Biochim Biophys Acta (2011) 2.17

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell (2006) 2.14

An intersubunit signaling network coordinates ATP hydrolysis by m-AAA proteases. Mol Cell (2009) 2.12

Indirect activation of a plant nucleotide binding site-leucine-rich repeat protein by a bacterial protease. Proc Natl Acad Sci U S A (2007) 2.09

The ClpXP protease unfolds substrates using a constant rate of pulling but different gears. Cell (2013) 2.06

Variable and tissue-specific subunit composition of mitochondrial m-AAA protease complexes linked to hereditary spastic paraplegia. Mol Cell Biol (2006) 2.00

The Nod-like receptor (NLR) family: a tale of similarities and differences. PLoS One (2008) 1.99

Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2. Chem Biol (2014) 1.96

Diverse pore loops of the AAA+ ClpX machine mediate unassisted and adaptor-dependent recognition of ssrA-tagged substrates. Mol Cell (2008) 1.96

The Hsp90 chaperone controls the biogenesis of L7Ae RNPs through conserved machinery. J Cell Biol (2008) 1.95

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes. Proc Natl Acad Sci U S A (2010) 1.90

Visualizing the ATPase cycle in a protein disaggregating machine: structural basis for substrate binding by ClpB. Mol Cell (2007) 1.82

TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton. J Cell Sci (2008) 1.80

Surveillance of nuclear pore complex assembly by ESCRT-III/Vps4. Cell (2014) 1.78

Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nat Struct Mol Biol (2007) 1.77

Mutations in the NB-ARC domain of I-2 that impair ATP hydrolysis cause autoactivation. Plant Physiol (2006) 1.75

The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). Biochem J (2007) 1.74

Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells. Proc Natl Acad Sci U S A (2007) 1.73

The Arabidopsis AAA ATPase SKD1 is involved in multivesicular endosome function and interacts with its positive regulator LYST-INTERACTING PROTEIN5. Plant Cell (2007) 1.70

The mycobacterial Mpa-proteasome unfolds and degrades pupylated substrates by engaging Pup's N-terminus. EMBO J (2010) 1.67

The 2.8 Å crystal structure of the dynein motor domain. Nature (2012) 1.65

Subunit organization of Mcm2-7 and the unequal role of active sites in ATP hydrolysis and viability. Mol Cell Biol (2008) 1.61

The early endosome: a busy sorting station for proteins at the crossroads. Histol Histopathol (2010) 1.60

Regulated protein turnover: snapshots of the proteasome in action. Nat Rev Mol Cell Biol (2014) 1.57

Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol (2013) 1.56

Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing. J Cell Biol (2007) 1.56

Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine. Cell (2013) 1.56

m-AAA protease-driven membrane dislocation allows intramembrane cleavage by rhomboid in mitochondria. EMBO J (2007) 1.54

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors. Proc Natl Acad Sci U S A (2011) 1.54

The role of bacterial enhancer binding proteins as specialized activators of σ54-dependent transcription. Microbiol Mol Biol Rev (2012) 1.53

Two distinct surveillance mechanisms monitor meiotic chromosome metabolism in budding yeast. Curr Biol (2006) 1.52

Structure of the 26S proteasome with ATP-γS bound provides insights into the mechanism of nucleotide-dependent substrate translocation. Proc Natl Acad Sci U S A (2013) 1.50

CryoEM structure of Hsp104 and its mechanistic implication for protein disaggregation. Proc Natl Acad Sci U S A (2010) 1.49

A force-activated trip switch triggers rapid dissociation of a colicin from its immunity protein. PLoS Biol (2013) 1.48

LULL1 retargets TorsinA to the nuclear envelope revealing an activity that is impaired by the DYT1 dystonia mutation. Mol Biol Cell (2009) 1.47

Cytoplasmic recycling of 60S preribosomal factors depends on the AAA protein Drg1. Mol Cell Biol (2007) 1.46

A camel passes through the eye of a needle: protein unfolding activity of Clp ATPases. Mol Microbiol (2006) 1.43

Cellular functions of NSF: not just SNAPs and SNAREs. FEBS Lett (2007) 1.42

Structure of an apoptosome-procaspase-9 CARD complex. Structure (2010) 1.42

Potent, Reversible, and Specific Chemical Inhibitors of Eukaryotic Ribosome Biogenesis. Cell (2016) 1.41

ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proc Natl Acad Sci U S A (2011) 1.41

Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss. Am J Hum Genet (2015) 1.40

An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence. Nat Immunol (2010) 1.39

Mechanistic insights into the recycling machine of the SNARE complex. Nature (2015) 1.38

Molecular basis for the unique role of the AAA+ chaperone ClpV in type VI protein secretion. J Biol Chem (2011) 1.37

ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. Proc Natl Acad Sci U S A (2007) 1.37

The molecular basis of N-end rule recognition. Mol Cell (2008) 1.36

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase. J Biol Chem (2008) 1.36

Chemical enhancement of torsinA function in cell and animal models of torsion dystonia. Dis Model Mech (2010) 1.33

Apoptosome structure, assembly, and procaspase activation. Structure (2013) 1.33

Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33

Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33

Stepwise artificial evolution of a plant disease resistance gene. Proc Natl Acad Sci U S A (2013) 1.33

Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole. Curr Genet (2006) 1.32

Polypeptide translocation by the AAA+ ClpXP protease machine. Chem Biol (2009) 1.32

Protein rescue from aggregates by powerful molecular chaperone machines. Nat Rev Mol Cell Biol (2013) 1.31

ClpXP protease degrades the cytoskeletal protein, FtsZ, and modulates FtsZ polymer dynamics. Proc Natl Acad Sci U S A (2009) 1.30

Collaboration between the ClpB AAA+ remodeling protein and the DnaK chaperone system. Proc Natl Acad Sci U S A (2007) 1.30

INO80 subfamily of chromatin remodeling complexes. Mutat Res (2007) 1.29

Interaction of torsinA with its major binding partners is impaired by the dystonia-associated DeltaGAG deletion. J Biol Chem (2009) 1.26

Dynamic and static components power unfolding in topologically closed rings of a AAA+ proteolytic machine. Nat Struct Mol Biol (2012) 1.26

The barley magnesium chelatase 150-kd subunit is not an abscisic acid receptor. Plant Physiol (2009) 1.25

Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope. Hum Mol Genet (2008) 1.25

Regulation of Torsin ATPases by LAP1 and LULL1. Proc Natl Acad Sci U S A (2013) 1.21

Universal allosteric mechanism for Gα activation by GPCRs. Nature (2015) 1.21

Chromatin loading of E2F-MLL complex by cancer-associated coregulator ANCCA via reading a specific histone mark. Mol Cell Biol (2010) 1.21

Protection of repetitive DNA borders from self-induced meiotic instability. Nature (2011) 1.20

Structure and function of the AAA+ protein CbbX, a red-type Rubisco activase. Nature (2011) 1.20

Expansion of mutation spectrum, determination of mutation cluster regions and predictive structural classification of SPAST mutations in hereditary spastic paraplegia. Eur J Hum Genet (2008) 1.20

Mycobacterium tuberculosis ClpX interacts with FtsZ and interferes with FtsZ assembly. PLoS One (2010) 1.19

Toward an integrated structural model of the 26S proteasome. Mol Cell Proteomics (2010) 1.19

Stimulation of transit-peptide release and ATP hydrolysis by a cochaperone during protein import into chloroplasts. J Cell Biol (2006) 1.18

TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun (2011) 1.18

Breaching the nuclear envelope in development and disease. J Cell Biol (2014) 1.18

The complexities of p97 function in health and disease. Mol Biosyst (2010) 1.17

Asymmetric nucleotide transactions of the HslUV protease. J Mol Biol (2008) 1.16

siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells. Hum Mol Genet (2008) 1.15

Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15

Role of Schlafen 2 (SLFN2) in the generation of interferon alpha-induced growth inhibitory responses. J Biol Chem (2009) 1.14

Biosynthesis of the dystonia-associated AAA+ ATPase torsinA at the endoplasmic reticulum. Biochem J (2007) 1.14

A conserved membrane attachment site in alpha-SNAP facilitates N-ethylmaleimide-sensitive factor (NSF)-driven SNARE complex disassembly. J Biol Chem (2009) 1.14

The early-onset torsion dystonia-associated protein, torsinA, is a homeostatic regulator of endoplasmic reticulum stress response. Hum Mol Genet (2010) 1.13

Loading clamps for DNA replication and repair. DNA Repair (Amst) (2009) 1.12

Novel mechanism of hexamer ring assembly in protein/RNA interactions revealed by single molecule imaging. Nucleic Acids Res (2008) 1.12

Polar positioning of a conjugation protein from the integrative and conjugative element ICEBs1 of Bacillus subtilis. J Bacteriol (2010) 1.11

Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol (2007) 1.11

The type VI secretion system: a tubular story. EMBO J (2009) 1.11

Peroxisomal protein import and ERAD: variations on a common theme. Nat Rev Mol Cell Biol (2010) 1.11

Conserved arginine residues implicated in ATP hydrolysis, nucleotide-sensing, and inter-subunit interactions in AAA and AAA+ ATPases. J Struct Biol (2004) 2.15

Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction. Mol Biol Cell (2006) 2.02

Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo. Blood (2009) 2.00

Munc13-4 is a limiting factor in the pathway required for platelet granule release and hemostasis. Blood (2010) 2.00

A family with tau-negative frontotemporal dementia and neuronal intranuclear inclusions linked to chromosome 17. Brain (2006) 1.75

A novel role for platelet secretion in angiogenesis: mediating bone marrow-derived cell mobilization and homing. Blood (2011) 1.61

Cellular functions of NSF: not just SNAPs and SNAREs. FEBS Lett (2007) 1.42

PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest (2009) 1.41

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion. Blood (2012) 1.35

Munc18b/STXBP2 is required for platelet secretion. Blood (2012) 1.30

Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor. J Biol Chem (2004) 1.27

Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J Biol Chem (2004) 1.23

Granule stores from cellubrevin/VAMP-3 null mouse platelets exhibit normal stimulus-induced release. Blood (2003) 1.18

Arf6 plays an early role in platelet activation by collagen and convulxin. Blood (2005) 1.12

The platelet release reaction: just when you thought platelet secretion was simple. Curr Opin Hematol (2008) 1.10

Requirements for the catalytic cycle of the N-ethylmaleimide-Sensitive Factor (NSF). Biochim Biophys Acta (2011) 1.08

Platelet secretion is kinetically heterogeneous in an agonist-responsive manner. Blood (2012) 1.06

Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signalling pathway. Nat Commun (2013) 1.05

IκB kinase phosphorylation of SNAP-23 controls platelet secretion. Blood (2013) 1.03

Mast cell degranulation requires N-ethylmaleimide-sensitive factor-mediated SNARE disassembly. J Immunol (2003) 1.02

Distinct roles for Rap1b protein in platelet secretion and integrin αIIbβ3 outside-in signaling. J Biol Chem (2011) 1.01

Dissecting the N-ethylmaleimide-sensitive factor: required elements of the N and D1 domains. J Biol Chem (2009) 1.00

Application of a Saccharomyces cerevisiae model to study requirements for trafficking of Yersinia pestis YopM in eucaryotic cells. Infect Immun (2003) 1.00

A role for Sec1/Munc18 proteins in platelet exocytosis. Biochem J (2003) 1.00

Primary platelet signaling cascades and integrin-mediated signaling control ADP-ribosylation factor (Arf) 6-GTP levels during platelet activation and aggregation. J Biol Chem (2008) 0.97

Asymmetric accumulation of hippocampal 7S SNARE complexes occurs regardless of kindling paradigm. Epilepsy Res (2006) 0.95

Uncoupling the ATPase activity of the N-ethylmaleimide sensitive factor (NSF) from 20S complex disassembly. Biochemistry (2002) 0.90

Platelet secretion and hemostasis require syntaxin-binding protein STXBP5. J Clin Invest (2014) 0.89

Nucleotide-dependent conformational changes in the N-Ethylmaleimide Sensitive Factor (NSF) and their potential role in SNARE complex disassembly. J Struct Biol (2012) 0.89

Hexahistidine-tag-specific optical probes for analyses of proteins and their interactions. Anal Biochem (2009) 0.87

Levetiracetam prevents kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes. Epilepsia (2008) 0.87

The Src family kinases and protein kinase C synergize to mediate Gq-dependent platelet activation. J Biol Chem (2012) 0.85

Plasma membrane Ca(2+)-ATPase (PMCA) translocates to filopodia during platelet activation. Thromb Haemost (2004) 0.82

Studies of secretion using permeabilized platelets. Methods Mol Biol (2004) 0.82

Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release. Epilepsia (2011) 0.81

Protein expression in platelets from six species that differ in their open canalicular system. Platelets (2010) 0.81

Platelets from Munc18c heterozygous mice exhibit normal stimulus-induced release. Thromb Haemost (2004) 0.79

Murine platelets are not regulated by O-linked beta-N-acetylglucosamine. Arch Biochem Biophys (2008) 0.78

Platelet activation and its patient-specific consequences. Thromb Res (2007) 0.78

Histidine-tag-directed chromophores for tracer analyses in the analytical ultracentrifuge. Methods (2010) 0.77

Demonstration of differential quantitative requirements for NSF among multiple vesicle fusion pathways of GLUT4 using a dominant-negative ATPase-deficient NSF. Biochem Biophys Res Commun (2005) 0.77

Thiosulfinates modulate platelet activation by reaction with surface free sulfhydryls and internal thiol-containing proteins. Platelets (2007) 0.76

The ins and outs of endocytic trafficking in platelet functions. Curr Opin Hematol (2017) 0.75