Published in Circ Res on March 30, 2007
Role of mitochondrial dysfunction in insulin resistance. Circ Res (2008) 3.45
Resveratrol induces mitochondrial biogenesis in endothelial cells. Am J Physiol Heart Circ Physiol (2009) 2.65
Mitochondrial reactive oxygen species drive proinflammatory cytokine production. J Exp Med (2011) 2.35
Endothelial dysfunction in diabetes mellitus: molecular mechanisms and clinical implications. Rev Endocr Metab Disord (2010) 2.19
eNOS, metabolic syndrome and cardiovascular disease. Trends Endocrinol Metab (2009) 2.04
Chemistry and antihypertensive effects of tempol and other nitroxides. Pharmacol Rev (2008) 1.91
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. J Mol Med (Berl) (2010) 1.90
The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach. Am J Pathol (2008) 1.35
Coexpression network analysis in abdominal and gluteal adipose tissue reveals regulatory genetic loci for metabolic syndrome and related phenotypes. PLoS Genet (2012) 1.31
Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. J Biol Chem (2009) 1.24
Endothelial nitric oxide synthase transgenic models of endothelial dysfunction. Pflugers Arch (2010) 1.22
Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. J Biol Chem (2009) 1.20
Modulating an oxidative-inflammatory cascade: potential new treatment strategy for improving glucose metabolism, insulin resistance, and vascular function. Int J Clin Pract (2008) 1.10
Insulin reduces plasma arginase activity in type 2 diabetic patients. Diabetes Care (2007) 1.10
Coronary heart disease is associated with a mutation in mitochondrial tRNA. Hum Mol Genet (2013) 1.08
Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol (2013) 1.01
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells (2012) 1.00
Resistance training increases muscle mitochondrial biogenesis in patients with chronic kidney disease. Clin J Am Soc Nephrol (2010) 1.00
Cardiac dysfunction and oxidative stress in the metabolic syndrome: an update on antioxidant therapies. Curr Pharm Des (2013) 0.99
Mitochondrial DNA injury and mortality in hemodialysis patients. J Am Soc Nephrol (2008) 0.97
Intersection between metabolic dysfunction, high fat diet consumption, and brain aging. J Neurochem (2010) 0.96
Diet-induced metabolic disturbances as modulators of brain homeostasis. Biochim Biophys Acta (2008) 0.91
Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence. ARYA Atheroscler (2011) 0.89
Mitochondrial trifunctional protein defects: clinical implications and therapeutic approaches. Adv Drug Deliv Rev (2008) 0.88
Mitochondrial dysfunction in obesity: potential benefit and mechanism of Co-enzyme Q10 supplementation in metabolic syndrome. J Diabetes Metab Disord (2014) 0.88
Assessing mitochondrial redox status by flow cytometric methods: vascular response to fluid shear stress. Curr Protoc Cytom (2011) 0.87
Pulsatile shear stress increased mitochondrial membrane potential: implication of Mn-SOD. Biochem Biophys Res Commun (2009) 0.86
Mitochondrial dysfunction in metabolic syndrome and asthma. J Allergy (Cairo) (2013) 0.84
Lipoprotein concentration, particle number, size and cholesterol efflux capacity are associated with mitochondrial oxidative stress and function in an HIV positive cohort. Atherosclerosis (2014) 0.84
Maternal immunization affects in utero programming of insulin resistance and type 2 diabetes. PLoS One (2012) 0.83
Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria. Exp Mol Med (2009) 0.82
Role of lipotoxicity in endothelial dysfunction. Heart Fail Clin (2012) 0.82
Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess. Am J Physiol Endocrinol Metab (2012) 0.82
Effects of a high fat diet on liver mitochondria: increased ATP-sensitive K+ channel activity and reactive oxygen species generation. J Bioenerg Biomembr (2010) 0.82
Endogenous myoglobin in breast cancer is hypoxia-inducible by alternative transcription and functions to impair mitochondrial activity: a role in tumor suppression? J Biol Chem (2011) 0.81
Nutritional models of foetal programming and nutrigenomic and epigenomic dysregulations of fatty acid metabolism in the liver and heart. Pflugers Arch (2013) 0.81
Hydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesity. Nutr Metab (Lond) (2016) 0.81
Asthma and metabolic syndrome: Current knowledge and future perspectives. World J Clin Cases (2015) 0.80
Control of muscle mitochondria by insulin entails activation of Akt2-mtNOS pathway: implications for the metabolic syndrome. PLoS One (2008) 0.80
Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies. Biochim Biophys Acta (2016) 0.79
Estrogen and mitochondria function in cardiorenal metabolic syndrome. Prog Mol Biol Transl Sci (2014) 0.79
Cyclovirobuxine D Attenuates Doxorubicin-Induced Cardiomyopathy by Suppression of Oxidative Damage and Mitochondrial Biogenesis Impairment. Oxid Med Cell Longev (2015) 0.78
Nitric oxide, interorganelle communication, and energy flow: a novel route to slow aging. Front Cell Dev Biol (2015) 0.77
Deficiency of eNOS exacerbates early-stage NAFLD pathogenesis by changing the fat distribution. BMC Gastroenterol (2015) 0.77
TRC150094 attenuates progression of nontraditional cardiovascular risk factors associated with obesity and type 2 diabetes in obese ZSF1 rats. Diabetes Metab Syndr Obes (2011) 0.77
Mitochondria as pharmacological targets. Br J Pharmacol (2010) 0.76
Perspective: A Historical and Scientific Perspective of Sugar and Its Relation with Obesity and Diabetes. Adv Nutr (2017) 0.75
Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols. Front Pharmacol (2017) 0.75
Phenolics from Garcinia mangostana alleviate exaggerated vasoconstriction in metabolic syndrome through direct vasodilatation and nitric oxide generation. BMC Complement Altern Med (2016) 0.75
Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy. J Biol Chem (2016) 0.75
Luteolin alleviates methylglyoxal-induced cytotoxicity in osteoblastic MC3T3-E1 cells. Cytotechnology (2016) 0.75
MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Mucosal Immunol (2017) 0.75
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (2003) 6.66
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science (2003) 3.91
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol (2009) 3.40
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proc Natl Acad Sci U S A (2004) 2.44
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation (2005) 2.35
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A (2007) 2.34
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
Branched-chain amino acid supplementation promotes survival and supports cardiac and skeletal muscle mitochondrial biogenesis in middle-aged mice. Cell Metab (2010) 2.02
On the possible interaction between vaccines and drugs. Eur J Clin Pharmacol (2013) 1.99
Kawasaki disease and pertussis epidemics. Epidemiology (2014) 1.97
Paroxysmal Sympathetic Hyperactivity in Pediatric Rehabilitation: Clinical Factors and Acute Pharmacological Management. J Head Trauma Rehabil (2015) 1.96
Nitric oxide and mitochondrial biogenesis. J Cell Sci (2006) 1.89
Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol (2007) 1.82
HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment. Proc Natl Acad Sci U S A (2008) 1.80
Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J (2009) 1.78
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol (2004) 1.74
Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol (2003) 1.74
Leptin is induced in the ischemic cerebral cortex and exerts neuroprotection through NF-kappaB/c-Rel-dependent transcription. Stroke (2008) 1.72
Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A (2006) 1.72
Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci (2009) 1.71
Nitric oxide release combined with nonsteroidal antiinflammatory activity prevents muscular dystrophy pathology and enhances stem cell therapy. Proc Natl Acad Sci U S A (2006) 1.69
Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci (2006) 1.64
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A (2009) 1.62
Regulation of oxygen distribution in tissues by endothelial nitric oxide. Circ Res (2009) 1.61
AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J (2009) 1.55
Retracted Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1. Cell Metab (2012) 1.54
The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning. J Hypertens (2008) 1.52
Inflammatory and alternatively activated human macrophages attract vessel-associated stem cells, relying on separate HMGB1- and MMP-9-dependent pathways. J Leukoc Biol (2009) 1.51
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc Natl Acad Sci U S A (2010) 1.50
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem (2003) 1.49
Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats. Diabetes (2003) 1.43
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response. Nat Cell Biol (2004) 1.38
Limited sampling strategies for the estimation of atazanavir daily exposure in HIV-infected patients. Fundam Clin Pharmacol (2011) 1.38
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci U S A (2004) 1.34
Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium. Arterioscler Thromb Vasc Biol (2005) 1.31
Inhibition of cellular respiration by endogenously produced carbon monoxide. J Cell Sci (2006) 1.29
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A (2004) 1.26
Retracted Follistatin induction by nitric oxide through cyclic GMP: a tightly regulated signaling pathway that controls myoblast fusion. J Cell Biol (2006) 1.25
Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes. Diabetes (2008) 1.25
Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells. J Pathol (2002) 1.22
Inter- and intra-patient variability of raltegravir pharmacokinetics in HIV-1-infected subjects. J Antimicrob Chemother (2011) 1.22
S-nitrosation of mitochondrial complex I depends on its structural conformation. J Biol Chem (2007) 1.21
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol (2003) 1.20
Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle. Proc Natl Acad Sci U S A (2011) 1.18
Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. J Biol Chem (2006) 1.18
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res (2006) 1.17
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. Eur Heart J (2005) 1.16
Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism. EMBO J (2012) 1.16
Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production. J Neurochem (2011) 1.16
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Proc Natl Acad Sci U S A (2011) 1.15
Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. Arterioscler Thromb Vasc Biol (2009) 1.15
Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting. J Histochem Cytochem (2005) 1.11
On the association between human papillomavirus vaccine and primary ovarian failure. Am J Reprod Immunol (2013) 1.11
Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury? J Biol Chem (2009) 1.10
Mitochondrial biogenesis as a cellular signaling framework. Biochem Pharmacol (2004) 1.09
Necdin mediates skeletal muscle regeneration by promoting myoblast survival and differentiation. J Cell Biol (2007) 1.08
The first ALS2 missense mutation associated with JPLS reveals new aspects of alsin biological function. Brain (2006) 1.07
Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response. Cell Res (2005) 1.07
Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling. Proc Natl Acad Sci U S A (2002) 1.07
Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO. Circ Res (2005) 1.05
Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation. Proc Natl Acad Sci U S A (2007) 1.04
Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus. FEBS Lett (2002) 1.03
Ex vivo treatment with nitric oxide increases mesoangioblast therapeutic efficacy in muscular dystrophy. J Cell Sci (2006) 1.02
Linezolid plasma concentrations and occurrence of drug-related haematological toxicity in patients with gram-positive infections. Int J Antimicrob Agents (2013) 1.02
The low-affinity receptor for neurotrophins p75NTR plays a key role for satellite cell function in muscle repair acting via RhoA. Mol Biol Cell (2009) 1.02
Requirement of inducible nitric oxide synthase for skeletal muscle regeneration after acute damage. J Immunol (2013) 1.01
Sphingosine 1-phosphate mediates proliferation and survival of mesoangioblasts. Stem Cells (2007) 1.00
Nitric oxide sustains long-term skeletal muscle regeneration by regulating fate of satellite cells via signaling pathways requiring Vangl2 and cyclic GMP. Stem Cells (2012) 1.00
Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. J Physiol (2003) 1.00
GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. Br J Pharmacol (2005) 1.00
Nitric oxide deficiency determines global chromatin changes in Duchenne muscular dystrophy. FASEB J (2009) 1.00
Activation of acid sphingomyelinase and its inhibition by the nitric oxide/cyclic guanosine 3',5'-monophosphate pathway: key events in Escherichia coli-elicited apoptosis of dendritic cells. J Immunol (2004) 0.99
Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. Diabetes (2010) 0.99
Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy. Biochim Biophys Acta (2003) 0.99
Nitric oxide boosts chemoimmunotherapy via inhibition of acid sphingomyelinase in a mouse model of melanoma. Cancer Res (2007) 0.98
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. J Biol Chem (2010) 0.97
Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. J Neurosci Res (2004) 0.96
Employment precariousness and poor mental health: evidence from Spain on a new social determinant of health. J Environ Public Health (2013) 0.95
Nitric oxide in myogenesis and therapeutic muscle repair. Mol Neurobiol (2012) 0.95
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. Biochem Biophys Res Commun (2004) 0.95
Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascul Pharmacol (2003) 0.95
Nitric oxide donor and non steroidal anti inflammatory drugs as a therapy for muscular dystrophies: evidence from a safety study with pilot efficacy measures in adult dystrophic patients. Pharmacol Res (2012) 0.94
The Employment Precariousness Scale (EPRES): psychometric properties of a new tool for epidemiological studies among waged and salaried workers. Occup Environ Med (2010) 0.93
Co-administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans. Br J Pharmacol (2010) 0.92
Single-domain protein A-engineered magnetic nanoparticles: toward a universal strategy to site-specific labeling of antibodies for targeted detection of tumor cells. ACS Nano (2010) 0.92
Retracted Mitochondrial dysfunction and HIF1alpha stabilization in inflammation. J Cell Sci (2008) 0.92
Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt. Mol Pharmacol (2003) 0.91