Published in Am J Physiol Regul Integr Comp Physiol on October 14, 2004
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Conditional deletion of Gata3 shows its essential function in T(H)1-T(H)2 responses. Nat Immunol (2004) 4.41
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Validation of ITD mutations in FLT3 as a therapeutic target in human acute myeloid leukaemia. Nature (2012) 4.01
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The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med (2009) 3.30
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
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Mechanisms of sepsis-induced cardiac dysfunction. Crit Care Med (2007) 2.79
Slippage of mitotic arrest and enhanced tumor development in mice with BubR1 haploinsufficiency. Cancer Res (2004) 2.79
Statin use and mortality in the bacteremic critically ill patient. Crit Care Med (2006) 2.57
An integrated functional genomics screening program reveals a role for BMP-9 in glucose homeostasis. Nat Biotechnol (2003) 2.53
SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell (2010) 2.52
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The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis. Crit Care Med (2007) 2.45
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proc Natl Acad Sci U S A (2004) 2.44
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Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation (2005) 2.35
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A (2007) 2.34
Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients. Intensive Care Med (2012) 2.33
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Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27
The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals. Crit Care Med (2011) 2.23
Detecting tissue-specific regulation of alternative splicing as a qualitative change in microarray data. Nucleic Acids Res (2004) 2.17
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease. J Struct Biol (2005) 2.15
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit. Crit Care (2005) 2.03
Towards precise classification of cancers based on robust gene functional expression profiles. BMC Bioinformatics (2005) 2.01
Understanding the benefits and harms of oxygen therapy. Intensive Care Med (2015) 2.00
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Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure. Am J Physiol Regul Integr Comp Physiol (2003) 1.95
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Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix. Cell Metab (2011) 1.87
Acceptable donor-specific antibody levels allowing for successful deceased and living donor kidney transplantation after desensitization therapy. Transplantation (2008) 1.84
Effects of levosimendan on systemic and regional hemodynamics in septic myocardial depression. Intensive Care Med (2005) 1.83
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Tracking changes in cardiac output: methodological considerations for the validation of monitoring devices. Intensive Care Med (2009) 1.76
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Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol (2003) 1.74
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Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci (2009) 1.71
Selective expression of the Cre recombinase in late-stage thymocytes using the distal promoter of the Lck gene. J Immunol (2005) 1.68
Potential metabolic consequences of statins in sepsis. Crit Care Med (2011) 1.64
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Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res (2007) 1.62
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A (2009) 1.62
Regulation of oxygen distribution in tissues by endothelial nitric oxide. Circ Res (2009) 1.61
Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis. Crit Care Med (2007) 1.58
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AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J (2009) 1.55
Retracted Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1. Cell Metab (2012) 1.54
Temporal changes in tissue cardiorespiratory function during faecal peritonitis. Intensive Care Med (2011) 1.54
Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia. Shock (2011) 1.52
The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning. J Hypertens (2008) 1.52
Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology (2011) 1.50
Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis. Crit Care Med (2007) 1.50
Genetic background of catecholaminergic polymorphic ventricular tachycardia in Japan. Circ J (2013) 1.50
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc Natl Acad Sci U S A (2010) 1.50
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem (2003) 1.49
Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial. Crit Care Med (2008) 1.48
The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage. Intensive Care Med (2009) 1.48
N-halosuccinimide/BF3-H2O, efficient electrophilic halogenating systems for aromatics. J Am Chem Soc (2004) 1.47
Cinnabar is not converted into methylmercury by human intestinal bacteria. J Ethnopharmacol (2011) 1.45
Low-molecular-weight polyethylene glycol improves survival in experimental sepsis. Crit Care Med (2010) 1.45
Potential for serious environmental threats from uncontrolled co-processing of wastes in cement kilns. Environ Sci Technol (2012) 1.44
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Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats. Diabetes (2003) 1.43
The FTc is not an accurate marker of left ventricular preload. Intensive Care Med (2006) 1.42
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