Published in Proc Natl Acad Sci U S A on March 14, 2011
CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci U S A (2011) 2.06
Mitochondrial regulation of cell cycle and proliferation. Antioxid Redox Signal (2012) 1.19
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Proc Natl Acad Sci U S A (2011) 1.15
The Fbw7 and betaTRCP E3 ubiquitin ligases and their roles in tumorigenesis. Front Biosci (Landmark Ed) (2012) 1.12
Endothelial PFKFB3 plays a critical role in angiogenesis. Arterioscler Thromb Vasc Biol (2014) 0.99
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Increased concentrations of fructose 2,6-bisphosphate contribute to the Warburg effect in phosphatase and tensin homolog (PTEN)-deficient cells. J Biol Chem (2013) 0.91
GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes. PLoS One (2012) 0.90
Coordination of cell growth and division by the ubiquitin-proteasome system. Semin Cell Dev Biol (2012) 0.89
EBV-miR-BART10-3p facilitates epithelial-mesenchymal transition and promotes metastasis of nasopharyngeal carcinoma by targeting BTRC. Oncotarget (2015) 0.88
The Ubiquitin Proteome of Toxoplasma gondii Reveals Roles for Protein Ubiquitination in Cell-Cycle Transitions. Cell Host Microbe (2015) 0.86
Retinoblastoma protein promotes oxidative phosphorylation through upregulation of glycolytic genes in oncogene-induced senescent cells. Aging Cell (2015) 0.85
Akt-dependent activation of the heart 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase (PFKFB2) isoenzyme by amino acids. J Biol Chem (2013) 0.85
Energy Metabolism of the Brain, Including the Cooperation between Astrocytes and Neurons, Especially in the Context of Glycogen Metabolism. Int J Mol Sci (2015) 0.82
MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation. Autophagy (2014) 0.81
The expression pattern of PFKFB3 enzyme distinguishes between induced-pluripotent stem cells and cancer stem cells. Oncotarget (2015) 0.81
Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions. BMC Evol Biol (2012) 0.80
Nonparametric Bayesian evaluation of differential protein quantification. J Proteome Res (2013) 0.79
Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells. World J Gastroenterol (2014) 0.79
Notch3 overexpression causes arrest of cell cycle progression by inducing Cdh1 expression in human breast cancer cells. Cell Cycle (2016) 0.78
AMP-activated protein kinase is dispensable for maintaining ATP levels and for survival following inhibition of glycolysis, but promotes tumour engraftment of Ras-transformed fibroblasts. Oncotarget (2015) 0.77
Linking metabolism and cell cycle progression via the APC/CCdh1 and SCFβTrCP ubiquitin ligases. Proc Natl Acad Sci U S A (2011) 0.77
Two-way communication between the metabolic and cell cycle machineries: the molecular basis. Cell Cycle (2015) 0.77
Inhibition of Nek2 by small molecules affects proteasome activity. Biomed Res Int (2014) 0.77
The double trouble of metabolic diseases: the diabetes-cancer link. Mol Biol Cell (2015) 0.76
Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Res (2016) 0.75
Metabolic control of the cell cycle. Cell Cycle (2015) 0.75
Oncogenic regulation of tumor metabolic reprogramming. Oncotarget (2016) 0.75
E3 ligase SCFβTrCP induced DYRK1A degradation is essential for cell cycle progression in HEK293 cells. J Biol Chem (2016) 0.75
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The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol (2009) 3.40
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal (2009) 2.92
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E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A (2009) 1.62
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc Natl Acad Sci U S A (2010) 1.50
DNA replication licensing in somatic and germ cells. J Cell Sci (2004) 1.21
Cdh1: a master G0/G1 regulator. Nat Cell Biol (2008) 1.16
Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. Exp Cell Res (2005) 1.07
Insulin and ischemia stimulate glycolysis by acting on the same targets through different and opposing signaling pathways. J Mol Cell Cardiol (2002) 1.02
Historical review: an energy reservoir for mitosis, and its productive wake. Trends Biochem Sci (2003) 0.80
Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS. Science (2005) 6.69
Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide. Science (2003) 6.66
Redistribution of intracellular oxygen in hypoxia by nitric oxide: effect on HIF1alpha. Science (2003) 3.91
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1. Nat Cell Biol (2009) 3.40
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals. Proc Natl Acad Sci U S A (2004) 2.44
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice: key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation (2005) 2.35
Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A (2007) 2.34
Regulation of hypoxia-inducible factor-1alpha by nitric oxide through mitochondria-dependent and -independent pathways. Biochem J (2003) 2.27
TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. J Clin Invest (2006) 2.04
Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscler Thromb Vasc Biol (2007) 1.82
Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages. Am J Physiol Regul Integr Comp Physiol (2004) 1.74
Y-27632, a Rho-kinase inhibitor, inhibits proliferation and adrenergic contraction of prostatic smooth muscle cells. J Urol (2003) 1.74
Mitochondria as signaling organelles in the vascular endothelium. Proc Natl Acad Sci U S A (2006) 1.72
Glycolysis: a bioenergetic or a survival pathway? Trends Biochem Sci (2009) 1.71
The cell cycle and cancer. J Pathol (2011) 1.67
Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res (2007) 1.62
E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation. Proc Natl Acad Sci U S A (2009) 1.62
Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells. Nat Methods (2007) 1.61
Regulation of oxygen distribution in tissues by endothelial nitric oxide. Circ Res (2009) 1.61
AMPKalpha1 regulates the antioxidant status of vascular endothelial cells. Biochem J (2009) 1.55
Retracted Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1. Cell Metab (2012) 1.54
The deleterious effect of high concentrations of D-glucose requires pro-inflammatory preconditioning. J Hypertens (2008) 1.52
Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma. Clin Cancer Res (2005) 1.50
Anaphase-promoting complex/cyclosome-Cdh1 coordinates glycolysis and glutaminolysis with transition to S phase in human T lymphocytes. Proc Natl Acad Sci U S A (2010) 1.50
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem (2003) 1.49
Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments. J Natl Cancer Inst (2002) 1.48
Two phases of nitrergic neuropathy in streptozotocin-induced diabetic rats. Diabetes (2003) 1.43
Nitric oxide induces coupling of mitochondrial signalling with the endoplasmic reticulum stress response. Nat Cell Biol (2004) 1.38
Endogenous NO regulates superoxide production at low oxygen concentrations by modifying the redox state of cytochrome c oxidase. Proc Natl Acad Sci U S A (2004) 1.34
Inhibition of cellular respiration by endogenously produced carbon monoxide. J Cell Sci (2006) 1.29
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A (2004) 1.26
S-nitrosation of mitochondrial complex I depends on its structural conformation. J Biol Chem (2007) 1.21
Commitment point during G0-->G1 that controls entry into the cell cycle. Mol Cell Biol (2003) 1.21
DNA replication licensing in somatic and germ cells. J Cell Sci (2004) 1.21
Rubisco activase is required for optimal photosynthesis in the green alga Chlamydomonas reinhardtii in a low-CO(2) atmosphere. Plant Physiol (2003) 1.21
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol (2003) 1.20
Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res (2006) 1.17
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. Eur Heart J (2005) 1.16
Nitric oxide, cytochrome C oxidase, and the cellular response to hypoxia. Arterioscler Thromb Vasc Biol (2009) 1.15
Molecular basis for the differential use of glucose and glutamine in cell proliferation as revealed by synchronized HeLa cells. Proc Natl Acad Sci U S A (2011) 1.15
Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. J Biol Chem (2004) 1.14
Cell cycle markers in clinical oncology. Curr Opin Cell Biol (2007) 1.12
Lack of oxygen deactivates mitochondrial complex I: implications for ischemic injury? J Biol Chem (2009) 1.10
Hexameric ring structure of human MCM10 DNA replication factor. EMBO Rep (2007) 1.10
Mitochondrial biogenesis as a cellular signaling framework. Biochem Pharmacol (2004) 1.09
Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells. Exp Cell Res (2005) 1.07
Nitric oxide: orchestrating hypoxia regulation through mitochondrial respiration and the endoplasmic reticulum stress response. Cell Res (2005) 1.07
Inhibition of mitochondrial respiration by endogenous nitric oxide: a critical step in Fas signaling. Proc Natl Acad Sci U S A (2002) 1.07
Discrepancies between nitroglycerin and NO-releasing drugs on mitochondrial oxygen consumption, vasoactivity, and the release of NO. Circ Res (2005) 1.05
Cytochrome c oxidase regulates endogenous nitric oxide availability in respiring cells: a possible explanation for hypoxic vasodilation. Proc Natl Acad Sci U S A (2007) 1.04
Biomarkers in bladder cancer. Histopathology (2010) 1.04
Molecular architecture of the DNA replication origin activation checkpoint. EMBO J (2010) 1.04
Fulfilling the metabolic requirements for cell proliferation. Biochem J (2012) 1.00
Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies. J Physiol (2003) 1.00
GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. Br J Pharmacol (2005) 1.00
Monitoring cytochrome redox changes in the mitochondria of intact cells using multi-wavelength visible light spectroscopy. Biochim Biophys Acta (2003) 0.99
Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Pathol (2010) 0.99
Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res (2009) 0.98
Nitric oxide from inflammatory-activated glia synergizes with hypoxia to induce neuronal death. J Neurosci Res (2004) 0.96
Employment precariousness and poor mental health: evidence from Spain on a new social determinant of health. J Environ Public Health (2013) 0.95
DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma. Clin Cancer Res (2007) 0.95
Inhibition of mitochondrial respiration by the anticancer agent 2-methoxyestradiol. Biochem Biophys Res Commun (2004) 0.95
Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascul Pharmacol (2003) 0.95
The Employment Precariousness Scale (EPRES): psychometric properties of a new tool for epidemiological studies among waged and salaried workers. Occup Environ Med (2010) 0.93
Cdc6 is a rate-limiting factor for proliferative capacity during HL60 cell differentiation. Exp Cell Res (2007) 0.93
Retracted Mitochondrial dysfunction and HIF1alpha stabilization in inflammation. J Cell Sci (2008) 0.92
Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt. Mol Pharmacol (2003) 0.91
Molecular structure of human geminin. Nat Struct Mol Biol (2004) 0.91
Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide. J Cell Sci (2006) 0.91
NHS "reform" in England: where is the public interest? BMJ (2012) 0.91
Increased expression of arginase II in patients with different forms of arthritis. Implications of the regulation of nitric oxide. J Rheumatol (2002) 0.89
Nitric oxide from inducible nitric oxide synthase sensitizes the inflamed aorta to hypoxic damage via respiratory inhibition. Shock (2005) 0.88
Employment precariousness in Spain: prevalence, social distribution, and population-attributable risk percent of poor mental health. Int J Health Serv (2011) 0.87
DNA replication licensing in peripheral B-cell lymphoma. J Pathol (2005) 0.87
Characterization of the non-nitrergic NANC relaxation responses in the rabbit vaginal wall. Br J Pharmacol (2002) 0.86
Expression of Ki67, PCNA and the chromosome replication licensing protein Mcm2 in glial cells of the ageing human hippocampus increases with the burden of Alzheimer-type pathology. Neurosci Lett (2005) 0.86
Elevated immunoglobulin E against recombinant Brugia malayi gamma-glutamyl transpeptidase in patients with bancroftian filariasis: association with tropical pulmonary eosinophilia or putative immunity. Infect Immun (2003) 0.86
Psychosocial factor exposures in the workplace: differences between immigrants and Spaniards. Eur J Public Health (2011) 0.85
DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma. Clin Cancer Res (2009) 0.85
Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival. Mol Cancer (2014) 0.84