Published in Nat Protoc on January 01, 2007
Mitochondrial DNA stress primes the antiviral innate immune response. Nature (2015) 3.82
A vaccine strategy that protects against genital herpes by establishing local memory T cells. Nature (2012) 3.65
Long-lived intestinal tuft cells serve as colon cancer-initiating cells. J Clin Invest (2014) 1.90
Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration. Proc Natl Acad Sci U S A (2009) 1.78
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
Species and strain differences in rodent sciatic nerve anatomy: implications for studies of neuropathic pain. Pain (2008) 1.65
Perineural invasion and associated pain in pancreatic cancer. Nat Rev Cancer (2011) 1.64
Rapid optical control of nociception with an ion-channel photoswitch. Nat Methods (2012) 1.33
Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons. Nat Neurosci (2013) 1.25
Interaction with phosphoinositides confers adaptation onto the TRPV1 pain receptor. PLoS Biol (2009) 1.22
Substance P signaling mediates BMP-dependent heterotopic ossification. J Cell Biochem (2011) 1.21
A neuron-specific role for autophagy in antiviral defense against herpes simplex virus. Cell Host Microbe (2012) 1.21
TRPV1 and TRPA1 function and modulation are target tissue dependent. J Neurosci (2011) 1.20
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology (2010) 1.20
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain (2008) 1.20
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1. J Allergy Clin Immunol (2013) 1.18
Decrease in phosphatidylinositol 4,5-bisphosphate levels mediates desensitization of the cold sensor TRPM8 channels. J Physiol (2011) 1.16
Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem (2011) 1.16
Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Mol Pain (2010) 1.15
An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. PLoS One (2014) 1.15
Sox11 transcription factor modulates peripheral nerve regeneration in adult mice. Brain Res (2008) 1.14
Purification and culture of dorsal root ganglion neurons. Cold Spring Harb Protoc (2014) 1.10
Neuroepithelial circuit formed by innervation of sensory enteroendocrine cells. J Clin Invest (2015) 1.09
Inhibition of Kinesin-5, a microtubule-based motor protein, as a strategy for enhancing regeneration of adult axons. Traffic (2011) 1.07
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nat Struct Mol Biol (2012) 1.07
Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil. Brain Res (2008) 1.06
Lentiviral gene transfer into the dorsal root ganglion of adult rats. Mol Pain (2011) 1.03
Tau pathology is present in vivo and develops in vitro in sensory neurons from human P301S tau transgenic mice: a system for screening drugs against tauopathies. J Neurosci (2013) 1.02
Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy. Nat Neurosci (2013) 1.01
Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice. Pain (2010) 0.99
Corneal neurotoxicity due to topical benzalkonium chloride. Invest Ophthalmol Vis Sci (2012) 0.99
Direct injection into the dorsal root ganglion: technical, behavioral, and histological observations. J Neurosci Methods (2011) 0.98
Painful, degenerating intervertebral discs up-regulate neurite sprouting and CGRP through nociceptive factors. J Cell Mol Med (2014) 0.95
G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci (2015) 0.94
Probing localized neural mechanotransduction through surface-modified elastomeric matrices and electrophysiology. Nat Protoc (2010) 0.94
Vascular endothelial growth factor promotes anatomical and functional recovery of injured peripheral nerves in the avascular cornea. FASEB J (2013) 0.92
TRPA1 mediates bladder hyperalgesia in a mouse model of cystitis. Pain (2014) 0.91
Defining the nociceptor transcriptome. Front Mol Neurosci (2014) 0.91
Immunogenicity and efficacy of intramuscular replication-defective and subunit vaccines against herpes simplex virus type 2 in the mouse genital model. PLoS One (2012) 0.91
Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception. Neuroscience (2011) 0.89
Insulin receptor substrate 2 expression and involvement in neuronal insulin resistance in diabetic neuropathy. Exp Diabetes Res (2011) 0.89
Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth. J Neurosci (2011) 0.89
Vaxfectin-adjuvanted plasmid DNA vaccine improves protection and immunogenicity in a murine model of genital herpes infection. J Gen Virol (2012) 0.89
The mast cell degranulator compound 48/80 directly activates neurons. PLoS One (2012) 0.88
Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol. J Neurosci (2013) 0.88
Complementary effects of two growth factors in multifunctionalized silk nanofibers for nerve reconstruction. PLoS One (2014) 0.88
The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol Pain (2011) 0.88
Vaginal memory T cells induced by intranasal vaccination are critical for protective T cell recruitment and prevention of genital HSV-2 disease. J Virol (2014) 0.88
Cyclosporine immunomodulation retards regeneration of surgically transected corneal nerves. Invest Ophthalmol Vis Sci (2012) 0.88
Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes. J Neurophysiol (2015) 0.87
Adenosine triphosphate drives head and neck cancer pain through P2X2/3 heterotrimers. Acta Neuropathol Commun (2014) 0.87
A novel DNA vaccine technology conveying protection against a lethal herpes simplex viral challenge in mice. PLoS One (2013) 0.86
Kv7.2 regulates the function of peripheral sensory neurons. J Comp Neurol (2014) 0.86
A simple, step-by-step dissection protocol for the rapid isolation of mouse dorsal root ganglia. BMC Res Notes (2016) 0.85
The PDZ-domain protein Whirlin facilitates mechanosensory signaling in mammalian proprioceptors. J Neurosci (2015) 0.85
Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury. PLoS One (2011) 0.85
Scaffolding by A-kinase anchoring protein enhances functional coupling between adenylyl cyclase and TRPV1 channel. J Biol Chem (2012) 0.85
Demethylating drugs as novel analgesics for cancer pain. Clin Cancer Res (2014) 0.84
Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling. Brain (2013) 0.84
A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. J Physiol (2013) 0.84
In vivo disruption of latent HSV by designer endonuclease therapy. JCI Insight (2016) 0.83
Direct live monitoring of heterotypic axon-axon interactions in vitro. Nat Protoc (2012) 0.83
Postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity. Sheng Li Xue Bao (2008) 0.83
Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome. Pain (2014) 0.83
Astrocytes in the optic nerve head express putative mechanosensitive channels. Mol Vis (2015) 0.83
Inhibition of Vascular Endothelial Growth Factor Receptor 2 Exacerbates Loss of Lower Motor Neurons and Axons during Experimental Autoimmune Encephalomyelitis. PLoS One (2016) 0.82
Cell-autonomous regulation of Mu-opioid receptor recycling by substance P. Cell Rep (2015) 0.82
The role of TLR4 in the paclitaxel effects on neuronal growth in vitro. PLoS One (2013) 0.81
TRPV1 expression level in isolectin B₄-positive neurons contributes to mouse strain difference in cutaneous thermal nociceptive sensitivity. J Neurophysiol (2015) 0.81
Genetically Targeted All-Optical Electrophysiology with a Transgenic Cre-Dependent Optopatch Mouse. J Neurosci (2016) 0.80
Microtubule-associated type II protein kinase A is important for neurite elongation. PLoS One (2013) 0.80
Therapeutic Benefit of Extended Thymosin β4 Treatment Is Independent of Blood Glucose Level in Mice with Diabetic Peripheral Neuropathy. J Diabetes Res (2015) 0.80
Potencies of cocaine methiodide on major cocaine targets in mice. PLoS One (2009) 0.80
Fish oil concentrate delays sensitivity to thermal nociception in mice. Pharmacol Res (2011) 0.80
Acid-sensing ion channels are tuned to follow high-frequency stimuli. J Physiol (2016) 0.80
Characterization of cutaneous and articular sensory neurons. Mol Pain (2016) 0.80
TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11. Neuroscience (2012) 0.79
Novel method to assess axonal excitability using channelrhodopsin-based photoactivation. J Neurophysiol (2015) 0.79
Artemin promotes functional long-distance axonal regeneration to the brainstem after dorsal root crush. Proc Natl Acad Sci U S A (2015) 0.79
Light-activated serotonin for exploring its action in biological systems. Chem Biol (2013) 0.79
Optimization of adult sensory neuron electroporation to study mechanisms of neurite growth. Front Mol Neurosci (2012) 0.79
In vitro models of axon regeneration. Exp Neurol (2016) 0.78
Human epidermal neural crest stem cells as a source of Schwann cells. Development (2015) 0.78
Structural and functional interactions between six-transmembrane μ-opioid receptors and β2-adrenoreceptors modulate opioid signaling. Sci Rep (2015) 0.78
Molecular and preclinical basis to inhibit PGE2 receptors EP2 and EP4 as a novel nonsteroidal therapy for endometriosis. Proc Natl Acad Sci U S A (2015) 0.77
Gi-DREADD Expression in Peripheral Nerves Produces Ligand-Dependent Analgesia, as well as Ligand-Independent Functional Changes in Sensory Neurons. J Neurosci (2016) 0.77
Fragile X mental retardation protein (FMRP) and the spinal sensory system. Results Probl Cell Differ (2012) 0.77
Preparation of primary neurons for visualizing neurites in a frozen-hydrated state using cryo-electron tomography. J Vis Exp (2014) 0.77
Protection from genital herpes disease, seroconversion and latent infection in a non-lethal murine genital infection model by immunization with an HSV-2 replication-defective mutant virus. Virology (2015) 0.77
Artemin Immunotherapy Is Effective in Preventing and Reversing Cystitis-Induced Bladder Hyperalgesia via TRPA1 Regulation. J Pain (2015) 0.76
VEGF-B promotes recovery of corneal innervations and trophic functions in diabetic mice. Sci Rep (2017) 0.76
The murine intravaginal HSV-2 challenge model for investigation of DNA vaccines. Methods Mol Biol (2014) 0.76
Muscle IL1β Drives Ischemic Myalgia via ASIC3-Mediated Sensory Neuron Sensitization. J Neurosci (2016) 0.76
Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion. Int J Inflam (2016) 0.76
δ-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones. Naunyn Schmiedebergs Arch Pharmacol (2011) 0.76
Neuronal cadherin (NCAD) increases sensory neurite formation and outgrowth on astrocytes. Neurosci Lett (2012) 0.76
Augmentation of glycolytic metabolism by meclizine is indispensable for protection of dorsal root ganglion neurons from hypoxia-induced mitochondrial compromise. Free Radic Biol Med (2016) 0.76
A central role for R7bp in the regulation of itch sensation. Pain (2017) 0.75
Red ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons. J Ginseng Res (2015) 0.75
Mask use, hand hygiene, and seasonal influenza-like illness among young adults: a randomized intervention trial. J Infect Dis (2010) 3.02
TRPV1 unlike TRPV2 is restricted to a subset of mechanically insensitive cutaneous nociceptors responding to heat. J Pain (2008) 2.56
Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J Neurosci (2004) 2.24
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci (2006) 1.82
Glial cell line-derived neurotrophic factor is a survival factor for isolectin B4-positive, but not vanilloid receptor 1-positive, neurons in the mouse. J Neurosci (2002) 1.81
Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci (2006) 1.76
Convergence of bladder and colon sensory innervation occurs at the primary afferent level. Pain (2006) 1.68
Glial cell-line-derived neurotrophic factor expression in skin alters the mechanical sensitivity of cutaneous nociceptors. J Neurosci (2006) 1.43
Differences in spinal distribution and neurochemical phenotype of colonic afferents in mouse and rat. J Comp Neurol (2006) 1.30
TRPV1 and TRPA1 function and modulation are target tissue dependent. J Neurosci (2011) 1.20
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology (2010) 1.20
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain (2008) 1.20
TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci (2013) 1.17
Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Mol Pain (2010) 1.15
Facemasks, hand hygiene, and influenza among young adults: a randomized intervention trial. PLoS One (2012) 1.11
Development, plasticity and modulation of visceral afferents. Brain Res Rev (2008) 1.11
The P2Y agonist UTP activates cutaneous afferent fibers. Pain (2004) 1.10
Cutaneous C-polymodal fibers lacking TRPV1 are sensitized to heat following inflammation, but fail to drive heat hyperalgesia in the absence of TPV1 containing C-heat fibers. Mol Pain (2010) 1.09
Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil. Brain Res (2008) 1.06
Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice. Am J Physiol Gastrointest Liver Physiol (2007) 1.06
TPRV1 expression defines functionally distinct pelvic colon afferents. J Neurosci (2009) 1.05
Reduced thermal sensitivity and Nav1.8 and TRPV1 channel expression in sensory neurons of aged mice. Neurobiol Aging (2005) 1.05
Distribution and neurochemical identification of pancreatic afferents in the mouse. J Comp Neurol (2008) 1.04
Overexpression of NGF or GDNF alters transcriptional plasticity evoked by inflammation. Pain (2005) 0.99
Neonatal colon insult alters growth factor expression and TRPA1 responses in adult mice. Pain (2010) 0.99
Palaeontology: Jurassic fossils and mammalian antiquity. Nature (2013) 0.98
Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation. Pain (2011) 0.98
The skin as a neurotrophic organ. Neuroscientist (2007) 0.97
Paleontology. Marsupial origins. Science (2003) 0.94
Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res (2014) 0.93
Phenotypic characterization of gastric sensory neurons in mice. Am J Physiol Gastrointest Liver Physiol (2006) 0.92
The P2Y2 receptor sensitizes mouse bladder sensory neurons and facilitates purinergic currents. J Neurosci (2010) 0.92
p21 (CDKN1A) is a negative regulator of p53 stability. Cell Cycle (2007) 0.91
NT3 expressed in skin causes enhancement of SA1 sensory neurons that leads to postnatal enhancement of Merkel cells. J Comp Neurol (2004) 0.91
Dichotomizing axons in spinal and vagal afferents of the mouse stomach. Dig Dis Sci (2007) 0.90
Neurturin overexpression in skin enhances expression of TRPM8 in cutaneous sensory neurons and leads to behavioral sensitivity to cool and menthol. J Neurosci (2013) 0.88
In search of analgesia: emerging roles of GPCRs in pain. Mol Interv (2009) 0.85
Phenotypic switching of nonpeptidergic cutaneous sensory neurons following peripheral nerve injury. PLoS One (2011) 0.85
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. Cancer Res (2002) 0.84
Overexpression of neurotrophin 4 in skin enhances myelinated sensory endings but does not influence sensory neuron number. J Comp Neurol (2006) 0.84
Rescue of NGF-deficient mice I: transgenic expression of NGF in skin rescues mice lacking endogenous NGF. Brain Res Mol Brain Res (2004) 0.83
Time and dose-dependent risk of pneumococcal pneumonia following influenza: a model for within-host interaction between influenza and Streptococcus pneumoniae. J R Soc Interface (2013) 0.83
Cell cycle arrest drastically extends the duration of gene silencing after transient expression of short hairpin RNA. Cell Cycle (2006) 0.83
Postnatal roles of glial cell line-derived neurotrophic factor family members in nociceptors plasticity. Sheng Li Xue Bao (2008) 0.83
Artemin growth factor increases nicotinic cholinergic receptor subunit expression and activity in nociceptive sensory neurons. Mol Pain (2014) 0.82
Altered inflammatory gene expression underlies increased susceptibility to murine postoperative ileus with advancing age. Am J Physiol Gastrointest Liver Physiol (2007) 0.79
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther (2006) 0.78
Heat detection without TRPV1. J Pain (2008) 0.77
Rescue of NGF-deficient mice II: basal forebrain cholinergic projections require NGF for target innervation but not guidance. Brain Res Mol Brain Res (2004) 0.76
Case reports: cutaneous small vessel vasculitis due to famciclovir therapy. J Drugs Dermatol (2005) 0.75
Thysanoptera dermatitis presenting as folie à deux. Arch Dermatol (2012) 0.75
Abdominal pain and the neurotrophic system in ulcerative colitis. Inflamm Bowel Dis (2014) 0.75
Single-well "push-pull" partitioning tracer test for NAPL detection in the subsurface. Environ Sci Technol (2002) 0.75