Published in J Neurosci on February 10, 2010
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology (2010) 1.20
Endogenous PI3K/Akt and NMDAR act independently in the regulation of CREB activity in lumbosacral spinal cord in cystitis. Exp Neurol (2013) 0.92
Distribution of ecto-nucleotidases in mouse sensory circuits suggests roles for nucleoside triphosphate diphosphohydrolase-3 in nociception and mechanoreception. Neuroscience (2011) 0.89
The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors. Mol Pain (2011) 0.88
Inhibition of G protein-coupled P2Y2 receptor induced analgesia in a rat model of trigeminal neuropathic pain. Mol Pain (2014) 0.87
Coupling of P2Y receptors to G proteins and other signaling pathways. Wiley Interdiscip Rev Membr Transp Signal (2015) 0.86
Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. Am J Physiol Regul Integr Comp Physiol (2014) 0.85
Neuroprotective roles of the P2Y(2) receptor. Purinergic Signal (2012) 0.84
In vivo regulation of brain-derived neurotrophic factor in dorsal root ganglia is mediated by nerve growth factor-triggered Akt activation during cystitis. PLoS One (2013) 0.81
P2Y Receptors Sensitize Mouse and Human Colonic Nociceptors. J Neurosci (2016) 0.80
P2Y receptors in Alzheimer's disease. Biol Cell (2014) 0.79
Receptors, channels, and signalling in the urothelial sensory system in the bladder. Nat Rev Urol (2016) 0.77
P2Y receptors in the mammalian nervous system: pharmacology, ligands and therapeutic potential. CNS Neurol Disord Drug Targets (2012) 0.77
Enhancement of purinergic signalling by excessive endogenous ATP in resiniferatoxin (RTX) neuropathy. Purinergic Signal (2012) 0.77
The roles of P2Y2 purinergic receptors in osteoblasts and mechanotransduction. PLoS One (2014) 0.76
Spinal astrocytic activation contributes to mechanical allodynia in a rat model of cyclophosphamide-induced cystitis. Mol Pain (2016) 0.75
Purinergic Signalling: Therapeutic Developments. Front Pharmacol (2017) 0.75
Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92
Molecular physiology of P2X receptors. Physiol Rev (2002) 13.61
Physiology and pathophysiology of purinergic neurotransmission. Physiol Rev (2007) 6.05
Unique features of action potential initiation in cortical neurons. Nature (2006) 4.49
ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes--a possible sensory mechanism? J Physiol (1997) 3.43
Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther (2005) 2.82
Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia. Proc Natl Acad Sci U S A (2001) 2.36
P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP. J Physiol (2005) 2.25
P2X receptors in peripheral neurons. Prog Neurobiol (2001) 1.91
Purinergic signalling. Br J Pharmacol (2006) 1.83
Cell damage excites nociceptors through release of cytosolic ATP. Pain (2002) 1.82
Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol (2003) 1.73
Possible involvement of P2Y2 metabotropic receptors in ATP-induced transient receptor potential vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci (2003) 1.69
Augmented stretch activated adenosine triphosphate release from bladder uroepithelial cells in patients with interstitial cystitis. J Urol (2001) 1.62
Bladder activation: afferent mechanisms. Urology (2002) 1.62
Quantitation of extracellular UTP using a sensitive enzymatic assay. Br J Pharmacol (1999) 1.61
P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci U S A (1996) 1.55
Neural upregulation in interstitial cystitis. Urology (2007) 1.52
Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J Physiol (2005) 1.44
Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. J Neurosci (2005) 1.33
Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J Neurophysiol (2007) 1.29
UTP as an extracellular signaling molecule. News Physiol Sci (2001) 1.28
Localisation of P2Y1 and P2Y4 receptors in dorsal root, nodose and trigeminal ganglia of the rat. Histochem Cell Biol (2003) 1.27
Neurons and glial cells differentially express P2Y receptor mRNAs in the rat dorsal root ganglion and spinal cord. J Comp Neurol (2006) 1.25
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain (2008) 1.20
Interstitial cystitis: a chronic pelvic pain syndrome. Med Clin North Am (2004) 1.18
Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin. J Neurosci (2005) 1.17
ATP and UTP excite sensory neurons and induce CREB phosphorylation through the metabotropic receptor, P2Y2. Eur J Neurosci (2002) 1.16
Increase in intracellular Ca(2+) and calcitonin gene-related peptide release through metabotropic P2Y receptors in rat dorsal root ganglion neurons. Neuroscience (2002) 1.12
P2Y receptors and pain transmission. Purinergic Signal (2004) 1.12
Sensitization of pelvic afferent nerves in the in vitro rat urinary bladder-pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment. Am J Physiol Renal Physiol (2008) 1.12
The P2Y agonist UTP activates cutaneous afferent fibers. Pain (2004) 1.10
Pressure, volume, and chemosensitivity in afferent innervation of urinary bladder in rats. Am J Physiol (1997) 1.07
Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol (2008) 1.03
Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats. J Neurophysiol (2001) 1.01
Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. J Physiol (2009) 0.97
Segmental localization of sensory cells that innervate the bladder. J Comp Neurol (1980) 0.96
Chronic pelvic pain of bladder origin: epidemiology, pathogenesis and quality of life. J Reprod Med (2004) 0.95
Afferent and sympathetic innervation of the dome and the base of the urinary bladder of the female rat. Brain Res Bull (1992) 0.94
Distribution of sacral afferent axons in cat urinary bladder. Am J Anat (1973) 0.94
ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors. Am J Physiol Regul Integr Comp Physiol (2006) 0.93
Regulation of human recombinant P2X3 receptors by ecto-protein kinase C. J Neurosci (2005) 0.92
Differential purinergic signaling in bladder sensory neurons of naïve and bladder-inflamed mice. Pain (2009) 0.91
Distribution of lumbar and sacral afferent axons in submucosa of cat urinary bladder. Anat Rec (1975) 0.90
Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis. Urology (2001) 0.87
Decrease of current responses at human recombinant P2X3 receptors after substitution by Asp of Ser/Thr residues in protein kinase C phosphorylation sites of their ecto-domains. Neurosci Lett (2005) 0.83
Basic and clinical aspects of visceral hyperalgesia. Gastroenterology (1994) 4.39
Characterization of a rat model of incisional pain. Pain (1996) 3.55
Chronic pain and medullary descending facilitation. Trends Neurosci (2002) 3.54
Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity. Nat Protoc (2007) 2.88
Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain (1993) 2.82
The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci (2005) 2.68
Visceral pain: a review of experimental studies. Pain (1990) 2.47
Colorectal distension as a noxious visceral stimulus: physiologic and pharmacologic characterization of pseudaffective reflexes in the rat. Brain Res (1988) 2.44
Possible chemical contribution from chromic gut sutures produces disorders of pain sensation like those seen in man. Pain (1993) 1.93
Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci U S A (1999) 1.89
Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo. J Neurosci (2006) 1.82
The role of steroids and their effects on phospholipase A2. An animal model of radiculopathy. Spine (Phila Pa 1976) (1998) 1.77
Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold. J Neurosci (2006) 1.76
A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neuroscience (1992) 1.57
Neural upregulation in interstitial cystitis. Urology (2007) 1.52
The possible role of glia in nociceptive processing and hyperalgesia in the spinal cord of the rat. Neuropharmacology (1994) 1.51
Effect of adjuvant drugs on the action of local anesthetics in isolated rat sciatic nerves. Reg Anesth Pain Med (2012) 1.49
Role of neurokinin 3 receptors on responses to colorectal distention in the rat: electrophysiological and behavioral studies. Gastroenterology (1999) 1.49
Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat. J Neurophysiol (1997) 1.48
Characterization of mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat. J Neurophysiol (1994) 1.47
Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J Physiol (2005) 1.44
Neurotoxicity of adjuvants used in perineural anesthesia and analgesia in comparison with ropivacaine. Reg Anesth Pain Med (2011) 1.40
Inside information: the unique features of visceral sensation. Mol Interv (2008) 1.38
TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J Neurosci (2004) 1.34
Acid-sensing properties in rat gastric sensory neurons from normal and ulcerated stomach. J Neurosci (2005) 1.33
Mechanosensitive properties of pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol (1994) 1.33
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat. Neuroscience (1992) 1.32
Characterization of Adelta- and C-fibers innervating the plantar rat hindpaw one day after an incision. J Neurophysiol (2002) 1.32
A psychophysiological study in humans using phasic colonic distension as a noxious visceral stimulus. Pain (1990) 1.32
Characterization of mouse lumbar splanchnic and pelvic nerve urinary bladder mechanosensory afferents. J Neurophysiol (2007) 1.29
Gastric ulcers reduce A-type potassium currents in rat gastric sensory ganglion neurons. Am J Physiol Gastrointest Liver Physiol (2003) 1.24
Descending facilitatory pathways from the RVM initiate and maintain bilateral hyperalgesia after muscle insult. Pain (2007) 1.24
Short-term sensitization of colon mechanoreceptors is associated with long-term hypersensitivity to colon distention in the mouse. Gastroenterology (2007) 1.21
Intracolonic zymosan produces visceral hyperalgesia in the rat that is mediated by spinal NMDA and non-NMDA receptors. Brain Res (1996) 1.21
Mechanosensitive pelvic nerve afferent fibers innervating the colon of the rat are polymodal in character. J Neurophysiol (1998) 1.20
Thermal nociception and TRPV1 function are attenuated in mice lacking the nucleotide receptor P2Y2. Pain (2008) 1.20
Synergistic role of TRPV1 and TRPA1 in pancreatic pain and inflammation. Gastroenterology (2010) 1.20
Quantitative assessment and characterization of visceral nociception and hyperalgesia in mice. Am J Physiol Gastrointest Liver Physiol (2002) 1.19
Visceral organ cross-sensitization - an integrated perspective. Auton Neurosci (2009) 1.19
Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology (2002) 1.18
The pharmacology of gastrointestinal nociceptive pathways. Curr Opin Pharmacol (2002) 1.18
Increased nerve growth factor expression triggers bladder overactivity. J Pain (2004) 1.18
TRPV1 and TRPA1 antagonists prevent the transition of acute to chronic inflammation and pain in chronic pancreatitis. J Neurosci (2013) 1.17
Peripheral and central P2X receptor contributions to colon mechanosensitivity and hypersensitivity in the mouse. Gastroenterology (2009) 1.17
Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-D-aspartate-produced facilitation of the nociceptive tail-flick reflex. Eur J Pharmacol (1992) 1.17
Differential responses of bladder lumbosacral and thoracolumbar dorsal root ganglion neurons to purinergic agonists, protons, and capsaicin. J Neurosci (2005) 1.17
Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways. Am J Physiol Gastrointest Liver Physiol (2005) 1.16
Effects of kappa opioids in the inflamed rat colon. Pain (1999) 1.15
Gi- and Gq-coupled ADP (P2Y) receptors act in opposition to modulate nociceptive signaling and inflammatory pain behavior. Mol Pain (2010) 1.15
Role of glutamate receptors and nitric oxide in the rostral ventromedial medulla in visceral hyperalgesia. Pain (1998) 1.15
Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. J Neurophysiol (1992) 1.14
Cyclophosphamide-induced bladder inflammation sensitizes and enhances P2X receptor function in rat bladder sensory neurons. J Neurophysiol (2007) 1.14
Characterization of silent afferents in the pelvic and splanchnic innervations of the mouse colorectum. Am J Physiol Gastrointest Liver Physiol (2010) 1.14
Irritable bowel syndrome: methods, mechanisms, and pathophysiology. Neural and neuro-immune mechanisms of visceral hypersensitivity in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol (2012) 1.14
Vagal afferent modulation of nociception. Brain Res Brain Res Rev (1992) 1.13
The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat. Neuroscience (1994) 1.13
Characterization of neuronal responses to noxious visceral and somatic stimuli in the medial lumbosacral spinal cord of the rat. J Neurophysiol (1987) 1.12
The effect of epidural injection of betamethasone or bupivacaine in a rat model of lumbar radiculopathy. Spine (Phila Pa 1976) (1998) 1.12
Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat. J Neurophysiol (1988) 1.11
Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat. J Neurophysiol (2002) 1.11
Further behavioral evidence that colorectal distension is a 'noxious' visceral stimulus in rats. Neurosci Lett (1991) 1.10
Convergence of sensory pathways in the development of somatic and visceral hypersensitivity. Am J Physiol Gastrointest Liver Physiol (2006) 1.10
Descending facilitatory influences from the rostral medial medulla mediate secondary, but not primary hyperalgesia in the rat. Neuroscience (1999) 1.10
The P2Y agonist UTP activates cutaneous afferent fibers. Pain (2004) 1.10
Facilitation and attenuation of a visceral nociceptive reflex from the rostroventral medulla in the rat. Gastroenterology (2002) 1.09
Models of gastric hyperalgesia in the rat. Am J Physiol Gastrointest Liver Physiol (2002) 1.07
Differential c-fos expression in the nucleus of the solitary tract and spinal cord following noxious gastric distention in the rat. Neuroscience (1996) 1.06
Tonic cholinergic inhibition of spinal mechanical transmission. Pain (1991) 1.05
Noxious colorectal distention induced-c-Fos protein in limbic brain structures in the rat. Neurosci Lett (1996) 1.05
Capsaicin sensitivity and voltage-gated sodium currents in colon sensory neurons from rat dorsal root ganglia. Am J Physiol (1999) 1.05
Spinal serotonin receptors mediate descending facilitation of a nociceptive reflex from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Res (1991) 1.04
Effects of opioids on mechanosensitive pelvic nerve afferent fibers innervating the urinary bladder of the rat. J Neurophysiol (1997) 1.04
Characterization of mechanosensitive splanchnic nerve afferent fibers innervating the rat stomach. Am J Physiol Gastrointest Liver Physiol (2001) 1.04
Acute effect of an incision on mechanosensitive afferents in the plantar rat hindpaw. J Neurophysiol (2002) 1.03
Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain (1990) 1.03
Effects of intracolonic acetic acid on responses to colorectal distension in the rat. Brain Res (1995) 1.03
Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin. Life Sci (1979) 1.02
The peptide content of colonic afferents decreases following colonic inflammation. Peptides (1999) 1.02
Inhibition of spinal nociceptive transmission from the midbrain, pons and medulla in the rat: activation of descending inhibition by morphine, glutamate and electrical stimulation. Brain Res (1988) 1.02
Central mechanisms in pain. Med Clin North Am (1999) 1.02
Kappa, but not mu or delta, opioids attenuate responses to distention of afferent fibers innervating the rat colon. Gastroenterology (1996) 1.01
Mouse colon sensory neurons detect extracellular acidosis via TRPV1. Am J Physiol Cell Physiol (2007) 1.00
Spinal mu and delta, but not kappa, opioid-receptor agonists attenuate responses to noxious colorectal distension in the rat. Pain (1995) 0.99
Applied principles of neurogastroenterology: physiology/motility sensation. Gastroenterology (2006) 0.99
Fos-like proteins in the lumbosacral spinal cord following noxious and non-noxious colorectal distention in the rat. Pain (1992) 0.99
A distension control device useful for quantitative studies of hollow organ sensation. Physiol Behav (1987) 0.98
Analgesic synergy between intrathecal opioids and local anesthetics. Anesth Analg (1991) 0.98
Purinergic receptor P2Y1 regulates polymodal C-fiber thermal thresholds and sensory neuron phenotypic switching during peripheral inflammation. Pain (2011) 0.98
Interactions between visceral and cutaneous nociception in the rat. II. Noxious visceral stimuli inhibit cutaneous nociceptive neurons and reflexes. J Neurophysiol (1991) 0.98
Long-term sensitization of mechanosensitive and -insensitive afferents in mice with persistent colorectal hypersensitivity. Am J Physiol Gastrointest Liver Physiol (2012) 0.98
Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission. Pain (1993) 0.97
Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat. Brain Res (1991) 0.97
Mechanosensitive properties of gastric vagal afferent fibers in the rat. J Neurophysiol (1999) 0.97
Characterization of coeruleospinal inhibition of the nociceptive tail-flick reflex in the rat: mediation by spinal alpha 2-adrenoceptors. Brain Res (1986) 0.97
Cystitis increases colorectal afferent sensitivity in the mouse. Am J Physiol Gastrointest Liver Physiol (2009) 0.97
Interactions between visceral and cutaneous nociception in the rat. I. Noxious cutaneous stimuli inhibit visceral nociceptive neurons and reflexes. J Neurophysiol (1991) 0.96