Published in J Cell Biol on April 02, 2007
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev (2010) 3.27
Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci (2011) 2.51
Agonist-selective mechanisms of GPCR desensitization. Br J Pharmacol (2007) 2.17
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem (2010) 2.06
Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci (2008) 2.03
G-protein-coupled receptor phosphorylation: where, when and by whom. Br J Pharmacol (2008) 1.44
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code. J Biol Chem (2010) 1.40
Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors. Traffic (2010) 1.35
Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci Signal (2011) 1.25
GPCRs regulate the assembly of a multienzyme complex for purine biosynthesis. Nat Chem Biol (2011) 1.15
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A (2010) 1.15
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol (2011) 1.00
Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J Biol Chem (2013) 0.97
Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor. J Neurochem (2012) 0.93
Role of Phosphorylation in the Control of Clathrin-Mediated Internalization of GPCR. Int J Cell Biol (2011) 0.90
CK2 negatively regulates Galphas signaling. Proc Natl Acad Sci U S A (2009) 0.84
Endothelin-1 receptor antagonists regulate cell surface-associated protein disulfide isomerase in sickle cell disease. FASEB J (2013) 0.83
A G Protein-biased Designer G Protein-coupled Receptor Useful for Studying the Physiological Relevance of Gq/11-dependent Signaling Pathways. J Biol Chem (2016) 0.81
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. J Biol Chem (2009) 0.81
Induction of cardiac fibrosis by β-blocker in G protein-independent and G protein-coupled receptor kinase 5/β-arrestin2-dependent Signaling pathways. J Biol Chem (2012) 0.81
A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Mol Cell Proteomics (2008) 0.81
CK2 phosphorylation of an acidic Ser/Thr di-isoleucine motif in the Na+/H+ exchanger NHE5 isoform promotes association with beta-arrestin2 and endocytosis. J Biol Chem (2011) 0.80
Roles of the α1A-adrenergic receptor carboxyl tail in protein kinase C-induced phosphorylation and desensitization. Naunyn Schmiedebergs Arch Pharmacol (2010) 0.80
CK2-An Emerging Target for Neurological and Psychiatric Disorders. Pharmaceuticals (Basel) (2017) 0.78
CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo. Proc Natl Acad Sci U S A (2015) 0.78
Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling. Mol Pharmacol (2012) 0.78
How adenylate cyclase choreographs the pas de deux of the receptors heteromerization dance. Neuroscience (2013) 0.78
Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins. Sci Rep (2016) 0.77
ERK5 activation by Gq-coupled muscarinic receptors is independent of receptor internalization and β-arrestin recruitment. PLoS One (2013) 0.77
Measurement of inositol 1,4,5-trisphosphate in living cells using an improved set of resonance energy transfer-based biosensors. PLoS One (2015) 0.76
Unraveling a molecular determinant for clathrin-independent internalization of the M2 muscarinic acetylcholine receptor. Sci Rep (2015) 0.75
Muscarinic receptor regulates extracellular signal regulated kinase by two modes of arrestin binding. Proc Natl Acad Sci U S A (2017) 0.75
Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J (1995) 14.45
Seven-transmembrane receptors. Nat Rev Mol Cell Biol (2002) 11.50
One-thousand-and-one substrates of protein kinase CK2? FASEB J (2003) 6.89
Mammalian G proteins and their cell type specific functions. Physiol Rev (2005) 4.40
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci U S A (2003) 3.99
The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A (2003) 3.24
GPS: a comprehensive www server for phosphorylation sites prediction. Nucleic Acids Res (2005) 2.44
Multifaceted roles of beta-arrestins in the regulation of seven-membrane-spanning receptor trafficking and signalling. Biochem J (2003) 2.42
Mice lacking the M3 muscarinic acetylcholine receptor are hypophagic and lean. Nature (2001) 2.39
A functional role for the two-pore domain potassium channel TASK-1 in cerebellar granule neurons. Proc Natl Acad Sci U S A (2000) 2.01
Characterization of agonist stimulation of cAMP-dependent protein kinase and G protein-coupled receptor kinase phosphorylation of the beta2-adrenergic receptor using phosphoserine-specific antibodies. Mol Pharmacol (2004) 1.79
2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2. Biochem Biophys Res Commun (2004) 1.70
Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells. Biochemistry (2005) 1.34
Localization of the sites mediating desensitization of the beta(2)-adrenergic receptor by the GRK pathway. Mol Pharmacol (2000) 1.32
c-Src tyrosine kinase binds the beta 2-adrenergic receptor via phospho-Tyr-350, phosphorylates G-protein-linked receptor kinase 2, and mediates agonist-induced receptor desensitization. J Biol Chem (2001) 1.25
Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation. J Biol Chem (1993) 1.21
Phosphorylation and regulation of a Gq/11-coupled receptor by casein kinase 1alpha. J Biol Chem (2000) 1.17
Sequestration of human muscarinic acetylcholine receptor hm1-hm5 subtypes: effect of G protein-coupled receptor kinases GRK2, GRK4, GRK5 and GRK6. J Pharmacol Exp Ther (1998) 1.09
Analysis of ligand-stimulated CC chemokine receptor 5 (CCR5) phosphorylation in intact cells using phosphosite-specific antibodies. J Biol Chem (2002) 1.09
Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)-muscarinic receptor and their role in receptor regulation. J Biol Chem (2000) 1.07
Specificity of g protein-coupled receptor kinase 6-mediated phosphorylation and regulation of single-cell m3 muscarinic acetylcholine receptor signaling. Mol Pharmacol (2003) 1.05
G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. Am J Physiol Lung Cell Mol Physiol (2003) 1.05
Caspase-mediated apoptosis in neuronal excitotoxicity triggered by nitric oxide. Mol Med (1997) 1.03
Hierarchical phosphorylation of delta-opioid receptor regulates agonist-induced receptor desensitization and internalization. J Biol Chem (2000) 1.03
Phosphorylation of the Gq/11-coupled m3-muscarinic receptor is involved in receptor activation of the ERK-1/2 mitogen-activated protein kinase pathway. J Biol Chem (2000) 1.03
Development and exploitation of CK2 inhibitors. Mol Cell Biochem (2005) 1.00
Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function. J Biol Chem (2001) 1.00
The C-terminal tail of the M3-muscarinic receptor possesses anti-apoptotic properties. J Biol Chem (2003) 0.98
Cholinergic stimulation of amylase secretion from pancreatic acinar cells studied with muscarinic acetylcholine receptor mutant mice. J Pharmacol Exp Ther (2005) 0.96
Identification of a novel receptor kinase that phosphorylates a phospholipase C-linked muscarinic receptor. J Biol Chem (1996) 0.91
Activation of the mitogen-activated protein kinase pathway by a Gq/11-coupled muscarinic receptor is independent of receptor internalization. J Biol Chem (1999) 0.90
Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway. Biochem J (2004) 0.90
Phosphorylation of a phosphoinositidase C-linked muscarinic receptor by a novel kinase distinct from beta-adrenergic receptor kinase. FEBS Lett (1993) 0.90
Cyclic AMP has distinct effects from Ca(2+) in evoking priming and fusion/exocytosis in parotid amylase secretion. Pflugers Arch (2002) 0.87
Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation. Trends Pharmacol Sci (2002) 0.83
Roles of cholecystokinin receptor phosphorylation in agonist-stimulated desensitization of pancreatic acinar cells and receptor-bearing Chinese hamster ovary cholecystokinin receptor cells. Mol Pharmacol (1997) 0.81
Muscarinic m3 receptors and dynamics of intracellular Ca2+ cerebellar granule neurons. Eur J Pharmacol (1993) 0.78
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat Med (2003) 2.97
Matuzumab binding to EGFR prevents the conformational rearrangement required for dimerization. Cancer Cell (2008) 2.21
Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum. Nat Commun (2011) 1.77
Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias. J Biol Chem (2010) 1.46
Differential G-protein-coupled receptor phosphorylation provides evidence for a signaling bar code. J Biol Chem (2010) 1.40
Phosphorylation by casein kinase 2 induces PACS-1 binding of nephrocystin and targeting to cilia. EMBO J (2005) 1.35
Protein kinases of malaria parasites: an update. Trends Parasitol (2008) 1.29
Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. J Biol Chem (2003) 1.27
G-protein-coupled receptor regulation of P2X1 receptors does not involve direct channel phosphorylation. Biochem J (2004) 1.22
The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonism. Mol Pharmacol (2013) 1.18
Mechanism of B-cell receptor-induced phosphorylation and activation of phospholipase C-gamma2. Mol Cell Biol (2004) 1.17
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A (2010) 1.15
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
Mechanism of tyrosine phosphorylation and activation of phospholipase C-gamma 1. Tyrosine 783 phosphorylation is not sufficient for lipase activation. J Biol Chem (2004) 1.11
Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications. Clin Cancer Res (2003) 1.09
The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation. J Biol Chem (2008) 1.01
Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptor. J Biol Chem (2004) 1.01
Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol (2011) 1.00
Co-ordinated covalent modification of G-protein coupled receptors. Curr Pharm Des (2006) 0.99
The C-terminal tail of the M3-muscarinic receptor possesses anti-apoptotic properties. J Biol Chem (2003) 0.98
The tyrosine kinase Pyk2 regulates Arf1 activity by phosphorylation and inhibition of the Arf-GTPase-activating protein ASAP1. J Biol Chem (2003) 0.98
A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. PLoS Pathog (2012) 0.97
An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission. Cell Rep (2013) 0.95
Insights into the Plasmodium falciparum schizont phospho-proteome. Microbes Infect (2012) 0.95
Protective autophagy is involved in resistance towards MET inhibitors in human gastric adenocarcinoma cells. Biochem Biophys Res Commun (2013) 0.95
Regulation of casein kinase-2 (CK2) activity by inositol phosphates. J Biol Chem (2004) 0.94
Identification of phosphorylation sites in the COOH-terminal tail of the μ-opioid receptor. J Neurochem (2012) 0.93
Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal (2003) 0.92
Autocatalytic formation of green heme: evidence for H2O2-dependent formation of a covalent methionine-heme linkage in ascorbate peroxidase. J Am Chem Soc (2004) 0.90
Signalling of the M3-muscarinic receptor to the anti-apoptotic pathway. Biochem J (2004) 0.90
A putative homologue of CDC20/CDH1 in the malaria parasite is essential for male gamete development. PLoS Pathog (2012) 0.89
EMD 1214063 and EMD 1204831 constitute a new class of potent and highly selective c-Met inhibitors. Clin Cancer Res (2013) 0.89
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS Lett (2002) 0.88
Full and partial agonists of muscarinic M3 receptors reveal single and oscillatory Ca2+ responses by beta 2-adrenoceptors. J Pharmacol Exp Ther (2009) 0.87
Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor. J Biol Chem (2012) 0.87
Nephrocystin-4 regulates Pyk2-induced tyrosine phosphorylation of nephrocystin-1 to control targeting to monocilia. J Biol Chem (2011) 0.87
The proto-oncogene SET interacts with muscarinic receptors and attenuates receptor signaling. J Biol Chem (2006) 0.87
An evolutionary perspective on the kinome of malaria parasites. Philos Trans R Soc Lond B Biol Sci (2012) 0.85
Regulated and constitutive activation of specific signalling pathways by the human S1P5 receptor. Br J Pharmacol (2003) 0.85
Physiological role of G-protein coupled receptor phosphorylation. Handb Exp Pharmacol (2012) 0.85
The reactivity of heme in biological systems: autocatalytic formation of both tyrosine-heme and tryptophan-heme covalent links in a single protein architecture. Biochemistry (2007) 0.84
Autocatalytic formation of a covalent link between tryptophan 41 and the heme in ascorbate peroxidase. Biochemistry (2007) 0.82
Peroxide-dependent formation of a covalent link between Trp51 and the heme in cytochrome c peroxidase. Biochemistry (2009) 0.81
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. J Biol Chem (2009) 0.81
The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. PLoS Pathog (2013) 0.81
Comparative analysis of functional assays for characterization of agonist ligands at G protein-coupled receptors. J Biomol Screen (2003) 0.80
Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling. Mol Pharmacol (2012) 0.78
The novel ATP-competitive inhibitor of the MET hepatocyte growth factor receptor EMD1214063 displays inhibitory activity against selected MET-mutated variants. Mol Cancer Ther (2013) 0.77
The role of M(3)-muscarinic receptor signaling in insulin secretion. Commun Integr Biol (2011) 0.77
Parasite protein kinases: at home and abroad. Cell Host Microbe (2010) 0.77
Examining site-specific GPCR phosphorylation. Methods Mol Biol (2011) 0.76
Protein kinase Cdelta as gonadotropin-releasing hormone target isoenzyme in the alphaT3-1 gonadotrope cell line. Neuroendocrinology (2004) 0.76
M1 muscarinic allosteric modulators slow prion neurodegeneration and restore memory loss. J Clin Invest (2016) 0.75
Assay and functional properties of the tyrosine kinase Pyk2 in regulation of Arf1 through ASAP1 phosphorylation. Methods Enzymol (2005) 0.75
Conformationally constrained mimetics of laminin peptide YIGSR as precursors for antimetastatic disintegrins. J Med Chem (2009) 0.75