Published in Trends Pharmacol Sci on July 06, 2008
Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol Bull (2011) 4.27
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery. Pharmacol Rev (2010) 3.27
β-Arrestin-mediated receptor trafficking and signal transduction. Trends Pharmacol Sci (2011) 3.02
Diversity and modularity of G protein-coupled receptor structures. Trends Pharmacol Sci (2011) 2.89
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem (2010) 2.06
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The state of the human proteome in 2012 as viewed through PeptideAtlas. J Proteome Res (2012) 1.72
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Signal transduction by protease-activated receptors. Br J Pharmacol (2010) 1.64
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New concepts in pharmacological efficacy at 7TM receptors: IUPHAR review 2. Br J Pharmacol (2013) 1.43
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RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Proc Natl Acad Sci U S A (2010) 1.25
Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci Signal (2011) 1.25
Constitutive internalization of G protein-coupled receptors and G proteins via clathrin-independent endocytosis. J Biol Chem (2008) 1.19
The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A (2010) 1.15
Functionalized congener approach to the design of ligands for G protein-coupled receptors (GPCRs). Bioconjug Chem (2009) 1.15
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
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Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL). Mol Pharmacol (2011) 1.00
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Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network. J Biol Chem (2013) 0.97
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Novel GPCR paradigms at the μ-opioid receptor. Br J Pharmacol (2014) 0.93
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G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei--serpentine gateways to neuroendocrine homeostasis. Front Neuroendocrinol (2011) 0.92
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A finer tuning of G-protein signaling through regulated control of RGS proteins. Am J Physiol Heart Circ Physiol (2012) 0.91
CGRP in the trigeminovascular system: a role for CGRP, adrenomedullin and amylin receptors? Br J Pharmacol (2013) 0.90
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Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis. Traffic (2009) 0.90
Quantitative analysis of neuropeptide Y receptor association with beta-arrestin2 measured by bimolecular fluorescence complementation. Br J Pharmacol (2010) 0.90
Functional selectivity of GPCR signaling in animals. Curr Opin Cell Biol (2013) 0.90
Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human β-adrenoceptors. J Med Chem (2011) 0.89
GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors. J Biol Chem (2012) 0.88
Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail. J Biol Chem (2010) 0.88
Regulation of G protein-coupled receptors by allosteric ligands. ACS Chem Neurosci (2013) 0.87
Concomitant action of structural elements and receptor phosphorylation determines arrestin-3 interaction with the free fatty acid receptor FFA4. J Biol Chem (2014) 0.87
Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation. Br J Pharmacol (2012) 0.86
Identification of serine 348 on the apelin receptor as a novel regulatory phosphorylation site in apelin-13-induced G protein-independent biased signaling. J Biol Chem (2014) 0.84
Tuning up the right signal: chemical and genetic approaches to study GPCR functions. Curr Opin Cell Biol (2013) 0.84
S-nitrosylation-regulated GPCR signaling. Biochim Biophys Acta (2011) 0.83
G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs). J Biol Chem (2015) 0.83
Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs. PLoS One (2011) 0.83
Norbin: A promising central nervous system regulator. Commun Integr Biol (2010) 0.82
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Testosterone is essential for alpha(2)-adrenoceptor-induced antinociception in the trigeminal region of the male rat. Neurosci Lett (2009) 0.81
N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons. J Biol Chem (2009) 0.81
C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife (2015) 0.80
Arrestins differentially regulate histamine- and oxytocin-evoked phospholipase C and mitogen-activated protein kinase signalling in myometrial cells. Br J Pharmacol (2011) 0.80
Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. Nat Rev Mol Cell Biol (2016) 0.79
Engineered hyperphosphorylation of the β2-adrenoceptor prolongs arrestin-3 binding and induces arrestin internalization. Mol Pharmacol (2014) 0.78
Critical metabolic roles of β-cell M3 muscarinic acetylcholine receptors. Life Sci (2012) 0.78
Interhelical interaction and receptor phosphorylation regulate the activation kinetics of different human β1-adrenoceptor variants. J Biol Chem (2014) 0.78
EGFR phosphorylates and inhibits lung tumor suppressor GPRC5A in lung cancer. Mol Cancer (2014) 0.78
A naturally occurring GIP receptor variant undergoes enhanced agonist-induced desensitization, which impairs GIP control of adipose insulin sensitivity. Mol Cell Biol (2014) 0.78
ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells. Br J Pharmacol (2013) 0.78
A single amino acid residue controls Ca2+ signaling by an octopamine receptor from Drosophila melanogaster. FASEB J (2011) 0.78
CK2 acts as a potent negative regulator of receptor-mediated insulin release in vitro and in vivo. Proc Natl Acad Sci U S A (2015) 0.78
Influence of the accessory protein SET on M3 muscarinic receptor phosphorylation and G protein coupling. Mol Pharmacol (2012) 0.78
Constitutive phosphorylation by protein kinase C regulates D1 dopamine receptor signaling. J Neurochem (2010) 0.78
An Antibody Biosensor Establishes the Activation of the M1 Muscarinic Acetylcholine Receptor during Learning and Memory. J Biol Chem (2016) 0.78
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Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins. Sci Rep (2016) 0.77
Identification and functional characterization of the phosphorylation sites of the neuropeptide FF2 receptor. J Biol Chem (2014) 0.77
Phosphorylation and Internalization of Lysophosphatidic Acid Receptors LPA1, LPA2, and LPA3. PLoS One (2015) 0.77
Multiple regulatory roles of the carboxy terminus of Ste2p a yeast GPCR. Pharmacol Res (2011) 0.77
Predicting G protein-coupled receptor downstream signaling by tissue expression. Bioinformatics (2016) 0.76
Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling. Biochem J (2016) 0.75
Cardiac β2-Adrenergic Receptor Phosphorylation at Ser355/356 Regulates Receptor Internalization and Functional Resensitization. PLoS One (2016) 0.75
Novel Structural Approaches to Study GPCR Regulation. Int J Mol Sci (2016) 0.75
G protein-coupled receptor kinases as regulators of dopamine receptor functions. Pharmacol Res (2016) 0.75
Sequence-Specific Regulation of Endocytic Lifetimes Modulates Arrestin-Mediated Signaling at the µ Opioid Receptor. Mol Pharmacol (2017) 0.75
Analysis of Chemokine Receptor Trafficking by Site-Specific Biotinylation. PLoS One (2016) 0.75
Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific. Mol Pharmacol (2015) 0.75
Probing the stoichiometry of β2-adrenergic receptor phosphorylation by targeted mass spectrometry. J Mol Signal (2014) 0.75
The Diverse Roles of Arrestin Scaffolds in G Protein-Coupled Receptor Signaling. Pharmacol Rev (2017) 0.75
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The structural basis of arrestin-mediated regulation of G-protein-coupled receptors. Pharmacol Ther (2006) 3.15
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beta-Arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J Biol Chem (2004) 1.39
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AKAP79-mediated targeting of the cyclic AMP-dependent protein kinase to the beta1-adrenergic receptor promotes recycling and functional resensitization of the receptor. J Biol Chem (2006) 1.28
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Phosphorylation of the endogenous thyrotropin-releasing hormone receptor in pituitary GH3 cells and pituitary tissue revealed by phosphosite-specific antibodies. J Biol Chem (2007) 1.17
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M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1. Proc Natl Acad Sci U S A (2010) 1.15
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